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Rachel V Thomas

Teplizumab: UK NHS To Roll Out World-First Drug To Delay Onset Of Type 1 Diabetes

The National Health Service (NHS) has approved <span>teplizumab</span> for people with early-stage <span>type 1 <a href="https://www.healthandme.com/health/diabetes">diabetes</a></span> in England and Wales. 

Teplizumab (sold under the brand names <span>Tzield</span> and Teplizumab) is manufactured by French drug maker <span>Sanofi</span> and is the world's first immunotherapy to target the root cause of type 1 <span>diabetes</span> and slow its progression. 

It will be made available on the NHS in England and Wales as clinical trial evidence reviewed by the National Institute for Health and Care Excellence (NICE) showed that teplizumab can delay the onset of symptomatic type 1 diabetes by an average of nearly three years. 

“This is a genuinely exciting recommendation. For the first time, we have a treatment that can give people diagnosed at an early stage of type 1 diabetes precious extra time before they need to manage the full demands of the condition,” said Helen Knight, director of medicines evaluation at NICE. 

<h2>Who Is Eligible for Teplizumab? </h2>

Teplizumab is used to delay the onset of stage 3 type 1 diabetes in children aged 8 years and older, and adults, with stage 2 type 1 diabetes. 

In stage 1 type 1 diabetes, there are no symptoms, and blood sugar levels are normal, but blood tests show the immune system has begun attacking the insulin-producing cells in the pancreas. 

<strong>Also read: </strong><a href="https://www.healthandme.com/health-news/uk-met-office-warns-of-pollen-bomb-what-hay-fever-patients-need-to-know-article-154733562" data-type="tilCustomLink">UK Met Office Warns of 'Pollen Bomb': What Hay Fever Patients Need to Know</a>

At stage 2, the immune attack has progressed further. There are still no symptoms, but blood tests show early changes in blood sugar levels, indicating a high risk of developing symptomatic diabetes. 

Because stage 2 type 1 diabetes has no symptoms, specific tests are needed to diagnose it. There is currently no national screening program. But people are most likely to be identified through: 

<ul><li>Research studies such as ELSA and T1DRA, which screen children and young people aged 2 to 17. </li></ul><ul><li>Testing because of an increased risk, such as having a parent, sibling or child with type 1 diabetes. </li></ul><ul><li>Testing for other medical reasons, including concerns about blood sugar levels. </li></ul>

“Around 1,100 people could be eligible for treatment in the first year, with approximately 555 expected to take it up. From year three, the eligible population is expected to stabilise at around 820 people annually, with approximately 490 expected to receive treatment,” as per NICE. 

Read More: <a href="https://www.healthandme.com/health-news/no-women-aged-20-24-died-of-cervical-cancer-in-england-over-five-years-thanks-to-hpv-vaccine-article-154681867" data-type="tilCustomLink">No Women Aged 20-24 Died of Cervical Cancer in England Over Five Years, Thanks to HPV Vaccine</a>

Teplizumab helps regulate the immune system by attaching to a protein called CD3 on the surface of immune cells responsible for attacking insulin-producing cells. This slows damage to the pancreas and delays the onset of the disease. 

Evidence for teplizumab comes from the TN-10 clinical trial, which followed 76 children aged 8 years and older and adults with stage 2 type 1 diabetes who had a close family member with the condition. Of the participants, 44 received teplizumab and 32 received a placebo. 

Teplizumab delayed the onset of symptomatic type 1 diabetes by approximately 32 months. 

<h2>How Is Teplizumab Administered? </h2>

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Teplizumab is given through a drip into a vein once a day for 14 consecutive days. Each infusion takes at least 30 minutes, with the dose gradually increased during the first few days. It is a one-time treatment course. 

Patients will need to attend hospital every day during the treatment period, including weekends. The NICE committee noted that daily travel may be difficult for some people because of cost or practical considerations. 

Sanofi has agreed a commercial arrangement with <span>NHS England</span>, meaning teplizumab will be available to the NHS at a confidential discounted price.

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The National Health Service (NHS) has approved teplizumab for people with early-stage type 1 diabetes in England and Wales. Teplizumab (sold under the brand names Tzield and Teplizumab) is manufactured by French drug maker Sanofi and is the world's first immunotherapy to target the root cause of type 1 diabetes and slow its progression. It will be made available on the NHS in England and Wales as clinical trial evidence reviewed by the National Institute for Health and Care Excellence (NICE) showed that teplizumab can delay the onset of symptomatic type 1 diabetes by an average of nearly three years. “This is a genuinely exciting recommendation. For the first time, we have a treatment that can give people diagnosed at an early stage of type 1 diabetes precious extra time before they need to manage the full demands of the condition,” said Helen Knight, director of medicines evaluation at NICE. Who Is Eligible for Teplizumab? Teplizumab is used to delay the onset of stage 3 type 1 diabetes in children aged 8 years and older, and adults, with stage 2 type 1 diabetes. In stage 1 type 1 diabetes, there are no symptoms, and blood sugar levels are normal, but blood tests show the immune system has begun attacking the insulin-producing cells in the pancreas. Also read: UK Met Office Warns of 'Pollen Bomb': What Hay Fever Patients Need to KnowAt stage 2, the immune attack has progressed further. There are still no symptoms, but blood tests show early changes in blood sugar levels, indicating a high risk of developing symptomatic diabetes. Because stage 2 type 1 diabetes has no symptoms, specific tests are needed to diagnose it. There is currently no national screening program. But people are most likely to be identified through: Research studies such as ELSA and T1DRA, which screen children and young people aged 2 to 17. Testing because of an increased risk, such as having a parent, sibling or child with type 1 diabetes. Testing for other medical reasons, including concerns about blood sugar levels. “Around 1,100 people could be eligible for treatment in the first year, with approximately 555 expected to take it up. From year three, the eligible population is expected to stabilise at around 820 people annually, with approximately 490 expected to receive treatment,” as per NICE.  How Does Teplizumab Work? Read More: No Women Aged 20-24 Died of Cervical Cancer in England Over Five Years, Thanks to HPV VaccineTeplizumab helps regulate the immune system by attaching to a protein called CD3 on the surface of immune cells responsible for attacking insulin-producing cells. This slows damage to the pancreas and delays the onset of the disease. Evidence for teplizumab comes from the TN-10 clinical trial, which followed 76 children aged 8 years and older and adults with stage 2 type 1 diabetes who had a close family member with the condition. Of the participants, 44 received teplizumab and 32 received a placebo. Teplizumab delayed the onset of symptomatic type 1 diabetes by approximately 32 months. How Is Teplizumab Administered?     Teplizumab is given through a drip into a vein once a day for 14 consecutive days. Each infusion takes at least 30 minutes, with the dose gradually increased during the first few days. It is a one-time treatment course. Patients will need to attend hospital every day during the treatment period, including weekends. The NICE committee noted that daily travel may be difficult for some people because of cost or practical considerations. Sanofi has agreed a commercial arrangement with NHS England, meaning teplizumab will be available to the NHS at a confidential discounted price.

teplizumab: uk nhs to roll out first drug to delay onset of type 1 diabetes

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