Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

With the constant rising temperatures, many people are worried about their health and wellbeing. Heat related illness have become the main source of concern for many people, as they look for better ways to navigate in the heat. Different countries have published heat guidelines to ensure citizens do not fall ill. It is very important to know the signs of and symptoms of these heat-illnesses as they could save your life!

One such symptom could be a major cause of concern. The National Health Services UK explains that people who are experiencing heatstroke need to be on alert. If the symptoms do not get better withing 30 minutes, you must call for help.

When to Seek Emergency Help

According to the NHS, if someone shows signs of heatstroke and is still unwell after 30 minutes of resting in a cool place, being cooled down, and drinking fluids, you should contact emergency services. While heat exhaustion often improves on its own within 30 minutes of cooling down, if it progresses to heatstroke, it becomes a medical emergency.

The NHS explicitly states: "Call 999 now if you or someone else have signs of heatstroke, including still [being] unwell after 30 minutes of resting in a cool place, being cooled and drinking fluids."

Heat Alert Issued for Parts of England

This week, the UK Health Security Agency (UKHSA) issued a yellow heat alert for certain areas of England, warning that even moderate temperatures could be dangerous. The Met Office predicts temperatures could reach up to 30°C in the East of England, East Midlands, London, and Southeast regions.

The UKHSA emphasized that "whilst temperatures may not seem too high for the general population for now, data from UKHSA shows that even at these forecasted temperatures, vulnerable groups and health care services can be impacted."

Under the UKHSA and Met Office's Weather-Health alerting system, a yellow alert indicates potential impacts such as:

• Increased demand on healthcare services from vulnerable groups.
• A higher health risk for individuals over 65 years old or those with existing health conditions, like respiratory and cardiovascular diseases.

Heat Exhaustion vs. Heatstroke

It's crucial to understand the difference between heat exhaustion and heatstroke, as the latter requires immediate emergency attention. Signs of Heat Exhaustion include:

• Tiredness
• Dizziness
• Headache
• Feeling sick or being sick
• Excessive sweating; skin may be pale and clammy or develop a heat rash (note: changes in skin color can be harder to see on brown and black skin)
• Cramps in the arms, legs, and stomach
• Fast breathing or heartbeat
• A high temperature
• Feeling very thirsty
• Weakness
• If these symptoms don't improve after 30 minutes of cooling down, it could be progressing to heatstroke.
• What to do for Heat Exhaustion (to prevent heatstroke)

If someone is suffering from heat exhaustion, immediately move them to a cool place and remove any unnecessary clothing, such as jackets or socks. Encourage them to drink a sports or rehydration drink, or simply cool water. To help lower their body temperature, cool their skin by spraying or sponging them with cool water and fanning them. You can also apply cold packs, wrapped in a cloth, to their armpits or neck.

To stay safe when it's hot, the UKHSA also recommends a few key things. Try to stay out of the sun between 11 am and 3 pm, which is usually the hottest part of the day. Keep your home cool by closing windows and curtains in rooms that face the sun. If you do go outside, cover up with appropriate clothing, a hat, and sunglasses, seek shade, and remember to apply sunscreen often. Plan any physical activities like exercise or walking your dog for cooler times, such as the early morning or evening.

Diet may seem like a secondary issue for many of us, but for athletes, it plays a very important role. The food they eat today could change the course of their game the next day. Athletes like tennis superstar Novak Djokovic have special diets that help them perform their best. Sharing the juices he drinks every morning in an interview; we get a glimpse of what goes into being a professional player.

Why Does A Diet Play An Important Role

Different sports require different types of diet, for example John Hopkins Medicine explains that a runner athlete must go for a carbohydrate rich diet as they must expend a lot of energy in an extended period of time, meaning they must sustain a uniform strain of energy to make sure they complete their run. On the other hand, judo or wrestler athletes must focus on a protein-based diet that will help them build muscles and strength.

For elite athletes, every little detail matters – from what they eat to how they train and recover. It can all make the difference between winning and losing. When it comes to fueling the body for success, Novak Djokovic stands out. With an astonishing 24 Grand Slam titles, he's the most successful male player in history, surpassing even legends like Rafael Nadal and Roger Federer, and he's still competing at the highest level.

What Does Novak Djokovic Eat?

Recently, in a TikTok clip with sports journalist Graham Bensinger, Djokovic revealed a surprising part of his daily morning routine. When asked about a typical day, he shared: "When I rise from bed, I start with warm water and lemon so I can help my body to detoxify and then I would have celery juice on an empty stomach." While this might sound a bit unusual to most people, Djokovic's drink choices are actually supported by some interesting science.

Science Behind the Sips

Warm lemon water is a fantastic natural source of Vitamin C. This vitamin is crucial for many bodily functions and significantly boosts your immune system. It's also a powerful antioxidant, helping to fight off harmful molecules called free radicals and keeping your cells healthy.

Drinking this first thing in the morning, as Djokovic does, can also be great for your digestive system. The Cleveland Clinic explains that it also helps us stay hydrated and is a great remedy for kidney stones, weight loss friendly, as well as filled with antioxidants like vitamin C, protecting your body from diseases.

Adding celery juice to the mix offers similar benefits. It's also rich in Vitamin C, along with Vitamins A and K, and essential nutrients like potassium, folate, and magnesium. For a tennis player like Djokovic, Vitamin K is especially important for strong bones, while the other nutrients help with muscle recovery and healthy blood flow.

Beyond the scientific benefits, Djokovic himself says these drinks give him mental clarity and a general feeling of energy, setting him up for a positive start to his day.

Even if you're not planning to follow the exact routine of a world-class athlete, staying hydrated is always a good idea. The NHS recommends drinking six to eight cups or glasses of fluid throughout the day.

Do We Need Detoxifying Juices?

As an addition to your diet, these can be helpful, however many people go on juice cleanses, relying solely on the juice for sustenance, which is not healthy for your body. A big selling point for juice cleansers is their supposed ability to "detoxify" your system. It's true that drinking more fluids can help your kidneys work better, and some nutrients can assist your body in getting rid of waste.

However, there isn't enough scientific evidence to show that juice cleanses or other "detox" diets actually improve your body's natural ability to remove toxins. Your liver and kidneys are incredibly efficient at detoxifying your body on their own, without the need for special juice regimens.

Back in 2023, a 64-year-old man experienced something weird. He had green hair growing on his tongue. Initially he was prescribed antifungal medicine, however, the treatment did not work on him. What he had was called a hairy tongue.

A Visit To Doc

The patient's tongue turned green about two weeks before he paid a visit to the doctor. This was shortly after he had completed a course of antibiotics from a gum infection.

What initially happened was a discoloration and doctors thought that it was a case of oral thrush, which is a fungal infection. As a result, he was prescribed antifungal treatment, however, this did not do anything. Rather, there was moss-like growths.

When doctors had a closer look, they realized that the man's filiform papillae, which are the tiny, cone-shaped bumps that cover the surface of the tongue and give its rough texture were longer than from a healthy tongue. Though there were no signs of injury or change in taste reported from the patient.

What The Case Report Said?

The case report was published in the New England Journal of Medicine, where physicians wrote, "A diagnosis of hairy tongue was made."

What is hairy tongue? Hairy tongue or lingua villosa is a benign condition that causes hair-like growths of various colors to sprout on top of the tongue, said the report.

These growths are filiform papillae that haven’t shed as they normally do through regular friction — such as from brushing with a toothbrush, using a tongue scraper, or eating solid, textured foods. Under typical conditions, these tiny projections grow to about 1 millimeter before falling off naturally, in a process called desquamation, similar to how skin sheds, according to the Cleveland Clinic.

When this natural shedding doesn’t occur, the papillae can continue growing—reaching lengths of up to 0.7 inches (18 millimeters)—which can result in a condition known as hairy tongue. According to the American Academy of Oral Medicine, it affects roughly 13% of people at some point in their lives, most commonly in men and individuals over the age of 65.

As these bumps elongate into hair-like strands, they begin to trap food particles, bacteria, dead skin cells, and other debris—leading to the discolored, furry appearance of a hairy tongue. According to the American Academy of Oral Medicine, the tongue may appear brown, white, green, or even pink, depending on the underlying cause and factors like mouthwash use or certain candies.

What Causes Hairy Tongue—And Why It Sometimes Turns Black or Green

In many cases, hairy tongue takes on a jet-black appearance, a condition medically known as lingua villosa nigra, or black hairy tongue, according to a recent case report.

Several factors can increase the risk of developing a hairy tongue—regardless of its color. These include consuming a soft-food diet, drinking excessive amounts of coffee, tea, or alcohol, smoking, dehydration, poor oral hygiene, and taking certain oral medications that alter the mouth’s microbial balance. Regularly brushing the tongue is one of the most effective ways to prevent the papillae from becoming elongated and discolored.

In the case report, doctors treated a patient who presented with a green-colored tongue. They advised him to gently scrub his tongue with a toothbrush four times a day and to stop smoking. At a six-month follow-up, the patient’s tongue had returned to a normal appearance—even though he continued to smoke, the report noted.