Health and Me

Astik Ghosh

Pancreatic Cancer: What Is The Role Of Keratin 17 In Driving The Feared Disease?

<span>Pancreatic cancer</span> is one of the most feared diseases, and it causes thousands of lives to be wasted away due to this fatal disease. According to the Population-Based Cancer Registries (PBCRs) managed by the Indian Council of Medical Research (ICMR) and the IARC Global Cancer Observatory (GLOBOCAN), about 22,982 Indians have pancreatic cancer every year.

On the other hand, the American Cancer Society's US SEER Pancreatic Cancer Stat Facts shows the annual number of cases is 67,530. Thus, any lead to resisting cancer is good news for the world. Recently, a research team from Stony Brook Medicine and Luisa Escobar-Hoyos of Yale School of Medicine, led by Kenneth Shroyer and Natalia Marchenko, found an important fact to fight the fatal disease.

The study investigated the role of <span>Keratin 17</span> (K17) and found that the protein can be a driver of chemoresistance to gemcitabine. It is often used to treat various types of cancer. The study shows that the K17 can act as a target for the development of novel treatments.

They discovered that the protein is a key driver of chemoresistance to gemcitabine, an agent used to treat a wide range of cancers, including advanced tumors of the pancreas, lungs, and breast. 

<h2>How New Pancreatic Cancer Drug Daxorrasib Can Help You?</h2>

Daxaronrasib is a daily oral pill that has demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) compared with standard intravenous chemotherapy.

Described as a multi-selective inhibitor of RAS(ON) proteins, it is the first investigational drug in a new class of RAS inhibitors designed to target a broad spectrum of cancer-causing RAS mutations.

The drug works by blocking KRAS signalling proteins that drive tumor growth.

Read More: <a href="https://www.healthandme.com/health-news/new-pancreatic-cancer-drug-daxaronrasib-may-benefit-patients-with-lung-and-ovarian-tumors-too-article-154439036" data-type="tilCustomLink" target="_blank">New Pancreatic Cancer Drug Daxaronrasib May Benefit Patients With Lung And Ovarian Tumors Too</a>

Daraxonrasib is the first drug. It works by pairing up with a protein called cyclophilin A inside cells, acting like a molecular glue, glomming onto the mutated protein.

Pancreatic cancer is considered one of the most RAS-dependent cancers, with more than 90 per cent of patients carrying tumours driven by RAS protein mutations. Similar RAS-targeting drugs are also being developed for pancreatic, lung, and colon cancers.

The findings were presented at a plenary session of the American Society of Clinical Oncology’s meeting in Chicago on May 31 and simultaneously published in the New England Journal of Medicine.

Health Conditions A-Z

health

pancreatic-cancer-what-is-the-role-of-keratin-17-in-driving-the-feared-disease

pancreatic cancer

keratin 17

k17 protein

pancreatic cancer research

pancreatic tumors

cancer progression

cancer biomarkers

how-weather-changes-trigger-migraines-neurologist-explains

How Weather Changes Trigger Migraines, Neurologist Explains

weight-loss-1

Explained: Why You Are Unable To Lose Weight Despite Doing Everything Right

Health & Wellness

8 Sit-Up Variations to Strengthen Your Core and Build Stability

Benefits Of Ayurvedic Health Supplement Ashwagandha

9 Anti-Inflammatory Breakfast Options You Should Try

5 Foods You Should Avoid For PCOS, Says Gynecologist

Love Sitting With Your Legs Crossed? Here’s You Should Avoid It

6 Daily Foods That Are Secretly Increasing Your Calories

9 Brain Boosters You Should Do Everyday

Hip Exercises That Will Keep You Flexible As You Age

9 Leg Exercises Office Workers’ Should Do At Home

Benefits of Having Herbal Tea Every Morning

9 Daily Habits That Boost Your Brain Power

Lower-Body Exercises That Are Game-Changers

How Drinking Apple Cider Vinegar Helps You

Aging Myths You Should Never Believe

Superfoods That Support Your Gut Health

What Happens To Your Body When You Eat Instant Noodles Every Day?

Health Issues Premature Babies Often Face

Exercises Office Workers Should Do For Their Heart Health

Reasons Why You Should Add Raw Turmeric To Your Diet

Benefits Of Drinking Milk At Night: Why You Should Do It

Food That Provides Vitamin B12 Naturally In Your Diet

Surprising Health Benefits Of Fenugreek Seeds

9 Superfoods You Should Eat For Your Brain Health

What Does Mental Health Support Look Like At Work?

Long Stretches You Should Do To Unwind From Your Day

Colon Cancer In Young Adults: Early Symptoms You Should Know

Health Benefits Of Eating Dry Fruits Everyday

Are You At Risk For Fried Rice Syndrome?

These Tests Reveal How Well You Are Aging

Lower-Back Exercises You Should Do After A Long-Day's Work

Children’s Diet – What Kids Need To Eat For Immunity Building

Common Diabetes Myths That Could Hurt Your Health

Love Spicy Food? Here’s How It Affects Your Health

Superfood List: Veggies And Fruits You Must Have For Immunity

Foods People With IBS Should Avoid

Exercises To Improve Digestion

Easy Work Lunches You Can Make In The Morning

Hunger Vs Craving: Difference Explained In 60 seconds

These Things Can Cause Your Heart To Age Faster

High Carb Foods That Are Actually Healthy

Pancreatic cancer is one of the most feared diseases, and it causes thousands of lives to be wasted away due to this fatal disease. According to the Population-Based Cancer Registries (PBCRs) managed by the Indian Council of Medical Research (ICMR) and the IARC Global Cancer Observatory (GLOBOCAN), about 22,982 Indians have pancreatic cancer every year.On the other hand, the American Cancer Society's US SEER Pancreatic Cancer Stat Facts shows the annual number of cases is 67,530. Thus, any lead to resisting cancer is good news for the world. Recently, a research team from Stony Brook Medicine and Luisa Escobar-Hoyos of Yale School of Medicine, led by Kenneth Shroyer and Natalia Marchenko, found an important fact to fight the fatal disease.The study investigated the role of Keratin 17 (K17) and found that the protein can be a driver of chemoresistance to gemcitabine. It is often used to treat various types of cancer. The study shows that the K17 can act as a target for the development of novel treatments.They discovered that the protein is a key driver of chemoresistance to gemcitabine, an agent used to treat a wide range of cancers, including advanced tumors of the pancreas, lungs, and breast. How New Pancreatic Cancer Drug Daxorrasib Can Help You?Daxaronrasib is a daily oral pill that has demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) compared with standard intravenous chemotherapy.Described as a multi-selective inhibitor of RAS(ON) proteins, it is the first investigational drug in a new class of RAS inhibitors designed to target a broad spectrum of cancer-causing RAS mutations.The drug works by blocking KRAS signalling proteins that drive tumor growth.Read More: New Pancreatic Cancer Drug Daxaronrasib May Benefit Patients With Lung And Ovarian Tumors TooDaraxonrasib is the first drug. It works by pairing up with a protein called cyclophilin A inside cells, acting like a molecular glue, glomming onto the mutated protein.Pancreatic cancer is considered one of the most RAS-dependent cancers, with more than 90 per cent of patients carrying tumours driven by RAS protein mutations. Similar RAS-targeting drugs are also being developed for pancreatic, lung, and colon cancers.The findings were presented at a plenary session of the American Society of Clinical Oncology’s meeting in Chicago on May 31 and simultaneously published in the New England Journal of Medicine.

pancreatic cancer: what is the role of keratin 17 in driving the feared disease?

About Us

Contact Us

Terms & Conditions

Privacy Policy

Company

Health and Me is a premium website with content written and curated to function as a handbook for all Health concerns.

Pancreatic Cancer: What Is The Role Of Keratin 17 In Driving The Feared Disease?

How Weather Changes Trigger Migraines, Neurologist Explains

Explained: Why You Are Unable To Lose Weight Despite Doing Everything Right

Protein To Stop Brain Decline, New Study Finds

Health Conditions A-Z

Pancreatic Cancer: What Is The Role Of Keratin 17 In Driving The Feared Disease?

How Weather Changes Trigger Migraines, Neurologist Explains

Explained: Why You Are Unable To Lose Weight Despite Doing Everything Right