A sedentary lifestyle is one of the biggest perpetrators of declining cognitive health. According to the Alzheimer's Drug Discovery Foundation there are many other factors like eating unhealthy processed foods, high LDL cholesterol, depression, traumatic brain injury, diabetes, smoking, high blood pressure etc., that can cause dementia. One of the best ways to prevent cognitive decline is said to be physical exercise. It reduces chronic inflammation, improves blood flow as well as releases proteins necessary for brain health. However, a new study shows physical activity is not the cure-all answer for decline in cognitive health.

The surprising thing was the link between how much time older adults spend sitting and their risk of getting Alzheimer's disease. What's even more interesting is that this risk seems to be higher even for people who make sure to get their daily exercise. The study found that those who sat for longer periods were more likely to experience a decline in their thinking skills and even showed signs of their brains shrinking over time, regardless of their exercise habits.

More Sedentary Time = Faster Brain Decline?

The study published in the Alzheimer’s & Dementia journal 2025, followed a group of adults aged 50 and older for an average of seven years. They used special watches to track exactly how much each person moved around during the day and how much time they spent being still. Over this period, they found a clear pattern: the more hours someone spent sitting down regularly, the worse their performance was on tests that measured their memory and how quickly they could process new information. This suggests that prolonged sitting has a negative impact on brain health over time.

Why Daily Exercise May Not Help Your Brain As Much?

One of the key findings of this study is that simply exercising once a day might not be enough to completely protect your brain if you spend the rest of your time sitting. The lead researcher emphasized that while exercise is definitely good for overall health, minimizing the total time you spend sitting down each day could be even more important for reducing your chances of developing Alzheimer's disease later in life. This highlights the need to think about our activity levels throughout the entire day, not just during planned workouts.

The results of the study were quite revealing with a large majority of the participants – about 87% – were meeting the recommended weekly amounts of physical activity set by health authorities. Despite getting enough exercise, these individuals still faced a higher risk of brain shrinkage and cognitive decline if they also spent a lot of time sitting down. This strongly suggests that being sedentary is an independent risk factor for Alzheimer's disease, meaning it can be harmful to the brain even if you are otherwise physically active.

Researchers emphasized the importance of breaking up long periods of sitting with movement. She stated that taking regular breaks to stand up and walk around throughout the day is likely a promising way to help prevent the kind of brain degeneration that can lead to cognitive decline and eventually Alzheimer's disease. This suggests that incorporating more short bursts of activity into our daily routines, rather than just focusing on a single workout, could be very beneficial for long-term brain health.

Vax-Before-Travel, an international publisher of vaccine information noted that in 2025 Lyme disease ticks have progressed westward into many midwestern states. It has also reported a significant increase. However, while the Tick Season is back, there is a new Lyme treatment on the horizon. But, with it, there are also unique symptoms that one has to be aware of.

Unique Symptoms Of Lyme Disease In 2025

The ongoing threat of ticks is usual when one is enjoying their time as the weather warms up. They can be found in your backyard and can transmit Lyme disease, a tickborne infection caused by the bacteria Borrelia burgdorferi.

While Lyme disease is usually resolved with a short course of antibiotics, it is not always a simple illness. Sometimes, it can lead to prolonged symptoms, if untreated.

As per American Medical Association (AMA), Lyme disease is the most common vector-borne disease in the US, with an estimated 476,000 people diagnosed and treated each year. The numbers are also corroborated with the Centers for Disease Control and Prevention (CDC).

The Maryland Government Health website also notes that for about 75% of those diagnosed with Lyme disease, the first sign is always a skin lesion. This appears within one to four weeks after being bitten by an infected deer tick. However, only about 20% of these lesions take on the classic bull's eye appearance, which is most commonly associated with Lyme disease. This means, 55% of those with lesions may not even be diagnosed with the condition, and may not get the treatment.

ALSO READ: Lyme Disease In US: How Worried Should You Be Of Ticks?

Here Are 7 Unique Symptoms Of Lyme Disease

Heart Problems

The Time reports that if Lyme is not treated early on, it can impact the cardiac, neurologic, and rheumatologic systems. The CDC notes that 1 out of 100 patients have Lyme bacteria in their heart tissues. The condition is also called Lyme carditis.

This leads to heart inflammation, light headedness, fainting, shortness of breath, heart palpitations, or chest pain.

Brain Fog

John Hopkins Medicine Lyme Disease Research Center notes that advanced brain imaging shows that Lyme disease brain fog is real. It can lead to various brain effects, including difficulty in focusing, thinking, reading, and absorbing information.

Bell's Palsy

There are 12 essential nerves, also known as the cranial nerves that originate in the brain and play an important role in sensory functions and movements in the different parts of the head, face, neck, and torso. Lyme disease can also affect those nerves, leading to Bell's Palsy, causing sudden weakness or even paralysis.

Eye Problems

Some people may experience eye irritation and conjunctivitis. The American Journal of Medicine's 1995 study also suggests that Lyme can cause sudden vision loss, damage to optic nerve, and neurotrophic keratitis (decreased corneal sensation). Other symptoms include blurry vision, eye floaters, tearing and extreme sensitivity to light.

Hearing Problems

A 2018 study published in Otolaryngologia Polska, reported of the 216 people with tickborne disease, 162 experienced otolaryngological symptoms—making them a “frequent manifestation,” according to the study authors. The most common hearing issues are tinnitus, vertigo and dizziness, headache, and unilateral sensorineural hearing or hearing loss in one ear.

Arthritis

It is one of the common symptoms of Lyme disease, especially in young people. It can be seen in form of a swollen knee, a low grade fever, or a kid limping. It usually starts at a fourth week of being bitten.

On a hopeful note, researchers at Northwestern University in Illinois recently screened over 500 antibiotics and FDA-approved compounds to identify treatments that specifically target the unique cellular makeup of Borrelia burgdorferi, the bacteria behind Lyme disease.

Their findings, published in Science Translational Medicine, revealed that piperacillin, an antibiotic from the penicillin family, successfully cured mice of Lyme disease at doses 100 times lower than doxycycline, the standard treatment currently in use.

Fatigue

This is not just any fatigue, but a weakness that is debilitating. A 2022 study published in the International Journal of Infectious Diseases noted that people with a history of Lyme were 8 to 15 times more likely to report severe or moderate fatigue than those who have never had the disease.

READ: Family Shares How A Lyme Disease Misdiagnosis Cost Their Son's Childhood

How Long Do These Symptoms Last?

As per the National Health Service, (NHS), UK, in case of a rash, it can appear up to 3 months after being bitten by an infected tick. However, in most common cases, it appears within 1 to 4 weeks, and stays for several weeks.

In cases of untreated Lyme disease, the symptoms may appear later, and may become chronic, like debilitating fatigue.

Breast cancer has a strange way of being both familiar and frightening. Almost everyone knows someone who has battled it, and yet the details of treatment often sound like an alien language. According to the World Health Organisation, breast cancer is the most common cancer among women worldwide, with 2.3 million new cases in 2022 alone. Among these, about 15 to 20 per cent are HER2-positive, the type that is fast-moving, aggressive, and hard to ignore.

Increasingly, the doctors are turning to a strategy that feels a bit like hitting “pause” before the main act—neoadjuvant therapy.

What Makes HER2-Positive Breast Cancer Tricky

HER2 (human epidermal growth factor receptor 2) is a protein that helps cells grow. In HER2-positive breast cancer, the cells get an overdose of this protein. As a result, the cancer multiplies faster than usual and is often linked to poorer outcomes.

“HER2-positive breast cancer is an aggressive type,” explains Dr Mandeep Singh Malhotra, co-founder, Art Of Healing Cancer. “It is very important to give the right information to patients and their families for better outcomes. With the right treatment sequence, it is possible to offer better treatment to patients.”

What Is Neoadjuvant Therapy?

Neoadjuvant therapy (NT) is like a warm-up session but for cancer treatment. Instead of rushing into surgery to remove the tumour, doctors first administer chemotherapy and targeted drugs. The idea is to shrink the tumour, make surgery easier, and gather valuable intel on how the cancer responds.

“Nowadays, when we talk about HER2-positive breast cancer, we talk about targeted therapy and dual targeted therapy involving both trastuzumab and pertuzumab,” says Dr Malhotra. Both are monoclonal antibodies, meaning they are lab-made molecules designed to stick to specific parts of cancer cells. Together with chemotherapy, they not only shrink tumours but also improve surgical outcomes.

Why Doctors Like It

One of the superpowers of neoadjuvant therapy is its ability to act as a kind of crystal ball. By giving treatment before surgery, doctors can tell which patients are “responders” and which are not.

“As Dr Malhotra puts it, “Even at early stages, if we give NT and then operate, we are able to prognosticate. Responders have a better prognosis. Non-responders have poorer prognosis and a higher chance of the cancer coming back.”

This ability to sort patients into risk categories allows doctors to tailor follow-up care more precisely. For example, non-responders may be put on more aggressive treatments, offered newer diagnostic tests like liquid biopsy, or monitored more closely.

The Big Advantage Over Surgery-First

Surgery-first and neoadjuvant-first have similar survival data, but the latter provides an extra layer of information.

“If we do upfront surgery in these patients, we lose the chance of prognostication,” says Dr Malhotra. “Secondly, even if we do the upfront surgery, we will still have to give chemo with targeted therapy after surgery. So the treatment does not change; the sequence changes. And with neoadjuvant therapy, we get the added benefit of knowing who is high risk and who is low risk.”

In other words, neoadjuvant therapy is not just about shrinking tumours; it is about outsmarting them.

What Patients Need to Keep in Mind

For patients, all of this can feel overwhelming. Surgery often seems like the most direct way to “get rid” of cancer, so the idea of delaying it can cause anxiety. But Dr Malhotra reassures patients that this approach is carefully designed.

“Even in very early-stage breast cancer, with a less than 1 cm tumour, I will not go for surgery first,” he says. “I will first give targeted chemotherapy. The reason is I see a lot of patients who have already had surgery and then are given the option of dual therapy. They are confused and afraid that the cancer will come back if they cannot afford either trastuzumab or pertuzumab.”

Interestingly, cost can also play a role. If patients achieve a complete response, meaning no invasive cancer remains after neoadjuvant therapy, sometimes treatment can be stopped earlier, sparing both physical and financial strain. “We lose this opportunity if surgery is opted for first,” Dr Malhotra adds.

The Future of HER2-Positive Breast Cancer Treatment

The shift towards neoadjuvant therapy represents a significant change in how doctors approach HER2-positive breast cancer. Instead of rushing in with surgery, the modern strategy is more like a chess game, carefully setting up each move to give patients the best possible outcome.

By combining chemotherapy with targeted drugs like trastuzumab and pertuzumab before surgery, doctors can shrink tumours, assess risk, personalise treatment, and often improve long-term survival.

Breast cancer treatment has always been a mix of science, strategy, and courage. Neoadjuvant therapy, especially in HER2-positive cases, is proving to be more than just a pre-surgery step. It is a game-changer, giving both patients and doctors a crucial edge in the fight.

As Dr Malhotra puts it, “Neoadjuvant therapy is not an inferior modality. With current data, we feel it is a superior one.”

Just like any other office worker, this 29-year-old woman, followed the same routine, long working hours, morning coffee runs and often ordering out due to exhaustion, “The way she described it, it sounded normal. And that’s what worried me the most.” What her tests revealed shocked even her doctor, with alarming rates of liver enzymes, her ultrasound showed stage 3 fatty liver. The kicker is, she never touched alcohol in her entire life!

Dr Obaidur Rahman, ortho & sports surgeon, shared this story on his social media handle, to help spread awareness about nonalcoholic fatty liver disease (NAFLD) and the growing rates of the disease among young adults. NAFLD is also known as MASLD or fatty liver disease according to British Liver Trust.

While many people believe it is a disease on people who drink alcohol are susceptible to, this common misconception leads to many people overlooking the signs and symptoms, until it is too late.

What Are The Early Symptoms of Fatty Liver?

In the video caption, Dr Obaidur mentioned that the patient had faint yellow eyes, swollen legs that left deep impressions when pressed as well as slow unsure steps. He explained how these symptoms would be more in line with a patient decades older than the 29 year-old. According to UK National Health Services, most people who have it don't experience any symptoms and don't even know they have it. When symptoms do appear, they can include:

• Feeling very tired
• General discomfort or feeling unwell
• Pain in the upper right side of your abdomen, under your ribs

Can Bad Lifestyle Habits Cause MASLD?

MASLD is when fat builds up in your liver because of extra body weight, high blood sugar, high cholesterol or high blood pressure (John Hopkins Medicine). While doctors don't know the exact cause of MASLD, it is strongly linked to several common health issues.

Obesity: Carrying extra weight, especially around the belly, is a major factor.

Insulin resistance and Type 2 diabetes: This is when your body doesn't use insulin properly, causing blood sugar levels to rise.

Metabolic syndrome: A combination of conditions that include high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

High cholesterol and high triglycerides: These are types of fats in your blood that, when too high, can contribute to liver fat.

Who Is At Risk for MASLD?

According to the American Liver Foundation, about 100 million people, which is around 25% in the US have been estimated to have MASLD. It is very common and certain factors make you more likely to get it. “Fuelled by sugar-laden “healthy” drinks, long hours of sitting, processed foods, and constant low-grade inflammation” Dr Obaidur details. Anyone could be at risk, some factors that determine that are:

• Are overweight, especially with a lot of fat around your stomach.
• Have a poor diet or don't get much physical activity.
• Have type 2 diabetes, high blood pressure, or high cholesterol.
• Are over 50 years old.
• Have polycystic ovary syndrome (PCOS).

What is the Treatment and Lifestyle Changes Needed for Fatty Liver?

The best way to treat MASLD is by making healthy lifestyle changes. These changes can help reduce liver fat and even repair some damage. They also lower your risk of other related health problems like heart disease and diabetes. Here's what you should do:

• Eat a healthy, balanced diet.
• Exercise regularly, aiming for at least 150 minutes a week.
• Lose weight if you are overweight.

Here's what you should avoid:

• Don't drink too much alcohol. Stick to the recommended limit of no more than 14 units per week.
• Don't smoke.