When we hear of breast cancer, the first thing that comes to mind is women. However, men are not exempt from this disease. Although it is rare, male breast cancer is on the rise, and more cases are being reported every year. Awareness of this overlooked condition can help break the misconceptions, promote early detection, and save lives.

Male breast cancer is less than 1% of all breast cancer diagnoses in the United States, with an estimated 2,800 cases in 2024. According to surgical oncologist Dr. Suneel Kaushik K, "The rarity of male breast cancer often leads to delayed diagnosis and treatment, making it crucial to foster awareness and education.

The lifetime risk of breast cancer in men is less than 1 in 1,000 at present. However, the incidence of this disease is on the increase, and most significantly so with increasing age in men. The average age at diagnosis for men is five years greater than that for women, and most men are diagnosed around the age of 67.

What Are the Risk Factors in Men

Several risk factors increase a man's likelihood of developing breast cancer. These include:

Advances in Age: The risk rises with age.

Genetics: Alterations of BRCA1 and BRCA2 are some of the most known alterations.

Family History: In case one's family has a history of breast cancer, risk will be high.

Lifestyle and Hormonal Factors: Excess weight, drinking, liver diseases, hormonal imbalance; including medical conditions like

gynecomastia and Klinefelter syndrome, also increase risk.

Radiation Exposure: Exposure to thoracic radiation treatment also increases risk.

According to Dr. Kaushik, "Knowing these risk factors is essential in identifying high-risk individuals who may benefit from early screening and monitoring."

Symptoms to Watch For

The symptoms of breast cancer in men are the same as those in women, but men often dismiss them because they are not aware of them.

Common signs include:

• A lump in the breast, usually painless
• Nipple discharge
• Dimpling, redness, or inversion of the skin or nipple

A man experiencing any of these should be clinically evaluated promptly to rule out cancer or detect it early.

Why Early Detection Counts

Mammography is not suggested in routine clinical practice in men due to the low prevalence of the disease. However, men considered to be at high risk-including family history and genetic tendency-should be encouraged for periodic mammography.

Dr. Kaushik emphasizes, "Early detection significantly improves treatment outcomes. For high-risk men, regular screenings and awareness of symptoms can make a life-saving difference."

How is Male Breast Cancer Different from Female

Male and female breast cancers have some similarities but also have many differences:

Most male breast cancers are invasive ductal carcinomas, with lobular carcinomas being extremely rare due to the absence of terminal lobules in the male breast.

A meta-analysis of male breast cancer reported that 99% of the tumors were estrogen receptor-positive, 82% progesterone receptor-positive, and 97% androgen receptor-positive. This all has implications for how a patient will be treated and what the prognosis will be, so these cases really require specialized care. Societal views of breast cancer as a "woman's disease" often lead to late presentation in males.

"Awareness is the first step to breaking barriers and encouraging men to take their symptoms seriously," Dr. Kaushik opines. "Healthcare providers play a key role in educating patients about risk factors and promoting vigilance."

Promotion of Awareness and Vigilance

Healthcare providers, advocacy groups, and communities should collaborate to raise awareness about male breast cancer. The steps toward this end are:

1. Promote symptoms and risk factors awareness amongst the general population.

2. Promote genetic testing and routine screening for those with a family history or genetic predisposition.

3. Normalize seeking care by openly discussing male breast cancer.

Breast cancer is not a disease that only afflicts women. Men, though less often, may suffer from this potentially fatal disease. Awareness, education, and aggressive healthcare can result in earlier diagnoses and better outcomes.

As Dr. Kaushik aptly states, “Addressing misconceptions about male breast cancer is not just about saving lives—it’s about ensuring equality in care and awareness for all.”

Men, just like women, should remain vigilant about their health, seek prompt medical attention if symptoms arise, and advocate for greater awareness of this under-recognized condition.

Dr Suneel Kaushik K is a Surgical Oncologist at American Oncology Institute (AOI) in Hyderabad, India

Britons who regularly take a commonly used supplement are being urged to cut back if they notice four particular symptoms, as excessive intake can be dangerous and, in some cases, life-threatening. Vitamins and minerals are essential for keeping the body functioning properly. While most nutrients should ideally come from a healthy, balanced diet, many people choose to top up their intake with supplements.

Iron is one such supplement. This mineral plays a key role in making haemoglobin, the substance in red blood cells that carries oxygen around the body. When iron levels are too low, it can lead to iron deficiency anaemia. This condition may cause symptoms such as constant tiredness, low energy, shortness of breath, and heart palpitations. To avoid this, some people turn to iron supplements.

Could You Be Overdoing Iron Supplements?

The NHS has issued guidance on its website, warning that taking “too much” iron can cause side effects. These include:

• Constipation
• Feeling sick
• Being sick
• Stomach pain

If these symptoms appear, it may be a sign that your iron intake needs to be reduced. In children, taking too much iron can be particularly dangerous and may even be fatal.

The NHS states: “Very high doses of iron can be fatal, particularly if taken by children, so always keep iron supplements out of the reach of children.” For adults, a high dose of iron is classed as more than 20mg.

How Much Iron Do You Need?

• 8.7mg a day for men aged 19 and over
• 14.8mg a day for women aged 19 to 49
• 8.7mg a day for women aged 50 and over
• Women who continue to have periods after the age of 50 may need the same amount of iron as women aged 19 to 49

The Department of Health and Social Care (DHSC) says that “most people” should be able to meet their iron needs through a varied and balanced diet. But for those who do take supplements, the NHS advises: “Do not take too much as this could be harmful.”

It adds that taking 17mg or less of iron supplements each day is “unlikely” to cause harm. The guidance continues: “But continue taking a higher dose if advised to by a GP.”

Good sources of iron include:

• Liver (but this should be avoided during pregnancy)
• Red meat (though the DHSC advises limiting red and processed meat due to a possible link to bowel cancer)
• Beans, such as red kidney beans, edamame beans, and chickpeas
• Nuts
• Dried fruit, including dried apricots
• Fortified breakfast cereals
• Soybean flour

Symptoms Of Iron Deficiency Anaemia

• Tiredness and low energy
• Shortness of breath
• Noticeable heartbeats, also known as heart palpitations
• Skin that appears paler than usual
• Headaches
• Ringing, buzzing, or hissing sounds in the ears or head, known as tinnitus
• Food tasting unusual
• Itchy skin
• A sore tongue
• Hair loss, with more hair coming out during brushing or washing
• Craving non-food items such as paper or ice, a condition called pica
• Difficulty swallowing, known as dysphagia
• Painful open sores at the corners of the mouth
• Changes to the nails, including spoon-shaped nails
• Restless legs syndrome

People in the UK who take a commonly prescribed medication are being reminded to follow a strict cut-off time. Ignoring this guidance could lead to disrupted sleep.

What Is Bumetanide?

Bumetanide is a diuretic, a type of medicine that helps the kidneys remove excess salt and water by increasing urine production. In the UK, it is prescribed for heart failure, a condition that affects close to one million people. Bumetanide is only available with a prescription and comes in tablet form as well as a liquid that is taken by mouth.

Bumetanide: NHS Says Avoid Taking It After 4 PM

The NHS website lists several key points patients should be aware of when using bumetanide. One of the most important relates to timing. According to NHS advice, bumetanide should not be taken after 4pm, as doing so may cause frequent urination during the night.

The NHS states: “Do not take bumetanide after 4pm or you may have to wake up in the night to go to the toilet.” Alongside this warning, the guidance also includes recommendations on when to take the medicine and what foods to avoid.

“You'll usually take bumetanide once a day, in the morning or afternoon – or twice a day, in the morning and afternoon,” the NHS explains. “Most people need to pee about 30 minutes after taking bumetanide, and again within a few hours.” The NHS also advises avoiding foods high in salt, such as processed foods or ready meals, as well as salt substitutes like Lo Salt, as these can interfere with how the medicine works. However, it adds: “You can take bumetanide with or without food.”

Some people are advised to take extra care when using bumetanide. The NHS says it is important to inform your doctor if you have:

• Ever had an allergic reaction to bumetanide or other medicines
• Low blood pressure (hypotension)
• Signs of dehydration, including thirst, a dry mouth, or dark-coloured urine
• Liver disease
• Diabetes
• Difficulty passing urine
• Gout

If you are due to have a glucose test, you should also let your doctor know that you are taking bumetanide.

Bumetanide: Common Side Effects

There are several common side effects associated with bumetanide that occur in more than one in 100 people. The NHS says there are ways to manage these symptoms:

• Needing to urinate more often than usual
• Feeling thirsty
• Dry mouth
• Headaches
• Feeling dizzy or confused
• Muscle cramps or muscle weakness

Patients are advised to speak to a doctor or pharmacist if the suggested coping measures do not help, or if side effects continue or worsen after a few days.

Bumetanide: Serious Side Effects

Serious side effects are uncommon, according to the NHS. However, you should contact your doctor or call 111 immediately if you experience:

• Unexplained bruising or bleeding, a high temperature, sore throat, or mouth ulcers, which may indicate a blood disorder
• Ringing in the ears (tinnitus) or hearing loss

The NHS also notes: “In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to bumetanide.” In 2023, the UK faced a national shortage of bumetanide, which was expected to ease in 2025.

Because of this shortage, many patients were switched to furosemide, another diuretic that is also subject to the same 4pm timing advice.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider regarding any questions about medications, health conditions, or before making changes to your treatment plan.

Scientists have found that a single dose of the shingles vaccine may do more than protect against the painful viral infection. It may also help slow biological ageing in older adults. Researchers from the University of Southern California say the vaccine, commonly given to seniors, could have benefits beyond shingles prevention. The findings come from a study involving over 3,800 people, which showed that vaccinated individuals had fewer signs of biological ageing and lower inflammation levels than those who had not received the shot.

What Is Shingles?

Shingles is a viral condition known for causing a painful, blistering rash. It can appear on different parts of the body but usually shows up as a band of blisters running along one side of the torso. The infection is caused by the varicella-zoster virus, the same virus responsible for chickenpox. Even after recovery from chickenpox, the virus remains dormant in the body and can reactivate years later as shingles, according to the Cleveland Clinic.

While shingles is not usually life-threatening, it can be extremely uncomfortable. Vaccination significantly reduces the risk of developing shingles. Starting treatment early can shorten the duration of the illness and lower the risk of complications. One of the most common complications is postherpetic neuralgia, a condition where nerve pain continues long after the rash has healed.

Shingles Vaccine May Slow Biological Aging In Older Adults

A recent study by the University of Southern California suggests that the shingles vaccine recommended for older adults may help slow down ageing at a biological level, in addition to preventing infection. “While more research is needed to confirm and expand on these results … our findings add to growing evidence that vaccines may support healthy ageing, not just prevent short-term illness,” said Eileen Crimmins, a co-author of the study, in a statement. To explore this further, Crimmins and her team focused on people who had received the shingles vaccine.

Shingles Virus Reactivates Later in Life

Although chickenpox is now uncommon in children, with cases dropping by over 97 percent since the vaccine became part of routine childhood immunisation in 1995, more than 95 percent of adults in the US were infected before that change, according to the CDC. At present, around one million Americans develop shingles every year.

Health authorities recommend that adults aged 50 and above receive two doses of the shingles vaccine. This not only lowers the risk of infection but also reduces the chances of postherpetic neuralgia, a lingering nerve pain that can persist for months or even years after the rash disappears.

Why Biological Age Matters More Than Your Actual Age

The researchers analysed data from more than 3,800 adults aged 70 and older, using information from the nationally representative US Health and Retirement Study. Blood samples were examined to assess seven different indicators of biological ageing.

Unlike chronological age, which simply counts years lived, biological ageing reflects how well the body’s organs and systems are functioning over time.

Shingles Vaccine: Lower Inflammation, Healthier Ageing

Results showed that vaccinated participants had noticeably lower levels of inflammation, a key factor linked to age-related conditions such as heart disease, frailty, and cognitive decline.

“By reducing this ongoing inflammation, possibly by stopping reactivation of the shingles virus, the vaccine may help support healthier ageing,” explained Jung Ki Kim, the study’s lead author.

“Although the exact biological processes are still unclear, the vaccine’s ability to lower inflammation makes it a promising tool in broader efforts to slow age-related decline and improve resilience,” she added.

Shingles Vaccine: What The Blood Markers Reveal About Ageing

The study also found that vaccinated individuals experienced slower changes in how genes are switched on and off, and in how genetic instructions are translated into proteins. These processes are known as epigenetic and transcriptomic ageing and are considered important markers of biological ageing.

When all seven ageing measures were combined into a single biological ageing score, those who had received the vaccine showed slower ageing overall compared with people who had not been vaccinated.

An image collage containing three visuals shows a gloved hand drawing blood into a tube, a longevity test kit with a swab and vial placed on an orange surface, and a screenshot of longevity test results displaying a bar chart of 117 biomarkers and a biological age of 29.3 years, which is 13.5 years younger than the actual age.

I gave lots of blood for six longevity tests — here’s how long I can expect to live

Can Vaccines Protect More Than Just Against Infection?

The findings build on earlier research that has linked adult vaccinations, including shingles and flu shots, to a lower risk of dementia and other neurodegenerative conditions such as Parkinson’s disease.

“This research strengthens the idea that vaccines may help promote healthy ageing by influencing biological systems beyond infection control,” said Kim, who is also a research associate professor of gerontology at USC.

Shingles Vaccine: Long-Term Benefits Seen Years After Vaccination

Importantly, the benefits appeared to last. Even participants who had received the shingles vaccine four or more years before their blood samples were taken still showed slower epigenetic, transcriptomic, and overall biological ageing compared to those who had not been vaccinated.

“These results suggest that shingles vaccination affects key processes associated with ageing,” said Crimmins, who is a USC University Professor and AARP Professor of Gerontology.

If future research confirms these findings, it could offer Americans another reason to get vaccinated and help improve vaccination rates, which remain low. Despite a rise during the pandemic period, only 30.1 percent of eligible Americans had received the shingles vaccine as of 2022.

The study highlights the potential for common vaccines to do more than prevent disease. They could play a significant role in promoting resilience, lowering inflammation, and supporting healthier ageing, especially in older adults.