Tooth agenesis happens when because of genetic and environmental factors, people are born missing some of their teeth.

In this case, certain teeth never develop and it can involve both primary and permanent teeth. Most commonly it affects permanent teeth.

There are three types of dental agenesis:

• Anodontia: Complete absence of teeth
• Hypodontia: Absence of one to six teeth
• Oligodontia: Absence of six more teeth

What Happens With Tooth Agenesis?

In most cases, it affects the lower second premolars, which are the teeth in front of your molars on the bottom. The next affected area is the upper second premolars, the teeth that are in front of your molars on the top. It can also affect the upper lateral incisors, which are the smaller teeth on either side of your top two front teeth.

Are There Any Symptoms?

If your tooth is small and peg-shaped, has gaps and spaces between your teeth, or are large, rectangular teeth that have extremely pulp chambers, also known as Taurodontic teeth.

Who Are At Risk?

Since it is also a symptom of genetic disorders, people with ectodermal dysplasia might also have:

• Hair thinning
• Nail abnormalities
• Lack of sweat glands
• Poor vision
• Hearing loss

Is There A Bright Side?

The ray of hope is that Japanese scientists were able to recreate these missing teeth in mice. In a 2021 paper titled Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signalling available on National Library of Medicine's platform, Japanese scientists found that if a second gene is knocked out, called the USAG-1 gene, then the tooth could grow back.

What can be done according to the scientists is that antibodies can be created that block this gene in humans so the teeth could grow. The research is in its phase 1 trials, which means that soon there will be a positive result for it.

How Is It Treated Now?

Without positive results on trials, there are yet to be any medicines that can regrow teeth in humans, however, there are ways to manage tooth agenesis. These options include:

• Dentures
• Dental Bridges
• Dental Implants
• Orthodontic treatment, such as braces

Women are spending thousands of pounds to address an intimate and largely unexpected side effect linked to rapid weight loss caused by so-called “fat jabs.” As these injections grow quickly in popularity, doctors say sudden and significant weight loss is leading some women to notice changes in their labia or vulva.

This has resulted in a rise in private cosmetic procedures commonly referred to as “labia puffing.” For those unversed, the vulva refers to the external female genital area, which includes the labia. The labia are the folds of skin that surround the vaginal opening.

Weight-Loss Injections Go Mainstream

Originally developed to manage Type 2 diabetes, weight-loss injections have entered the mainstream at remarkable speed. As per Mirror, in the UK alone, about 2.5 million people are now using these drugs, according to figures reported by The Telegraph in October. That means roughly one in every 20 adults. Most users access the injections privately, as they are rarely available through the NHS. The report also noted that sales of medications such as Mounjaro and Wegovy reached 2.5 million in July, marking a sevenfold increase compared to the previous year.

While headlines have largely focused on visible changes such as slimmer bodies and faces, including among celebrities like Sharon Osbourne and Serena Williams, medical professionals say other, less discussed effects are starting to emerge.

Changes Beyond Common Side Effects

Along with widely known side effects such as nausea, diarrhoea, constipation, abdominal pain, and vomiting, some women are now reporting noticeable changes in the appearance of their vulvas and labia.

Doctors explain that the issue is not weight loss itself, but the speed at which it happens. Rapid weight loss strips fat from many areas of the body, including the vulval region. For some women, this leads to a loss of volume in the labia, causing loose or sagging skin. This can result in irritation and discomfort during everyday activities such as sitting, cycling, or exercising.

Women Share Their Experiences

Many women have taken to online forums to describe what they are experiencing. As per Mirror, one Reddit user shared, “She [the gynaecologist] told me my vulva is saggy and I will continue to experience pain when biking or sitting unless I have surgery or fillers.”

Doctors say these outcomes are not surprising. Dr Michael Tahery, writing on his women’s health website, explained that “the rapid weight loss that occurs throughout the body may result in visible sagging of the labia or vagina because of overall fat and volume loss.”

He added that this sagging can be caused by loose labia, excess skin in the vaginal area, wrinkles, or a combination of these factors. “It’s also common for rapid weight loss to cause the labia to suddenly feel out of proportion compared to how it previously felt,” he noted.

Not Just a Cosmetic Concern

For many women, the impact goes beyond appearance. The loss of natural cushioning can increase friction and sensitivity, turning once-comfortable activities into painful experiences. As a result, more women are seeking help from private clinics, where corrective procedures can cost around $2,000, or approximately £1,479. The treatment, often called labia puffing, focuses on restoring volume to the outer lips of the vulva.

What Is Labia Puffing?

Speaking to The Daily Star, Dr Shazia Malik, consultant gynaecologist at The Portland Hospital, explained how the procedure works. “Labia puffing uses dermal fillers, such as hyaluronic acid or fat, to restore volume to the labia majora, which are the outer lips of the vulva,” she said. “It is a minimally invasive procedure designed to improve appearance by increasing fullness, smoothness, and symmetry.”

Dr Malik also pointed out that the demand is not limited to women using weight-loss injections. “The procedure is most commonly sought by women who want to regain a more youthful, fuller appearance due to ageing, weight loss, or childbirth,” she explained.

A Wider Impact of Rapid Weight Loss

The growing interest in these procedures highlights how dramatically weight-loss injections can change the body. Unlike gradual weight loss achieved through diet and exercise, the speed at which fat can disappear with these drugs means changes can occur in areas people do not expect. For some women, these sudden shifts are significant enough to push them toward cosmetic interventions to feel comfortable again.

Alzheimer’s disease and other types of dementia affect memory, thinking ability, and day-to-day functioning. While certain risk factors such as age and genetics cannot be altered, others are within our control. One such factor is obstructive sleep apnea, a condition that is both common and treatable.

Obstructive sleep apnea, or OSA, occurs when breathing repeatedly stops and restarts during sleep. Growing evidence suggests that untreated sleep apnea may raise the risk of memory loss, cognitive decline, and dementia, including Alzheimer’s disease. The encouraging part is that timely treatment may help safeguard brain health.

What Is Obstructive Sleep Apnea?

During sleep, the muscles at the back of the throat naturally relax. In people with obstructive sleep apnea, these muscles relax excessively and block the airway. As a result, breathing pauses briefly until the brain signals the body to wake up just enough to resume breathing. Nebraska Medicine neurologist Dr Daniel Murman explains that this cycle can occur dozens or even hundreds of times each night. Although a person may spend six to eight hours in bed, the repeated interruptions mean the sleep remains shallow and unrefreshing.

Symptoms Of Sleep Apnea

Many people live with sleep apnea without realising it. According to the Cleveland Clinic, some common signs to watch for include:

• Loud and persistent snoring
• Pauses in breathing during sleep, often noticed by a partner
• Gasping or snorting sounds at night
• Excessive sleepiness during the day
• Difficulty concentrating or staying alert
• Morning headaches or waking up feeling unrested

In more serious cases, repeated breathing pauses can lower oxygen levels during sleep. Over time, this oxygen deprivation can damage several organs, including the brain.

How Sleep Apnea Affects The Brain

Untreated sleep apnea can impact the brain in both immediate and long-term ways. “In the short term, disrupted sleep makes clear thinking more difficult,” says Dr Murman. “People may notice problems with attention, reaction time, multitasking, and memory. These issues can resemble early signs of dementia but may improve once sleep apnea is treated.”

Over longer periods, frequent drops in oxygen levels combined with poor sleep quality may lead to lasting brain changes. Research has consistently shown a strong association between untreated sleep apnea and an increased risk of:

• All forms of dementia
• Alzheimer’s disease
• Vascular cognitive decline linked to blood vessel damage

Although studies are ongoing, scientists believe sleep apnea may harm the brain through multiple biological pathways.

Having Sleep Apnoea Increases Risk Of Anxiety And Dementia: Study

A long-term ageing study published in JAMA Network Open also found that sleep apnoea is linked to a higher risk of mental health conditions over time. Researchers from the Ottawa Hospital Research Institute analysed data from more than 30,000 adults aged 45 to 85, who were followed for an average of three years. Around 7,500 participants had sleep apnoea.

“In this national Canadian cohort study of 30,097 individuals, those at high risk of obstructive sleep apnoea had about 40 per cent higher odds of mental health conditions at both the start of the study and follow-up,” the authors wrote. “Over time, a high risk of OSA remained linked to a 44 per cent increase in the likelihood of developing new mental health conditions.”

The researchers also noted that middle-aged and older adults at high risk of sleep apnoea consistently reported poorer mental health outcomes. Women, people with lower incomes, and those with poorer overall health and life satisfaction were more likely to develop new mental health concerns. The findings underline the need for routine mental health screening among older adults at risk of sleep apnoea.

Previous research has already connected sleep apnoea with a higher risk of cognitive impairment and dementia. The study’s authors emphasised that future research should explore whether combining screening and prevention strategies could improve both mental wellbeing and long-term brain health.

Winters can be especially demanding for many women going through menopause or perimenopause. As the colder months arrive, concerns like dry, irritated skin, unexpected hair fall, and increased joint pain become more common. This rise in symptoms is not caused by cold weather alone. It is largely driven by the way seasonal changes interact with the hormonal transitions of menopause. To understand this better, we spoke to Tamanna Singh, Co-founder of Menoveda and a Certified Menopause Coach, who explained why these changes happen.

What Is Menopause?

Menopause is a natural biological phase when a woman’s menstrual cycles stop permanently, signalling the end of her reproductive years. It is officially diagnosed after 12 consecutive months without a period and usually occurs between the ages of 45 and 55, as the ovaries gradually reduce estrogen production.

The phase leading up to this, called perimenopause, involves fluctuating hormones that can trigger symptoms such as hot flashes, mood changes, and sleep disturbances. Postmenopause refers to the stage after menopause, according to the Mayo Clinic.

How Long Does Menopause Last?

Menopause itself is a single milestone rather than a prolonged phase. Once a woman has gone a full year without a menstrual period, she is considered menopausal. After this point, she enters postmenopause, which continues for the rest of her life.

Menopausal Symptoms Worsening During Winters

One of the key changes during menopause is the steady decline in estrogen levels. Estrogen supports skin moisture, collagen formation, healthy hair growth cycles, and joint lubrication. As this hormone decreases, the body becomes more reactive to environmental factors, with winter dryness having a stronger impact.

Menopause In Winters: Why Skin Feels Drier in January

Tamanna Singh explains, “Cold air contains less moisture, and indoor heating further removes the skin’s natural oils. Lower estrogen levels weaken the skin’s protective barrier, increasing water loss. This leads to dryness, flaking, itching, and in some cases, eczema-like conditions. The skin also takes longer to repair itself, which makes winter-related irritation more difficult to manage.”

The Hair Fall Connection

Hair follicles respond closely to hormonal changes. Tamanna notes, “During menopause, shifting estrogen levels and increased androgen activity shorten the hair’s growth phase, leading to more shedding. Winter adds further stress through reduced blood flow to the scalp, dietary imbalances after festive eating, and low Vitamin D levels due to limited sunlight. Combined, these factors make January a common time for noticeable hair thinning and hair fall.”

Why Joint Pain Worsens During Menopause?

Estrogen also plays a role in reducing inflammation and keeping joints well-lubricated. As estrogen levels fall, women may experience stiffness, swelling, and discomfort, which tend to worsen in cold weather. Lower temperatures cause muscles and connective tissues to tighten, reducing flexibility. Staying less active during winter months further adds to joint stiffness and pain.

What Can Help?

Managing these concerns calls for a well-rounded approach. Tamanna recommends:

• Skin: Use rich, oil-based moisturisers regularly and maintain good hydration.
• Hair: Ensure sufficient intake of protein, iron, and biotin, and practice gentle scalp massage to improve blood circulation.
• Joints: Engage in light strength training, yoga, and regular movement to support flexibility. Adequate Vitamin D and calcium intake is especially important during winter.

Winter does not create menopausal symptoms. It simply intensifies what the body is already dealing with. With the right awareness, consistent care, and small seasonal adjustments, women can navigate the colder months with more ease and confidence.