Tanya Dutt

India's First Dengue Vaccine Enters Phase-3 Clinical Trials- All You Should Know

Dengue Vaccine in India

The increasing incidence of <span><a href="https://www.healthandme.com/health/dengue">Dengue</a></span> cases in India has brought forth an urgent need for effective solutions. This mosquito-borne disease, caused by the dengue virus, has been a significant public health challenge in the country, resulting in numerous cases of severe illness and even death. The development and introduction of a <span>dengue vaccine</span> in India mark a pivotal step in combating this health crisis. 

The ongoing phase-3 clinical trial of the country’s first-ever dengue vaccine, DengiAll, offers a promising advancement in the fight against dengue, potentially reducing the disease's impact on millions of people.

The advent of DengiAll, developed by Panacea Biotec in collaboration with the <span>Indian Council of Medical Research</span> (ICMR), signifies a new era in dengue prevention. This vaccine aims to offer comprehensive protection against all four strains of the dengue virus, crucial in preventing the onset of severe symptoms and complications associated with the disease. 

This development is particularly important as dengue cases in India have been rising due to urbanization, increased mobility, and changing climatic conditions, making traditional methods of mosquito control less effective.

<h2>Importance of the Dengue Vaccine in India</h2>India has experienced a significant increase in dengue cases over the years, making the disease a public health priority. According to the PIB press release, DengiAll is designed to reduce the incidence of dengue fever and severe dengue, thereby addressing a major gap in current preventive measures. 

The launch of DengiAll's phase-3 clinical trial, announced on August 13, 2024, is a significant stride towards providing a viable preventive measure against dengue fever. This trial, coordinated by the Indian Council of Medical Research (ICMR), will be conducted across several Indian states, including Delhi, Gujarat, and Kerala. The trial is intended to assess the vaccine's safety and efficacy in preventing dengue among individuals aged 18 and above.

<h2>Dengue Vaccine: All about the Clinical Trial</h2>The phase-3 clinical trial of DengiAll is a randomized, double-blind, and placebo-controlled study, intended to be carried out in two stages: a primary stage and a booster stage. Participants in the primary stage will receive two doses of the vaccine, while those in the booster stage will receive a single dose. The trial will enroll 10,335 participants across 10 sites in India, and the trial will last 18 months.

The study’s main objective is to evaluate the vaccine's efficacy in preventing symptomatic, virologically confirmed dengue (VCD). Researchers will also monitor any adverse reactions and the overall impact of the vaccine on preventing the disease. This meticulous approach ensures that the vaccine is safe and effective for large-scale deployment.

<h2>Public Health and Policy Implications</h2>The successful development and deployment of DengiAll could revolutionize dengue prevention in India. As highlighted in the PIB release, the vaccine's introduction is expected to significantly reduce the burden of dengue on public health systems and communities. The <span>Ministry of Health and Family Welfare</span>, along with other health authorities, is keen on integrating this vaccine into the national immunization program, ensuring widespread access and implementation.

The phase-3 clinical trial of the DengiAll vaccine represents a significant step towards a future where dengue fever is no longer a looming threat. The vaccine's potential to curb dengue cases will not only improve public health but also alleviate the economic and social impact of the disease on families and communities. 

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The increasing incidence of Dengue cases in India has brought forth an urgent need for effective solutions. This mosquito-borne disease, caused by the dengue virus, has been a significant public health challenge in the country, resulting in numerous cases of severe illness and even death. The development and introduction of a dengue vaccine in India mark a pivotal step in combating this health crisis. The ongoing phase-3 clinical trial of the country’s first-ever dengue vaccine, DengiAll, offers a promising advancement in the fight against dengue, potentially reducing the disease's impact on millions of people.The advent of DengiAll, developed by Panacea Biotec in collaboration with the Indian Council of Medical Research (ICMR), signifies a new era in dengue prevention. This vaccine aims to offer comprehensive protection against all four strains of the dengue virus, crucial in preventing the onset of severe symptoms and complications associated with the disease. This development is particularly important as dengue cases in India have been rising due to urbanization, increased mobility, and changing climatic conditions, making traditional methods of mosquito control less effective.Importance of the Dengue Vaccine in IndiaIndia has experienced a significant increase in dengue cases over the years, making the disease a public health priority. According to the PIB press release, DengiAll is designed to reduce the incidence of dengue fever and severe dengue, thereby addressing a major gap in current preventive measures. The launch of DengiAll's phase-3 clinical trial, announced on August 13, 2024, is a significant stride towards providing a viable preventive measure against dengue fever. This trial, coordinated by the Indian Council of Medical Research (ICMR), will be conducted across several Indian states, including Delhi, Gujarat, and Kerala. The trial is intended to assess the vaccine's safety and efficacy in preventing dengue among individuals aged 18 and above.Dengue Vaccine: All about the Clinical TrialThe phase-3 clinical trial of DengiAll is a randomized, double-blind, and placebo-controlled study, intended to be carried out in two stages: a primary stage and a booster stage. Participants in the primary stage will receive two doses of the vaccine, while those in the booster stage will receive a single dose. The trial will enroll 10,335 participants across 10 sites in India, and the trial will last 18 months.The study’s main objective is to evaluate the vaccine's efficacy in preventing symptomatic, virologically confirmed dengue (VCD). Researchers will also monitor any adverse reactions and the overall impact of the vaccine on preventing the disease. This meticulous approach ensures that the vaccine is safe and effective for large-scale deployment.Public Health and Policy ImplicationsThe successful development and deployment of DengiAll could revolutionize dengue prevention in India. As highlighted in the PIB release, the vaccine's introduction is expected to significantly reduce the burden of dengue on public health systems and communities. The Ministry of Health and Family Welfare, along with other health authorities, is keen on integrating this vaccine into the national immunization program, ensuring widespread access and implementation.The phase-3 clinical trial of the DengiAll vaccine represents a significant step towards a future where dengue fever is no longer a looming threat. The vaccine's potential to curb dengue cases will not only improve public health but also alleviate the economic and social impact of the disease on families and communities. 

india's first dengue vaccine enters phase-3 clinical trials- all you should know

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Aarushi Bhadury

‘Kissing Bug’ Epidemic In US: What You Need To Know About Chagas Disease, Is it Contagious?

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US Health officials have declared <span>Chagas disease</span>, a potentially deadly infection spread by the ‘kissing bugs’, an epidemic. These bugs have been found in 32 states, and at least eight Americans have caught the disease from local transmission. This has led scientists to urge the CDC and the WHO to officially declare the illness as endemic in the U.S., which means it's a disease that is naturally present in the region. Experts believe that over 300,000 people in the U.S. may have Chagas disease, but very few of them know it. 

According to UCLA Health, Chagas disease, a potentially life-threatening condition, is most commonly spread by the “kissing bug,” which gets its name because it tends to bite people on the face while they sleep. After biting, the bug defecates on the skin, leaving behind a parasite called T. cruzi. When the person scratches the itchy bite, they accidentally rub the parasite into the wound, and that's how it enters the bloodstream. Chagas disease can also be passed from a pregnant person to their baby, through organ transplants and blood transfusions, or by eating uncooked food that has been contaminated with the parasite. 

<h2><span rel="noindex">Is Chagas Disease Contagious</span>? </h2>

No, the Cleveland Clinic explains that this disease cannot spread from person to person. Many people with Chagas disease have no symptoms at all, which is why it's often called a "silent disease." In the early stage, which lasts about two months, some people might experience a swollen eyelid, fever, or body aches, but these symptoms are easily mistaken for other common illnesses. 

Over a person’s lifetime, about 20% of those infected will develop serious, long-term problems, most often affecting the heart. Chagas disease can slowly damage the heart, leading to an enlarged heart, heart failure, or even a heart attack. It can also cause digestive problems, like an enlarged colon. 

<h2>What Are Signs And Symptoms of Chagas Disease?</h2>

According to the World Health Organization (WHO), Chagas disease happens in two main stages. For most people, the first stage goes unnoticed, but it can lead to very serious problems later on. 

This early phase lasts for about two months after a person is infected. Most people have no symptoms at all, or they experience mild, general symptoms that could be caused by anything else, such as a fever, headache, muscle pain, or swelling. In rare cases, a person might see a specific sign, like a skin sore where they were bitten, or a purple swelling of one eyelid. 

The second stage of the disease can last for a person's entire life. During this time, the parasites hide mainly in the heart and muscles of the digestive system. About 10 to 30 years after being infected, up to a third of people will develop serious heart problems, and up to 1 in 10 will have digestive issues, such as an enlarged food pipe or colon. Over time, this can lead to an irregular heartbeat, slow heart failure, and in some cases, sudden death. 

<h2><span rel="noindex">How To Treat Chagas Disease</span>? </h2>

Anti-parasite medications are only effective at treating Chagas disease during its very early stage. Once the disease has been in the body for a while, there is no cure, though symptoms of heart failure can be managed with medication or even a heart transplant. 

Doctors recommend that anyone who is from or has traveled to Latin America and begins to experience heart problems should be tested for Chagas disease. It's also worth noting that the U.S. blood supply has been tested for Chagas since 2007. 

<h2>How Can We Prevent Chagas Disease? </h2>

WHO explains that because Chagas disease is carried by "kissing bugs" and is so widespread among wild animals throughout the Americas, it's not possible to completely wipe it out. Instead, public health efforts are focused on stopping the disease from spreading to humans, making sure infected people get diagnosed early, and providing them with lifelong medical care. To prevent the spread of Chagas disease, health organizations recommend a few key approaches: 

This is considered the most effective way to prevent the disease. It includes spraying homes and surrounding areas with bug-killing chemicals and making sure houses are built and kept clean to prevent the insects from living in cracks in the walls. 

People can protect themselves with personal measures like using bed nets and practicing good hygiene when handling food. 

Screening blood donors is necessary to prevent the disease from spreading through blood transfusions and organ transplants. 

It is also important to test newborns and other children of infected mothers, as the disease can be passed during pregnancy. 

Kissing Bug Epidemic

Chagas Disease

US Chagas Disease Epidemic

US Kissing Bug Epidemic

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is chagas disease contagious

what is chagas disease in human

kissing bug parasite

chagas symptoms

kissing bug

US Health officials have declared Chagas disease, a potentially deadly infection spread by the ‘kissing bugs’, an epidemic. These bugs have been found in 32 states, and at least eight Americans have caught the disease from local transmission. This has led scientists to urge the CDC and the WHO to officially declare the illness as endemic in the U.S., which means it's a disease that is naturally present in the region. Experts believe that over 300,000 people in the U.S. may have Chagas disease, but very few of them know it. What Is Chagas Disease? According to UCLA Health, Chagas disease, a potentially life-threatening condition, is most commonly spread by the “kissing bug,” which gets its name because it tends to bite people on the face while they sleep. After biting, the bug defecates on the skin, leaving behind a parasite called T. cruzi. When the person scratches the itchy bite, they accidentally rub the parasite into the wound, and that's how it enters the bloodstream. Chagas disease can also be passed from a pregnant person to their baby, through organ transplants and blood transfusions, or by eating uncooked food that has been contaminated with the parasite. Is Chagas Disease Contagious? No, the Cleveland Clinic explains that this disease cannot spread from person to person. Many people with Chagas disease have no symptoms at all, which is why it's often called a "silent disease." In the early stage, which lasts about two months, some people might experience a swollen eyelid, fever, or body aches, but these symptoms are easily mistaken for other common illnesses. Over a person’s lifetime, about 20% of those infected will develop serious, long-term problems, most often affecting the heart. Chagas disease can slowly damage the heart, leading to an enlarged heart, heart failure, or even a heart attack. It can also cause digestive problems, like an enlarged colon. What Are Signs And Symptoms of Chagas Disease?According to the World Health Organization (WHO), Chagas disease happens in two main stages. For most people, the first stage goes unnoticed, but it can lead to very serious problems later on. The First Stage This early phase lasts for about two months after a person is infected. Most people have no symptoms at all, or they experience mild, general symptoms that could be caused by anything else, such as a fever, headache, muscle pain, or swelling. In rare cases, a person might see a specific sign, like a skin sore where they were bitten, or a purple swelling of one eyelid. The Second Stage The second stage of the disease can last for a person's entire life. During this time, the parasites hide mainly in the heart and muscles of the digestive system. About 10 to 30 years after being infected, up to a third of people will develop serious heart problems, and up to 1 in 10 will have digestive issues, such as an enlarged food pipe or colon. Over time, this can lead to an irregular heartbeat, slow heart failure, and in some cases, sudden death. How To Treat Chagas Disease? Anti-parasite medications are only effective at treating Chagas disease during its very early stage. Once the disease has been in the body for a while, there is no cure, though symptoms of heart failure can be managed with medication or even a heart transplant. Doctors recommend that anyone who is from or has traveled to Latin America and begins to experience heart problems should be tested for Chagas disease. It's also worth noting that the U.S. blood supply has been tested for Chagas since 2007. How Can We Prevent Chagas Disease? WHO explains that because Chagas disease is carried by "kissing bugs" and is so widespread among wild animals throughout the Americas, it's not possible to completely wipe it out. Instead, public health efforts are focused on stopping the disease from spreading to humans, making sure infected people get diagnosed early, and providing them with lifelong medical care. To prevent the spread of Chagas disease, health organizations recommend a few key approaches: Controlling the bugs This is considered the most effective way to prevent the disease. It includes spraying homes and surrounding areas with bug-killing chemicals and making sure houses are built and kept clean to prevent the insects from living in cracks in the walls. Personal protection People can protect themselves with personal measures like using bed nets and practicing good hygiene when handling food. Screening donors Screening blood donors is necessary to prevent the disease from spreading through blood transfusions and organ transplants. Checking newborns It is also important to test newborns and other children of infected mothers, as the disease can be passed during pregnancy.  

‘kissing bug’ epidemic in us: what you need to know about chagas disease, is it contagious?

NHS Says Martha’s Rule To be Followed At All Hospitals In England: All About This New Rule?

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<span>Martha</span>'s rule is a scheme rolled out in 2021 after the death of a 13-year-old, NHS has now declared that all acute inpatient sites will offer the service, that has now saved thousands of lives. 

Martha’s rule was set up after the death of young Martha Mills who developed sepsis while she was under the care of King’s College Hospital under NHS Foundation Trust in south London in 2021. 

Her death was a wakeup call for health authorities and her parents, both of whom had brought up their concerns regarding their daughter’s care multiple times, while they were completely ignored. Having this facility could help many families feel at ease and know that they can easily ask for second opinions. 

<h2><span rel="noindex">Who Is Martha</span> from Martha's Rule? </h2>

What if you knew your loved one was getting sicker in the hospital, but no one was listening? That's the heartbreaking situation that led to Martha's Rule, a new system designed to make sure every patient's voice is heard. 

In 2021, Martha was in the hospital for an injury. While she was there, she developed a serious and life-threatening condition called sepsis. Her family saw that she was getting sicker and sicker, and they frantically tried to get the doctors and nurses to listen to their fears. Sadly, they were not heard, and Martha passed away. 

The rule was put in place when the authorities ruled out that young Martha may have survived if the doctors had identified the warning signs of her declining condition and transferred her into intensive care. Her parents, in their grief, decided to fight to make sure no other family would have to go through the same tragedy. 

Martha's Rule is a way to make sure that patients, families, and caregivers can have their concerns heard and addressed in a hospital. It is being introduced for patients staying overnight in hospitals across England. The rule has three main parts: 

<ul><li>Patients will be asked daily how they are feeling, and their answers will be officially recorded. </li><li>Hospital staff can, at any time, ask for an urgent review from a different team if they are worried about a patient but feel their concerns are not being listened to. </li><li>Patients, their families, and caregivers will always have a way to ask for this urgent review as well. This will be clearly advertised in the hospital.</li></ul>

If a family member or patient feels worried about a worsening condition and their concerns are not being addressed by their main care team, they can call a dedicated number for a rapid review from a different, independent team. 

<h2>Has Martha’s Rule Saved Anyone? </h2>

According to NHS UK, yes. From September 2024 to June 2025, there were 4,906 calls made to the helpline. The highest number of these calls, about 72%, came from patients and their families. Of all the calls, 2,132 were related to a patient's health getting worse quickly. Of those, 241 calls led to potentially life-saving changes in care, including: 

<ul><li>93 urgent transfers to an intensive care unit.</li><li>49 transfers to a different hospital or a higher level of care. </li></ul>

For another 720 calls, the rule led to other important changes, such as starting a new medication like an antibiotic or getting a new scan. This data highlights just how important it is to listen to the concerns of patients and families. 

<h2>How Martha’s Rule Makes Healthcare So Access? </h2>

After the positive results from the first year, the NHS began introducing Martha's Rule to all remaining hospitals in England in April 2025. This includes hospitals that treat adults and children. The program is also being tested in a small number of maternity and mental health units to see if it can be expanded even further. 

Professor Meghana Pandit, NHS National Medical Director, said, “There have now been almost 5,000 calls made to the hotlines, with hundreds of potentially life-saving interventions triggered, which is why we are now expanding Martha’s Rule to all acute hospitals in England.” 

The health officials acknowledge that, this mistake cost the life of a young girl, but keeping her spirit live through this rule and many others who have used this rule for their loved one. As Health and Social Care Secretary, Wes Streeting said, “No family should ever have to go through what Merope and Paul endured when they lost Martha, but her parents’ tireless campaigning has created a lasting legacy that is already having a potentially lifesaving impact across England.”

marthas rule

martha

merope mills

marthas rule NHS

New NHS rule for second opinion

what is marthas rule

who is martha

how does marthas rule work

Martha's rule is a scheme rolled out in 2021 after the death of a 13-year-old, NHS has now declared that all acute inpatient sites will offer the service, that has now saved thousands of lives. Martha’s rule was set up after the death of young Martha Mills who developed sepsis while she was under the care of King’s College Hospital under NHS Foundation Trust in south London in 2021. Her death was a wakeup call for health authorities and her parents, both of whom had brought up their concerns regarding their daughter’s care multiple times, while they were completely ignored. Having this facility could help many families feel at ease and know that they can easily ask for second opinions. Who Is Martha from Martha's Rule? What if you knew your loved one was getting sicker in the hospital, but no one was listening? That's the heartbreaking situation that led to Martha's Rule, a new system designed to make sure every patient's voice is heard. In 2021, Martha was in the hospital for an injury. While she was there, she developed a serious and life-threatening condition called sepsis. Her family saw that she was getting sicker and sicker, and they frantically tried to get the doctors and nurses to listen to their fears. Sadly, they were not heard, and Martha passed away. The rule was put in place when the authorities ruled out that young Martha may have survived if the doctors had identified the warning signs of her declining condition and transferred her into intensive care. Her parents, in their grief, decided to fight to make sure no other family would have to go through the same tragedy. How Does Martha's Rule Work?Martha's Rule is a way to make sure that patients, families, and caregivers can have their concerns heard and addressed in a hospital. It is being introduced for patients staying overnight in hospitals across England. The rule has three main parts: Patients will be asked daily how they are feeling, and their answers will be officially recorded. Hospital staff can, at any time, ask for an urgent review from a different team if they are worried about a patient but feel their concerns are not being listened to. Patients, their families, and caregivers will always have a way to ask for this urgent review as well. This will be clearly advertised in the hospital.If a family member or patient feels worried about a worsening condition and their concerns are not being addressed by their main care team, they can call a dedicated number for a rapid review from a different, independent team. Has Martha’s Rule Saved Anyone? According to NHS UK, yes. From September 2024 to June 2025, there were 4,906 calls made to the helpline. The highest number of these calls, about 72%, came from patients and their families. Of all the calls, 2,132 were related to a patient's health getting worse quickly. Of those, 241 calls led to potentially life-saving changes in care, including: 93 urgent transfers to an intensive care unit.49 transfers to a different hospital or a higher level of care. For another 720 calls, the rule led to other important changes, such as starting a new medication like an antibiotic or getting a new scan. This data highlights just how important it is to listen to the concerns of patients and families. How Martha’s Rule Makes Healthcare So Access? After the positive results from the first year, the NHS began introducing Martha's Rule to all remaining hospitals in England in April 2025. This includes hospitals that treat adults and children. The program is also being tested in a small number of maternity and mental health units to see if it can be expanded even further. Professor Meghana Pandit, NHS National Medical Director, said, “There have now been almost 5,000 calls made to the hotlines, with hundreds of potentially life-saving interventions triggered, which is why we are now expanding Martha’s Rule to all acute hospitals in England.” The health officials acknowledge that, this mistake cost the life of a young girl, but keeping her spirit live through this rule and many others who have used this rule for their loved one. As Health and Social Care Secretary, Wes Streeting said, “No family should ever have to go through what Merope and Paul endured when they lost Martha, but her parents’ tireless campaigning has created a lasting legacy that is already having a potentially lifesaving impact across England.”

nhs says martha’s rule to be followed at all hospitals in england: all about this new rule?

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The U.S. vaccine advisory landscape is facing a seismic shift as Health Secretary Robert F. Kennedy Jr. moves to reshape the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP). According to an internal CDC document reviewed by Reuters, Kennedy has nominated seven new members to the ACIP, following his controversial ousting of all 17 previous panelists in June. The move has drawn scrutiny from public health experts who fear that vaccine guidance could be increasingly influenced by political considerations rather than scientific consensus.

The ACIP has long been a cornerstone of U.S. vaccine policy, advising the CDC on which vaccines should be administered, to whom, and on what schedule after Food and Drug Administration (FDA) approval. The committee’s recommendations form the basis for insurance coverage across the country and are integral to maintaining herd immunity and public trust in vaccines. Kennedy’s decision to fire all 17 members mid-year and replace them with a hand-picked cohort of eight advisers — one of whom has since left — marks an unprecedented intervention in the advisory process.

Among the seven prospective members named in the latest internal document is Dr. Raymond Pollak, a semi-retired transplant surgeon with a background in immunology. Pollak confirmed that he has been asked to serve on the panel but remains cautious. “I’m being considered pending the vetting process. If I was offered the position, I would think carefully about it,” he told reporters.

Other appointees include Dr. Joseph Fraiman, an emergency medicine specialist in New Orleans; Dr. John Gaitanis, a pediatric neurologist; Dr. Catherine Stein, an epidemiology professor; Hillary Blackburn, a trained pharmacist; and Evelyn Griffin, an obstetrician-gynecologist. None of these professionals were immediately available for comment. Retsef Levi, PhD, will chair the newly restructured COVID-19 Immunization Workgroup, drawing particular concern from infectious disease specialists.

<h2>What Are The Concerns Over Panel Independence?</h2>

The rapid overhaul of ACIP has sparked widespread debate about the independence and credibility of the panel. Critics argue that Kennedy, a long-standing vaccine skeptic, has moved to stack the committee with individuals whose views align with his own. The firing of CDC Director Susan Monarez last week further amplified these concerns. Monarez reportedly resisted policy changes advanced by Kennedy and was asked to merely rubber-stamp committee recommendations. Her departure prompted resignations from three top CDC officials, citing the secretary’s anti-vaccine policies as their reason.

<h2>Does This Pull The Stakes Down For Vaccine Policy in US?</h2>

The ACIP is scheduled to meet on September 18, with discussions likely to include recommendations for hepatitis B, measles-mumps-rubella-varicella, and respiratory syncytial virus (RSV) vaccines, according to the Federal Register. Traditionally, the CDC director holds final approval over these recommendations. With the new panel in place, public health experts worry that guidance on critical vaccines — including COVID-19 immunizations — could diverge from established scientific evidence, potentially affecting millions of Americans.

Levi, who will lead the COVID-19 Immunization Workgroup, has previously expressed skepticism about mRNA COVID vaccines. In a 2023 video posted on social media, he asserted that all COVID mRNA vaccination programs “should stop immediately,” claiming that they failed to deliver on efficacy promises and caused “unprecedented levels of harm, including the death of young people and children.” Such statements have alarmed epidemiologists and infectious disease specialists, who warn that this rhetoric could erode public trust in vaccines and heighten vulnerability to preventable diseases.

<h2>Implications for Public Health and Vaccine Uptake</h2>

Public health experts emphasize that vaccine recommendations are not merely technical decisions; they have real-world consequences for community immunity, disease outbreaks, and healthcare costs. The credibility of ACIP is pivotal in maintaining high vaccination rates, especially for routine childhood immunizations and COVID-19 boosters. Should the panel’s guidance shift toward skepticism of established vaccines, experts fear a rise in vaccine hesitancy, lower immunization coverage, and a resurgence of preventable diseases.

Insurance coverage is closely tied to ACIP recommendations. Altering the panel’s guidance could potentially influence which vaccines are covered by public and private insurers, affecting accessibility and uptake. Given the ongoing threat of seasonal influenza, RSV, and COVID-19, changes to vaccine policy may have profound implications for hospitalizations, morbidity, and mortality, particularly among vulnerable populations such as children, the elderly, and immunocompromised individuals.

<h2>Is There Too Much Political Interference in Health Policy-Making?</h2>

Kennedy’s actions are part of a broader national debate on the role of politics in public health. While previous <span>ACIP appointments</span> have been largely insulated from political influence, recent interventions signal a shift toward a more politicized approach to vaccine policy. Experts caution that such moves could undermine decades of public trust in the CDC, an institution that has long been regarded as the gold standard in epidemiology and disease prevention.

The revamp of ACIP also underscores tensions within the CDC and the U.S. Department of Health and Human Services (HHS). Multiple top officials have resigned or been replaced in recent months, raising questions about institutional stability and the agency’s ability to respond effectively to public health crises.

The upcoming ACIP meeting on September 18 will be closely monitored by public health officials, epidemiologists, and the media. Key topics likely to be addressed include routine childhood vaccines, COVID-19 booster policies, and emerging infectious diseases such as RSV. Observers will be watching not just the committee’s recommendations but also the process by which they are finalized and approved.

Experts urge the public to remain vigilant and informed about vaccine guidance, noting that evidence-based practices remain critical for preventing disease outbreaks and safeguarding community health. While the political dynamics are evolving, the scientific principles underpinning immunization safety, efficacy, and population protection continue to be essential in maintaining public health.

Robert F. Kennedy Jr.’s appointment of seven new members to the CDC’s ACIP marks a turning point in U.S. vaccine policy. The unprecedented shake-up raises questions about the independence, credibility, and scientific rigor of the nation’s primary vaccine advisory body. With critical vaccine recommendations on the horizon, public health experts, policymakers, and citizens alike are bracing for the potential ramifications of a panel reshaped under political influence, highlighting the fragile balance between science and governance in safeguarding public health.

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The U.S. vaccine advisory landscape is facing a seismic shift as Health Secretary Robert F. Kennedy Jr. moves to reshape the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP). According to an internal CDC document reviewed by Reuters, Kennedy has nominated seven new members to the ACIP, following his controversial ousting of all 17 previous panelists in June. The move has drawn scrutiny from public health experts who fear that vaccine guidance could be increasingly influenced by political considerations rather than scientific consensus.The ACIP has long been a cornerstone of U.S. vaccine policy, advising the CDC on which vaccines should be administered, to whom, and on what schedule after Food and Drug Administration (FDA) approval. The committee’s recommendations form the basis for insurance coverage across the country and are integral to maintaining herd immunity and public trust in vaccines. Kennedy’s decision to fire all 17 members mid-year and replace them with a hand-picked cohort of eight advisers — one of whom has since left — marks an unprecedented intervention in the advisory process.Among the seven prospective members named in the latest internal document is Dr. Raymond Pollak, a semi-retired transplant surgeon with a background in immunology. Pollak confirmed that he has been asked to serve on the panel but remains cautious. “I’m being considered pending the vetting process. If I was offered the position, I would think carefully about it,” he told reporters.Other appointees include Dr. Joseph Fraiman, an emergency medicine specialist in New Orleans; Dr. John Gaitanis, a pediatric neurologist; Dr. Catherine Stein, an epidemiology professor; Hillary Blackburn, a trained pharmacist; and Evelyn Griffin, an obstetrician-gynecologist. None of these professionals were immediately available for comment. Retsef Levi, PhD, will chair the newly restructured COVID-19 Immunization Workgroup, drawing particular concern from infectious disease specialists.What Are The Concerns Over Panel Independence?The rapid overhaul of ACIP has sparked widespread debate about the independence and credibility of the panel. Critics argue that Kennedy, a long-standing vaccine skeptic, has moved to stack the committee with individuals whose views align with his own. The firing of CDC Director Susan Monarez last week further amplified these concerns. Monarez reportedly resisted policy changes advanced by Kennedy and was asked to merely rubber-stamp committee recommendations. Her departure prompted resignations from three top CDC officials, citing the secretary’s anti-vaccine policies as their reason.Does This Pull The Stakes Down For Vaccine Policy in US?The ACIP is scheduled to meet on September 18, with discussions likely to include recommendations for hepatitis B, measles-mumps-rubella-varicella, and respiratory syncytial virus (RSV) vaccines, according to the Federal Register. Traditionally, the CDC director holds final approval over these recommendations. With the new panel in place, public health experts worry that guidance on critical vaccines — including COVID-19 immunizations — could diverge from established scientific evidence, potentially affecting millions of Americans.Levi, who will lead the COVID-19 Immunization Workgroup, has previously expressed skepticism about mRNA COVID vaccines. In a 2023 video posted on social media, he asserted that all COVID mRNA vaccination programs “should stop immediately,” claiming that they failed to deliver on efficacy promises and caused “unprecedented levels of harm, including the death of young people and children.” Such statements have alarmed epidemiologists and infectious disease specialists, who warn that this rhetoric could erode public trust in vaccines and heighten vulnerability to preventable diseases.Implications for Public Health and Vaccine UptakePublic health experts emphasize that vaccine recommendations are not merely technical decisions; they have real-world consequences for community immunity, disease outbreaks, and healthcare costs. The credibility of ACIP is pivotal in maintaining high vaccination rates, especially for routine childhood immunizations and COVID-19 boosters. Should the panel’s guidance shift toward skepticism of established vaccines, experts fear a rise in vaccine hesitancy, lower immunization coverage, and a resurgence of preventable diseases.Insurance coverage is closely tied to ACIP recommendations. Altering the panel’s guidance could potentially influence which vaccines are covered by public and private insurers, affecting accessibility and uptake. Given the ongoing threat of seasonal influenza, RSV, and COVID-19, changes to vaccine policy may have profound implications for hospitalizations, morbidity, and mortality, particularly among vulnerable populations such as children, the elderly, and immunocompromised individuals.Is There Too Much Political Interference in Health Policy-Making?Kennedy’s actions are part of a broader national debate on the role of politics in public health. While previous ACIP appointments have been largely insulated from political influence, recent interventions signal a shift toward a more politicized approach to vaccine policy. Experts caution that such moves could undermine decades of public trust in the CDC, an institution that has long been regarded as the gold standard in epidemiology and disease prevention.The revamp of ACIP also underscores tensions within the CDC and the U.S. Department of Health and Human Services (HHS). Multiple top officials have resigned or been replaced in recent months, raising questions about institutional stability and the agency’s ability to respond effectively to public health crises.The upcoming ACIP meeting on September 18 will be closely monitored by public health officials, epidemiologists, and the media. Key topics likely to be addressed include routine childhood vaccines, COVID-19 booster policies, and emerging infectious diseases such as RSV. Observers will be watching not just the committee’s recommendations but also the process by which they are finalized and approved.Experts urge the public to remain vigilant and informed about vaccine guidance, noting that evidence-based practices remain critical for preventing disease outbreaks and safeguarding community health. While the political dynamics are evolving, the scientific principles underpinning immunization safety, efficacy, and population protection continue to be essential in maintaining public health.Robert F. Kennedy Jr.’s appointment of seven new members to the CDC’s ACIP marks a turning point in U.S. vaccine policy. The unprecedented shake-up raises questions about the independence, credibility, and scientific rigor of the nation’s primary vaccine advisory body. With critical vaccine recommendations on the horizon, public health experts, policymakers, and citizens alike are bracing for the potential ramifications of a panel reshaped under political influence, highlighting the fragile balance between science and governance in safeguarding public health.

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