Exosomes have become a buzzword in the beauty and dermatology industry, promising solutions for hair loss and improved skin health. But what exactly are they, and why is everyone talking about them?

Think of exosomes as tiny 'prime' packages delivered to help cells regenerate and heal. These microscopic vesicles, secreted by most human cells, contain genetic material, proteins, lipids, and growth factors that activate cellular repair and rejuvenation.

What Are Exosomes?

A helpful way to understand exosomes is to compare them to a courier service. "Exosomes are like FedEx, carrying bioactive proteins, growth factors, and nucleic acids," Dafna Gershoony, PA-C, CEO of ContōR told a leading publication. "If you imagine your body as a city, exosomes would be the postal service, delivering messages between cells to facilitate communication and repair."

Exosome Therapy: A Breakthrough In Regenerative Skincare

Exosomes are gaining recognition for their potential applications in medicine, particularly in wound healing and inflammation reduction. In aesthetic dermatology, they are being used for faster recovery post-procedures like microneedling and laser treatments. “Exosomes applied topically have shown positive results in skin and hair rejuvenation,” Gershoony notes.

Benefits Of Exosomes in Skincare

- Reduce healing time after skin treatments

- Improve skin firmness and elasticity

- Minimize fine lines, wrinkles, and age-related pigmentation

- Hydrate and nourish the skin

- Stimulate collagen and elastin production

A recent split-face study demonstrated that applying exosomes after microneedling led to an 11.3% increase in elastin production compared to the untreated side.

How Exosomes Compare To Stem Cell Therapy

Exosomes offer similar benefits to stem cell therapy without some of its risks. Unlike live stem cells, exosomes are non-living messenger molecules, reducing concerns about immune rejection, tumour formation, and infections. They also provide more consistent results than platelet-rich plasma (PRP) treatments, which depend on an individual’s natural platelet production.

Safe Ways To Use Exosomes

Choosing the Right Exosome Therapy

To ensure safety and efficacy, healthcare experts advise seeking treatment from a board-certified dermatologist. Green flags to look for include human-derived, cell-free products such as platelet-derived exosomes, which naturally support skin healing and regeneration. Reputable exosome therapies should come in sterile, single-use vials and be sourced through strict purification processes.

Red Flags To Watch Out For

Exosomes In Over-The-Counter Skincare

When to Incorporate Exosomes Into Your Routine

Exosome treatments should be started in your 30s, as collagen, hyaluronic acid, and natural exosome production start to decline. Anyone looking to even out skin tone, reduce scars, minimize pores, or improve skin texture can benefit from exosome therapy, as per experts.

Future of Exosome Skincare

Ever wondered what makes someone "cool"? A new international study published in the Journal of Experimental Psychology suggests that no matter where you live, "cool" people often act in similar ways.

Researchers from universities in Chile, the United States, and other countries found that people considered "cool" share six key personality traits. These traits were consistent across all 12 countries included in the study, which surveyed nearly 6,000 people from 2018 to 2022. Countries included Australia, Chile, China, Germany, India, Mexico, Nigeria, South Africa, South Korea, Spain, Turkey, and the United States.

Six Common Traits of "Cool" People

These traits were found to be consistent regardless of a person's age, gender, or education level. The study, identified the following traits in people seen as cool:

• Extroverted
• Pleasure-seekers (hedonistic)
• Powerful
• Adventurous
• Open to new experiences
• Independent

Coolness vs. Goodness

Interestingly, being a "good" person was linked to different traits, such as being calm, kind, warm, traditional, and secure. People who were seen as capable often had qualities that made them seem both cool and good.

Researchers explained that these "cool" traits are likely part of someone's core personality and aren't easily taught. Another lead researcher noted that while cool people are usually somewhat likable, their traits don't always mean they are morally "good," especially when considering being hedonistic and powerful.

Deeper Meaning of "Cool"

Reviewing the study's findings, researchers noted that "coolness" can have both positive and negative meanings in real life. They suggested that future research could explore the differences between "good coolness" and "bad coolness."

Researchers also pointed out that their study only included people who already understood the term "cool." It's not clear if people in very traditional or isolated cultures would view the same traits as admirable.

They emphasized that "cool" is a deeply embedded part of our social language. It acts as a quick way to understand someone's status, connections, and identity, especially in today's social media and influencer culture. Understanding "coolness" helps us see how quick judgments about traits influence behavior and social interactions.

Many of these personality traits have also been found to be genetic, so the question arises, are we born with these traits?

Is Human Personality Genetic?

In a 2020 study published in the Genes, Brain, and Behavior journal, researchers explained that our personality traits are simply the lasting ways we tend to think, feel, and act in different situations. Studies of twins and families show that our personality traits are partly inherited from our parents.

This means our genes play a role in shaping who we become. These traits can even give clues about future mental health conditions. What these genetic studies of personality have shown is that personality, like many brain-related diseases, is influenced by many genes working together (this is called being polygenic).

Five-Personality Traits That Are Connected To Genes

Researchers at Yale School of Medicine (YSM) published a study in 2024 Nature Human Behavior where they found several DNA spots linked to specific personality traits. Researchers used information from a large program called the Million Veteran Program. They looked at people's genes to find tiny differences, called "loci," that are connected to the "Big Five" personality traits

Extraversion: How outgoing you are.

Openness: How open you are to new experiences.

Agreeableness: How well you get along with others.

Neuroticism: How prone you are to negative feelings like worry or sadness.

Conscientiousness: How organized and disciplined you are.

The "Big Five" traits are a common way scientists measure personality. In this study, participants answered questions about their personality and also gave a blood sample for genetic testing.

By comparing their answers to their DNA, the team found 62 new genetic spots linked to neuroticism. They also found genetic spots for agreeableness for the very first time. When they combined all their results, they identified over 200 genetic spots across all five personality traits.

The team also looked at the genetic connections between personality traits and various mental health conditions. They found a strong overlap between neuroticism (a personality trait with a lot of negative feelings) and depression and anxiety.

On the other hand, people who scored high in agreeableness (meaning they tend to get along well with others) were less likely to experience these conditions. These links were already known, but this study provides new genetic proof.

With each research on such topics, we come one step forward to finding better answers and treatments for mental health conditions.

What most people dismiss as a routine sore throat could, in rare cases, signal something far more serious. Someone I know from very up close told me about her persistent throat infection; she complained of a severe sore throat. The weather is such that the first guess for all of us was a viral infection or a cold.

However, the sore throat persisted and did not go away. Like all of us do, she too searched it up on Google, and it showed signs of a spleen injury. Like most, she too ignored what Google said, thinking that internet diagnosis is often far-fetched. Until she felt an excruciating pain in her chest, abdomen, and throat, and felt like she could not breathe anymore. She had her friend call 9-1-1, and was finally taken to the ER, where she was told that it was a virus that caused her throat to be sore and enlarged her spleen, leading to a spleen rupture. She was taken to the surgery immediately, as the rupture had caused much internal bleeding. When she came out of the surgery, the doctors had informed her that she was lucky to come out of a "life-threatening surgery".

When I was told all this, all I wondered was, how could such a common cold symptom that we usually take so lightly, lead to something so serious?

I knew what I had to do, to speak to doctors and know more about it, so more people can know about it and detect it before it is too late.

The Kissing Disease: What Causes A Sore Throat To Attack the Spleen?

This condition could be caused by the Epstein-Barr virus—infectious mononucleosis or “mono”, which can present as a seemingly harmless illness, only to later escalate into complications like spleen rupture.

“It’s not uncommon to brush off a sore throat with home remedies and over-the-counter pills,” said Dr. Anirban Chattopadhyay, a critical care specialist at CMRI, Kolkata. “But if the sore throat persists for more than a week and comes with high fever, swollen glands, and overwhelming tiredness, one should start considering possibilities beyond a regular viral infection.”

Infectious mononucleosis, also known as glandular fever, spreads through saliva, which is why it’s nicknamed the “kissing disease.” Though often self-limiting, it is important to recognise its red flags early.

Splenomegaly And Its Rare, But Serious Outcome

One of mono’s lesser-known dangers is splenomegaly—or an enlarged spleen. This swelling, which occurs as the immune system fights the Epstein-Barr virus, can make the spleen fragile and susceptible to rupture. A rupture, though rare (affecting less than 1% of cases), is life-threatening.

Dr. Swati Rajagopal, Consultant in Infectious Disease and Travel Medicine at Aster CMI Hospital, Bengaluru explained, “The spleen helps filter blood and fight infections. During mono, it gets flooded with infection-fighting cells, which causes it to swell. While a swollen spleen is common in mono, rupture is thankfully very rare. But when it does occur, it’s a medical emergency.”

The danger is compounded by the fact that such a rupture can happen even without trauma. “A simple bump or strain during sports or exercise can cause it. That’s why we recommend patients avoid contact sports or any strenuous activity for at least three to four weeks during recovery,” she added.

How To Connect Sore Throat To Spleen Risk? Signs To Look Out For

Both Dr. Chattopadhyay and Dr. Rajagopal stressed that the challenge lies in linking everyday symptoms to a more serious underlying condition, especially in the absence of injury.

“If a patient has a sore throat that doesn’t improve over time and comes with deep fatigue, body aches, and pain in the upper left side of the abdomen, we start suspecting mono,” said Dr. Chattopadhyay. “That’s when we order diagnostic tests like a Monospot or white blood cell count, and sometimes imaging like an ultrasound or CT scan to check the spleen.”

According to Dr. Rajagopal, “Sudden sharp pain in the upper left belly or shoulder can be a red flag. Even without trauma, this could point to spleen involvement. Timely testing can prevent complications.”

Recovery And Caution Go Hand In Hand

For those diagnosed with mono, the recovery is generally supportive—rest, fluids, and time. However, the spleen remains a point of concern for a few weeks even after the fever subsides.

“Patients should not rush back into normal routines. Even after feeling better, the spleen can remain enlarged and vulnerable,” warned Dr. Rajagopal. “Follow-up visits may be necessary to ensure it returns to its normal size.”

Dr. Chattopadhyay added, “The advice is simple but critical—listen to your body. If symptoms change or worsen, especially with sudden pain or dizziness, seek help immediately.”

What begins as a sore throat may not always end there. While complications like spleen rupture are rare, the condition that causes them is not. “Mono isn’t uncommon,” said Dr. Rajagopal. “But ignoring the signs can turn a manageable illness into a dangerous one.”

So next time that cold lingers longer than it should—or feels strangely exhausting—it might be time to pay closer attention.

CBD or cannabidiol is a very popular component, not just in cannabis (marijuana) but it is also an important component in medical marijuana, Harvard Health explains. They further detail how CBD does not make people dependent on it or cause potential substance abuse. However while previous studies like 2024 study published in the Neuropsychopharmacology journal have shown that CBD is unlikely to cause significant harm to daily functioning or workplace performance, researchers have found that liver damage can be a likely outcome of long-term use.

Even though cannabidiol (CBD) products are everywhere these days—think capsules, gummies, edibles, oils, and lotions—a recent study suggests that even small amounts might not be entirely safe for your liver.

FDA Trial Investigates Low-Dose CBD Effects

Researchers from the Food and Drug Administration’s (FDA) Division of Applied Regulatory Science conducted a randomized, double-blind, placebo-controlled trial last year. The study aimed to assess how low-dose CBD affects liver function in a group of 201 healthy middle-aged men and women.

For four weeks, 201 volunteers were given either a typical amount of oral CBD (about 350 mg for someone weighing 154 pounds) or a dummy pill. They had weekly check-ups to see how their bodies were reacting.

Liver Enzyme Elevations Observed

The study, published in JAMA Internal Medicine, found that most people were fine. However, 5% showed significantly higher levels of a liver enzyme called aminotransferase. This enzyme is a known sign of liver damage or inflammation. Women seemed to be more affected than men. The good news is that these liver enzyme levels went back to normal within a week or two after people stopped taking CBD. Also, seven participants dropped out of the study because they were showing signs of possible liver injury caused by the CBD.

Researchers called these findings "important." They said it suggests that CBD itself, even without other drugs, might be a risk to liver health. Many people using over-the-counter CBD might not know about this potential for liver damage, assuming CBD is completely harmless.

What Liver Problems Look Like

Signs of liver damage include stomach discomfort, yellowing of the skin and eyes (jaundice), and feeling very tired. It's important to know that liver injuries caused by drugs don't always show up right away. In the government study, only one person with high liver enzymes actually felt symptoms within four weeks. This suggests that people might not realize they're hurting their liver. Experts say doctors should ask about regular CBD use during check-ups.

This isn't the first study to point out possible liver risks with CBD. Concerns came up before when a government agency reviewed data for CBD-based prescription drugs for childhood epilepsy. In those cases, 14% of patients had raised liver enzymes. While those patients were also taking other seizure medications, the new study suggests CBD alone can be a factor.

Research also shows that certain doses of CBD can affect liver cells in a way similar to acetaminophen (Tylenol). Acetaminophen, when taken too much, is a very common cause of drug-induced liver injury.

Who Might Be at Higher Risk?

Recent studies show that people who take very high doses of CBD, over 1000 mg per day, are most at risk of liver injury. However, there have been reports of liver injuries even in healthy people taking moderate doses, between 300 mg and 1000 mg per day.

We don't know much about why some people are more affected than others, but it's thought that genetics might play a role. CBD can also block certain liver enzymes needed to process medications.

In the new government study, most participants who had serious liver problems also showed signs of an immune condition where the body makes too many white blood cells called eosinophils.