People in the UK who take a commonly prescribed medication are being reminded to follow a strict cut-off time. Ignoring this guidance could lead to disrupted sleep.What Is Bumetanide?Bumetanide is a diuretic, a type of medicine that helps the kidneys remove excess salt and water by increasing urine production. In the UK, it is prescribed for heart failure, a condition that affects close to one million people. Bumetanide is only available with a prescription and comes in tablet form as well as a liquid that is taken by mouth.Bumetanide: NHS Says Avoid Taking It After 4 PMThe NHS website lists several key points patients should be aware of when using bumetanide. One of the most important relates to timing. According to NHS advice, bumetanide should not be taken after 4pm, as doing so may cause frequent urination during the night.The NHS states: “Do not take bumetanide after 4pm or you may have to wake up in the night to go to the toilet.” Alongside this warning, the guidance also includes recommendations on when to take the medicine and what foods to avoid.“You'll usually take bumetanide once a day, in the morning or afternoon – or twice a day, in the morning and afternoon,” the NHS explains. “Most people need to pee about 30 minutes after taking bumetanide, and again within a few hours.” The NHS also advises avoiding foods high in salt, such as processed foods or ready meals, as well as salt substitutes like Lo Salt, as these can interfere with how the medicine works. However, it adds: “You can take bumetanide with or without food.”Some people are advised to take extra care when using bumetanide. The NHS says it is important to inform your doctor if you have:Ever had an allergic reaction to bumetanide or other medicinesLow blood pressure (hypotension)Signs of dehydration, including thirst, a dry mouth, or dark-coloured urineLiver diseaseDiabetesDifficulty passing urineGoutIf you are due to have a glucose test, you should also let your doctor know that you are taking bumetanide.Bumetanide: Common Side EffectsThere are several common side effects associated with bumetanide that occur in more than one in 100 people. The NHS says there are ways to manage these symptoms:Needing to urinate more often than usualFeeling thirstyDry mouthHeadachesFeeling dizzy or confusedMuscle cramps or muscle weaknessPatients are advised to speak to a doctor or pharmacist if the suggested coping measures do not help, or if side effects continue or worsen after a few days.Bumetanide: Serious Side EffectsSerious side effects are uncommon, according to the NHS. However, you should contact your doctor or call 111 immediately if you experience:Unexplained bruising or bleeding, a high temperature, sore throat, or mouth ulcers, which may indicate a blood disorderRinging in the ears (tinnitus) or hearing lossThe NHS also notes: “In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to bumetanide.” In 2023, the UK faced a national shortage of bumetanide, which was expected to ease in 2025.Because of this shortage, many patients were switched to furosemide, another diuretic that is also subject to the same 4pm timing advice.Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider regarding any questions about medications, health conditions, or before making changes to your treatment plan.