Nisha Pandey

AI Analysed 400,000 Reddit Posts About Ozempic And Mounjaro And Found 2 Unusual Side-Effects Worth Noting

AI Analysed 400,000 Reddit Posts About Ozempic And Mounjaro: Here Are The Side Effects Worth Noting

A recent AI analysis of more than 400,000 Reddit posts about popular <span>GLP-1 drugs</span> like <span>Ozempic</span>, Wegovy, <span>Mounjaro</span> and <span>Zepbound</span> revealed several side effects that researchers may not have fully recorded in clinical trials. 

The study, published in <em>Nature Health</em>, analysed 410,198 Reddit posts from May 2019 through June 2025. Researchers identified 67,008 people who self-reported using semaglutide or tirzepatide, with 43.5% reporting at least one side effect. 

The findings do not prove that the drugs caused the symptoms. Instead, they did identify patterns in patients' own accounts that may need further investigation. 

<h2>What Side Effects Did The AI Find? </h2>

As expected, the analysis found gastrointestinal symptoms in majority. Among <a href="https://www.healthandme.com/health-wellness/exclusive-glp-1-drugs-are-the-new-statins-says-university-hospital-birmingham-professor-article-156104610" data-type="tilCustomLink">GLP-1 users</a> who reported side effects, the most common were: 

<ul><li>Nausea: 36.9%</li><li>Fatigue: 16.7%</li><li>Vomiting: 16.3%</li><li>Constipation: 15.3%</li><li>Diarrhoea: 12.6%</li></ul>

Researchers also found abdominal pain, reduced appetite, acid reflux, bloating, headache and dizziness among commonly reported symptoms. 

But two groups of symptoms stood out as they may be less represented in existing clinical-trial data and drug information. They are reproductive symptoms and complaints associated with temperature. 

Nearly 4% of people who reported side effects described reproductive symptoms, including irregular menstrual cycles, bleeding between periods and heavy bleeding. 

<a href="https://www.healthandme.com/health-news/wegovy-zepbound-are-not-approved-by-us-fda-for-children-under-12-so-why-are-prescriptions-rising-article-156100397" data-type="tilCustomLink">GLP-1 drug users</a> also described chills, feeling unusually cold, hot flashes and fever-like sensations.

Also read: <a href="https://www.healthandme.com/health-news/glp-1-drugs-mounjaro-zepbound-show-promise-for-1-billion-with-sleep-apnea-article-156140963" data-type="tilCustomLink">GLP-1 Drugs Mounjaro, Zepbound Show Promise For 1 Billion With Sleep Apnea</a> 

<h2>Effects Of Ozempic Or Mounjaro On Menstrual Cycles</h2>

The study was based on self-reported social-media posts, so researchers cannot establish whether semaglutide or tirzepatide directly caused menstrual changes, chills or <a href="https://www.healthandme.com/health-wellness/why-is-perimenopause-having-a-wellness-moment-the-everyday-changes-women-should-know-article-156029646" data-type="tilCustomLink">hot flashes</a>. 

Other factors may also influence these symptoms. People taking GLP-1 drugs may experience substantial weight loss, changes in food intake, metabolic changes or other health changes that could effect these symptoms. 

The researchers therefore describe these findings as safety signals, rather than confirmed adverse effects.

Also read: <a href="https://www.healthandme.com/health-wellness/are-glp-1-drugs-actually-changing-asthma-biology-or-are-people-simply-having-fewer-attacks-due-to-weight-loss-article-156127862" data-type="tilCustomLink">Are GLP-1 Drugs Actually Changing Asthma Biology, Or Are People Simply Having Fewer Attack Due To Weight Loss?</a> 

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Clinical trials help in determining whether a medication is effective. They also help in identifying its potential side-effects. But once millions of people begin using a drug, patients may describe symptoms in everyday settings that were uncommon or not specifically investigated during trials. 

Reddit provides researchers with a huge data collection of real-world experiences. AI can quickly scan hundreds of thousands of posts for recurring symptom patterns that would be extremely difficult to identify manually. 

However, Reddit users are not representative of all people taking GLP-1 drugs. The researchers noted that the population studied was younger, more likely to be male and disproportionately based in the US. 

The study does not provide evidence that people should stop <a href="https://www.healthandme.com/health-news/ozempic-hair-glp-1-drug-use-linked-to-7-higher-baldness-risk-in-men-article-156038778" data-type="tilCustomLink">Ozempic</a>, Mounjaro or other GLP-1 medications. Instead, it shows how AI-assisted analysis of patient experiences could help in addition to traditional drug-safety trials and monitoring. 

Common symptoms of GLP-1 medications remain nausea, vomiting, diarrhoea and constipation as they are backed by extensive research and clinical trials. 

The newly highlighted symptoms, particularly menstrual and temperature-related changes, need clinical research to determine whether they are genuinely caused by the drugs.

Health Conditions A-Z

health

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GLP 1

glp 1 drugs

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zepbound

glp-1 drugs

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A recent AI analysis of more than 400,000 Reddit posts about popular GLP-1 drugs like Ozempic, Wegovy, Mounjaro and Zepbound revealed several side effects that researchers may not have fully recorded in clinical trials. The study, published in Nature Health, analysed 410,198 Reddit posts from May 2019 through June 2025. Researchers identified 67,008 people who self-reported using semaglutide or tirzepatide, with 43.5% reporting at least one side effect. The findings do not prove that the drugs caused the symptoms. Instead, they did identify patterns in patients' own accounts that may need further investigation. What Side Effects Did The AI Find? As expected, the analysis found gastrointestinal symptoms in majority. Among GLP-1 users who reported side effects, the most common were: Nausea: 36.9%Fatigue: 16.7%Vomiting: 16.3%Constipation: 15.3%Diarrhoea: 12.6%Researchers also found abdominal pain, reduced appetite, acid reflux, bloating, headache and dizziness among commonly reported symptoms. But two groups of symptoms stood out as they may be less represented in existing clinical-trial data and drug information. They are reproductive symptoms and complaints associated with temperature. Nearly 4% of people who reported side effects described reproductive symptoms, including irregular menstrual cycles, bleeding between periods and heavy bleeding. GLP-1 drug users also described chills, feeling unusually cold, hot flashes and fever-like sensations.Also read: GLP-1 Drugs Mounjaro, Zepbound Show Promise For 1 Billion With Sleep Apnea Effects Of Ozempic Or Mounjaro On Menstrual CyclesThe study was based on self-reported social-media posts, so researchers cannot establish whether semaglutide or tirzepatide directly caused menstrual changes, chills or hot flashes. Other factors may also influence these symptoms. People taking GLP-1 drugs may experience substantial weight loss, changes in food intake, metabolic changes or other health changes that could effect these symptoms. The researchers therefore describe these findings as safety signals, rather than confirmed adverse effects.Also read: Are GLP-1 Drugs Actually Changing Asthma Biology, Or Are People Simply Having Fewer Attack Due To Weight Loss? Reliability Of Reddit Analysis             Clinical trials help in determining whether a medication is effective. They also help in identifying its potential side-effects. But once millions of people begin using a drug, patients may describe symptoms in everyday settings that were uncommon or not specifically investigated during trials. Reddit provides researchers with a huge data collection of real-world experiences. AI can quickly scan hundreds of thousands of posts for recurring symptom patterns that would be extremely difficult to identify manually. However, Reddit users are not representative of all people taking GLP-1 drugs. The researchers noted that the population studied was younger, more likely to be male and disproportionately based in the US. The study does not provide evidence that people should stop Ozempic, Mounjaro or other GLP-1 medications. Instead, it shows how AI-assisted analysis of patient experiences could help in addition to traditional drug-safety trials and monitoring. Common symptoms of GLP-1 medications remain nausea, vomiting, diarrhoea and constipation as they are backed by extensive research and clinical trials. The newly highlighted symptoms, particularly menstrual and temperature-related changes, need clinical research to determine whether they are genuinely caused by the drugs.