When Todd Engel, based in Maryland, first noticed a change in his vision, he did not think it would change the rest of his life. However, within months, the 62-year-old went from working a full-time job and driving to becoming legally blind in both eyes. Now, Engel is suing Novo Nordisk, the manufacturer of Ozempic - the drug he believes took away his vision.

An Irreversible Loss

Engel was prescribed Ozempic in 2023 to help manage his type 2 diabetes. After four months later, he was diagnosed with nonarthritic anterior ischemic optic neuropathy (NAION). It is a rare condition where blood flow to the optic nerve is blocked and causes sudden and irreversible vision loss.

"He made a comment to me about how it’s painful to know he’s never going to see his wife smile again," said Engel’s attorney Jonathan Orent, who spoke to NBC News. "But he knows her voice so well, he can tell when she is smiling."

As per the American Academy of Ophthalmology, NAION affects about 10 in every 100,000 people over the age of 50. For Engel, the diagnosis meant that he no longer would work his job as a motor equipment operator. He also lost his ability to drive and the way he connects with his family.

What Does His Lawsuit Allege?

Filed in New Jersey’s Middlesex County Superior Court, the lawsuit accuses Novo Nordisk of negligence, alleging the pharmaceutical giant failed to properly warn users about the potential risk of NAION. Engel's legal team argues that the company was aware of the condition during early clinical trials but still chose not to include it in the warning label.

“Nothing was or is stopping Defendant from adding a warning regarding the risk of NAION,” the lawsuit states.

Had Engel known about a potential link between Ozempic and blindness, Orent said, he would have chosen a different medication. “There are a wide number of medications that can be used to treat diabetes — and treat it effectively,” Orent said to NBC News.

What Do Research Say About Ozempic And Blindness?

Ozempic, and its active ingredient semaglutide, is part of a class of drugs known as GLP-1 receptor agonists, initially designed to treat Type 2 diabetes but now widely used for weight loss. Recent studies have hinted at a possible link between semaglutide and NAION — though causation hasn’t been confirmed.

A 2024 study which analyzed six years of medical records from Boston patients found that people with diabetes who took semglutide were four times more likely to be diagnosed with NAION.

Even more striking, overweight or obese people without diabetes who took the drug were over seven times more likely to be diagnosed with NAION.

However, researchers noted this study wasn’t a randomized clinical trial and said more investigation is needed before drawing conclusions.

In February 2024, a separate paper published in JAMA Ophthalmology reported a more modest increase in the risk of NAION for people with diabetes on Ozempic. Like the earlier study, it also stressed the need for further research.

What Do The Manufacturers Say?

Novo Nordisk's spokeperson told the NBC News that current evaluations, including internal safety reviews and a study from the University of Southern Denmark found no causal relationship between NAION and Ozempic.

The company said that NAION is not listed as an adverse drug reaction. “This also relates to eye conditions, which are well-known comorbidities for people living with diabetes,” the spokesperson said.

Sometimes it feels like our bladder has a mind of its own, ringing the washroom alarm at the most inconvenient times. However, what makes it more difficult is that many people, who have difficulty holding the urge or have any bladder issues, find it very difficult to make it in time.

Have you ever felt a sudden, strong urge to pee right when you see your front door, put your key in the lock, or open your garage? This common experience is called "latchkey incontinence." Researchers believe they've found ways to reduce these sudden urges and bladder leaks triggered by such familiar cues.

Solutions for Bladder Leaks

A recent study, published in the June issue of Continence, shows that both mindfulness training and brain stimulation helped reduce bladder leaks in people with latchkey incontinence. Bladder leaks can be very distressing. As one researcher explained, "Incontinence is a massive deal." People might avoid social activities or exercise because they worry about accidents, which can lead to loneliness and depression, especially for older adults.

The Science Behind the Urge

Latchkey incontinence is a type of situational urgency incontinence, meaning specific triggers make you feel like you need to urinate right away. Other common triggers include hearing or seeing running water, or walking past a public restroom.

This is similar to Pavlovian conditioning: after years of going to the bathroom once you're inside your house, your body learns to associate certain actions, like opening your front door, with the need to urinate. Earlier research connected latchkey incontinence to a specific part of the brain called the dorsolateral prefrontal cortex. This area becomes more active when people are shown their personal triggers. This part of the brain acts like the "executive control center" for your bladder, telling you it's time to go.

Testing New Treatments

For this study, researchers wanted to find ways to control this brain response. They worked with 61 women over 40 who experienced situational urgency incontinence. These women were divided into three groups while viewing photos of their personal triggers:

• One group listened to a 20-minute mindfulness exercise.
• Another group received brain stimulation through electrodes placed on their scalp.
• The third group received both mindfulness and brain stimulation.

The mindfulness exercise involved paying attention to different parts of their body, including any bladder sensations. After just four in-office sessions over five or six days, all three groups experienced less urgency and fewer leaks. The improvements were similar to those seen with other treatments like medication or physical therapy for the pelvic floor.

Hope and Future Directions

These results are very encouraging because they suggest that tools like mindfulness can be an alternative or an additional way to improve symptoms. Most participants completed the study, and some even sent "thank you cards," showing how much this research meant to them. Incontinence is often a difficult topic to discuss, and many people don't realize that treatments are available. As one researcher said, "You don’t have to suffer in silence."

Next, researchers plan to test the mindfulness therapy in living facilities for seniors and hope to eventually create a smartphone app that can help people manage their symptoms.

With the rising number of cases related to various heart related issues, health anxiety can provoke spiralling thoughts like "what if I am getting a heart attack now" or "can I prevent a heart attack"? If your body is whispering a warning that you can’t afford to ignore it.

In the high-stakes world of heart health, seconds count. Yet many people fail to recognize early warning signs of heart blockages until it's too late. While sophisticated tests like ECGs and angiograms are crucial, what if your own body could offer clues long before a medical emergency unfolds? According to leading cardiac experts, it often does.

So, how can you detect these warning signs without a single test? And what should you do if you're home alone when symptoms strike? A leading heart surgeon breaks it all down for you.

With rising cardiovascular disease rates worldwide—especially among younger adults—being able to identify early red flags of heart blockages from the comfort of your home isn’t just helpful; it could be life-saving. Dr. Jeremy London, a board-certified cardiovascular surgeon from Georgia and a popular voice in the heart health community, is on a mission to teach everyday people how to read their body’s signals and act swiftly in case of a cardiac emergency.

Spotting Heart Blockages Without Medical Tests

Dr. London emphasizes that no blood test or medical scan is a substitute for listening to your own body. “How can you tell that you may have important blockages of the heart arteries without a single blood test, X-ray, or ECG?” he asks. “Well, not surprisingly, you have to listen to your body.”

The human heart often signals distress long before it fails. According to Dr. London, four symptoms deserve immediate attention:

• Chest tightness or discomfort
• Persistent chest pain
• Shortness of breath
• Radiating pain to the jaw or arm

What’s critical, he says, is the pattern of these symptoms. “If these sensations worsen with exertion—like walking upstairs or brisk movement—and ease when you rest, that’s a red flag,” he explains. This pattern suggests the presence of a partially blocked artery struggling to meet the heart’s demand for oxygen during physical activity.

Dr. London likens it to a clogged pipe: “Let’s assume you have a blockage in the artery that feeds the front of the heart. When you move, that area becomes blood-starved and you experience symptoms. When you stop and rest, the demand drops, and so do the symptoms.”

What Are Silent Heart Blockages?

Not all heart blockages present textbook symptoms. Many people, especially women, diabetics, and older adults, may have "silent ischemia"—a form of heart disease without obvious discomfort. Dr. London cautions that while the presence of exertion-based chest pain is concerning, the absence of symptoms does not mean your arteries are clear.

This is why annual health checkups and paying close attention to subtle changes in physical endurance or energy levels are essential, especially for individuals over 40 or with a family history of cardiovascular issues.

What To Do If You Suspect a Heart Attack At Home?

If you feel you are experiencing a heart attack while alone at home is a terrifying scenario but there are crucial steps you can take to protect yourself until help arrives.

1. Call 911 Immediately

Time is the most critical factor. Don't wait for the symptoms to go away. Call emergency services without delay.

2. Make Yourself Easy to Find

“If it's nighttime, turn on all your lights—inside and out—so EMS can identify your home quickly,” says Dr. London. He adds, “Unlock or even better, open your front door. If you become incapacitated, responders won’t have to break in or waste time trying to gain entry.”

3. Sit or Lie Down

This reduces the risk of injury if you faint. A fall during a cardiac event could compound the danger with head trauma or bone fractures.

4. Inform Someone You Trust

If you can, alert a friend or family member. Not only can they come to assist, but they can also inform paramedics of your medical history, medications, or allergies if you’re unable to speak.

Dr. London strongly encourages households—especially those with elderly members or individuals at high risk of heart disease—to create a personalized emergency plan. “Preparation can save lives,” he says. Your plan should include:

• Emergency contact numbers
• Access to any prescribed medications like aspirin or nitroglycerin
• Easy access to doors and visible house numbers
• A buddy system or wellness check arrangement if living alone

Can You Prevent Blockages In Your Heart?

Spotting symptoms early is essential but preventing blockages in the first place is even better. A heart-healthy lifestyle can significantly reduce your risk:

Diet: Emphasize fiber-rich, whole foods while limiting saturated fats and processed sugar.

Exercise: Aim for at least 150 minutes of moderate activity per week.

Regular checkups: Keep tabs on cholesterol, blood pressure, and glucose levels.

Stress management: Chronic stress can raise cortisol and blood pressure, increasing cardiovascular risk.

Quit smoking: Tobacco use narrows arteries and increases plaque buildup.

Heart blockages often give off clues but only if we’re paying attention. Dr. Jeremy London’s insights offer a wake-up call to listen more closely to what our bodies are saying, especially during moments of physical exertion or unexplained fatigue.

Learning how to detect and respond to potential heart issues while at home doesn’t replace professional medical care but it can bridge the critical minutes between symptom onset and lifesaving intervention.

A sudden spike in cases of appendiceal adenocarcinoma, particularly among Gen X and millennials, has become a growing concern among medical professionals. Frequently misdiagnosed or neglected because of similar symptoms to other gastrointestinal conditions, this kind of cancer is unusual but bears remarkable similarities with a not-so-uncanny condition—diverticulitis. Familiarizing oneself with the unique characteristics of these two conditions is vital for the diagnosis at an early stage, appropriate treatment, and improved health outcomes.

Appendix cancer, which was once thought to be extremely rare, is now trending up in a disturbing direction. In a recent study in the Annals of Internal Medicine, Vanderbilt University Medical Center researchers crunched data from the U.S. National Cancer Institute's SEER program from 1975 to 2019. The results are eye-opening: rates of appendiceal adenocarcinoma (AA) have more than doubled among Generation X and quadrupled among millennials relative to those born in the mid-20th century.

Also Read: A Rare Appendix Cancer Among Millennials And Gen X, Study Reveals

Although still rare with only some 3,000 new cases diagnosed each year in the U.S.—this increase reflects the larger trend of increasing gastrointestinal cancers among young adults, such as colorectal and stomach cancers. What is so troubling about this increase is how easily symptoms of appendix cancer can be confused with other digestive complaints, particularly diverticulitis, a much more common condition.

What Is Appendix Cancer?

Appendix cancer (appendiceal cancer) occurs when cells in the appendix start to mutate and multiply out of control. The appendix—a small sac at the juncture of the small and large intestines—has been a mystery to scientists for a long time regarding its purpose. Some think it contributes minimally to immune well-being, while others consider it a vestigial organ. But one thing is certain: When cancer hits this organ, it can be hard to spot.

Symptoms of Appendix Cancer

The majority of the patients do not develop any symptoms until the disease becomes advanced or is incidentally found during surgery for appendicitis or other unrelated surgeries. If symptoms happen, they can be:

• Abdominal pain on the lower right side, which is persistent
• Bloating or distension in the abdomen
• Diarrhea due to the changes in bowel habits
• Vomiting, nausea, and early satiety
• Ascites (fluid accumulation in the abdomen)
• Unintended weight gain or rise in waistline

In some cases, appendix cancer can lead to pseudomyxoma peritonei (PMP)—a rare condition where mucin-producing tumor cells create jelly-like fluid that fills the abdominal cavity, causing further complications and discomfort.

Also Read: RFK Jr. Removes Entire CDC Vaccine Advisory Committee

What Are the Causes and Risk Factors of Appendix Cancer?

Although the exact reasons for this generational increase remain unclear, researchers suggest that lifestyle and environmental factors may be playing a major role. The consumption of ultra-processed foods, sugary beverages, and processed meats has increased sharply in recent decades. Additionally, obesity and metabolic syndrome—both risk factors for various cancers—are more prevalent among younger people today than in past generations.

While scientists haven’t pinpointed the exact causes of appendix cancer, several risk factors have been identified:

Age: Though it can occur at any age, most cases are diagnosed between 40 and 60 years.

Gender: Women are weakly more susceptible to developing appendix neuroendocrine tumors.

Smoking: Similar to most cancers, the risk is enhanced by smoking.

Family History: There can be a genetic factor in some instances, but more studies are necessary.

Underlying Conditions: People with diseases such as atrophic gastritis or pernicious anemia might be at greater risk.

What Is Diverticulitis?

Diverticulitis, which is far more prevalent, also may show symptoms similar to appendix cancer. Diverticulitis happens when diverticula—the tiny, bulging pouches that develop inside the colon—are inflamed or infected. These pouches are normally harmless, a state of affairs called diverticulosis, but they will cause trouble if bacteria become trapped and grow.

When diverticulitis hits, it can be mild or deadly, particularly if it results in complications such as bowel perforation or sepsis.

Symptoms of Diverticulitis

Most patients with diverticulitis develop:

• Persistent pain in the abdomen, typically the lower left quadrant (but can be right-sided in certain people, particularly those of Asian origin)
• Fever and chills
• Nausea and vomiting
• Tenderness or cramping of the abdomen
• Constipation or diarrhea

The inflammation may persist for a few days and is often accompanied by bloating and loss of appetite. In long-standing cases, recurrent inflammation may result in scarring and narrowing of the intestines, bowel obstructions, and long-term gastrointestinal problems.

Causes and Risk Factors for Diverticulitis

While diverticula are created through pressure on weakened areas of the colon wall, the cause of why some develop inflammation while others do not continues to be undetermined. Risk factors that contribute include:

Age: After 40 years of age, incidence rises

Diet: Fiber intake is low and red meat and fat are consumed in excess

Sedentary lifestyle: Physical inactivity leads to decreased gut motility

Obesity and Smoking: Both promote inflammation in the body

Certain Medications: NSAIDs, opioids, and steroids can either trigger or exacerbate the condition

Appendix Cancer vs. Diverticulitis: How To Tell the Difference Early?

Distinguishing between appendix cancer and diverticulitis based solely on symptoms is challenging—even for seasoned physicians—due to the significant overlap in abdominal discomfort, bowel changes, and nausea. However, the location and duration of pain, the presence of systemic symptoms (like fever vs. ascites), and advanced imaging can provide clues.

Pain in appendix cancer is usually chronic and fixed in the lower right quadrant, accompanied by bloating, early satiety, or ascites without explanation.

Diverticulitis is more likely to have fever, infection, and left lower quadrant abdominal pain, particularly in Western populations.

CT scans, colonoscopy, biopsies, and tumor markers play a critical role in establishing the diagnosis and excluding malignancies.

The outcomes of confusing one with the other can be dire. Although diverticulitis tends to heal with antibiotics, diet modification, and in some cases, surgery, appendix cancer needs oncological attention, typically through surgical removal of the appendix and surrounding tissues, followed by chemotherapy, especially in case of spread of the cancer.

With the rising prevalence of appendix cancer in younger adults, regular follow-up for unexplained or chronic abdominal symptoms—regardless of age—is more important than ever before. Doctors now encourage patients and clinicians to suspect less common possibilities such as appendix cancer when usual diagnoses cannot account for symptoms.

The spike in appendix cancer cases, especially among young adults, is a sign of a changing tide in gastrointestinal well-being. Diverticulitis, although still a prevalent and oftentimes benign illness, shares such similar symptoms that we can no longer afford to brush off chronic abdominal pain.

If you, or someone close to you, are having prolonged gastrointestinal complaints, don't write it off as diet or stress. Seek medical help immediately.