For over 15 years, Dr Anthony Shum, a pulmonologist at the University of California, San Francisco has been studying a rare genetic disorder called the COPA Syndrome. It stands for coatomer subunit alpha and is a rare, inherited disorder that affects the lungs, joint, and kidney. The National Organization for Rare Disorder also notes that it is a genetic autoimmune disorder that is caused by mutations in the COPA gene. This disease affects families unpredictably—some individuals with the mutation develop severe lung damage early in life, while others remain completely healthy. Now, Shum’s team has discovered a protective genetic variant that may offer new hope for treatment.

A Breakthrough

Researchers found that some relatives of COPA Syndrome patients stayed healthy despite carrying the same COPA gene mutation that causes the disease. The key difference? These unaffected individuals had a protective version of another gene called HAQ-STING.

When scientists introduced HAQ-STING into diseased lung cells from COPA patients, the cells returned to a balanced state, suggesting that this gene could be used as a therapy.

“We really think HAQ-STING could be a gene therapy tool and a step toward a cure,” said Shum, whose findings were published in the Journal of Experimental Medicine.

Families Who Solved The Mystery

Shum’s journey into COPA Syndrome research began in 2011 when he treated a young woman, Letasha, who had severe lung bleeding. Her mother, Betty Towe, mentioned that Letasha’s sister, Kristina, had suffered from similar symptoms. Over the years, Betty had taken both daughters on a four-hour trip to UCSF for treatment. After tracing their family history, Shum discovered that their distant relatives in Texas and Oakland also had lung problems and arthritis. In 2015, Shum, along with scientists from Baylor College of Medicine and Texas Children’s Hospital identified the COPA gene mutation. They realized that it was the common factor behind the illness. However, only some of the 30 individuals with the mutation actually developed symptoms, leaving a major question unanswered.

The Domino Effect

It was established that it occurs when a mutated COPA gene causes another gene STING to go overdrive. The STING that helps fight infections in COPA patients, remain permanently active, which leads to chronic inflammation that damages the lungs, kidneys, and joints. In 2020, while studying STING’s role in the disease, researchers discovered a key variation: HAQ-STING. This version of STING, present in about one-third of the population, appeared to neutralize the harmful effects of the COPA mutation.

To confirm their theory, the scientists needed both affected and unaffected family members to participate in the testing. Letasha, Kristina and Betty immediately volunteered. The researchers then analyzed DNA samples from 26 COPA patients and their healthy relatives. They also conducted CT scans and blood tests to ensure that unaffected members did not have any hidden symptoms. When the findings were all clear, it was revealed that all the healthy individuals had HAQ-STING, while none of the COPA patients did. This was the first known case of a common gene variant completely protecting against a severe genetic disease.

Encouraged by this discovery, researchers tested HAQ-STING’s effects in a lab setting. They introduced it into diseased lung cells from COPA patients, and the cells returned to normal function.

Way Ahead

Shum believes HAQ-STING could lead to game-changing treatments, including:

• Prenatal gene therapy for babies diagnosed with COPA Syndrome before birth
• Aerosol delivery of HAQ-STING for adults, directly targeting the lungs

Before publishing their findings, Shum called Betty with the news—her own HAQ-STING gene had protected her from the disease. He also informed Letasha and Kristina, who were overwhelmed with relief and joy.

“We always believed Dr. Shum would get to the bottom of it,” said Letasha. “This discovery is going to change lives.”

Delhi finds itself in a little relief as the AQI of the city has dropped to 221 as per the CAQM. GRAP IV restrictions have also been lifted, however, pollution and smog continues to take over the city. The Meteorological Department has issued a yellow alert for the next few days, which could affect road and air traffic.

While GRAP IV is now removed, measures under GRAP I, II, and III will continue. As per the IMD forecast, this is what could happen for the next 5 days in Delhi

• December 26: Dense fog will prevail in the morning. Visibility is likely to be low.
• December 27: Yellow alert, dense fog in the morning and afternoon.
• December 28: Yellow alert, moderate to dense fog expected in the early morning.
• December 29-30: Fog will reduce slightly, but moderate haze will prevail in the morning.

Union Transport Minister On Delhi's Pollution

Nitin Gadkari, Union Minister of Road Transport and Highways also highlighted the alarming conditions of Delhi's smog and pollution. He said, "I stay for hardly two days in Delhi, and get an infection," as he spoke on how pollution impacts one's health conditions. However, he did speak on the severity of pollution and highlighted how the transport sector could play a huge role to bring relief to Delhi.

He highlighted that fuel combustion and transport emission leads to most of Delhi pollution.

In an interview with the news agency ANI, the minister also said that his ministry and Central Government are working on several projects and initiatives that will free Delhi from air pollution in the next five years.

Gadkari stated that the Ministry of Road Transport and Highways is undertaking projects worth Rs 1 lakh crore in Delhi to ease traffic congestion. He stated that all these efforts will not only help free Delhi of air pollution but also reduce the country's imports, increase job opportunities, and help farmers.

Electric Buses, Cars, and Scooters

The minister highlighted that 40% of the air pollution in the National Capital region is due to the burning of fossil fuels. In this regard, the government introduced electric buses in the city and enabled automakers to introduce electric cars and two-wheelers in the country.

He further stated that alternate fuel vehicles, such as those that run on CNG, LPG, and flex fuels (E20), are also being introduced and that all these efforts combined will reduce the city's pollution levels.

CNG And Bitumin From Rice Straw

Gadkari pointed out that nearly 200 lakh tonnes of rice straw or parali is burnt in Haryana and Punjab, a major cause of air pollution in the Delhi-NCR region. In this regard, the government is setting up 400 plants to convert the rice straw into CNG. At the moment, 60 plants are operational.

The minister also discussed a new project in Panipat in which rice straw is being used to create 1 lakh litres of Ethanol, 1.5 tonnes of bitumen, and 78,000 tonnes of jet fuel.

As the year draws to a close and 2026 approaches, most women find themselves juggling work deadlines, family responsibilities, and festive plans. In the middle of it all, personal health often slips to the bottom of the list. But doctors say this is exactly the time to pause and take stock of your body, especially your reproductive and hormonal health.

“Annual gynecological screening is one of the simplest ways to prevent silent illnesses, detect early changes, and understand your reproductive health better,” says Dr Tanveer Aujla, Consultant Obstetrician and Gynecologist at Motherhood Hospitals, Noida. Many common conditions show little to no symptoms in the early stages, making routine testing crucial.

Why yearly gynecological check-ups matter

Women often ignore subtle signs like fatigue, irregular periods, unexplained weight changes, or mood swings, assuming they are part of a busy lifestyle. According to Dr Aujla, this delay can be risky. “Conditions like cervical abnormalities, breast lumps, thyroid disorders, vitamin deficiencies, or hormonal imbalance often develop quietly and show symptoms only later,” she explains. A yearly check-up helps catch problems early and allows women to plan their health with confidence, especially if pregnancy is on the horizon.

Pap smear and HPV testing for cervical health

One of the most important screenings is the Pap smear combined with HPV testing. The Pap test looks for abnormal cells on the cervix, while the HPV test detects high-risk viruses responsible for most cervical cancers. “Together, they form a powerful screening tool,” Dr Aujla says. Women between 25 and 65 years should undergo this test every three to five years, or as advised by their doctor.

Breast screening for early detection

Breast health should never be overlooked. Dr Aujla advises yearly mammograms for women above 40, along with clinical breast examinations or ultrasound scans when needed. “These screenings help identify lumps, cysts, or early tissue changes,” she notes. She also stresses the importance of monthly self-examination to check for lumps, pain, or changes like inverted nipples.

Thyroid testing for unexplained symptoms

Thyroid disorders are extremely common in women and often remain undiagnosed. “A simple TSH, T3, and T4 test can explain symptoms like fatigue, mood swings, irregular periods, weight changes, or fertility issues,” says Dr Aujla. Early diagnosis can significantly improve quality of life and prevent long-term complications.

Fertility markers and preconception screening

Tests like AMH offer insight into ovarian reserve and help women plan their reproductive timelines. Dr Aujla points out that this is especially important for women with PCOS, irregular cycles, or delayed family planning. Preconception screening, which includes anemia levels, vitamin D, rubella immunity, blood sugar, and hormonal panels, ensures the body is prepared for a safe pregnancy.

Other essential health screenings

Women over 30 or those with a sedentary lifestyle should also get diabetes and cholesterol tests. Bone health panels checking calcium and vitamin D help prevent future osteoporosis. STI screening is equally important, as infections like chlamydia or gonorrhea can silently damage reproductive health if left untreated.

“Whether you are planning pregnancy or simply want to stay healthy, these tests offer clarity, confidence, and peace of mind,” Dr Aujla concludes. Taking time for these screenings before the year ends is a small step that can protect your health for years to come.

Santa Claus is bad for your health! This is a statement by Dr Nathan Grills, a Public Health Fellow in the Department of Epidemiology and Preventative Medicine, Monash University, Australia. Why is he saying this right ahead of Christmas?

Writing for an article in the British Medical Journal's Christmas issue (BMJ), he says, "Santa only needs to affect health by 0.1% to damage million of lives". He says it would be better if his popularity was rather used to promote healthy living.

Why Is Santa Claus Unhealthy?

Santa Claus's portrayal is where the concerns lie. This was not the first time someone has talked about. In fact, The Conversation in December 2024, talked about this exactly. If you look at Santa, he stands anywhere between 5'6" to 6'6" and weighs between 80Kgs to 136Kgs. He also carries a lot of weight around his belly, which, some may say, keeps him insulated as he sleighs through the snowy lands, but is sure overweight and obese. These portrayal promotes an unhealthy living.

Dr Grils also writes that Santa should rather share Rudolf's snack of carrots and celery sticks than brandy and mince pies, and swap his reindeer for a bike or a walk.

After reviewing existing literature and online sources to understand Santa Claus’s possible impact on public health, the analysis found no peer-reviewed studies directly addressing the issue. What did stand out, however, was the exceptionally high level of awareness of Santa among children. In fact, surveys of American schoolchildren showed that Santa Claus was recognized more widely than almost any other fictional character, second only to Ronald McDonald.

The doctor says that Santa is also used for selling products, which are mostly harmful, and this happens on global scale, which means, people get inspired. "Santa sells, and sometimes he sells harmful products. Like Coca-Cola, Santa has become a major export item to the developing world."

While Santa has been banned from smoking, but his images of enjoying a pipe or cigar are easily found on Christmas cards. The depiction of Santa does form a public perception, argues the doctor.

Dr Grill also notes that Santa may be promoting potential drink-driving, especially when someone follows the tradition to leave him a brandy to wish him well on his travels, while he has billion houses to visit.

Can Santa Spread Diseases?

Dr Grill says that he can spread diseases. If Santa sneezes or coughs around 10 times a day, all the children who sit on his lap may also end up catching the flu along with their Christmas presents.

However, it is important to note that these are views expressed by the doctor and no actual studies have been conducted on the same, Though Dr Grill does indicate for more research before calling for authorities to regulate Santa's activities. For now, Dr Grill proposes a new image for Santa, a healthier one. A slim Santa on a treadmill.