Aging is not a linear process as many people think it is. While your chronological age may say a certain number, the way you live could cause you to be biologically older. Our chronological age is based on the number of years we have lived; however, our biological age could be higher or lower, based on how healthy our lifestyle choices are.

As we know, till a certain age, our body keeps growing and then comes to a halt. Studies like the 2013 study published in the Neuropsychiatric Disease and Treatment journal explain that our brain’s development is not complete until the age of 25, especially the prefrontal cortex. Like every living being, if we are developing, we will eventually deteriorate as well. However, at what age does this deterioration begin?

A groundbreaking study published in Nature Medicine found that a simple blood test can reliably estimate a person's age by analyzing the levels of hundreds of proteins. This "proteomic clock" offers a fascinating insight: biological aging isn't a smooth, linear process. Instead, it appears to accelerate in distinct phases.

Key Ages of Accelerated Aging

The study identified three significant periods when aging seems to speed up, on average: around ages 34, 60, and 78. Notably, the research suggests that the average person begins to show signs of physical deterioration as early as 34 years old. Based on these findings, "adulthood" was categorized as 34 to 60 years, "late maturity" from 60 to 78 years, and "old age" from 78 years onward.

To build this "proteomic clock," the scientists collected blood plasma (the liquid part of blood) from over 4,200 healthy people, ranging in age from 18 to 95. They used the information from more than half of these people to create their "clock." This clock was then able to correctly guess the age of the remaining people in the study. What's even more impressive is that they could make accurate age guesses using just 373 of the almost 3,000 proteins they first looked at. They even found that they could get a decent guess with as few as nine key proteins!

The study also showed that people whose blood proteins made them seem biologically younger than their actual age also did better on tests that measured how well their brain and body worked.

What This Means for Our Future

These findings have significant implications. This research suggests the potential for a blood test that could identify individuals who are biologically aging faster than their chronological age. Such individuals might be at a higher risk for age-related health issues like cardiovascular problems, Alzheimer's disease, and osteoarthritis earlier in life.

Furthermore, this research offers hope for developing interventions that could potentially slow down this "proteomic clock," keeping people biologically younger for longer. While it may sound like science fiction, the same research team has previously shown that it's possible to rejuvenate an older mouse by infusing it with blood from a younger mouse, hinting at future anti-aging treatments.

The discovery that the first burst of accelerated aging occurs in early mid-life, around age 34, is particularly intriguing, as it's well before the typical onset of noticeable aging signs and related health problems.

Lower back pain is a constant issue for many people. While it may seem like a minor inconvenience to some, it can severely impact their quality of life. For people who are suffering from ongoing back pain, finding relief can be incredibly challenging.

While there are medications available, there are side-effects one must consider. However, new research suggests that two types of therapy might offer a promising solution, especially for those who have been relying on opioid medications.

Therapies Show Promise for Opioid Users

A study published April 7 in JAMA Network Open found that mindfulness-based therapy (MBT) and cognitive behavioral therapy (CBT) significantly improved the quality of life for people managing chronic low back pain with opioids. Participants reported less pain and were able to reduce their opioid dosages in the months following the start of these therapies.

Researchers noted that the participants had lived with moderate to severe back pain for a long time, most for over five years, and had tried many other treatments without success. The improvements seen were therefore even more significant.

Addressing a Common and Stubborn Problem

Chronic low back pain affects a large number of people; data suggests that as many as 28% of Americans experience it. Despite its prevalence, effective treatments are often hard to come by. One study in March found that only 10% of non-surgical treatments for lower back pain actually work. This led researchers to explore whether CBT and MBT could offer a better approach.

Cognitive Behavioral Therapy (CBT) helps patients identify negative thoughts and behaviors, then uses problem-solving and self-reflection to change those patterns.

Mindfulness-Based Therapy (MBT) teaches people to observe their bodily sensations, feelings, and thoughts without reacting to them, often through meditation to focus on the present moment.

Promising Results from the Study

The study involved 770 adults who were using opioids for their chronic low back pain. On average, participants were about 58 years old and experienced moderate-to-severe pain, limitations in their daily activities, and a reduced quality of life.

Half of the participants received CBT, and the other half received MBT. They attended weekly two-hour group sessions for eight weeks. After this, they were encouraged to practice what they learned for 30 minutes daily, six days a week, for the remainder of the 12-month study. Although about 30% of participants dropped out by the six-month mark, those who continued reported:

• Less pain.
• Reduced daily opioid use.
• Better daily function.
• Improved quality of life.

These benefits lasted throughout the year, with over 65% of participants still reporting progress at the 12-month mark. Dr. Zgierska highlighted that chronic back pain usually doesn't get better on its own, often worsening over time, which makes these lasting improvements particularly striking. Since both therapies showed similar positive results, people can confidently choose the approach that best suits them, whether it's the structured nature of CBT or the mindfulness focus of MBT. Both in-person and online formats were found to be effective.

Supporting Evidence and Future Needs

While this JAMA Network Open study didn't include a control group or have much racial and ethnic diversity among its participants, its findings align with other research suggesting that behavioral therapies can help adults using opioids for chronic pain.

It's important to note that this area still needs more research. Only 17 studies have looked at MBT for chronic low back pain, and only three have directly compared it to CBT. However, previous studies have shown that both MBT and CBT are generally effective for pain relief, even if they haven't always included people on opioids for chronic back pain. The fact that this new research shows they help in more severe cases (with opioid use) further strengthens these findings.

Twins or multiple births are a rare occurrence. According to Twins Trust the likelihood of giving birth to twins is about one in 250, which is about 0.5%. While being a twin may be rare, them experiencing the same illness may cause many people to be shocked.

Ryan and Sean Collard, twin brothers from Hetton-Le-Hole, faced the same devastating cancer diagnosis within months of each other. Both have bravely overcome the disease and are now using their experiences to help other men. They've launched a men's health page dedicated to raising awareness about testicular cancer and offering support to young men going through similar struggles.

Ryan's Fight: Dismissed and Diagnosed

Ryan, who is now a primary school teacher, recalls being initially dismissed by a doctor who told him he was "too young" for cancer when he first reported his symptoms. He had severe issues, including passing out multiple times a day and half his body going numb, which eventually led to him being rushed to the hospital twice.

After pushing for answers through multiple appointments, Ryan, at just 23, was finally diagnosed with stage three choriocarcinoma, an aggressive form of testicular cancer. He shared on their joint Instagram page, 'Cancer Lads,' how frustrating it was to be initially brushed off.

Sean's Diagnosis and Their Shared Mission

Just as Ryan was recovering from his aggressive cancer, his twin brother, Sean, received his own devastating diagnosis of a less aggressive form of testicular cancer. Sean underwent surgery and chemotherapy and has since gone on to have two children. Ryan, now 31, is also married with a son, thanks to fertility treatment.

Ryan emphasized the power of connection, telling Chronicle Live, "It was only when I met other men who had a similar lived experience I felt really able to talk freely and feel properly understood. That is why I started an Instagram account." He wanted to create a space where others could find that same sense of understanding and release emotions.

Twins And Health Issues

There has always been a great interest in surrounding twins and their health. Questions like, ‘do both twins get affected if one of them sick?’ often occur to people. A 2023 study published in the Acta Obstetricia et Gynecologica Scandinavica. It shows that twins do face a higher risk of health complications compared to singletons, due to their risk of being born earlier.

According to Johns Hopkins Medicine, more than 60% of twins, and almost all higher-order multiples (like triplets or quadruplets), are born early, which means before 37 weeks of pregnancy. The more babies there are, the earlier they tend to arrive.

Babies from multiple pregnancies have about double the risk of being born with certain problems, including issues with the spine and brain (like spina bifida), digestive system, and heart.

Twin-to-Twin Transfusion Syndrome (TTTS) is also a cause of concern. This serious condition only happens with identical twins who share a single placenta. In about 15% of these cases, blood vessels in the placenta connect in a way that one twin gets too much blood (the "recipient"), and the other twin doesn't get enough (the "donor"). This can overload the recipient twin's heart and lead to too much amniotic fluid, while the donor twin will have very little fluid.

Why Talking Matters: A Call for Men to Speak Up

The brothers' story highlights a critical issue: men often delay seeking help for health concerns. Data from Macmillan confirms this, showing that nearly half (48%) of men in their 30s admit they wait for health problems to disappear on their own. This figure is twice as high as men aged 60 or over, underscoring the vital importance for men, especially younger ones, to open up and talk about their health.

Every two seconds, someone in the world needs blood—but far too few people step forward to donate. Whether it’s for accident victims, cancer patients, or those undergoing major surgeries, the demand for safe, healthy blood is constant and often urgent. Yet many potential donors hesitate, held back by fear, misinformation, or uncertainty. On World Blood Donor Day and beyond, it’s time to break down those doubts, understand the life-saving impact of one donation, and discover how giving blood could be easier—and more rewarding—than you think.

While blood donation is widely regarded as an act of altruism, what often goes unnoticed is the remarkable impact it has—not just on the recipients, but also on the donors themselves. Despite major awareness campaigns, myths and fears still prevent a significant portion of eligible individuals from rolling up their sleeves.

Every single blood donation has the potential to save up to three lives. According to Dr. Lopita Bhattacharya, a medical officer blood bank at BM Birla Heart Hospital, “One pint of donated blood is separated into red cells, plasma, and platelets, each of which can be administered to patients based on individual needs—be it trauma victims, cancer patients, surgical patients, or those with chronic blood disorders.”

At any NABH-accredited blood bank, no part of donated blood goes to waste. “Safety, accuracy, and quality are given utmost priority. The entire process is handled with the latest technology and rigorous screening,” she adds.

Dr. Umakant Mokalikar, Blood Centre Incharge at Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune echoes the sentiment. “There is no substitute for human blood. Every donor plays a vital role in the healthcare system, especially in emergencies. Blood donation is truly a humanitarian act.”

Busting Common Myths Around Blood Donation

Despite awareness, misinformation continues to hinder blood donation drives. Experts say that correcting these myths is the first step to building a more robust and reliable donor base.

Myth 1: Blood donation makes you weak.

Fact: “The fluid components are replaced within 24 hours, and red blood cells regenerate within weeks,” says Dr. Bhattacharya. Healthy men can safely donate every 3 months; women, every 4 months.

Myth 2: The process is painful or too time-consuming.

Fact: “The blood draw itself only takes 8–10 minutes. Including the screening and post-donation rest, the entire visit wraps up in under 45 minutes,” Dr. Bhattacharya clarifies.

Myth 3: Only rare blood types are needed.

Fact: Common blood types are often in higher demand due to their compatibility across patient populations. “Every blood type is essential—be it for surgeries, maternity care, or injuries,” she notes.

Myth 4: Older adults or thin individuals should not donate.

Fact: If you're between 18–65 years, in good health, and meet minimum weight and hemoglobin thresholds, you’re eligible. First-time donors can donate until age 60.

Myth 5: Women can't donate blood.

Fact: “Aside from temporary conditions like menstruation or lactation, women can and should donate blood if they meet eligibility,” Dr. Mokalikar emphasizes.

Myth 6: Blood donation may cause infections.

Fact: The process uses sterile, one-time-use equipment. “There’s zero risk of catching infections,” he reassures.

Are There Any Health Benefits for Donors?

Donating blood is not just a selfless gesture; it comes with tangible health perks.

Improved heart health: “Regular donation helps lower iron overload in the body, which is linked to reduced risk of cardiovascular diseases,” Dr. Bhattacharya shares.

Calorie burn: One blood donation session can burn around 600–650 calories, similar to a light workout.

Stimulates red blood cell production: “Donation encourages bone marrow to generate fresh red cells, helping keep your circulatory system active,” she explains.

A mini health screening: Donors undergo blood pressure, hemoglobin, and pulse checks. Blood is also screened for infections like HIV, Hepatitis B & C, providing an early warning system for the donor’s own health.

Mental well-being: “The psychological benefit—knowing you’ve potentially saved lives—releases endorphins and improves mood,” adds Dr. Mokalikar.

What Happens To Your Body After Donating Blood?

Once donated, your blood is processed into three core components:

Packed Red Blood Cells (PRBCs): Used in trauma, surgeries, and patients with anemia or cancer.

Platelet Concentrates: Vital for patients with clotting disorders, infections, or undergoing chemotherapy.

Fresh Frozen Plasma (FFP): Used in patients with liver failure or bleeding disorders.

This separation maximizes the utility of a single donation—reaching three different patients with three different medical needs.

According to WHO, less than 1% of the eligible population donates blood in many countries—a number that needs urgent improvement. “If more people come forward regularly, hospitals will have the reserves to act swiftly during crises like accidents, natural disasters, or major surgeries,” urges Dr. Mokalikar.

He adds, “Blood donation is not a one-time favor. Men can donate every 3 months, and women every 4 months. Routine donations help keep blood stocks consistent and reliable.”

Blood donation is one of the most powerful acts of human kindness, and one of the simplest. The entire process—from screening to actual donation and rest—takes less than an hour but leaves a lasting impact. As Dr. Bhattacharya puts it, “It’s free, it’s safe, and it helps others while improving your own health. Why wait?”