With the increasing pollution and toxic fog in the UK, US, and Canada, there are growing concerns in asthma, especially in children. A new, quick and easy way for kids is the new nasal swab test. This, when performed on kids can diagnose the specific immune system drivers behind their asthma. It can also open the door to better treatments, say the researchers.

The test diagnoses a child's asthma subtype, also known as endotype. “Because asthma is a highly variable disease with different endotypes, which are driven by different immune cells and respond differently to treatments, the first step toward better therapies is accurate diagnosis of endotype,” senior researcher Dr. Juan Celedon, chief of pulmonary medicine at the UPMC Children’s Hospital of Pittsburgh, said in a news release from the hospital.

How common is asthma?

Asthma is the most common chronic disease, especially of childhood, affecting 1 in every 10 kids. These statistics are presented by the National Institutes of Health. As per the American College of Allergy Asthma and Immunology, it affects 6 million children in the United States, also verified by the Centers for Disease Control and Prevention (CDC). The Asthma and Allergy Foundation of America states that around 8.4% male children have asthma, while 5.5% female children have it, making it the most common and costly disease in children in the United States.

Types of Asthma

Asthma is a complex condition that affects millions of children, and diagnosing its specific type has traditionally been a challenging process. Doctors categorize asthma into different subtypes based on the immune cells that trigger airway inflammation. The main types are T2-high, caused by T helper 2 cells; T17-high, driven by T helper 17 cells; and low-low, where neither of these cells seems to play a role.

Identifying these subtypes typically involves a highly invasive procedure where a small sample of lung tissue is taken while the child is under anesthesia. This sample undergoes genetic analysis to determine the specific asthma type. However, this procedure is rarely used, especially for children with milder asthma, due to the risks involved.

Instead, doctors often rely on indirect tests, such as blood work, lung function assessments, and allergy tests, to make an educated guess about the asthma subtype. While these methods can help identify T2-high asthma, they are not entirely accurate and cannot reliably diagnose T17-high or low-low asthma.

What does the new test do?

This diagnostic gap led researchers to develop a new, less invasive approach. In a study published in the Journal of the American Medical Association, researchers introduced a nasal swab test that analyzes the presence of specific genetic markers associated with the different asthma subtypes.

The study involved nearly 460 children from Puerto Rican and African American backgrounds, groups that face higher asthma rates and a greater risk of severe outcomes. By analyzing nasal samples from these children, the researchers identified eight key genes linked to T2 or T17 immune cells. The nasal swab accurately determined each child’s asthma subtype, providing a much-needed alternative to invasive lung tissue sampling.

This new test has significant implications for asthma treatment. For example, children with T2-high asthma, which was found in 29% of the study participants, could benefit from advanced therapies specifically targeting the immune cells responsible for their condition. However, treatments for T17-high and low-low asthma are not yet available.

The availability of a simple and precise test could pave the way for further research into these less understood subtypes. By identifying T17-high and low-low asthma more easily, researchers can begin to explore new treatment options tailored to these types.

This tool could also answer important questions about how asthma evolves over time. For instance, researchers have long wondered why asthma symptoms worsen for some children during puberty, remain unchanged for others, and improve in some cases. There are also notable differences in asthma incidence between genders: boys are more likely to have asthma during childhood, but the condition becomes more common in women during adulthood.

With this nasal swab test, scientists can now explore whether asthma subtypes change over time or in response to treatment. The ability to track these changes could lead to a deeper understanding of asthma and how to manage it more effectively.

This breakthrough provides hope for a future where diagnosing and treating asthma is simpler, more accurate, and better tailored to each child’s specific needs.

Gemma Illingworth was only 31 when she died from a rare and aggressive type of dementia. A bright, independent artist who painted, traveled the world, and valued life's creative liberties, Gemma's life is not only tragic — it's a valuable lesson in the crucial need to recognize subtle neurological symptoms early on. Diagnosed at 28 with posterior cortical atrophy (PCA), a rare dementia that attacks the brain's visual processing area, Gemma's condition worsened quickly.

Her premature death highlights an increasing public health issue: overlooked early warning signs of cognitive and neurodegenerative impairment. For policymakers, healthcare professionals, and family members, her tale is both a warning and a reminder.

What is Posterior Cortical Atrophy?

Posterior Cortical Atrophy (PCA) is a rare, progressive neurodegenerative illness usually regarded as a subtype of Alzheimer's disease. In contrast to normal Alzheimer's, which first compromises memory, PCA attacks the rear portion of the brain — the occipital and parietal lobes — that are involved in visual and spatial processing. Some of the symptoms are:

• Trouble reading, identifying objects, or estimating distances
• Visual confusion or disorientation
• Hand-eye coordination difficulties
• Trouble with daily visual activities

Because of its atypical presentation, PCA often goes misdiagnosed as depression, anxiety, or even ophthalmological issues. This diagnostic challenge delayed Gemma’s care for years, despite her early struggles with sight, time perception, and coordination — red flags that now, in hindsight, point clearly to the disease’s onset.

The Missed Signs of Early-Onset Alzheimer's

Gemma's family recalls her as "ditsy," a girl who was unusual but self-reliant. From an early age, she had difficulty with her eyesight, telling the time, and coordination. Her difficulties were attributed to her character and not taken as possible signs of a neurological disorder.

It was not until 2020, during the COVID-19 lockdown, that her condition progressed quickly. She was no longer able to process visual information on her computer screen, and she had to cease working. Her symptoms were first blamed on anxiety and depression. It was not until thorough neurological testing in 2021 that PCA was diagnosed. By this time, the disease had progressed significantly.

This delay in diagnosis had a devastating impact — and it serves as a powerful reminder that even subtle neurological symptoms should not be ignored or dismissed.

Once diagnosed, Gemma's ability to live independently quickly declined. She began needing help with basic tasks: dressing, using the stove, managing appointments. She would call her mother up to 20 times a day. Eventually, she returned home, requiring full-time care.

Her sister Jess remembered, "She didn't know what [PCA] really meant, but that was obviously a blessing in disguise." Even with the dire prognosis, Gemma was relieved at first, believing she could now "fix" whatever was amiss.

But there was no cure. Her illness affected her ability to eat, swallow, talk, and walk. Her family took care of her at home until she died in November 2023, surrounded by loved ones. Her sense of humor, they reported, never left her — one of the few things the disease couldn't steal.

In Gemma's memory, her best friend and siblings completed the 2024 London Marathon, raising more than $47,000 for the National Brain Appeal and Rare Dementia Support (RDS).

"RDS couldn't cure Gemma, but they supported us through it the best way possible," her brother Ben explained. Their aim now is not to let other families endure the same suffering.

The funds raised support research, education, and family care for those with rare dementias — a community frequently ignored in popular discussions of memory decline and aging.

Why Early Detection is Important?

Dementia is commonly regarded as an old person's disease. Gemma's experience shatters the stereotype. Although PCA is uncommon, dementias in younger people are increasingly being diagnosed by neurologists globally.

Cognitive decline does not necessarily begin with memory loss. It may begin subtly — in the guise of visual problems, coordination problems, repeated disorientation, or even mood swings. That's why it's important that clinicians, educators, and families realize early symptoms can be disguised as behavioral idiosyncrasies or psychological problems. Early diagnosis can:

Give time for appropriate care planning and lifestyle changes

Halt progression with cognitive therapies or medications (where indicated)

Provide emotional relief and clarity for patients and families

How to Recognize and Prevent Early Memory Decline?

Although prevention of dementia is not always possible, early identification can dramatically enhance quality of life. Following are the preventive steps anyone can take:

1. Be Alert to Atypical Symptoms

Observe sudden or progressive change in visual-spatial awareness, particularly in young adults. Difficulty judging distances, recognizing objects, or maneuvering in familiar spaces may require neurological assessment.

2. Prioritize Complete Health Evaluations

When symptoms occur, push for full testing. This should involve neuroimaging (MRI or CT), cognitive screening, and — if necessary — spinal fluid analysis.

3. Get Early Intervention

Work with experts like neuropsychologists, neurologists, and occupational therapists early on. They can offer tools and coping strategies to deal with daily activities.

4. Emphasize Brain Health

A diet high in antioxidants (berries, greens), exercise, mental stimulation, and adequate sleep all help improve brain function and lower the risk of cognitive impairment.

5. Know Your Family History

Certain dementias are linked to genetics. If family history exists, don't wait on neurological evaluation if symptoms develop.

Sleep isn't simply a nightly routine, it's an important pillar of health that dictates everything from mood and energy levels to memory and brain structure. Although the risks of short sleep are well-known, increasing research indicates that sleeping too much is equally, if not more, troubling when it comes to the long-term health of your brain.

A recent study by Professor Jianfeng Feng at the University of Warwick has put forward a new understanding of the sleep-health connection: short and long sleep durations are both biologically different patterns with differing, but significant, risks to mental, emotional, and physical health. The results are a wake-up call for the way we consider our sleep behaviors—not only how much we're lacking, but how much we might be overdoing it.

The study team looked at data from about 500,000 UK Biobank adults aged 38 to 73 and measured how their sleep time corresponded to brain structure and function. Study participants were divided into short sleepers (fewer than 7 hours) and long sleepers (longer than 7 hours), with their brain imaging, genetic information, and health outcomes compared.

Short sleepers had less brain matter in areas of emotional regulation and complained of more depression symptoms, tiredness, and muscle-skeletal complaints.

Long sleepers, on the other hand, exhibited signs of more loss of brain matter in areas of memory, worse metabolic health, increased inflammation, and more risk markers for cognitive decline, Alzheimer's disease, and schizophrenia.

Professor Feng said, "Short sleep is usually an underlying cause of illness, while long sleep tends to be indicative of pre-existing conditions." Simply put, long sleep won't necessarily lead to disease—it could be an early warning sign for them.

Why Oversleeping Is a Red Flag, Not a Luxury?

Sleeping nine or more hours a night on a regular basis—and still feeling tired—is medically referred to as hypersomnia. Unlike occasional weekend lie-ins, hypersomnia signals something deeper. Individuals often report hitting snooze repeatedly, waking up unrefreshed, and struggling with concentration or memory throughout the day.

As per recent evidence in JAMA Neurology, long sleepers scored significantly worse on cognitive assessments such as the Digit Symbol Substitution Test (DSST) and self-reported lower cognitive abilities. The relationship was strongest in older populations, where sleep for more than 10 hours per night was associated with increased risks for dementia and cognitive disorders.

This inverted U-shaped relationship between sleep length and brain functioning—where too little and too much sleep are both associated with worse results—is repeatedly confirmed by various studies.

Oversleeping and Mental Health

Oversleeping isn't only a sign of cognitive problems—it's also associated with mental health. Hypersomnia and depression tend to go hand in hand. About 15% of people with major depressive disorder describe oversleeping as a symptom. Others use excessive sleep as a defense against emotional pain, but it boomerangs. Prolonged sleep worsens depressive symptoms and impairs daytime functioning, creating a vicious cycle.

One big study of more than 24,000 U.S. adults discovered that those who slept more than 10 hours a day had a greater incidence of psychiatric disorders and higher psychological distress. These individuals also had higher rates of early life trauma and unhealed emotional wounds, indicating more profound psychological underpinnings for chronic oversleeping.

Cardiovascular, Metabolic and Inflammatory Risks

The physical health consequences of excessive sleeping are just as disturbing. The American Heart Association research published in Circulation reported that long sleepers had as much as a 50% increased risk of cardiovascular mortality, especially among patients with coronary artery disease.

Oversleeping also leads to:

• Obesity and Type 2 diabetes
• Increased BMI and greater cholesterol imbalance
• Higher pro-inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6), which are linked to systemic inflammation and risk of disease

Dr. Arshed Quyymi, director of Emory Clinical Cardiovascular Research Institute, highlights the risk: "There is almost a 40 to 50% higher risk of dying if you are sleeping too little or too much."

What is the U-Shaped Curve?

Many meta-analyses reproduce the U-shaped relation between sleep and cognition. Severe durations at both extremes of the curve have been related to increased brain aging. More sophisticated findings, however, indicate that short and long sleep may have an impact on various cognitive abilities. For instance:

Short sleep has a damaging effect on attention, emotional processing, and working memory

Long sleep is related to impairment of decision-making, processing speed, and executive function

These observations highlight the need for individually tailored sleep advice, considering both patient-specific genetic, psychological, and physiological factors.

How to Identify and Address Oversleeping?

So, what can you do if you think you're sleeping too much? Begin by assessing whether this habit has continued for longer than 6-8 weeks and whether you continually feel un-rested after "enough" hours. Prolonged hypersomnia should trigger a visit to a sleep specialist or healthcare provider to exclude underlying causes such as sleep apnea, depression, or thyroid disease.

At-home remedies to reset your sleep habit are:

• Implementing a consistent wake-up time even on weekends
• Positioning the alarm in an inaccessible location to deter snoozing
• Prioritizing early morning activities such as a walk or breakfast rendezvous
• Brushing teeth and washing face the moment you wake up
• Prohibiting returning to bed after rising
• A well-organized, deliberate morning routine can facilitate a stronger, healthier circadian rhythm and better daytime alertness.

Sleep is a keystone of mental and physical well-being, but moderation is required. While chronic sleep loss can impair emotional control and cardiovascular health, routine sleeping too much can herald early neurological deterioration, inflammation, and concealed psychological anguish.

Health professionals are now urging us to shift our way of speaking about sleep—not just about avoiding too little, but about recognizing the dangers of too much. Individualized sleep profiles, according to age, lifestyle, and medical conditions, could provide the best way forward.

If you’re waking up tired every day despite long hours of sleep, it may not be rest your body is craving—it may be time for a deeper health check-in.

India launched massive strikes on terror camps in Pakistan and PoK late night yesterday. The aerial operation came in response to the Pahalgam terror attacks that resulted in 26 people getting killed and several others getting injured last month. As tensions continue to rise in both countries, people in India have been asked to participate in mock drills to prepare for possible emergencies.

While people on both sides of the border prepare for a possible war, mental health experts have raised concerns about the psychological cost of such a situation. They opined that it could result in escalated stress, anxiety and fear. A recent study published in the International Journal of Mental Health Systems earlier this year aunderscored the escalating mental health crisis in Ukraine, exacerbated by the ongoing conflict. The study reveals that prior to the full-scale invasion, approximately 30% of Ukrainians had experienced mental health disorders, with depressive disorders surpassing the EU average. The conflict has severely strained the nation’s mental health infrastructure, underscoring the urgent need for comprehensive reforms and targeted interventions to address the rising rates of anxiety, PTSD, and depression among civilians and displaced populations.

How To Manage Anxiety In Such a Situation, As Per Expert

Dr Shilpi Saraswat, Clinical Psychologist at Sakra World Hospital, Bengaluru, recommends avoiding unnecessary exposure to news and staying in a supportive social circle when stuck in such situations. Here are a few steps you should follow:

1. Limit news exposure: Set boundaries on news consumption to avoid excessive exposure.

2. Stay informed, not overwhelmed: Focus on credible sources and updates rather than constant coverage.

3. Practice self-care: Engage in activities that promote relaxation and stress reduction, such as exercise, meditation, or hobbies.

4. Social support: Connect with loved ones, friends, or support groups to share feelings and concerns.

5. Grounding techniques: Use mindfulness exercises, deep breathing, or physical activity to stay present and focused.

Coping Strategies For Families And Children

If you are someone who resides with the elderly and children, Dr Saraswat recommends having an open discussion with them on the current situation. "Encourage honest discussions about feelings and concerns," he said. Moreover, you must provide reassurance and comfort to them. To avoid anxieties, it is also advised to maintain regular routines and activities to provide a sense of stability. You should also acknowledge and validate children's feelings, helping them process emotions. Moreover, monitor and limit children's exposure to news and media coverage.

Differentiating Normal Stress Responses from Serious Mental Health Concerns

1. Normal stress responses: Anxiety, worry, and fear are common reactions to stressful situations.

2. Signs of more serious concerns: Persistent symptoms, such as intrusive thoughts, nightmares, or avoidance behaviours, may indicate PTSD or other mental health concerns.

3. Panic disorders: Recurring panic attacks, persistent fear of having attacks, or avoidance behaviours may indicate a panic disorder.

4. Seek professional help: If symptoms persist or interfere with daily life, consult a mental health professional for guidance and support.