For decades, lung cancer has been synonymous with smoking. But the data is shifting—and fast. Today, 10–20% of lung cancer cases in the U.S. are found in people who have never smoked a single cigarette. A new large-scale international study has now unearthed some of the strongest evidence yet that air pollution may be a major culprit—and it’s leaving a genetic trail behind.

Researchers have discovered that fine particulate matter in polluted air, commonly from traffic, industrial emissions, and smog, is strongly associated with DNA mutations that are also found in smokers’ lung tumors. These mutations may be key drivers of lung cancer development in never-smokers.

The research, involving whole-genome sequencing of lung tumors from 871 never-smokers across 28 regions in four continents, found that individuals living in highly polluted environments had significantly more driver mutations—the kind that directly trigger cancer.

The investigators matched tumor samples with long-term air pollution exposure estimates, using ground and satellite data for fine particulate matter (PM2.5). They found that non-smokers exposed to high levels of pollution were nearly four times more likely to exhibit the SBS4 mutational signature—a genetic fingerprint commonly linked to tobacco smoke.

Additionally, they identified a 76% increase in a separate signature associated with accelerated biological aging. This is alarming, considering these were individuals with no direct tobacco exposure.

What makes this finding even more significant is that researchers discovered TP53 and EGFR mutations—both known to be aggressive lung cancer markers—more frequently in people living in polluted areas. These genetic changes are typically hallmarks of cancers in smokers.

This implies that air pollution could be triggering similar molecular pathways to those activated by cigarette smoke.

But there was a twist: a new mutational signature, SBS40a, was found in 28% of never-smokers but not in smokers. The origin of this marker remains unclear, but it suggests that pollution may not be the only hidden risk.

Rise of Environmental Carcinogens

The study adds to a growing body of evidence that air pollution is not just an irritant—it’s a carcinogen. Fine particles can be inhaled deep into the lungs, where they may damage DNA directly or trigger chronic inflammation that promotes tumor growth.

Even more surprising, another carcinogen showed up in the data: aristolochic acid, found in some traditional Chinese herbal remedies. This compound was associated with a distinct mutational signature in patients from Taiwan, hinting at a possible secondary environmental risk factor for lung cancer in never-smokers.

The rise of lung cancer in non-smokers is especially noticeable in East Asia, where rates remain disproportionately high—particularly among women. While genetic predisposition may play a role, this new evidence points clearly to environmental exposures as a key contributor.

And it’s not just an Asian problem. In Western countries, urban dwellers are also exposed to dangerously high levels of air pollution. The World Health Organization estimates that 99% of the world’s population breathes air that exceeds safe pollution thresholds. This means the risk is truly global.

The power of this new research lies in its use of whole-genome sequencing to link pollution to DNA changes. These mutational signatures act as a kind of molecular journal, recording every environmental insult a cell has endured.

The ability to map those changes and match them to known pollutants gives researchers a more precise way to trace cancer origins—not just infer them from epidemiological studies.

While this study can’t definitively prove causation, the strong correlation between pollution exposure and cancer-driving mutations makes it clear that dirty air is more than just a nuisance—it's a potential trigger for deadly disease.

Researchers acknowledge some limitations. Pollution estimates were regional, not personal, meaning it’s unclear how much exposure each participant had. Self-reported smoking histories can also be unreliable.

Still, the pattern is unmistakable. Air pollution behaves like a mutagen, leaving behind signatures that align with known cancer mechanisms. And it appears to affect never-smokers in a strikingly similar fashion to tobacco users—down to the very DNA damage.

This study raises serious public health questions: If environmental exposure to polluted air can cause DNA mutations tied to cancer, what safeguards are in place to protect those most vulnerable?

Governments and public health agencies may need to reconsider air quality regulations, urban zoning, and access to clean air—especially in densely populated cities where pollution levels remain dangerously high.

Healthcare systems might also need to adapt. Traditional lung cancer screenings focus on long-time smokers, but this research could shift how we think about early detection in non-smokers, especially those living in high-risk environments.

Lung cancer has long been viewed through the lens of personal responsibility: if you smoked, you knew the risks. But this research changes that narrative. The air we breathe—something no one can fully avoid—is now emerging as a significant threat.

For non-smokers around the world, especially women and urban residents, this is a wake-up call. Your lungs may be at risk not because of personal choices, but because of public ones—decisions about pollution control, urban planning, and clean energy.

The future of lung cancer prevention may lie not just in quitting cigarettes, but in cleaning up the air we all share.

Every year, thousands of seemingly healthy people—often young, active, and without obvious warning signs—die suddenly due to cardiac arrest. For decades, doctors have struggled to reliably identify which patients with heart conditions are at high risk and who might be unnecessarily undergoing invasive interventions. That may be about to change.

In a breakthrough that could transform how we predict—and prevent—sudden cardiac death, scientists at Johns Hopkins University have developed an artificial intelligence model that vastly outperforms current clinical standards in identifying people most at risk. Their new system, known as MAARS (Multimodal AI for Arrhythmia Risk Stratification), not only forecasts risk with up to 93% accuracy in vulnerable age groups, but also explains why someone is high risk—something most algorithms fail to do.

The focus of the study is hypertrophic cardiomyopathy (HCM), one of the most common inherited heart conditions. It affects around 1 in 200 to 500 people globally and is a leading cause of sudden cardiac death in athletes and young adults. While most individuals with HCM live normal lives, a subset is at high risk for lethal arrhythmias—heart rhythm disturbances that can cause the heart to stop without warning. And here’s the catch: right now, doctors only have a 50-50 shot at predicting who will be affected.

“Currently we have patients dying in the prime of their life because they aren’t protected,” said Dr. Natalia Trayanova, senior author of the study and a leading figure in AI cardiology research. “And others are putting up with defibrillators for the rest of their lives with no benefit.”

Trayanova is referring to implantable cardioverter defibrillators (ICDs)—tiny devices inserted into the chest that deliver electric shocks to correct abnormal heart rhythms. They save lives in the right patients but come with physical, emotional, and financial burdens when used unnecessarily.

The need for a more precise, personalized tool has never been greater.

What the AI Model Does Differently?

Published in Nature Cardiovascular Research, the new model represents a significant departure from traditional clinical guidelines used across the US and Europe.

MAARS doesn’t rely on a single data source. Instead, it analyzes a multimodal spectrum of information—ranging from electronic health records and patient histories to contrast-enhanced cardiac MRI images that reveal scarring, or fibrosis, within the heart.

Scarring is a key factor in determining sudden death risk in HCM. But interpreting these raw images is extremely challenging for even seasoned cardiologists. That’s where AI has the edge.

“People have not used deep learning on those images,” Trayanova explained. “We are able to extract this hidden information in the images that is not usually accounted for.”

The AI essentially spots dangerous patterns in the heart’s scar tissue that the human eye—and even conventional software—can’t see.

How Accurate Is It?

In clinical tests involving real-world patients from Johns Hopkins Hospital and Sanger Heart & Vascular Institute in North Carolina, the results were staggering:

• Traditional clinical guidelines correctly predicted sudden cardiac death risk only 50% of the time.
• The MAARS model achieved an overall accuracy of 89%.
• In patients aged 40 to 60—a group particularly vulnerable to undetected risk—the model was 93% accurate.

What makes this even more valuable is its ability to provide explanations. The system doesn't just say "this patient is high risk"—it breaks down the why, giving cardiologists critical information to tailor treatment plans.

“This significantly enhances our ability to predict those at highest risk compared to our current algorithms,” said co-author Dr. Jonathan Crispin, a Johns Hopkins cardiologist. “It has the power to transform clinical care.”

Why This Could Be Transformative?

MAARS isn't the first AI model from Trayanova’s lab. In 2022, her team built another tool that provided survival predictions for patients with prior heart attacks, known as infarcts. But this latest model breaks new ground by tackling one of the most elusive forms of cardiac risk—arrhythmias caused by scarring in inherited heart conditions. The potential benefits are wide-ranging:

• Lives saved by identifying at-risk patients who might otherwise be missed.
• Better quality of life for patients who avoid unnecessary ICD implantation.
• More personalized treatment plans based on detailed, AI-generated insight.

Importantly, the model was trained and validated across diverse demographics, showing consistent performance regardless of age, gender, or ethnicity.

The researchers aren’t stopping here. They plan to expand MAARS to include other forms of arrhythmia-related heart diseases, such as cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy—conditions that also carry a high risk of sudden death but suffer from diagnostic ambiguity.

They’re also working to test the model in larger, more varied populations to move it closer to clinical adoption.

A New Era in Cardiology?

Artificial intelligence has long been hyped as the future of medicine. But MAARS is more than hype—it’s a working proof of concept that shows how deep learning can complement medical expertise, not replace it.

AI may soon become your cardiologist’s most powerful diagnostic tool—one that sees what even the best-trained human eyes might miss. And when lives are on the line, that kind of clarity could mean everything.

India is struggling with alarmingly high levels of premature deliveries and low birth weights in infants, and the cause could be one of the nation's most pressing environmental threats—air pollution.

As per India's National Family Health Survey-5 (2019–21), about 13% of infants were born pre-term and 17% were low birth weight, with the research identifying airborne fine particulate matter or PM2.5 as a key driver of these negative birth outcomes. The results, published in PLoS Global Public Health, are the outcome of cross-institutional collaboration between Indian and global research centers. By uniting large-scale health survey data with air quality remote sensing, the scientists have mapped not only the extent of the problem but also its underlying environmental causes.

The research, conducted in association with India's leading scientific institutions such as IIT Delhi, International Institute for Population Sciences (Mumbai), and collaborating UK and Irish partners, merged public health information with high-resolution satellite images to evaluate the impact of air pollution on pregnancies. With sophisticated spatial modeling and statistical analysis, researchers found that increased exposure to PM2.5 during pregnancy was associated with a 70% greater risk of preterm birth and a 40% greater chance of low birth weight.

This is a major public health issue, with both outcomes having long-term health consequences for infants, from cognitive disabilities to chronic conditions such as diabetes and heart disease in adult life.

What Connects Air Pollution with Preterm Births?

At the center of the crisis is fine particulate matter (PM2.5)—small airborne particles smaller than 2.5 microns in diameter, emitted primarily from the combustion of fossil fuels and biomass. The particles are tiny enough to reach deep into the lungs and into the bloodstream, and they threaten the health of mothers and fetuses equally.

The research determined that higher exposure to PM2.5 during pregnancy was linked with a 40% increased likelihood of low birth weight and a 70% increased risk of preterm delivery. The rise of 10 microgram per cubic meter (μg/m³) in PM2.5 exposure was correlated with a 5% increase in the prevalence of low birth weight and a 12% increase in preterm delivery.

These results are consistent with global evidence, including a recent meta-analysis, which reported a similar dose-response pattern between exposure to PM2.5 and adverse birth outcomes globally. Exposure to other PM2.5 components—black carbon, nitrates, and sulfates—has also been associated with spontaneous preterm birth, especially in the second trimester.

The research identified glaring regional inequities. States in the higher Gangetic plains of North India, including Punjab, Delhi, Uttar Pradesh, Haryana, and Bihar, demonstrated the greatest PM2.5 levels. These states also had the greatest rates of premature births and low birth-weight babies. For example, Himachal Pradesh reported a whopping 39% premature birth rate, followed by Uttarakhand (27%), Rajasthan (18%), and Delhi (17%).

Conversely, the northeastern states of Mizoram, Manipur, and Tripura did notably better, with reduced air pollution rates and associated improved outcomes at birth. The results indicate the imperative for focused policy action in northern India, where urbanization, agricultural burning, and the use of fossil fuels are pushing perilously bad air quality.

Can Climate Change Is Add to the Crisis?

Aside from air pollution, other climate factors like temperature and changes in rainfall patterns also affected pregnancy outcomes, according to the Indian study. The study observes that intense heat waves, irregular monsoons, and water shortages—characteristics of the climate emergency—can directly affect the health of the mother and fetus.

With this convergence of environmental and reproductive health, specialists are increasingly advocating for the incorporation of climate adaptation measures in public health planning. Localized heat action plans, improved water management systems, and effective risk communication systems are among these.

How Air Pollution Harms Pregnancies?

The journey from contaminated air to poor birth outcomes is both subtle and direct. PM2.5 and its components have the ability to penetrate the placental barrier, leading to inflammation and oxidative stress in the placental tissue. This inflammation is directly related to preterm labor, low birth weight, and even neurodevelopmental delay in children.

Black carbon, one of the dominant fractions of PM2.5, has been found to interfere with fetal development and raise the risk of preeclampsia and preterm rupture of membranes, further putting mother and child at risk. The additive effect is increased odds of babies being born too early or too light, with health consequences for life.

India's National Clean Air Programme (NCAP), initiated in 2019, plans to lower PM levels by 20–30% in 122 non-attainment cities by 2024. It's good that it is a move towards improvement, but according to researchers, efforts need to be scaled up and enforced more strictly, particularly in the northern belt where pollution levels are still critically high.

The researchers of the study also suggest greater public health outreach, including education campaigns for pregnant women, frontline health workers, and policymakers. Education about air quality monitoring, prenatal care access, and simple measures to avoid exposure are crucially necessary.

How Pregnant Women Can Protect Themselves?

Although systemic change is necessary, there are also measures individuals—particularly pregnant women—can take to lower their risk:

• Monitor local air quality and limit outdoor activities when pollution levels are high.
• Use air purifiers and maintain clean indoor environments.
• Avoid heavily trafficked roads and industrial areas whenever possible.
• Eat a diet rich in antioxidants, which may help counteract some of the harmful effects of air pollutants.

Yet, with air pollution still on the increase, such individual precautions need to be supplemented by strong public health and policy measures so that meaningful protection for both mothers and infants is guaranteed.

This research reinforces a growing body of international evidence that links air pollution to reproductive and neonatal health risks. According to the World Health Organization, over 90% of the global population breathes unsafe outdoor air, and half are exposed to indoor pollution from traditional cooking methods involving coal, dung, or wood.

Worldwide, 15 million babies are born prematurely each year, and so preterm birth is the predominant cause of neonatal deaths. By which standards is the Indian study a local health concern—it's a global warning for health.

For the first time in a quarter-century, the United States is seeing more cases of measles during a single year than at any point since the disease was last declared eliminated in 2000. A startling 1,277 cases were reported as of mid‑2025—already more than the former yearly record of 1,274, which was set in 2019. Adding to alarms, three lives—two kids in Texas and an adult in New Mexico—have already been lost this year, equaling the number of U.S. measles deaths since elimination.

This comeback highlights both the vulnerability of public health gains and the lethal effects of waning vaccination levels.

What "Elimination" Meant—and Why It's Slipping Away?

In 2000, when the U.S. marked measles elimination, it meant zero sustained domestic transmission for over a year—a feat achieved due to successful vaccination and disease surveillance. A strong two-dose schedule of the measles-mumps-rubella (MMR) vaccine, accessible since the 1970s, fueled that achievement.

But since 2021, national school-age MMR coverage has slipped below the all-important 95% herd immunity bar that experts say is critical to widespread protection. More than 125,000 kindergartners alone had exemptions from one or more mandatory vaccines during the 2023–24 school year. That set the stage for contagion to spread—particularly in clusters of unvaccinated communities.

In West Texas, an undervaccinated area in late January sparked a huge outbreak. Over 750 cases have been traced to the region, spreading to Oklahoma and New Mexico and prompting an early vaccination campaign. Counties reacted by administering early doses of MMR as young as six months old, and in Texas, early infant vaccination jumped—the rate was eight times higher than in 2019, according to Truveta health data.

Communities rallied with pop-up vaccination sites, state-level policy interventions, and an increased uptake of MMR. Nevertheless, smaller outbreaks in 38 states and 27 discrete clusters indicate a more pervasive susceptibility.

Why Cases Are Skyrocketing Now?

Waning MMR Coverage: Sustained vaccine skepticism and exemptions have eroded herd immunity in communities.

Highly Infectious Virus: Measles spreads more quickly and widely than many respiratory diseases—up to 90% infection of susceptible close contacts. It only takes one contagious person to initiate large outbreaks.

Global Spread: Measles is endemic throughout the world. Imported cases in countries where the virus is circulating continuously are the lifeblood of ongoing outbreaks.

Local Susceptibility: With an unvaccinated cluster present, the virus circulates nearly unimpeded.

In 2019, misinformation-driven outbreaks infected Orthodox Jewish communities in New York. Now, the epicenter is Texas, but the virus is spreading extensively—eliciting extensive alarm.

While the epicenter is still West Texas, the virus has now spread in several states:

New Mexico & Oklahoma: Connected to initial outbreak, with overlapping transmission chains.

Kansas: 83 cases, all but one related to primary Texas outbreak.

Wyoming: Expressed a measles case for the first time since 2010—an unvaccinated kid in rural Casper.

Utah, Michigan, Florida: New instances of travel-associated cases have surfaced, emphasizing the national risk.

Public health authorities are cautioning that if transmission persists after January 2026, the U.S. will forfeit its measles elimination status, which is reversing a big public health achievement.

Why Is Measles A Continental Health Threat?

The Reuters Health update is a reflection of the U.S. crisis. Pan American Health Organization (PAHO) indicates a 29-fold increase in measles in the Americas compared to last year. There have been 3,170 cases in Canada since 1998 and Mexico had 2,597 cases in 2025—with 10 related deaths. Mennonites and other isolated communities' vaccine skepticism is driving the comeback.

The CDC has estimated a mere 8% of the 2025 cases in fully or partially vaccinated persons. In other words, more than 90% infected were unvaccinated. Hospitalizations have been glaringly high: 155 patients, including numerous young children. Specifically, 28% of these cases are in children under age 5—the exact age group that the MMR vaccine is supposed to protect.

MMR vaccine is one of the most effective medical tools ever—93% effective after one dose, and as much as 97% after two. Yet its effectiveness hinges on widespread coverage, not simple use. There are several forces at play:

Vaccine Hesitancy & Misinformation: Sustained disinformation efforts—across social media and conspiracy networks—chips away at confidence in vaccines.

Policy Vacuum: The U.S. lacks a permanent CDC director. HHS Secretary Robert F. Kennedy Jr. surprised with a pro-vaccine public statement this spring, but his past record of vaccine skepticism and disregarding CDC advisory panels erodes faith.

Educational Shifts: Additional states have broadened vaccine exemption policies, granting greater refusal under medical, religious, or philosophical reasons.

At levels of community coverage below 95%, outbreaks become nearly inevitable.

Has U.S. Failed its Children?

Others suggest 2025 represents a systemic public health collapse. The pathogen's general return is a reflection not of biology but policy abandonment and frayed solidarity. Vaccination is not just individual defense—it's a social compact.

Others notice a silver lining: almost universal alarm, rapid policy response, and vaccination catch-up campaigns are proving the system responsive—if communities reassert collective responsibility.

This isn't about erecting barriers, but about renewing the networks of trust that allow vaccines to protect whole communities.

We stand at a crossroads, The resurgence of measles illustrates how progress can vanish when vigilance does. Yet while 2025 has set new records, it also sparked renewed urgency—and rare moments of collective action.

We can't risk losing what was once seen as core public health. At the center of this battle is a simple, evidence-based fact: Vaccination saves lives—not only individuals, but communities. America has to choose: is this the time we repair the fissures in public trust and systems—or do we allow measles take back territory?