Your Donut Is The Reason Behind Your Depression—Research Shows Shocking Link Between Ultra-Processed Food And Mental Health

Updated May 27, 2025 | 01:00 AM IST

SummaryResearchers have claimed that any improvement in depression is associated with a reduction in microplastic exposure due to dietary substitutions.
Your Donut Is The Reason Behind Your Depression—Research Shows Shocking Link Between Ultra Processed Food And Mental Health

Credit: Canva

Your noodles, soft drinks and chips are ruining your mental health. A new viewpoint article published in the journal Brain Medicine highlights a possible role of microplastics in influencing the association between ultra-processed food intake and mental health adversities.

Ultra-processed foods, such as instant noodles, carbonated drinks, and packaged foods, are industrial formulations made from substances derived from whole foods. These food products contain high amounts of industrial additives and involve sophisticated packaging. The consumption of ultra-processed foods is rapidly increasing worldwide, especially in high-income countries. In the United States, these foods are associated with more than 50% of energy intake. Convenience, affordability, accessibility, aggressive marketing, and lifestyle changes are the major factors driving the global dietary shift from whole foods to ultra-processed foods.

Ultra Processed Food Leading To Depression

According to an umbrella review published in The BMJ and referenced in the viewpoint, people who consume ultra-processed foods have a 22% higher risk of depression, a 48% higher risk of anxiety, and a 41% higher risk of poor sleep outcomes compared to those with lower intake.

Recent observational studies indicate that excessive consumption of ultra-processed food is associated with poor sleep quality, physical health adversities, depression, and anxiety. This evidence is further supported by studies reporting that higher consumption of nutrient-rich, unprocessed foods potentially reduces the risk of mental disorders. Small randomized controlled trials, particularly those examining Mediterranean diet interventions in people with depression, have demonstrated moderate-to-large improvements in depressive symptoms. The findings of recent interventional studies also clearly indicate a link between dietary intake and mental health.

Microplastics as a contributing factor

Mental health adversities associated with ultra-processed food intake might be attributed to their poor nutrient profiles, energy density, and physical or chemical properties related to industrial processing and packaging methods, which introduce bisphenols and microplastics as contaminants.

Similar to ultra-processed foods, microplastics are known to induce oxidative stress, inflammation, immune dysfunction, altered metabolism, impaired cell growth and organ development, and carcinogenicity.

Microplastics and nanoplastics can increase the risk of neuropsychiatric disorders by inducing oxidative stress in the brain, causing nerve cell damage, and influencing the functionality of neurotransmitters, such as acetylcholine, γ-aminobutyric acid, and glutamate. However, it is important to note that much of the mechanistic evidence on microplastics and neurological effects comes from animal and cell culture studies, with limited direct human data.

Sources Of Microplastics

Because of processing and packaging methods, ultra-processed foods contain high amounts of microplastics. These foods are often stored and heated in plastic containers, a significant source of microplastics. For example, chicken nuggets can contain 30 times more microplastics per gram than chicken breast, and microwaving some plastic containers may release millions of microplastic and nanoplastic particles within minutes. Besides microplastics, bisphenol A used in plastic production can be released and mixed with ultra-processed foods when plastics degrade. Bisphenol A has been specifically associated with autism and depression in some human studies. These observations clearly indicate that excessive consumption of ultra-processed foods can accumulate microplastics and bisphenol A in the body.

Microplastics in the human brain

Emerging evidence highlights the presence of microplastics in the human brain. These microplastics, mainly polyethylene, are smaller in diameter (less than 200 nanometers) and are 7 to 30 times higher than those found in other organs, such as the liver or kidney. A recent study also found a 50% increase in brain microplastic concentration from 2016 to 2024, paralleling the ongoing rise of ultra-processed foods. One recent study found that people with dementia had three to five times higher levels of brain microplastics, but the authors emphasize this correlation does not imply causation.

Although some human studies have shown a link between bisphenol A exposure and risk of autism, depression, and anxiety, no evidence is currently available linking microplastic exposure to mental health adversities. This gap in knowledge is partly due to the difficulty in quantifying microplastic exposures in the human brain from an observational perspective and the ethical limitations surrounding microplastic exposure in interventional studies.

Implications for dietary intervention

Identifying microplastics in the brain and throughout the body raises significant health concerns. Several studies have highlighted the potential negative impact of microplastics on immune functions, genetic stability, and endocrine functions.

The SMILES trial is the first randomized controlled trial to investigate the efficacy of adjunctive dietary intervention in treating moderate to severe depression. The main aim of the dietary intervention was to replace nutrient-deficient, ultra-processed foods with nutrient-rich, unprocessed foods. The trial findings indicated significant improvement in depression among participants who consumed the intervention diet for 12 weeks. Compared to the 8% control group participants, remission was achieved for 32% of intervention group participants. This means that for approximately every four people who adopted the dietary changes, one additional person experienced remission from depression, compared to the control group (a measure known as the “number needed to treat,” which was 4.1).

Although the trial did not directly measure microplastic accumulation in participants’ bodies, it is imperative to hypothesise that the improvement in depression is associated with a reduction in microplastic exposure due to dietary substitutions. However, this remains a hypothesis requiring further investigation, as microplastic exposure was not directly measured.

The viewpoint notes that it would be valuable to conduct post-hoc analyses in such dietary trials, retrospectively estimating changes in microplastic content due to dietary interventions and their potential effect on mental health outcomes, as more data on microplastic content in foods becomes available.

Need For New Dietary Index

While the paper notes that research quantifying the microplastic content of various ultra-processed food items is becoming increasingly available, it does not state that methods are already well-established for all foods. It would be of prime importance to evaluate the changes in microplastic content due to dietary interventions and their subsequent effect on various mental health outcomes.

Several diet-based risk indices have been developed to assess the long-term impact of dietary exposure on physical and mental health. The Dietary Inflammatory Index has been developed to assess the inflammatory potential of a person’s diet based on the foods they consume. Similarly, the Nova food classification system has been developed to categorise foods based on the extent and purpose of industrial processing.

Given the significant utility of these indices, the authors of this article propose designing a Dietary Microplastic Index to assess the microplastic content and risk of accumulation based on the foods consumed. Currently, no nutritional population-based surveys estimate or track microplastic intake via diet, which precludes robust analysis of long-term microplastic exposure and adverse mental health outcomes. The global rise in the intake of microplastic-enriched ultra-processed foods, together with the simultaneous induction in mental health adversities, highlights the need for more research to investigate this association in humans.

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From Euphoria To Exhaustion: What It's Like Living With Bipolar Disorder

Updated May 29, 2025 | 04:00 PM IST

SummaryBipolar disorder is a mental health condition marked by extreme mood swings—ranging from manic highs to depressive lows—often disrupting sleep, energy, decision-making, and day-to-day functioning without warning. We discuss two real world cases of bipolar disorder and how living with it might feel like.
From Euphoria To Exhaustion: What It's Like Living With Bipolar Disorder

Credits: Canva (representational only)

Living with bipolar disorder is like riding an emotional roller coaster without a seatbelt. For nearly 40 million people worldwide, the disorder shifts between extremes of euphoria and despair, creating a complex reality that often goes unseen, misunderstood, or misrepresented. The term “bipolar” may casually get tossed around in everyday conversation, but for those diagnosed, it is a life-altering condition that requires continuous self-awareness, resilience, and adaptation.

In this feature, we explore the raw, honest experiences of individuals like Martin Hemmann and Becca Brown, who live with bipolar disorder, drawing back the curtain on what it truly means to navigate this unpredictable terrain.

What Is Bipolar Disorder?

Bipolar disorder is a chronic mental health condition characterized by extreme mood swings that include emotional highs (mania or hypomania) and lows (depression). There are three main types:

Bipolar I Disorder: Defined by manic episodes lasting at least seven days or requiring hospitalization, often followed by depressive episodes.

Bipolar II Disorder: Characterized by patterns of depressive episodes and hypomania, which is less severe than full-blown mania.

Cyclothymic Disorder: Involves chronic fluctuations between mild depressive and hypomanic symptoms over two years or more.

Though often glamorized or dismissed in pop culture, bipolar disorder is far more than a fluctuation in mood—it’s a serious, often debilitating condition that deeply affects how a person thinks, behaves, feels, and relates to the world.

Martin Hemmann, a musician from Germany, describes his life with bipolar disorder as a delicate dance between opposites. “When I woke up, I felt as if there was a grey fog in my head,” he shares. This haze, a hallmark of the depressive phase, can make simple tasks like getting out of bed or brushing one’s teeth feel insurmountable.

During these lows, Martin grapples with feelings of hopelessness, emptiness, and guilt. “I’ve learned to tell people around me who I am, and how I react,” he says. Open communication and personal routines such as meditation, breathing exercises, and staying physically active help him gain control during darker periods.

But when the pendulum swings in the opposite direction—toward mania—Martin experiences a rush of energy and heightened creativity. These manic episodes, while seemingly productive, come with their own dangers: impulsivity, sleep disturbances, and risky behavior.

Becca Brown, a performer living with Bipolar II, offers a similar yet unique perspective. She describes mania as moments of hyperactivity that can feel like being on caffeine overload. “I would just decide to clean my entire house, rearrange the furniture, stay up all night writing something,” she recalls. But the aftermath is sobering. “The next day I would look at all the things I wrote and be like, none of that makes sense. None of it is good.”

The stereotype of mania as a “fun” or “creative” side of bipolar disorder is misleading. While some individuals channel their manic energy into art or work, the reality often includes dangerous impulsivity, poor judgment, and emotional volatility.

Bipolar disorder doesn’t just affect the individual—it ripples out into their relationships, careers, and communities. Martin’s former partner, Verena Heinz, explains the challenge of unpredictability. “The ups and downs, which change so fast… that was the biggest challenge.”

This unpredictability can strain even the strongest bonds. For Martin’s parents, his suicide attempt six years ago was a devastating wake-up call. “It was very difficult to understand, because Martin also has a lot of humor and a joyful side,” they share. Their confusion and guilt underscore how invisible mental illness can be, especially when the individual appears “high-functioning.”

The stigma surrounding mental health—particularly bipolar disorder—can be a significant barrier to diagnosis, treatment, and acceptance. Martin puts it plainly in his speech: “People don’t talk about mental problems. I learned that early on—at school, at the club, at home.”

Both Martin and Becca emphasize the importance of treatment and personal coping strategies. While Martin has weaned off formal medication, he relies on physical activity, cold-water therapy, and structured routines to maintain his balance. “Sport is possibly the most important means of dealing with my depression,” he explains. “It creates a balance between the body and the mind.”

Becca, too, finds healing in creativity. “One of the best things about my life is that I get to get on stage or in front of a camera and play a character or even be myself,” she says.

Their stories reveal an important truth: there is no one-size-fits-all approach to managing bipolar disorder. Medication, therapy, physical health, creative outlets, community support, and open communication are all pieces of the puzzle—and each person’s journey is deeply personal.

Martin has chosen to speak openly about his journey—not just for himself, but to inspire others. At a recent public event in Germany, he delivered a powerful 18-minute speech recounting his struggles, setbacks, and survival.

“I’m nervous. I’d rather swim under a sheet of ice, climb into the ring, or go climbing without a rope,” he jokes before sharing the core message: “Germany, we have to talk. I suffer from heavy depression… But now I’m talking. I’m not going to stop talking.”

His courage moved an entire audience, many of whom also live with depression or know someone who does. “Martin has given them hope,” his manager Max reflects.

Recovery from bipolar disorder is not linear. There are relapses, side effects, misdiagnoses, and emotional wear-and-tear. Just as Martin planned a 200-kilometer walk to Zwolle to symbolize his healing, he was halted by a sudden joint infection. Life with bipolar disorder is full of such detours—but also full of resilience.

“I think we’re only as limited insofar as we set ourselves limits,” Martin affirms. Even on the hardest days, when depression whispers “you can’t,” Martin insists: “But I can get out of bed. I have arms and legs.”

Why Bipolar Disorder Difficult To Diagnose?

Bipolar disorder remains difficult to diagnose. Its symptoms often mimic or overlap with other mental health conditions, and the cyclical nature of the illness can delay accurate identification. Experts caution against simplistic portrayals or dramatic misrepresentations; understanding the disorder requires nuance. Diagnosis is not about labeling a mood but recognizing patterns over time.

Managing and Recognizing Symptoms of Bipolar Disorder

Effective management doesn't aim to "fix" moods but to achieve long-term stability through consistent, personalized care. A strategic blend of medical, psychological, and lifestyle interventions is often necessary.

Awareness is the first line of defense. Identifying triggers or shifts early can prevent a full-blown episode.

Track Mood Patterns: Use journaling or digital mood tracking apps to observe changes and trends over time.

Sleep as a Signal: Disruptions in sleep—whether insomnia or excessive sleep—can precede mood shifts.

Watch Energy Levels: Notice any significant increases in energy or physical agitation, or conversely, unexplained fatigue.

Daily Life Hacks for Stability

Small, consistent habits can build a powerful foundation for mental health.

Establish a Routine: Regular sleep, wake, and meal times help regulate the body’s natural rhythms.

Build a Support System: Involvement from trusted friends, family, and peer support groups (like NAMI) can be crucial in maintaining emotional balance.

Avoid Triggers: Minimize or eliminate stimulants such as caffeine, alcohol, and recreational drugs, which can exacerbate mood fluctuations.

Treatment

Professional support is vital. A combination of therapies can offer relief and structure:

Consult a Psychiatrist: A mental health specialist can make a formal diagnosis and develop a treatment plan.

Engage in Therapy: Cognitive Behavioral Therapy (CBT), family-focused therapy, and interpersonal therapy are effective tools.

Adhere to Medications: Commonly prescribed medications include mood stabilizers (like lithium), anticonvulsants, and atypical antipsychotics—tailored to each patient’s needs.

Living with bipolar disorder is not about extremes—it’s about everything in between. It’s about learning to surf the waves instead of drowning in them. It’s about telling your story, even when your voice shakes. And most of all, it’s about rewriting the narrative around mental illness—from fear to understanding, from stigma to solidarity.

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Don’t Miss These Subtle Signs Of Heat-Illness In Your Legs

Updated May 29, 2025 | 03:00 PM IST

SummaryHeat can trigger stressful situations not just for the environment but also for the human body. These however are avoidable conditions, if you recognize the signs.
Don’t Miss This Signs Of Heat-Illness In Your Legs

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With the ongoing heatwave, people have been very concerned regarding their health and well-being. While people may not realize it, heatwave not only is a natural hazard, but it has a great impact on society, which includes heat related deaths, as per the World Health Organization (WHO).

Heat affects us in many ways, whether it is affecting our body temperature, our appetite, or even our moods. However, one should not take high temperatures outside lightly. Heat can often trigger serious conditions, many of which need immediate action to rectify. One must know signs and early symptoms to avoid falling into a dangerous situation. One such sign of heat-illness can show up in your legs as well- Heat Cramps.

Pain in Your Muscles Due To Heat

Heat cramps are sharp, painful muscle spasms. They often happen when you're doing intense exercise or heavy work in hot weather. Not drinking enough water can make you more likely to get them. You'll most likely feel this pain or sudden, strong muscle tightening in your stomach area, arms, or legs. Remember, heat cramps can also be an early sign that you're heading towards heat exhaustion.

If you experience sudden, strong muscle tightening or painful twists, especially in your calves, thighs, or hamstrings, while working or exercising in hot conditions, it's a strong indicator of heat cramps. These cramps can be incredibly painful and are a direct result of dehydration and electrolyte imbalance. They can also be an early warning sign that you are heading towards heat exhaustion, so it's vital to address them immediately by resting, hydrating, and replacing lost electrolytes.

Heat-Related Illnesses And Types Of It

Heat cramps, along with some other illnesses, are types of heat stress. When you're in the hot weather, your body's amazing natural cooling system kicks in, sweating. As sweat evaporates from your skin, it carries heat away, helping to keep your core temperature stable. However, there are times when this system gets overwhelmed, and your body can get dangerously hot. This condition is known as heat stress. Understanding the different forms of heat stress and knowing how to protect yourself is crucial for staying safe in warm weather.

Dehydration

This is simply when your body doesn't have enough water. You lose water through sweating, and if you don't drink enough, you get dehydrated.

Heat Exhaustion

This happens if you stay in the heat for too long, especially if you're already dehydrated. Your body gets overworked trying to cool down.

Heat Cramps

These are painful muscle spasms. They often hit your legs, but can also affect your stomach or arms. They usually happen when you're working or exercising hard in the heat.

Heat Syncope

This is when you feel dizzy or even faint because of the heat.

Heat Rash

This looks like small red bumps on your skin, often in areas where you sweat a lot.

Heat Stroke

This is the most serious kind of heat illness. It's an emergency where your body can't cool itself down anymore, and your body temperature rises very quickly.

How to Protect Yourself from Heat Stress?

Taking a few simple steps can really help you avoid getting sick from the heat:

Drink plenty of fluids: Make sure to drink water and sports drinks before and while you're out in the heat. Don't wait until you're thirsty!

Wear light, loose clothes: Choose light-colored clothes that fit loosely. This helps your body stay cooler by reflecting sunlight and letting air move around.

Stay out of the sun during the hottest time: Try to avoid being in direct sunlight between 10:00 am and 4:00 pm, as this is usually when the sun is strongest.

Find a cool spot: If you start to feel too hot, move to a cool place right away. This could be an air-conditioned building, a shady spot, or even just a cooler room indoors.

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Bizarre Medical Case: Teen Without Vaginal Opening Becomes Pregnant, Stuns Doctors

Updated May 29, 2025 | 02:00 PM IST

SummaryYou may have heard many medical mysteries, but nothing like the case where a teen girl without a vaginal opening became pregnant. How did that happen? To know, continue to read.
Bizarre Medical Case: Teen Without Vaginal Opening Becomes Pregnant, Stuns Doctors

Credits: Canva

There are many bizarre medical cases and medical mysteries, but this is something you may not have heard before. This is the story of a 15-year-old girl form Lesotho, a country within South Africa, who became pregnant without having any vaginal opening.

How Did She Know About Her Pregnancy?

The girl was admitted in the hospital due to the complaints of abdominal pain. Tests revealed that she was nine month pregnant. What came as a shocker that she had no vaginal opening, thus never had sexual intercourse. This left doctors amused, wondering how she may have gotten pregnant? She had a rare birth defect called distal vaginal atresia.

What is Distal Vaginal Atresia?

This is condition where the vagina is closed or absent. This condition occurs with other developmental problems in a female baby. Most often the baby also has Bardet-Biedl syndrome, Fraser Syndrome or Rokitansky-Mayer-Küster -Hauser syndrome.

Bardet-Biedl syndrome is a rare disorder affecting many parts of the body. Loss of vision, obesity, kidney problems and intellectual disorders are common characteristics of the syndrome.

Fraser syndrome is a rare disorder affecting development starting before birth. Babies born with Fraser syndrome typically have eyes that are completely covered by skin and usually malformed, fingers and toes that are joined together, and abnormalities of the urinary tract.

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder in females causing the vagina and uterus to be underdeveloped or absent. It is often associated with kidney anomalies. This condition often accompanies a cloacal malformation, the surgical treatment which includes a variety of vaginal replacement techniques.

People with distal vaginal atresia do have menstruation, but the blood does not exit, which forms blockage and buildup within the uterus. This condition is called hematometra or hematocolpos, which can cause pelvic pain and discomfort.

This is a rare condition which affects 1 in 10,000 to 15,000 female children.

How Did She Become Pregnant?

While her body does not have a vaginal opening, but she does have a uterus, which means she can get pregnant if semen is injected and fertilized through in-vitro fertilization. However, this was not the case with her.

The girl later revealed that while she did notice her body change, she "did not believe she was pregnant." However, when she was told she was pregnant, she delivered her child though a C-section delivery.

In later interviews, she revealed that she had suffered stab wounds to her abdomen shortly after she had performed oral sex on her partner. At that time she confided in a nurse that her ex-partner had violently attacked her, when he found her in act with the current partner.

The medical team that attended her then concluded that it could be due to the stomach would which may have allowed the sperm she swallowed to reach her reproductive organs. This may have resulted into an unexpected conception.

Another shocker is that sperm does not survive in the digestive acid that stomach produces. However, the doctors believe that the sperm may have survived as at that time the girl was malnourished and the acidity levels in her digestive system may be low.

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