Health and Me

Ishita Roy

More New Moms Turning to Ozempic After Birth, But Experts Are Worried

Danish researchers were studying the use of medicines on women during and after pregnancy. What they realized is that number of women consuming Ozempic and Wegovy after childbirth has increased. As per their observation, in 2018, less than 5 prescriptions for every 10,000 women post six months of their childbirth were there. However, this number increased to 34 in mid-2022, and by mid-2024, there were 173 prescriptions.

That comes close to 2 percent of all postpartum women. Most of these women were in their 30s, had more than one child, and while many were overweight, they did not have diabetes. They also had no previous history of using GLP-1 medications.

This spike surprised researchers because the postpartum phase is usually a time when the body naturally sheds some pregnancy weight and undergoes major hormonal changes. “In a period characterized by natural weight loss and marked hormonal change, this was unexpected,” said Mette Bliddal, a pharmacologist at the University of Southern Denmark and the study’s first author, as reported by the New York Times. The findings were published in JAMA.

The analysis reviewed 382,277 pregnancies in Denmark from early 2018 through June 2024. Researchers used national health registries to track every live birth and every prescription filled for GLP-1 drugs during the postpartum period. This made it possible to see the rise in real time.

Although semaglutide, the ingredient in Ozempic and Wegovy, is widely used for weight loss, its safety in the months after childbirth is still unclear. This is a time when many mothers are breastfeeding and adjusting to changing hormone levels, sleep disruptions, and recovery from pregnancy.

<h2>What We Know and Don’t Know About Breastfeeding Safety</h2>

Right now, evidence around the safety of GLP-1 drugs for breastfeeding mothers is very limited. While semaglutide has not been detected in measurable amounts in breast milk and no immediate negative effects have been seen in infants, researchers caution that long-term effects on a baby’s metabolism, growth, or pancreas remain unknown.

Major medical groups are also hesitant to give a firm recommendation. The American College of Obstetricians and Gynecologists has not released guidelines because the drugs are too new and the data isn’t strong enough. First Exposure, a Canadian research network that evaluates drug safety in pregnancy and breastfeeding, advises against using these medications while breastfeeding. They also recommend stopping them one to two months before trying to conceive.

Experts say the caution comes from the lack of solid research. GLP-1 drugs are large molecules that usually do not transfer easily into breast milk and would likely break down in a baby’s stomach. Still, the uncertainty is significant enough that researchers prefer mothers avoid them during breastfeeding.

Another concern is that these appetite-suppressing medications could affect milk production, nutrient content, or even leave mothers dehydrated. Dr. Bliddal noted that the postpartum period is a time when “the body is working hard to regain its balance.” Without knowing how weight loss drugs interact with these processes, many specialists believe it is safer to avoid them until more is known.

Even small changes in breast milk composition could matter for infant development. Since there is no clear data on how GLP-1 drugs might alter fat content or nutrients in breast milk, researchers urge caution.

Health Conditions A-Z

health

women use ozempic post pregnancy

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weight loss drugs

postpartum use of weight loss drugs

ozempic

wegovy

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Danish researchers were studying the use of medicines on women during and after pregnancy. What they realized is that number of women consuming Ozempic and Wegovy after childbirth has increased. As per their observation, in 2018, less than 5 prescriptions for every 10,000 women post six months of their childbirth were there. However, this number increased to 34 in mid-2022, and by mid-2024, there were 173 prescriptions. That comes close to 2 percent of all postpartum women. Most of these women were in their 30s, had more than one child, and while many were overweight, they did not have diabetes. They also had no previous history of using GLP-1 medications.This spike surprised researchers because the postpartum phase is usually a time when the body naturally sheds some pregnancy weight and undergoes major hormonal changes. “In a period characterized by natural weight loss and marked hormonal change, this was unexpected,” said Mette Bliddal, a pharmacologist at the University of Southern Denmark and the study’s first author, as reported by the New York Times. The findings were published in JAMA.How Was The Study Conducted?The analysis reviewed 382,277 pregnancies in Denmark from early 2018 through June 2024. Researchers used national health registries to track every live birth and every prescription filled for GLP-1 drugs during the postpartum period. This made it possible to see the rise in real time.Although semaglutide, the ingredient in Ozempic and Wegovy, is widely used for weight loss, its safety in the months after childbirth is still unclear. This is a time when many mothers are breastfeeding and adjusting to changing hormone levels, sleep disruptions, and recovery from pregnancy.What We Know and Don’t Know About Breastfeeding SafetyRight now, evidence around the safety of GLP-1 drugs for breastfeeding mothers is very limited. While semaglutide has not been detected in measurable amounts in breast milk and no immediate negative effects have been seen in infants, researchers caution that long-term effects on a baby’s metabolism, growth, or pancreas remain unknown.Major medical groups are also hesitant to give a firm recommendation. The American College of Obstetricians and Gynecologists has not released guidelines because the drugs are too new and the data isn’t strong enough. First Exposure, a Canadian research network that evaluates drug safety in pregnancy and breastfeeding, advises against using these medications while breastfeeding. They also recommend stopping them one to two months before trying to conceive.Experts say the caution comes from the lack of solid research. GLP-1 drugs are large molecules that usually do not transfer easily into breast milk and would likely break down in a baby’s stomach. Still, the uncertainty is significant enough that researchers prefer mothers avoid them during breastfeeding.Why Researchers Are ConcernedAnother concern is that these appetite-suppressing medications could affect milk production, nutrient content, or even leave mothers dehydrated. Dr. Bliddal noted that the postpartum period is a time when “the body is working hard to regain its balance.” Without knowing how weight loss drugs interact with these processes, many specialists believe it is safer to avoid them until more is known.Even small changes in breast milk composition could matter for infant development. Since there is no clear data on how GLP-1 drugs might alter fat content or nutrients in breast milk, researchers urge caution.