Ozempic and Wegovy have received a lot of publicity as revolutionizing treatment options for obesity. Both medications form a class of GLP-1 receptor agonists, which mimic a hormone in the body called glucagon-like peptide-1 and are involved in the regulation of appetite and blood sugar. Indeed, in initial clinical studies, the majority of those on the drugs lost 15% to 22% of body weight, hence much optimism. For most patients, these medications are underwhelming for about 20% of patients due to minimal weight loss or other challenges.

Take a closer look at why the weight loss drugs may not work for everyone, together with what options exist when they don't deliver the expected outcomes.

Why Weight Loss Drugs May Not Work

While GLP-1 receptor agonists have produced phenomenal responses in a majority of patients, it remains a reality that these drugs work differently for different people. Here's why:

1. Genetic and Hormonal Variability

Weight loss medications interact with complex systems in the body that differ from person to person. Genetics, hormones, and individual brain responses to energy regulation play significant roles in determining how a person responds to drugs like Ozempic and Wegovy.

2. Underlying Medical Conditions

Other conditions, such as sleep apnea, may be prevalent and prevent or delay the achievement of weight loss goals. Prescription drugs like antidepressants, steroids, or contraceptives are other medications that can nullify weight loss medication benefits.

3. Unrealistic Expectations

Often, they come to these medications with enormous hopes; expecting the promised rapid and dramatic weight loss. Progress creates disappointment if it has not stalled. In patients who rigidly follow recommended lifestyle modifications, frustration and disappointment are most common.

Why it is Important to Identify Non-responders

For most patients, the effectiveness of GLP-1 receptor agonists is evident within a few weeks of treatment. Weight loss typically begins within a few weeks of initiating therapy and tends to increase with dosage. However, some patients respond very little, if at all, despite strict adherence to their regimen.

For nonresponders, this can feel like a dead end. However, understanding the unique complexities of obesity is essential. This condition stems from brain dysfunction, and the pathways that contribute to weight regulation differ among individuals.

Alternative Treatment Options

When Ozempic or Wegovy doesn’t yield desired results, there are still many paths to explore:

1. Switching to Another GLP-1 Drug

For example, some patients who don't respond well to one GLP-1 receptor agonist might find success with another drug in the same class. Newer medications, such as Zepbound, target other hormone pathways and seem promising even for those not responsive to earlier drugs.

2. Use of Older Medications

While there is much to say about newer drugs, older treatments can still be useful and work for some patients. One can also seek the help of a medical provider specializing in obesity treatments in order to identify the best alternatives.

3. Lifestyle Changes

Diet, exercise, sleep, and stress management continue to be integral components of any weight loss program. New changes may be small but can make an enormous difference in one's health and success.

4. Medical Management of Obesity

It is a complex disorder, and most patients should receive a multidisciplinary treatment. Collaboration with an obesity-aware doctor may mean access to tailored treatment plans, ranging from psychological support all the way to metabolic testing, and many others.

Why Side Effects of Weight Loss Drug Ozempic May Be a Barrier

For others, side effects like nausea, vomiting, or diarrhea hinder them from continuing with these drugs. These symptoms often reduce as the body becomes accustomed, but for some, they might be severe enough to stop treatment altogether. In those instances, alternative drugs or procedures become vital to find.

Long-term effects of Ozempic or Wegovy on the Brain

Another largely unexplored area relates to GLP-1 drugs' long-term effects on the brain's regulation of hunger and satiety. Although GLP-1 drugs suppress appetite and can lead to effective weight loss, emerging research suggests that they may also affect brain reward mechanisms, changing the way patients experience foods.

This aspect could prove of paramount significance in the future treatment of obesity. Perhaps GLP-1 receptor agonists do indeed affect and rewire the brain's reward pathways and will thus provide sustained benefits beyond discontinuation. However, more research is required to understand this phenomenon fully.

While for many, Ozempic and Wegovy have revolutionized obesity treatment, these are certainly not a one size fits all. Nonresponders need not lose hope- alternative strategies and medications abound. A consultation with an obesity expert healthcare provider is essential to put together a comprehensive, tailored treatment plan.

The route toward effective weight loss may be challenging, but with the evolution of obesity medicine and a better understanding of individual needs, there is a path forward for everyone.

Sleep takes up nearly one-third of a person’s life, yet many still wonder what really happens while we rest. Until the mid-20th century, scientists believed sleep was simply a time when the body and brain shut down.

Research now shows that sleep is far from passive, it’s an active, restorative process essential for mental and physical health. As Johns Hopkins neurologist and sleep expert Dr. Mark Wu explains, the brain remains deeply engaged during sleep, performing vital tasks that influence memory, mood, and overall well-being.

The Stages of Sleep

Experts say the human sleep cycle has four main stages that repeat throughout the night. The first three make up non-rapid eye movement (non-REM) sleep, while the fourth is REM sleep, the stage most closely linked with dreaming.

In the first stage of non-REM sleep, the brain and body begin to shift from wakefulness to rest. Brain activity slows, muscles relax, and it is common to experience small, sudden twitches.

During the second stage, the body’s temperature drops slightly, and breathing and heart rate slow. Brainwaves continue to decelerate, though quick bursts of activity may still appear as the brain processes and stores information.

The third stage marks deep sleep, which is the most restorative phase. Here, the body fully relaxes, and the heart rate, breathing, and brain activity reach their lowest levels. This stage is crucial for waking up feeling refreshed and for healing and repair processes throughout the body.

The final stage is REM sleep, which begins about 90 minutes after you fall asleep. It starts short, roughly 10 minutes, but lasts longer with each cycle. During REM, the eyes move rapidly beneath the eyelids, breathing quickens, and heart rate and blood pressure rise to near waking levels. This is when most dreaming occurs. Interestingly, as people age, the amount of REM sleep they experience gradually decreases.

How The Body Regulates Sleep

According to Dr. Wu, two main forces govern sleep: the circadian rhythm and the body’s sleep drive.

The circadian rhythm acts as the body’s internal clock, controlled by a cluster of brain cells that respond to light and darkness. This rhythm triggers the release of melatonin at night and halts it when morning light appears. People who are completely blind often struggle with sleep because their brains can’t register these light cues properly, as per the John Hopkins Study.

The sleep drive works much like hunger. The longer you stay awake, the stronger your urge to sleep becomes. Unlike hunger, though, your body can override your willpower, if exhaustion sets in, it can force sleep to happen, even during daily activities or while driving. In extreme fatigue, brief “microsleep” moments lasting just a few seconds can occur without a person realizing it. However, taking long naps later in the day can reduce this natural sleep pressure, making it harder to fall asleep at night.

Why Sleep Matters For Your Brain

Anyone who has felt mentally sluggish after a sleepless night knows how strongly rest affects the brain. Adequate sleep is key to brain plasticity—the ability to learn, adapt, and form memories. Without it, the brain struggles to retain new information and perform cognitive tasks. Scientists also believe that deep sleep allows the brain to clear out toxins that build up during waking hours, improving long-term brain health.

Sleep impacts far more than the mind. Poor sleep can worsen conditions like depression, high blood pressure, migraines, and even seizures. It weakens the immune system, leaving the body more vulnerable to infection. Metabolism also suffers, as just one night without enough rest can temporarily throw the body into a prediabetic state.

As Dr. Wu explains, “There are countless ways sleep supports health.” From mental clarity to physical repair, the hours we spend asleep are some of the most important for keeping the body and brain functioning at their best.

When COVID-19 first emerged, it was largely seen as a respiratory illness. Over time, doctors discovered that the virus can affect nearly every major organ, including the heart, kidneys, liver, and skin. While cough, fever, and fatigue remain common signs, some people also develop unusual skin reactions. So, can COVID-19 actually lead to rashes? Here’s what experts have found.

Can COVID-19 Really Cause Rashes?

When COVID-19 first emerged, it was largely seen as a respiratory illness. Over time, doctors discovered that the virus can affect nearly every major organ, including the heart, kidneys, liver, and skin. While cough, fever, and fatigue remain common signs, some people also develop unusual skin reactions. So, can COVID-19 actually lead to rashes? Here’s what experts have found.

What Do COVID-19 Rashes Look Like?

Skin changes linked to COVID-19 are not among the most common symptoms, but they do occur. These rashes may appear on the neck, mouth, or toes and are often caused by inflammation in the body, as per Health website. They can look like flat or raised patches, small round spots, or itchy bumps. In some people, these rashes appear while they’re infected; in others, they show up weeks later.

Why Do These Rashes Occur?

Researchers believe COVID-related rashes are connected to how the virus interacts with the body’s ACE2 receptors, which are found in the skin. When the virus attaches to these receptors, it can trigger the release of inflammatory proteins called cytokines. This inflammation may lead to skin irritation, itchiness, or lesions.

Common Types of COVID-19 Rashes

1. COVID Toes

One of the most recognized skin signs of the virus, “COVID toes,” resembles chilblains, which are cold-weather sores. They appear as pink, red, or purple patches, sometimes with swelling or blistering. This condition is seen more often in younger people and may occur even after other symptoms fade.

2. Hives (Urticaria)

Hives tend to appear suddenly and can spread across any part of the body. They’re itchy, raised, and may come and go within hours or days.

3. Neck Eczema

Some people develop eczema-like rashes on the neck, chest, or trunk during or after COVID-19. The patches can be itchy and vary in color depending on skin tone—pink on lighter skin and brown, gray, or purple on darker skin.

4. Oral Rash

COVID can also cause soreness or peeling inside the mouth or on the lips. The area may feel dry, irritated, or scaly as it heals.

5. Vesicular and Papular Rash

These small, itchy bumps can be filled with fluid (vesicular) or solid (papular). They may appear anywhere on the body and are often linked with ongoing inflammation.

6. Pityriasis Rosea

This condition begins with a single large patch on the chest, back, or abdomen, followed by smaller spots that form a tree-like pattern. Though harmless, it can take several weeks or months to fade.

7. Purpuric or Vasculitic Rash

These rashes appear as dark, bruise-like spots caused by small blood vessel damage under the skin. The color may range from red and purple to brown or black, depending on skin tone.

How Long Do COVID Rashes Last?

The duration depends on the type of rash and the person’s immune response. Most clear up within 2 to 12 days, but some, especially in long COVID cases, may persist for weeks.

How Are COVID Rashes Treated?

Many rashes resolve without any special treatment. To relieve itching or pain, applying mild hydrocortisone cream can help. For more severe or persistent cases, doctors may recommend:

• Antihistamines to reduce itching
• Corticosteroids to lower inflammation
• Blood thinners if the rash is linked to blood vessel irritation

Your doctor will determine the safest treatment depending on the type of rash and overall health.

Disclaimer: This article is for general informational purposes only and should not be considered medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication, or if you experience any unusual symptoms or side effects.

It is a common theme for people to feel down and sad in winter. However, why do shorter, colder days often bring on feelings of loneliness and gloom? There is a biological reason behind it. As the days get shorter, many people feel a dip in energy or mood, but for millions, this signals Seasonal Affective Disorder (SAD), which is a serious form of depression that shouldn't be ignored. Experts from West Virginia University (WVU) caution that SAD symptoms are very similar to major depressive disorder and must be taken seriously.

What Causes SAD?

SAD is much more than just feeling down when it gets dark. It's a genuine type of depression most often seen during the winter months, especially in places far north where daylight is scarce. The basic problem is simple: less natural light hits your eyes. This drop in sunlight confuses your brain's chemistry.

It messes with two vital brain chemicals: serotonin, which helps stabilize your mood, and melatonin, which controls when you sleep and wake up. This lack of light also throws off your body's internal clock, called the circadian rhythm. When all these elements get disrupted, it triggers feelings of low energy and depression.

What Are The Symptoms Of SAD?

SAD involves a cluster of symptoms that persist and significantly interfere with your daily life. The pattern is usually predictable: symptoms begin in the fall, peak in the winter, and disappear by spring. Symptoms often include:

• Feelings of hopelessness.
• Loss of interest in activities you once enjoyed.
• Significant changes in sleep (often sleeping more, or having disrupted sleep).
• Changes in appetite or increased food cravings.
• Difficulty concentrating and persistent fatigue.

The risk of SAD is higher among younger people, women, and those with a family history of mood disorders.

Can You Treat/Prevent Seasonal Affective Disorder?

Because Seasonal Affective Disorder is highly predictable, experts advise starting preventative treatments early in the fall. Seeing a healthcare provider is essential to determine the best plan and timing for treatment, rather than waiting for severe symptoms to appear later in winter.

Light Therapy

This involves sitting daily before a special light box emitting 10,000 lux of bright white light. Doing this for 30 to 60 minutes each morning is the most common and effective treatment for SAD, as it helps correct the imbalance caused by reduced sunlight exposure.

Cognitive-Behavioral Therapy (CBT)

This form of talk therapy teaches you practical skills to manage negative thinking patterns and behaviors linked to depression. CBT helps individuals reframe their outlook on winter and build effective coping mechanisms to reduce the impact of SAD symptoms.

Medication

In certain situations, a healthcare provider may prescribe antidepressant medication to help regulate mood-affecting brain chemicals like serotonin. This is often considered alongside light therapy or counseling, especially if symptoms of depression are severe or persistent.

Lifestyle Changes

Simple daily habits are powerful tools. Regular exercise boosts mood and energy, while maintaining a consistent sleep schedule keeps your body's internal clock stable. These practical steps offer significant support alongside clinical treatments.