FDA Approves TNKase To Treat Ischemic Strokes In Adults

Updated Mar 7, 2025 | 08:52 AM IST

SummaryIt is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion.
Ischemic Stroke

Credits: Canva

The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

  • Loss of coordination or clumsiness
  • Blurry vision or double vision
  • Dizziness or vertigo
  • Nausea and vomiting
  • Neck stiffness
  • Mood swings or sudden personality changes
  • Confusion or agitation
  • Seizures
  • Memory loss (amnesia)
  • Headaches which are sudden and severe
  • Passing out or fainting
  • Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

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Mumbai Locals Suffer Burns After Hydrogen Filled Balloons Erupt In Lift

Updated Feb 8, 2026 | 03:56 PM IST

SummaryTwo people have suffered burn injuries in Mumbai after a cluster of gas-filled balloons exploded and turned into a ball of fire inside a lift in Anmol Towers, a residential building in Mumbai's Goregaon West, earlier this week. Officials believe the balloons were filled with hydrogen and police have registered a case against the vendor
Mumbai Locals Suffer Burns After Hydrogen Filled Balloons Erupt In Lift

Credit: X

Two people have suffered burn injuries in Mumbai after a cluster of gas-filled balloons exploded and turned into a ball of fire inside a residential building’s lift earlier this week.

The incident occured at Anmol Towers, a residential building opposite a petrol pump in Mumbai's Goregaon West and police have registered a case against the balloon vendor, according to NDTV.

CCTV footage shows a woman entering the lift with a small trolley, followed by a man carrying several balloons packed in a large bag. Moments later, the balloons mysteriously caught fire, leading to the blast inside the elevator.

Despite flames briefly covering the CCTV camera, the woman and two men were seen running out of the elevator seconds later. In the end, the clip shows the elevator doors shutting as flames erupt at the centre of the lift.

It was unclear what type of gas was used to inflate the balloons. However, while many consumers assume decorative balloons are filled with helium, a non-combustible gas, authorities and safety experts suggest that it is highly possible that hydrogen was used instead.

Mumbai police have urged the public to exercise caution and warned balloon sellers against using flammable gases, particularly in residential buildings and enclosed areas.

Why Is Hydrogen Dangerous?

Hydrogen has a very wide range of flammability in air (4-75 percent by volume) and requires very low energy to ignite. It often causes explosions rather than just fires, especially in confined spaces.

In high concentrations in enclosed areas, hydrogen acts as a simple asphyxiant by displacing oxygen, which can lead to dizziness, unconsciousness, or death. Additionally, hydrogen fires burn with a nearly invisible, pale blue flame, making them almost impossible to detect with the naked eye during daylight.

Moreover, hydrogen gas also burns faster than most conventional fuels, increasing the risk of deflagration (subsonic) or detonation (supersonic).

On the other hand, as a noble gas, helium has a completely filled outer shell of electrons, meaning it does not react with other elements or catch fire in the presence of oxygen and heat.

Along with this, unlike hydrogen, which is also lighter than air but highly explosive, helium will not ignite even if exposed directly to a flame or spark and it can can act as a buffer and actually suppress flames by displacing oxygen in the immediate area.

What To Do If You Suffer From Burns?

For minor burns, immediately run cool (not cold) water over the area for 10–20 minutes, remove jewelery or tight clothing near the injured area and cover with a sterile bandage. A minor burn might need emergency care if it affects the eyes, mouth, hands or genitals.

However, for serious and large burns, protect the burned person from further harm and ensure that they are breathing. Loosely cover the area with gauze or a clean cloth and raise the burned area above heart level, if possible.

As you call emergency services, watch for symptoms of shock which include cool, clammy skin, weak pulse and shallow breathing.

Seek immediate care for burns, which:

  • May be deep, involving all layers of the skin.
  • May cause the skin to be dry and leathery.
  • May appear charred or have patches of white, brown or black.
  • Are larger than 3 inches (about 8 centimeters) in diameter.
  • Cover the hands, feet, face, groin, buttocks or a major joint, or encircle an arm or a leg.
  • Are accompanied by smoke inhalation.
  • Begin swelling very quickly.

Globally, about 10 million people experience burns and about 180,000 die from them each year.

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Nipah Virus Fatality Reported in Bangladesh, One Woman Dead

Updated Feb 8, 2026 | 11:19 AM IST

SummaryA woman between the ages of 40 and 50 developed a fever and headache-like symptoms consistent with the virus, followed by hypersalivation, disorientation and convulsion on 21 January in Bangladesh. She died on January 28 and was confirmed to be infected with the virus the day after. Although she had no travel history, she regularly consumed raw date palm sap.
Nipah Virus Fatality Reported in Bangladesh, One Woman Dead

A woman with no travel history has died from Nipah virus in Bangladesh, the World Health Organization has confirmed.

The patient, aged between 40 and 50, developed a fever and headache-like symptoms consistent with the virus, followed by hypersalivation, disorientation and convulsion on 21 January.

The case was reported in the northern Naogaon district, Sharmin Sultana, senior scientific officer at the Institute of Epidemiology, Disease Control and Research, later said.

She died on January 28 and was confirmed to be infected with the virus the day after. Although she had no travel history, she regularly consumed raw date palm sap, reports suggest.

The WHO said all 35 people who had contact with the now-deceased patient were being monitored and have tested negative for the virus. No new cases had been detected to date.

Since its emergence in 2001, Bangldesh has reported cases of Nipah virus in humans every year. In 2025, four laboratory-confirmed fatal cases were reported in the country.

What's Happening In India?

The Nipah virus outbreak began in West Bengal, India in January with two hospital nurses at AIIMS, Kolkata, testing positive for the infection and being quarantined, prompting widespread testing. Soon after, five cases, including a doctor and a staff member, were confirmed and over 100 people were quarantined.

However, one of the nurses, a 25-year-old unidentified man has now made a recovery and revealed his experience with the virus, claiming that despite irritation in the throat and uncertainty about what lay ahead, he had faith in his doctors and fellow nurses.

In an interview with the Metro, he said: “After I was taken off ventilation and regained consciousness, I came to know that I have Nipah. I still had the tube in my mouth, and there was irritation. Despite the irritation and my fear, I had faith in the doctors and nurses.

“I have suffered and I know the symptoms. I will tell people when they should get checked for the Nipah virus. I want to raise awareness about the virus and its symptoms.

“I am not sure how I came in contact with the deadly virus. Maybe it was while treating a patient. But I will continue to work as a nurse. I am waiting to rejoin the hospital,” he added.

The unidentified healthcare professional remains very weak physically and is undergoing physiotherapy to regain his strength. “I was bedridden for over a month. I am still very weak and have an unstable gait. So, I am undergoing physiotherapy,” he said.

The other nurse, a woman, remains in a coma but has been taken off ventilation support, a hospital official confirmed this week.

Nipah Virus: What Is It And What Are Its Symptoms?

According to WHO, Nipah virus is a zoonotic illness which means it is mostly transmitted from animals to humans through bats. However, it can also spread through fruits that have been contaminated by the saliva, urine or droppings of infected bats. Human-to-human transmission can also occur through close contact with an infected person or their bodily fluids.

The illness has a 75 percent fatality rate, and there are no vaccines to protect the public.

The virus was first identified in 1998 during an outbreak among pig farmers in Malaysia and soon made its way to India and Bangladesh in 2001, with cases often involving family members or caregivers tending to the infected patient.

READ MORE: Nipah vs Bird Flu in India: Which Virus Poses A Greater Threat To Humans?

Although the Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in people. Some of its common symptoms include:

  • Fever
  • Headache
  • Breathing difficulties
  • Cough and sore throat
  • Diarrhea
  • Vomiting
  • Muscle pain and severe weakness
In 2018, another outbreak occurred in Kerala, India, where 23 confirmed and suspected cases were reported. The virus spread across three hospitals, with both primary and secondary infections traced back to one initial patient.

Samples collected from the patient’s home and workplaces, including pets and partially eaten fruits dropped by bats, all tested negative for the virus, and the exact source of the infection could not be identified.

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Wet Wipes Warning: Patient Dies Using An Infected, Non-Sterile Wipe

Updated Feb 7, 2026 | 01:44 PM IST

SummaryUK authorities warned against non-sterile, alcohol-free wet wipes after 59 infections and one death linked to Burkholderia stabilis. Four products were recalled. Risk remains low but higher for immunocompromised people, especially when wipes contact wounds or medical devices in home settings.
Wet Wipes Warning: Patient Dies Using An Infected, Non-Sterile Wipe

Credits: Canva

Wet Wipes Waring: 59 people have fallen ill, with one dead, after using non-alcoholic, non-sterile, infected wet wipes in UK. The UK Health Security Agency (UKHSA) and Medicines and Healthcare products Regulatory Agency (MHRA) issued a warning, and said that there is still "an ongoing risk of infection associated with their use". The bacteria that is causing this infection is burkholderia stabilis or B. stabilis.

Wet Wipes Warning: Which Ones Not To Use

Wet Wipes Warning: Patient Dies Using An Infected, Non-Sterile Wipe

The UKHSA also in its warning included names of four different wet wipes and asked people to avoid using them.

  • ValueAid Alcohol Free Cleaning Wipes
  • Stereoplast Sterowipe Alcohol Free Cleansing Wipes
  • Reliwipe Alcohol Free Cleansing Wipes
  • Microsafe Moist Wipe Alcohol Free

Wet Wipes Warning: What Actually Happened?

The Pharmaceutical Journal noted that the UKHSA and MHRA published a joint statement that warned people that they should not use non-sterile, non-alcoholic wipes in their homes and first-aid kits.

After an outbreak investigation conducted by MHRA in 2025, four products were identified to be contaminated with Burkholderia stabilis. “There have been 59 confirmed cases of Burkholderia stabilis associated with some non-sterile alcohol-free wipe products — identified in an outbreak in the United Kingdom from January 2018 to 3 February 2026,” the statement said.

“A small number of cases continue to be detected. These have included some serious infections which have required hospital treatment and one death has been attributed to Burkholderia stabilis infection.”

UKHSA and MHRA is telling people to look out for wipes marked 'sterile' to be used on wounds or broken skin.

Wet Wipes Warning: What Is Burkholderia Stabilis?

UKHSA on its official website notes: 'Burkholderia are a type of bacteria found naturally in the environment, including in soil and water. Burkholderia stabilis is one species within this group. While many people never encounter problems with this type of bacteria, it can cause serious infections in certain circumstances, particularly among vulnerable individuals.'

Read: Does Bigger Penis Help You Ski Better? Why Olympians Are Injecting Hyaluronic Acid - Explained

Wet Wipes Warning: Who Is At More Risk Of B. Stabilis Infection?

  • Those with weakened immune systems – including people undergoing chemotherapy, organ transplant recipients, or those with conditions that affect immune function
  • Individuals with other risk factors such as cystic fibrosis
  • Patients at home with intravenous lines

Wet Wipes Warning: How Can Someone Get Infected By B. Stabilis?

The UKHSA notes: "The risk of acquiring infection is generally very low. Infections can occur through contact with contaminated products on broken or damaged skin, or through introduction of bacteria through medical devices such as intravenous lines."

Wet Wipes Warning: What Are The Common Symptoms Of B. Stabilis Infection?

  • Symptoms of a wound infection can include redness, swelling, increased pain, warmth around a wound or or break in skin, and pus or other drainage from the wound / break in skin
  • Symptoms of infection involving an intravenous line can include signs such as redness, swelling, or pain around the insertion site and / or fever and chills
  • In more serious cases, symptoms associated with bloodstream infection (sepsis).

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