Health and Me

Tanya Dutt

Nutritionist Reveals The Secret To Longevity: Why Add Years Of Healthspan Is Important Than Just Years Of Lifespan

When people talk about <span>longevity</span>, the conversation often stops at numbers, living into the 80s, 90s, or even reaching 100. But what if those extra decades are spent in sickness, weakness, or disability? Nutritionist Deepthi Devatha encourages us to reorient. "The more significant conversation is about healthspan," she explains. "It's the period of time when our bodies and minds are still vital, active contributors, not mere passengers on a ride of decline."

This change of mindset is changing how scientists, physicians, and people view aging. It's not a matter of living longer—it's about being more vital longer.

Longevity merely refers to the measurement of long life. Life expectancy in the U.S. has increased from 47 years in 1900 to 77.5 years in 2022. Medicine, sanitation, and technology advanced us to this point. Yet, though genetics contributes about 25% to lifespan, the other 75% depends on lifestyle: what we eat, how we exercise, and how we deal with stress.

That's why longevity is not so much years on the calendar as what those years are like. Living into the 90s is worth a great deal more if you can still exercise, travel, and dine with family without being burdened by chronic disease. 

<h2><span rel="noindex">Healthspan vs Lifespan</span>: What's The Difference?</h2>

While lifespan calculates the years we live from birth until death, healthspan calculates the years that we live in good health, without being affected by significant diseases or disabilities. The aim is to bridge the two.

In Australia, for example, the average healthspan is about 70 years, while life expectancy is 81.2 years for men and 85.3 years for women. That leaves a decade or more when many people struggle with chronic disease. For First Nations Australians, the gap is even starker, with average life expectancy nearly 10 years shorter due to historical inequities, discrimination, and limited access to healthcare.

This disparity shows why healthspan is significant. Piling on healthy years not only enhances quality of life—it takes a dent out of disease's societal and economic cost.

Declines in energy, physical activity, and the body's capacity to keep its systems in balance naturally come with aging. Researchers also examine the genetic mechanisms, such as DNA repair and telomere length maintenance, that affect how cells age. Genetics is not, however, destiny.

A new 20-year study discovered that embracing healthy behaviors, particularly in older age, can both enhance healthspan and life expectancy even in individuals who have a genetic inclination towards reduced lifespan. Lifestyle does not simply add years but colors the character of those years.

In Devatha's opinion, the largest error that people commit is believing that longevity is in costly pills or advanced anti-aging molecules. "The most powerful longevity tools we have aren't in a pill; they're on our plates and in our routines," she clarifies.

She cites food timing as a strong lever. Limiting meals to an 8–10 hour period may kick off the body's cellular housekeeping cycle, ridding it of junk and enhancing glucose control. While diets rich in highly colored fruits and vegetables, olive oil, legumes, and fish build a gut ecosystem that dampens inflammation and supports immunity. "Our gut is an invisible organ of immunity and mood control," she says.

<h2>What Role Diet Plays In Longetivity?</h2>

The silver lining is that aiding longevity does not need drastic diets. Plain, steady habits are ideal:

Muscle power in protein: 20–30 grams at each meal maintains muscle mass, an effective shield against age-related frailty.

Brain health from fatty fish: Consuming two servings of salmon, mackerel, or sardines weekly aids cognitive function.

Colorful plate: Berries, leafy greens, and spices such as turmeric provide antioxidants and anti-inflammatory effects.

As Devatha puts it, "It's not complicated plans or trends; it's about being clever with the food you take on a daily basis."

<h2>Why Movement, Mindset, and Balance is Important For Wellness?</h2>

Nutrition is the base, but it's most effective with other health behaviors. Physical fitness keeps muscles strong, the heart healthy, and the mind well. Managing stress—through exercise such as meditation, yoga, or even just emphasizing rest—will reduce the long-term stress on the body.

Social bonding is also an underrated aspect. Loneliness has been associated with reduced lifespan and decreased healthspan. Solid community bonding and fulfilling relationships make individuals more resistant, not just psychologically but physically as well.

The conversation around healthspan is gaining traction worldwide, partly because longer lives are straining healthcare systems. In the US, chronic diseases like diabetes, cardiovascular illness, and dementia often dominate the final decades of life. By focusing on prevention through diet, exercise, and lifestyle, societies can shift the narrative—from disease management to health maintenance.

It's not simply a matter of lasting long enough to have more birthdays. It's a matter of making those birthdays rich in mobility, independence, and joy.

The quest for longevity is individual, yet it is also profoundly social. If individuals prioritize extending their healthspan, the impact trickles down to benefit families, communities, and even economies. <span>Healthy aging</span> enables individuals to continue sharing their abilities, experience, and vitality with the world for a longer period of time.

And the transformations that drive this shift—eating whole foods, exercising every day, reducing stress, and staying engaged—are accessible to nearly everyone.

Longevity is no longer a matter of counting years—it's a matter of making years count. As Devatha underscores, "By taking charge of what you eat and how you move, you take charge of your well-being. It's the difference between just getting through the day and truly thriving."

<em>Deepthi Devatha is a Nutritionist at Nutrify Today in India</em>

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When people talk about longevity, the conversation often stops at numbers, living into the 80s, 90s, or even reaching 100. But what if those extra decades are spent in sickness, weakness, or disability? Nutritionist Deepthi Devatha encourages us to reorient. "The more significant conversation is about healthspan," she explains. "It's the period of time when our bodies and minds are still vital, active contributors, not mere passengers on a ride of decline."This change of mindset is changing how scientists, physicians, and people view aging. It's not a matter of living longer—it's about being more vital longer.Longevity merely refers to the measurement of long life. Life expectancy in the U.S. has increased from 47 years in 1900 to 77.5 years in 2022. Medicine, sanitation, and technology advanced us to this point. Yet, though genetics contributes about 25% to lifespan, the other 75% depends on lifestyle: what we eat, how we exercise, and how we deal with stress.That's why longevity is not so much years on the calendar as what those years are like. Living into the 90s is worth a great deal more if you can still exercise, travel, and dine with family without being burdened by chronic disease. Healthspan vs Lifespan: What's The Difference?While lifespan calculates the years we live from birth until death, healthspan calculates the years that we live in good health, without being affected by significant diseases or disabilities. The aim is to bridge the two.In Australia, for example, the average healthspan is about 70 years, while life expectancy is 81.2 years for men and 85.3 years for women. That leaves a decade or more when many people struggle with chronic disease. For First Nations Australians, the gap is even starker, with average life expectancy nearly 10 years shorter due to historical inequities, discrimination, and limited access to healthcare.This disparity shows why healthspan is significant. Piling on healthy years not only enhances quality of life—it takes a dent out of disease's societal and economic cost.How Aging Works?Declines in energy, physical activity, and the body's capacity to keep its systems in balance naturally come with aging. Researchers also examine the genetic mechanisms, such as DNA repair and telomere length maintenance, that affect how cells age. Genetics is not, however, destiny.A new 20-year study discovered that embracing healthy behaviors, particularly in older age, can both enhance healthspan and life expectancy even in individuals who have a genetic inclination towards reduced lifespan. Lifestyle does not simply add years but colors the character of those years.In Devatha's opinion, the largest error that people commit is believing that longevity is in costly pills or advanced anti-aging molecules. "The most powerful longevity tools we have aren't in a pill; they're on our plates and in our routines," she clarifies.She cites food timing as a strong lever. Limiting meals to an 8–10 hour period may kick off the body's cellular housekeeping cycle, ridding it of junk and enhancing glucose control. While diets rich in highly colored fruits and vegetables, olive oil, legumes, and fish build a gut ecosystem that dampens inflammation and supports immunity. "Our gut is an invisible organ of immunity and mood control," she says.What Role Diet Plays In Longetivity?The silver lining is that aiding longevity does not need drastic diets. Plain, steady habits are ideal:Muscle power in protein: 20–30 grams at each meal maintains muscle mass, an effective shield against age-related frailty.Brain health from fatty fish: Consuming two servings of salmon, mackerel, or sardines weekly aids cognitive function.Colorful plate: Berries, leafy greens, and spices such as turmeric provide antioxidants and anti-inflammatory effects.As Devatha puts it, "It's not complicated plans or trends; it's about being clever with the food you take on a daily basis."Why Movement, Mindset, and Balance is Important For Wellness?Nutrition is the base, but it's most effective with other health behaviors. Physical fitness keeps muscles strong, the heart healthy, and the mind well. Managing stress—through exercise such as meditation, yoga, or even just emphasizing rest—will reduce the long-term stress on the body.Social bonding is also an underrated aspect. Loneliness has been associated with reduced lifespan and decreased healthspan. Solid community bonding and fulfilling relationships make individuals more resistant, not just psychologically but physically as well.The conversation around healthspan is gaining traction worldwide, partly because longer lives are straining healthcare systems. In the US, chronic diseases like diabetes, cardiovascular illness, and dementia often dominate the final decades of life. By focusing on prevention through diet, exercise, and lifestyle, societies can shift the narrative—from disease management to health maintenance.It's not simply a matter of lasting long enough to have more birthdays. It's a matter of making those birthdays rich in mobility, independence, and joy.The quest for longevity is individual, yet it is also profoundly social. If individuals prioritize extending their healthspan, the impact trickles down to benefit families, communities, and even economies. Healthy aging enables individuals to continue sharing their abilities, experience, and vitality with the world for a longer period of time.And the transformations that drive this shift—eating whole foods, exercising every day, reducing stress, and staying engaged—are accessible to nearly everyone.Longevity is no longer a matter of counting years—it's a matter of making years count. As Devatha underscores, "By taking charge of what you eat and how you move, you take charge of your well-being. It's the difference between just getting through the day and truly thriving."Deepthi Devatha is a Nutritionist at Nutrify Today in India

nutritionist reveals the secret to longevity: why add years of healthspan is important than just years of lifespan

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For many, beer is more than just a drink—it’s part of social culture, celebrations, and downtime rituals. But new research suggests there may be something more unsettling hiding in your pint glass, toxic “forever chemicals.” A recent study published in ACS Environmental Science &amp; Technology has revealed that over 95 percent of beers tested across the United States and abroad contain traces of per- and polyfluoroalkyl substances (PFAS).

PFAS are a large family of manmade chemicals developed in the mid-20th century for their resistance to water, oil, heat, and stains. They’re found in non-stick cookware, water-resistant clothing, food packaging, firefighting foams, and even cosmetics. Their industrial versatility, however, comes at a steep cost: PFAS do not naturally break down, earning them the nickname “forever chemicals.”

Mounting evidence links PFAS exposure to health problems, including hormonal disruption, weakened immunity, high cholesterol, liver damage, fertility challenges, and increased risks of certain cancers. The U.S. Environmental Protection Agency (EPA) recently set strict new limits on PFAS in drinking water, underscoring the urgency of the problem.

Beer is made primarily of water, and researchers suspected that if municipal water supplies were contaminated with PFAS, those chemicals might carry over into the brewing process. That’s exactly what this new study confirmed.

The research team, led by Jennifer Hoponick Redmon, adapted an EPA-approved method normally used for testing drinking water and applied it to beer. They examined 23 beers from across the U.S. including those brewed in North Carolina, Michigan, Colorado, California, Massachusetts, Pennsylvania, Wisconsin, and Missouri as well as beers imported from Mexico and the Netherlands.

The findings were striking: PFAS were present in 95 percent of samples, with contamination levels strongly correlating to the quality of local water supplies. Beers brewed near the Cape Fear River Basin in North Carolina, a region notorious for PFAS pollution, contained the highest concentrations and the widest mix of chemicals.

<h2>Why This Study Say About <span rel="noindex">Forever Chemicals</span> In Beer?</h2>

This is the first study to directly link municipal water contamination to PFAS levels in U.S. retail beer. While breweries often use filtration systems, these methods are not designed to capture PFAS. As a result, the contamination that begins in local rivers and reservoirs can persist all the way into the finished product.

The results highlight an uncomfortable reality: PFAS contamination doesn’t just stay in the water—it spreads into food and beverages consumed daily. Beer is only the latest product to show evidence of contamination, joining an already long list that includes bottled water, fish, dairy, and vegetables.

“As an occasional beer drinker myself, I wondered whether PFAS in water supplies was making its way into our pints,” said Redmon in a statement. “I hope these findings inspire water treatment strategies and policies that help reduce the likelihood of PFAS in future pours.”

Her comments echo a growing consensus among environmental health experts that solving PFAS contamination requires systemic change. Since individual breweries can do little to alter the chemical composition of municipal water, solutions must come from upgrading public water systems and enforcing stricter industrial discharge regulations.

<h2>What Are The Health Risks Beyond the Glass?</h2>

For consumers, the immediate concern is how much PFAS exposure from beer actually contributes to long-term health risks. The EPA’s new standards set the safe threshold for certain PFAS, including perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), at near-zero levels in drinking water. While the amounts found in beer are relatively small per serving, scientists warn that cumulative exposure across multiple sources—water, food, packaging, and now beer—poses a real risk over time.

The issue extends far beyond breweries. PFAS contamination has been detected in rivers, groundwater, and public water systems across the United States and around the globe. A seven-fold increase in Google searches for “PFAS” in the past five years reflects rising public concern as awareness grows.

Everyday products contribute to the exposure cycle: waterproof clothing, stain-resistant upholstery, non-stick pans, and even cosmetics like waterproof mascaras can shed PFAS into the environment. Once in the ecosystem, they seep into soil, water, and eventually our bodies.

For casual drinkers, a pint of beer is unlikely to be the sole driver of PFAS-related health risks. However, the study reinforces a broader message: PFAS are everywhere, and beer is another reminder of how pervasive they’ve become. Health experts emphasize that reducing exposure across all possible sources is key, since the chemicals accumulate in the body over time.

As Dr. Redmon’s team points out, the solution doesn’t lie in avoiding beer altogether—it lies in addressing the root of the problem: contaminated water systems and unchecked chemical pollution.

diet & nutrition

forever chemicals

pfas in beer

toxic chemicals in food

pfas health risks

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pfas exposure dangers

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For many, beer is more than just a drink—it’s part of social culture, celebrations, and downtime rituals. But new research suggests there may be something more unsettling hiding in your pint glass, toxic “forever chemicals.” A recent study published in ACS Environmental Science & Technology has revealed that over 95 percent of beers tested across the United States and abroad contain traces of per- and polyfluoroalkyl substances (PFAS).PFAS are a large family of manmade chemicals developed in the mid-20th century for their resistance to water, oil, heat, and stains. They’re found in non-stick cookware, water-resistant clothing, food packaging, firefighting foams, and even cosmetics. Their industrial versatility, however, comes at a steep cost: PFAS do not naturally break down, earning them the nickname “forever chemicals.”Mounting evidence links PFAS exposure to health problems, including hormonal disruption, weakened immunity, high cholesterol, liver damage, fertility challenges, and increased risks of certain cancers. The U.S. Environmental Protection Agency (EPA) recently set strict new limits on PFAS in drinking water, underscoring the urgency of the problem.How Did PFAS End Up in Beer?Beer is made primarily of water, and researchers suspected that if municipal water supplies were contaminated with PFAS, those chemicals might carry over into the brewing process. That’s exactly what this new study confirmed.The research team, led by Jennifer Hoponick Redmon, adapted an EPA-approved method normally used for testing drinking water and applied it to beer. They examined 23 beers from across the U.S. including those brewed in North Carolina, Michigan, Colorado, California, Massachusetts, Pennsylvania, Wisconsin, and Missouri as well as beers imported from Mexico and the Netherlands.The findings were striking: PFAS were present in 95 percent of samples, with contamination levels strongly correlating to the quality of local water supplies. Beers brewed near the Cape Fear River Basin in North Carolina, a region notorious for PFAS pollution, contained the highest concentrations and the widest mix of chemicals.Why This Study Say About Forever Chemicals In Beer?This is the first study to directly link municipal water contamination to PFAS levels in U.S. retail beer. While breweries often use filtration systems, these methods are not designed to capture PFAS. As a result, the contamination that begins in local rivers and reservoirs can persist all the way into the finished product.The results highlight an uncomfortable reality: PFAS contamination doesn’t just stay in the water—it spreads into food and beverages consumed daily. Beer is only the latest product to show evidence of contamination, joining an already long list that includes bottled water, fish, dairy, and vegetables.“As an occasional beer drinker myself, I wondered whether PFAS in water supplies was making its way into our pints,” said Redmon in a statement. “I hope these findings inspire water treatment strategies and policies that help reduce the likelihood of PFAS in future pours.”Her comments echo a growing consensus among environmental health experts that solving PFAS contamination requires systemic change. Since individual breweries can do little to alter the chemical composition of municipal water, solutions must come from upgrading public water systems and enforcing stricter industrial discharge regulations.What Are The Health Risks Beyond the Glass?For consumers, the immediate concern is how much PFAS exposure from beer actually contributes to long-term health risks. The EPA’s new standards set the safe threshold for certain PFAS, including perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), at near-zero levels in drinking water. While the amounts found in beer are relatively small per serving, scientists warn that cumulative exposure across multiple sources—water, food, packaging, and now beer—poses a real risk over time.The issue extends far beyond breweries. PFAS contamination has been detected in rivers, groundwater, and public water systems across the United States and around the globe. A seven-fold increase in Google searches for “PFAS” in the past five years reflects rising public concern as awareness grows.Everyday products contribute to the exposure cycle: waterproof clothing, stain-resistant upholstery, non-stick pans, and even cosmetics like waterproof mascaras can shed PFAS into the environment. Once in the ecosystem, they seep into soil, water, and eventually our bodies.For casual drinkers, a pint of beer is unlikely to be the sole driver of PFAS-related health risks. However, the study reinforces a broader message: PFAS are everywhere, and beer is another reminder of how pervasive they’ve become. Health experts emphasize that reducing exposure across all possible sources is key, since the chemicals accumulate in the body over time.As Dr. Redmon’s team points out, the solution doesn’t lie in avoiding beer altogether—it lies in addressing the root of the problem: contaminated water systems and unchecked chemical pollution.

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Heavy drinking is a recognized risk factor for liver injury, but a new report by the University of California San Diego reveals an previously unrecognized mechanism that amplifies this damage. Long-term drinking not only causes direct damage to the liver but also initiates a toxic cycle involving the gut, in which bacteria spill into the blood and attack the liver, leading to cumulative injury.

This new research, published in Nature, combines human liver biopsies and mouse models of alcohol-associated liver disease to reveal a molecular pathway that could redefine our understanding of alcohol-related liver damage.

The research points out a protein known as <span>mAChR4</span>, which is present in the small intestine, and is critical in supporting the immune defenses of the gut. Prolonged alcohol consumption inhibits the synthesis of mAChR4 and hence the creation of GAPs, or goblet cell-associated antigen passages. GAPs are the unique structures that facilitate the education of the immune system in order to effectively respond to microbes.

When GAPs do not form, gut bacteria have a greater likelihood of leaking from the intestines and infecting organs such as the liver. Inside the liver, the bacteria have the ability to increase inflammation and tissue damage, adding to the liver damage that has been inflicted by alcohol. In essence, alcohol compromises the gut-liver barrier while, at the same time, establishing an environment in which bacterial invasion can occur, making it a self-sustaining cycle of harm.

The UC San Diego researchers determined that restoring mAChR4 function had the potential to fix GAPs and strengthen the immune system's attack on rogue gut bacteria. This therapy, which may be accomplished with drugs that directly stimulate mAChR4 or by altering related signaling pathways, decreased liver damage in laboratory models.

Although limiting alcohol intake is the most straightforward method of safeguarding the liver, targeting mAChR4 represents a promising therapeutic strategy for alcohol abusers or individuals already damaged by liver injury. Curiously, mAChR4 is also expressed in the brain, where it modulates habit formation and addiction. Reduced levels of this protein have been noted in individuals with alcohol use disorder, paving the way for future treatments that target both liver function and addictive behavior.

<h2>Effects of Alcohol on Gut and <span rel="noindex">Liver Health</span></h2>

Outside the liver, alcohol can significantly interfere with gut health in several ways. Six mechanisms explain how long-term drinking damages the digestive tract:

Alcohol loosens the lower esophageal sphincter, permitting stomach acid to flow back and produce heartburn or gastroesophageal reflux disease (GERD).

Excessive drinking upsets the balance of bacteria in the intestines, favoring "bad" bacteria that stimulate inflammation and intestinal permeability. This causes a leaky gut syndrome, where poisons enter the blood.

Alcohol interferes with mucus production within the stomach, which makes the lining susceptible to inflammation, pain, nausea, and vomiting.

Alcohol changes sugar metabolism and microbial equilibrium, in addition to stimulating yeast overgrowth, all of which promote gas production and bloating.

Long-term drinking results in <span>alcoholic fatty liver</span> disease and alcoholic steatohepatitis. Fat deposition, inflammation, and toxin-induced cell damage can evolve into cirrhosis, liver cancer, or liver failure, sometimes requiring transplantation.

Alcohol is metabolized by the pancreas into poisonous byproducts that can inflame the organ in an illness known as pancreatitis. Regular heavy alcohol consumption, particularly along with smoking, increases the risk for acute and chronic pancreatitis and long-term complications such as diabetes and pancreatic carcinoma.

The recognition of mAChR4 as a central figure in the gut-liver axis reveals a number of avenues for research. Drug therapies that enhance mAChR4 function within the gut would restore GAP function, reinforcing immunity against translocating bacteria. At the same time, drugs that increase mAChR4 function in the brain would decrease alcohol craving and treat the disorder itself, attacking both cause and effect of chronic alcoholism.

This dual potential makes mAChR4 an especially attractive target in the fight against alcohol-related disease. Clinical trials of mAChR4-targeted drugs are already in progress for other neurological disorders like schizophrenia, which provides the hope that those drugs might one day find use against alcohol-related liver disease as well.

<h2>What Is The Alcohol and the Gut-Liver Axis?</h2>

Appreciation of gut-liver interaction puts the wider public health significance of chronic alcohol use into perspective. Interventions to address gut integrity, immune response, and liver defense may be able to complement traditional measures aimed at decreased alcohol consumption.

In addition, increased awareness of how alcohol impacts not only the liver but also gut bacteria may encourage behavior change. Most individuals downplay the insidious, long-term effects of alcohol on digestive health, thinking damage to the liver only follows decades of misuse. Changes in gut barrier function and bacterial translocation, however, can hasten liver injury even in moderate chronic drinkers.

<h2>How Can You Prevent and Treat Alcohol-related Liver Damage?</h2>

For individuals, the clearest path to protecting liver health remains reducing alcohol intake. However, for those who struggle with dependency, therapies targeting mAChR4 may provide an adjunctive strategy to prevent liver injury while supporting recovery.

Nutrition and lifestyle also contribute to sustaining liver and gut health. A diet high in fiber, probiotics, and anti-inflammatory food can promote healthy gut bacteria and immune function, possibly preventing some of the adverse effects of alcohol.

The UC San Diego research reveals a key feedback loop of alcohol-induced liver damage: long-term drinking compromises gut barriers, enabling bacteria to travel to the liver, exacerbating injury. Targeting mAChR4 might interrupt this self-destructive process, providing new hope for treating alcohol-related liver disease.

This study supports an important message: alcohol not only harms the liver outright; it upsets the gut-liver axis and compounds damage. With advancing science, learning more about the molecular mechanisms underlying these effects can inform preventive measures and novel treatments and offer hope for millions globally affected by alcohol-associated liver disease.

liver health

alcohol liver damage

gut bacteria liver

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leaky gut alcohol

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alcohol and pancreatitis

liver disease treatment

Heavy drinking is a recognized risk factor for liver injury, but a new report by the University of California San Diego reveals an previously unrecognized mechanism that amplifies this damage. Long-term drinking not only causes direct damage to the liver but also initiates a toxic cycle involving the gut, in which bacteria spill into the blood and attack the liver, leading to cumulative injury.This new research, published in Nature, combines human liver biopsies and mouse models of alcohol-associated liver disease to reveal a molecular pathway that could redefine our understanding of alcohol-related liver damage.The research points out a protein known as mAChR4, which is present in the small intestine, and is critical in supporting the immune defenses of the gut. Prolonged alcohol consumption inhibits the synthesis of mAChR4 and hence the creation of GAPs, or goblet cell-associated antigen passages. GAPs are the unique structures that facilitate the education of the immune system in order to effectively respond to microbes.When GAPs do not form, gut bacteria have a greater likelihood of leaking from the intestines and infecting organs such as the liver. Inside the liver, the bacteria have the ability to increase inflammation and tissue damage, adding to the liver damage that has been inflicted by alcohol. In essence, alcohol compromises the gut-liver barrier while, at the same time, establishing an environment in which bacterial invasion can occur, making it a self-sustaining cycle of harm.The UC San Diego researchers determined that restoring mAChR4 function had the potential to fix GAPs and strengthen the immune system's attack on rogue gut bacteria. This therapy, which may be accomplished with drugs that directly stimulate mAChR4 or by altering related signaling pathways, decreased liver damage in laboratory models.Although limiting alcohol intake is the most straightforward method of safeguarding the liver, targeting mAChR4 represents a promising therapeutic strategy for alcohol abusers or individuals already damaged by liver injury. Curiously, mAChR4 is also expressed in the brain, where it modulates habit formation and addiction. Reduced levels of this protein have been noted in individuals with alcohol use disorder, paving the way for future treatments that target both liver function and addictive behavior.Effects of Alcohol on Gut and Liver HealthOutside the liver, alcohol can significantly interfere with gut health in several ways. Six mechanisms explain how long-term drinking damages the digestive tract:1. Acid RefluxAlcohol loosens the lower esophageal sphincter, permitting stomach acid to flow back and produce heartburn or gastroesophageal reflux disease (GERD).2. DiarrheaExcessive drinking upsets the balance of bacteria in the intestines, favoring "bad" bacteria that stimulate inflammation and intestinal permeability. This causes a leaky gut syndrome, where poisons enter the blood.3. GastritisAlcohol interferes with mucus production within the stomach, which makes the lining susceptible to inflammation, pain, nausea, and vomiting.4. BloatingAlcohol changes sugar metabolism and microbial equilibrium, in addition to stimulating yeast overgrowth, all of which promote gas production and bloating.5. Liver DamageLong-term drinking results in alcoholic fatty liver disease and alcoholic steatohepatitis. Fat deposition, inflammation, and toxin-induced cell damage can evolve into cirrhosis, liver cancer, or liver failure, sometimes requiring transplantation.6. Pancreatic DamageAlcohol is metabolized by the pancreas into poisonous byproducts that can inflame the organ in an illness known as pancreatitis. Regular heavy alcohol consumption, particularly along with smoking, increases the risk for acute and chronic pancreatitis and long-term complications such as diabetes and pancreatic carcinoma.The recognition of mAChR4 as a central figure in the gut-liver axis reveals a number of avenues for research. Drug therapies that enhance mAChR4 function within the gut would restore GAP function, reinforcing immunity against translocating bacteria. At the same time, drugs that increase mAChR4 function in the brain would decrease alcohol craving and treat the disorder itself, attacking both cause and effect of chronic alcoholism.This dual potential makes mAChR4 an especially attractive target in the fight against alcohol-related disease. Clinical trials of mAChR4-targeted drugs are already in progress for other neurological disorders like schizophrenia, which provides the hope that those drugs might one day find use against alcohol-related liver disease as well.What Is The Alcohol and the Gut-Liver Axis?Appreciation of gut-liver interaction puts the wider public health significance of chronic alcohol use into perspective. Interventions to address gut integrity, immune response, and liver defense may be able to complement traditional measures aimed at decreased alcohol consumption.In addition, increased awareness of how alcohol impacts not only the liver but also gut bacteria may encourage behavior change. Most individuals downplay the insidious, long-term effects of alcohol on digestive health, thinking damage to the liver only follows decades of misuse. Changes in gut barrier function and bacterial translocation, however, can hasten liver injury even in moderate chronic drinkers.How Can You Prevent and Treat Alcohol-related Liver Damage?For individuals, the clearest path to protecting liver health remains reducing alcohol intake. However, for those who struggle with dependency, therapies targeting mAChR4 may provide an adjunctive strategy to prevent liver injury while supporting recovery.Nutrition and lifestyle also contribute to sustaining liver and gut health. A diet high in fiber, probiotics, and anti-inflammatory food can promote healthy gut bacteria and immune function, possibly preventing some of the adverse effects of alcohol.The UC San Diego research reveals a key feedback loop of alcohol-induced liver damage: long-term drinking compromises gut barriers, enabling bacteria to travel to the liver, exacerbating injury. Targeting mAChR4 might interrupt this self-destructive process, providing new hope for treating alcohol-related liver disease.This study supports an important message: alcohol not only harms the liver outright; it upsets the gut-liver axis and compounds damage. With advancing science, learning more about the molecular mechanisms underlying these effects can inform preventive measures and novel treatments and offer hope for millions globally affected by alcohol-associated liver disease.

Aarushi Bhadury

Gut Doctor Reveals The Top 3 Causes Of Bloating You Should Stop Ignoring

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A common phrase that many people say things like ‘I feel so bloated’ or ‘My stomach looks so bloated’ but what does it exactly mean? When a person feels bloated it is more than just an aesthetic or look issue. It's not just the fact that their abdomen looks swollen, but it means that they are feeling lot of pressure in their stomach due to build up of gas. 

It is an uncomfortable sensation that can distract you from your work, make it difficult to focus on important things as well as causing you abdominal pain. 

Considering this, and it being a common issue for many people, you will find a barrage of online advice telling you to drink ‘anti-bloating’ drink or try ‘that anti-bloating’ exercise. To deal with this, however, one must know exactly why they are bloated in the first place. 

<h2>What Are The <span rel="noindex">Top 3 Causes Of Bloating</span>?</h2>

Dr. <span>Saurabh Sethi</span>, a gastroenterologist, addresses a very common concern in his practice: chronic bloating. He explains that if you feel bloated every time you eat, it's likely due to one of three reasons he frequently sees in his patients. 

While many people believe they know the cause, Dr. Sethi points out that the most common culprit is often overlooked. He aims to provide clarity on these issues, noting that the final reason he discusses is the one most likely causing problems for the average person. By understanding the root cause, individuals can take the right steps toward finding relief. 

<h4>Number 3 Reason for Bloating Constipation </h4>

Dr. Sethi explains that a common cause of bloating is constipation, and it isn't always what you think. While many people believe they're fine as long as they have a daily bowel movement, the real issue can be a "slow colon." This means food waste moves through your digestive system at a sluggish pace. 

When this happens, food sits in your intestines for a much longer time than it should. This creates a perfect environment for the bacteria in your gut to break down the leftover food through a process called fermentation. This process releases a significant amount of gas, leading to that uncomfortable feeling of fullness, pressure, and bloating you experience after eating. 

<h4>Number 2 Reason for Bloating: IBS or Functional Dyspepsia </h4>

In this case, the main problem is an overly sensitive gut. Dr. Sethi points out that for people with <span>Irritable Bowel Syndrome</span> (IBS) or functional dyspepsia, the nerves and muscles in the intestines can move in a chaotic or irregular way. Instead of a smooth, coordinated process, the muscles can spasm or move too quickly or too slowly. 

This irregular motion can easily trap pockets of gas, causing pressure and a visibly distended abdomen. This gut dysfunction is often linked to an imbalance in the gut's bacterial environment, which can make the intestines more sensitive to normal digestive processes and cause them to overreact, leading to heightened symptoms of gas and bloating. 

<h4>Number 1 Reason for Bloating: Diet </h4>

According to Dr. Sethi, your diet is the most frequent and significant cause of chronic bloating. The primary culprits are specific types of carbohydrates that your small intestine has a hard time fully absorbing. These include lactose found in dairy products, fructose from many fruits and sweeteners like high-fructose corn syrup, and fructans in common foods like wheat, onions, and garlic. 

When these undigested carbs reach your large intestine, the bacteria there have a feast, releasing a huge amount of gas as a byproduct. Dr. Sethi emphasizes that even healthy foods, such as broccoli, beans, and certain fruits, can trigger these symptoms if your digestive system is sensitive to these particular ingredients. 

gut health

saurabh sethi

irritable bowel syndrome

Causes Of Bloating

Top 3 Causes Of Bloating

gut doctor advice

A common phrase that many people say things like ‘I feel so bloated’ or ‘My stomach looks so bloated’ but what does it exactly mean? When a person feels bloated it is more than just an aesthetic or look issue. It's not just the fact that their abdomen looks swollen, but it means that they are feeling lot of pressure in their stomach due to build up of gas. It is an uncomfortable sensation that can distract you from your work, make it difficult to focus on important things as well as causing you abdominal pain. Considering this, and it being a common issue for many people, you will find a barrage of online advice telling you to drink ‘anti-bloating’ drink or try ‘that anti-bloating’ exercise. To deal with this, however, one must know exactly why they are bloated in the first place. What Are The Top 3 Causes Of Bloating?Dr. Saurabh Sethi, a gastroenterologist, addresses a very common concern in his practice: chronic bloating. He explains that if you feel bloated every time you eat, it's likely due to one of three reasons he frequently sees in his patients. While many people believe they know the cause, Dr. Sethi points out that the most common culprit is often overlooked. He aims to provide clarity on these issues, noting that the final reason he discusses is the one most likely causing problems for the average person. By understanding the root cause, individuals can take the right steps toward finding relief. Number 3 Reason for Bloating Constipation Dr. Sethi explains that a common cause of bloating is constipation, and it isn't always what you think. While many people believe they're fine as long as they have a daily bowel movement, the real issue can be a "slow colon." This means food waste moves through your digestive system at a sluggish pace. When this happens, food sits in your intestines for a much longer time than it should. This creates a perfect environment for the bacteria in your gut to break down the leftover food through a process called fermentation. This process releases a significant amount of gas, leading to that uncomfortable feeling of fullness, pressure, and bloating you experience after eating. Number 2 Reason for Bloating: IBS or Functional Dyspepsia In this case, the main problem is an overly sensitive gut. Dr. Sethi points out that for people with Irritable Bowel Syndrome (IBS) or functional dyspepsia, the nerves and muscles in the intestines can move in a chaotic or irregular way. Instead of a smooth, coordinated process, the muscles can spasm or move too quickly or too slowly. This irregular motion can easily trap pockets of gas, causing pressure and a visibly distended abdomen. This gut dysfunction is often linked to an imbalance in the gut's bacterial environment, which can make the intestines more sensitive to normal digestive processes and cause them to overreact, leading to heightened symptoms of gas and bloating. Number 1 Reason for Bloating: Diet According to Dr. Sethi, your diet is the most frequent and significant cause of chronic bloating. The primary culprits are specific types of carbohydrates that your small intestine has a hard time fully absorbing. These include lactose found in dairy products, fructose from many fruits and sweeteners like high-fructose corn syrup, and fructans in common foods like wheat, onions, and garlic. When these undigested carbs reach your large intestine, the bacteria there have a feast, releasing a huge amount of gas as a byproduct. Dr. Sethi emphasizes that even healthy foods, such as broccoli, beans, and certain fruits, can trigger these symptoms if your digestive system is sensitive to these particular ingredients. 

gut doctor reveals the top 3 causes of bloating you should stop ignoring

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