Hangover star Ken Jeong's wife Tran Ho Jeong in 2007 discovered a hard lump in her breast while she was breastfeeding their newborn twins Alexa and Zooey. She was diagnosed with stage 3 triple negative breast cancer (TNBC) in 2008. What Is Stage 3 Triple Negative Breast Cancer?As per the American Cancer Society, it is an advanced aggressive, and fast-growing cancer that has spread to nearby lymph nodes or tissue, however, does not distant organs. It is characterized by the absence of estrogen, progesterone and HER2 receptors, which requires a combined approach of chemotherapy, surgery, and sometimes also radiations As per the American Cancer Society, TNBC accounts for about 10 to 15 per cent of all breast cancers.At stage 3, TNBC has grown extensively and invaded nearby tissues and is likely to spread to lymph nodes. However, it has not metastasized to distant organs. Hangover Star Ken Jeong's Wife Cancer JourneyAs doctors said, for Tran, it was a "year of hell". She underwent 16 rounds of chemotherapy when Ken was filming The Hangover. This was then followed by a mastectomy and radiation therapy. "I am going to survive this. I am going to fight. I have to live for the girls and for Ken," she said. After two years of battle, Tran was finally declared cancer free in 2010. Ken called it "the greatest moment" of his life. View this post on Instagram A post shared by Ken Jeong (@kenjeong)]]> What Happens In Breast Cancer?As per the World Health Organization (WHO), breast cancer is the most common cancer globally with around 2.3 million new cases every year. At the rate of 1 in every 8 person in both sexes and a quarter of all cancer in women with 70% mortality occurs due to constrained resources.It is a disease where abnormal breast cells grow out of control and form tumors. If it is left unchecked, the tumors can spread throughout the body and become fatal.It originates in the milk ducts or the milk-producing lobules of the breast. The earliest form is not life-threatening and can be detected in the early stages. Cancer cells can spread into nearby breast tissue and create tumors that cause lumps or thickening. These invasive cancers can spread to nearby lymph nodes or other organs and metastasis can be life-threatening and fatal.Signs And Symptoms Of Breast CancerThe common signs are:A breast lump or thickening, often without painChange in size, shape or appearance of breastsDimpling, redness, pitting or other changes in the skinChange in nipple appearance or the skin surrounding the nipple (areola)Abnormal or bloody fluid from the nippleTreatmentThe treatment depends on the stages and subtypes of the cancer. However, common treatments involve:Surgery to remove breast tumorRadiation therapy to reduce recurrence of breast cancer around the breast tissuesMedicals to kill cancer cells and prevent spreadTherapies like hormonal and chemotherapy or targeted biological therapy