Health and Me

Tanya Dutt

Appendix Cancer vs. Diverticulitis: Symptoms, Causes And How To Tell the Difference Early

Appendix Cancer vs. Diverticulitis: Symptoms, Causes, and How To Tell the Difference Early

A sudden spike in cases of appendiceal adenocarcinoma, particularly among Gen X and millennials, has become a growing concern among medical professionals. Frequently misdiagnosed or neglected because of similar symptoms to other gastrointestinal conditions, this kind of cancer is unusual but bears remarkable similarities with a not-so-uncanny condition—diverticulitis. Familiarizing oneself with the unique characteristics of these two conditions is vital for the diagnosis at an early stage, appropriate treatment, and improved health outcomes.

Appendix cancer, which was once thought to be extremely rare, is now trending up in a disturbing direction. In a recent study in the Annals of Internal Medicine, Vanderbilt University Medical Center researchers crunched data from the U.S. National Cancer Institute's SEER program from 1975 to 2019. The results are eye-opening: rates of appendiceal adenocarcinoma (AA) have more than doubled among Generation X and quadrupled among millennials relative to those born in the mid-20th century.

Also Read: <a href="https://www.healthandme.com/health-wellness/study-reveals-a-rare-appendix-cancer-among-millennials-and-gen-x-article-151825727" data-type="tilCustomLink" target="_blank">A Rare Appendix Cancer Among Millennials And Gen X, Study Reveals</a>

Although still rare with only some 3,000 new cases diagnosed each year in the U.S.—this increase reflects the larger trend of increasing gastrointestinal cancers among young adults, such as colorectal and stomach cancers. What is so troubling about this increase is how easily symptoms of appendix cancer can be confused with other digestive complaints, particularly diverticulitis, a much more common condition.

Appendix cancer (appendiceal cancer) occurs when cells in the appendix start to mutate and multiply out of control. The appendix—a small sac at the juncture of the small and large intestines—has been a mystery to scientists for a long time regarding its purpose. Some think it contributes minimally to immune well-being, while others consider it a vestigial organ. But one thing is certain: When cancer hits this organ, it can be hard to spot.

The majority of the patients do not develop any symptoms until the disease becomes advanced or is incidentally found during surgery for appendicitis or other unrelated surgeries. If symptoms happen, they can be:

<ul><li>Abdominal pain on the lower right side, which is persistent</li><li>Bloating or distension in the abdomen</li><li>Diarrhea due to the changes in bowel habits</li><li>Vomiting, nausea, and early satiety</li><li>Ascites (fluid accumulation in the abdomen)</li><li>Unintended weight gain or rise in waistline</li></ul>

In some cases, appendix cancer can lead to pseudomyxoma peritonei (PMP)—a rare condition where mucin-producing tumor cells create jelly-like fluid that fills the abdominal cavity, causing further complications and discomfort.

Also Read: <a href="https://www.healthandme.com/health-news/rfk-jr-removes-entire-cdc-vaccine-advisory-committee-article-151823769" data-type="tilCustomLink" target="_blank">RFK Jr. Removes Entire CDC Vaccine Advisory Committee</a>

<h2>What Are the Causes and Risk Factors of Appendix Cancer?</h2>

Although the exact reasons for this generational increase remain unclear, researchers suggest that lifestyle and environmental factors may be playing a major role. The consumption of ultra-processed foods, sugary beverages, and processed meats has increased sharply in recent decades. Additionally, obesity and metabolic syndrome—both risk factors for various cancers—are more prevalent among younger people today than in past generations.

While scientists haven’t pinpointed the exact causes of appendix cancer, several risk factors have been identified:

<strong>Age: </strong>Though it can occur at any age, most cases are diagnosed between 40 and 60 years.

<strong>Gender:</strong> Women are weakly more susceptible to developing appendix neuroendocrine tumors.

<strong>Smoking:</strong> Similar to most cancers, the risk is enhanced by smoking.

<strong>Family History: </strong>There can be a genetic factor in some instances, but more studies are necessary.

<strong>Underlying Conditions:</strong> People with diseases such as atrophic gastritis or pernicious anemia might be at greater risk.

Diverticulitis, which is far more prevalent, also may show symptoms similar to appendix cancer. Diverticulitis happens when diverticula—the tiny, bulging pouches that develop inside the colon—are inflamed or infected. These pouches are normally harmless, a state of affairs called diverticulosis, but they will cause trouble if bacteria become trapped and grow.

When diverticulitis hits, it can be mild or deadly, particularly if it results in complications such as bowel perforation or sepsis.

Most patients with diverticulitis develop:

<ul><li>Persistent pain in the abdomen, typically the lower left quadrant (but can be right-sided in certain people, particularly those of Asian origin)</li><li>Fever and chills</li><li>Nausea and vomiting</li><li>Tenderness or cramping of the abdomen</li><li>Constipation or diarrhea</li></ul>

The inflammation may persist for a few days and is often accompanied by bloating and loss of appetite. In long-standing cases, recurrent inflammation may result in scarring and narrowing of the intestines, bowel obstructions, and long-term gastrointestinal problems.

<h2>Causes and Risk Factors for Diverticulitis</h2>

While diverticula are created through pressure on weakened areas of the colon wall, the cause of why some develop inflammation while others do not continues to be undetermined. Risk factors that contribute include:

<strong>Age:</strong> After 40 years of age, incidence rises

<strong>Diet:</strong> Fiber intake is low and red meat and fat are consumed in excess

<strong>Sedentary lifestyle:</strong> Physical inactivity leads to decreased gut motility

<strong>Obesity and Smoking: </strong>Both promote inflammation in the body

<strong>Certain Medications:</strong> NSAIDs, opioids, and steroids can either trigger or exacerbate the condition

<h2>Appendix Cancer vs. Diverticulitis: How To Tell the Difference Early?</h2>

Distinguishing between appendix cancer and diverticulitis based solely on symptoms is challenging—even for seasoned physicians—due to the significant overlap in abdominal discomfort, bowel changes, and nausea. However, the location and duration of pain, the presence of systemic symptoms (like fever vs. ascites), and advanced imaging can provide clues.

Pain in appendix cancer is usually chronic and fixed in the lower right quadrant, accompanied by bloating, early satiety, or ascites without explanation.

Diverticulitis is more likely to have fever, infection, and left lower quadrant abdominal pain, particularly in Western populations.

CT scans, colonoscopy, biopsies, and tumor markers play a critical role in establishing the diagnosis and excluding malignancies.

The outcomes of confusing one with the other can be dire. Although diverticulitis tends to heal with antibiotics, diet modification, and in some cases, surgery, appendix cancer needs oncological attention, typically through surgical removal of the appendix and surrounding tissues, followed by chemotherapy, especially in case of spread of the cancer.

With the rising prevalence of appendix cancer in younger adults, regular follow-up for unexplained or chronic abdominal symptoms—regardless of age—is more important than ever before. Doctors now encourage patients and clinicians to suspect less common possibilities such as appendix cancer when usual diagnoses cannot account for symptoms.

The spike in appendix cancer cases, especially among young adults, is a sign of a changing tide in gastrointestinal well-being. Diverticulitis, although still a prevalent and oftentimes benign illness, shares such similar symptoms that we can no longer afford to brush off chronic abdominal pain.

If you, or someone close to you, are having prolonged gastrointestinal complaints, don't write it off as diet or stress. Seek medical help immediately.

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A sudden spike in cases of appendiceal adenocarcinoma, particularly among Gen X and millennials, has become a growing concern among medical professionals. Frequently misdiagnosed or neglected because of similar symptoms to other gastrointestinal conditions, this kind of cancer is unusual but bears remarkable similarities with a not-so-uncanny condition—diverticulitis. Familiarizing oneself with the unique characteristics of these two conditions is vital for the diagnosis at an early stage, appropriate treatment, and improved health outcomes.Appendix cancer, which was once thought to be extremely rare, is now trending up in a disturbing direction. In a recent study in the Annals of Internal Medicine, Vanderbilt University Medical Center researchers crunched data from the U.S. National Cancer Institute's SEER program from 1975 to 2019. The results are eye-opening: rates of appendiceal adenocarcinoma (AA) have more than doubled among Generation X and quadrupled among millennials relative to those born in the mid-20th century.Also Read: A Rare Appendix Cancer Among Millennials And Gen X, Study RevealsAlthough still rare with only some 3,000 new cases diagnosed each year in the U.S.—this increase reflects the larger trend of increasing gastrointestinal cancers among young adults, such as colorectal and stomach cancers. What is so troubling about this increase is how easily symptoms of appendix cancer can be confused with other digestive complaints, particularly diverticulitis, a much more common condition.What Is Appendix Cancer?Appendix cancer (appendiceal cancer) occurs when cells in the appendix start to mutate and multiply out of control. The appendix—a small sac at the juncture of the small and large intestines—has been a mystery to scientists for a long time regarding its purpose. Some think it contributes minimally to immune well-being, while others consider it a vestigial organ. But one thing is certain: When cancer hits this organ, it can be hard to spot.Symptoms of Appendix CancerThe majority of the patients do not develop any symptoms until the disease becomes advanced or is incidentally found during surgery for appendicitis or other unrelated surgeries. If symptoms happen, they can be:Abdominal pain on the lower right side, which is persistentBloating or distension in the abdomenDiarrhea due to the changes in bowel habitsVomiting, nausea, and early satietyAscites (fluid accumulation in the abdomen)Unintended weight gain or rise in waistlineIn some cases, appendix cancer can lead to pseudomyxoma peritonei (PMP)—a rare condition where mucin-producing tumor cells create jelly-like fluid that fills the abdominal cavity, causing further complications and discomfort.Also Read: RFK Jr. Removes Entire CDC Vaccine Advisory CommitteeWhat Are the Causes and Risk Factors of Appendix Cancer?Although the exact reasons for this generational increase remain unclear, researchers suggest that lifestyle and environmental factors may be playing a major role. The consumption of ultra-processed foods, sugary beverages, and processed meats has increased sharply in recent decades. Additionally, obesity and metabolic syndrome—both risk factors for various cancers—are more prevalent among younger people today than in past generations.While scientists haven’t pinpointed the exact causes of appendix cancer, several risk factors have been identified:Age: Though it can occur at any age, most cases are diagnosed between 40 and 60 years.Gender: Women are weakly more susceptible to developing appendix neuroendocrine tumors.Smoking: Similar to most cancers, the risk is enhanced by smoking.Family History: There can be a genetic factor in some instances, but more studies are necessary.Underlying Conditions: People with diseases such as atrophic gastritis or pernicious anemia might be at greater risk.What Is Diverticulitis?Diverticulitis, which is far more prevalent, also may show symptoms similar to appendix cancer. Diverticulitis happens when diverticula—the tiny, bulging pouches that develop inside the colon—are inflamed or infected. These pouches are normally harmless, a state of affairs called diverticulosis, but they will cause trouble if bacteria become trapped and grow.When diverticulitis hits, it can be mild or deadly, particularly if it results in complications such as bowel perforation or sepsis.Symptoms of DiverticulitisMost patients with diverticulitis develop:Persistent pain in the abdomen, typically the lower left quadrant (but can be right-sided in certain people, particularly those of Asian origin)Fever and chillsNausea and vomitingTenderness or cramping of the abdomenConstipation or diarrheaThe inflammation may persist for a few days and is often accompanied by bloating and loss of appetite. In long-standing cases, recurrent inflammation may result in scarring and narrowing of the intestines, bowel obstructions, and long-term gastrointestinal problems.Causes and Risk Factors for DiverticulitisWhile diverticula are created through pressure on weakened areas of the colon wall, the cause of why some develop inflammation while others do not continues to be undetermined. Risk factors that contribute include:Age: After 40 years of age, incidence risesDiet: Fiber intake is low and red meat and fat are consumed in excessSedentary lifestyle: Physical inactivity leads to decreased gut motilityObesity and Smoking: Both promote inflammation in the bodyCertain Medications: NSAIDs, opioids, and steroids can either trigger or exacerbate the conditionAppendix Cancer vs. Diverticulitis: How To Tell the Difference Early?Distinguishing between appendix cancer and diverticulitis based solely on symptoms is challenging—even for seasoned physicians—due to the significant overlap in abdominal discomfort, bowel changes, and nausea. However, the location and duration of pain, the presence of systemic symptoms (like fever vs. ascites), and advanced imaging can provide clues.Pain in appendix cancer is usually chronic and fixed in the lower right quadrant, accompanied by bloating, early satiety, or ascites without explanation.Diverticulitis is more likely to have fever, infection, and left lower quadrant abdominal pain, particularly in Western populations.CT scans, colonoscopy, biopsies, and tumor markers play a critical role in establishing the diagnosis and excluding malignancies.The outcomes of confusing one with the other can be dire. Although diverticulitis tends to heal with antibiotics, diet modification, and in some cases, surgery, appendix cancer needs oncological attention, typically through surgical removal of the appendix and surrounding tissues, followed by chemotherapy, especially in case of spread of the cancer.With the rising prevalence of appendix cancer in younger adults, regular follow-up for unexplained or chronic abdominal symptoms—regardless of age—is more important than ever before. Doctors now encourage patients and clinicians to suspect less common possibilities such as appendix cancer when usual diagnoses cannot account for symptoms.The spike in appendix cancer cases, especially among young adults, is a sign of a changing tide in gastrointestinal well-being. Diverticulitis, although still a prevalent and oftentimes benign illness, shares such similar symptoms that we can no longer afford to brush off chronic abdominal pain.If you, or someone close to you, are having prolonged gastrointestinal complaints, don't write it off as diet or stress. Seek medical help immediately.

appendix cancer vs. diverticulitis: symptoms, causes and how to tell the difference early

Ishita Roy

Ananda Lewis Passes Away at 52

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<span>Ananda Lewis</span>, celebrated TV host known for her authenticity and warmth, passed away at 52 after a long and brave battle with <span>breast cancer</span>. Once a beloved face on BET’s Teen Summit and MTV’s Total Request Live, she used her platform to engage young audiences with pressing social issues and celebrity interviews that left a mark.

Lewis first came into the spotlight through BET’s Teen Summit, where she led candid conversations on challenges facing Black youth. Her interviews with figures like Kobe Bryant, Tupac Shakur, and Hillary Clinton earned her critical acclaim, including an NAACP Image Award.

In 1997, she joined MTV, becoming a key voice on MTV Live, Hot Zone, and TRL. Though her move sparked criticism, she remained unapologetic. “Growth is necessary,” she told the Associated Press. “You’ve got to get out there and live your life.”

She later launched The Ananda Lewis Show in 2001, a daytime talk show aimed at real conversations, even if it followed a familiar format. The show lasted one season, but Lewis remained a powerful presence, later joining The Insider as a correspondent.

<h4>Breast <span rel="noindex">Cancer</span> Journey That She Shared With The World</h4>

In 2020, Lewis revealed that she had been living with stage 3 breast cancer since 2018—later advancing to stage 4. Her diagnosis came after years of ignoring persistent inflammation linked to mastitis from breastfeeding. A lump discovered in her right breast led to a biopsy, confirming it was invasive carcinoma.

Instead of following a conventional medical path, Lewis chose alternative treatments. “I wanted to understand why my body created cancer and how to change the terrain,” she explained. She focused on diet changes, stress management, detoxing, and holistic therapies like high-dose vitamin C, acupuncture, and cryoablation.

Lewis moved to Arizona in 2020 for 16 weeks of intensive integrative treatment. Her cancer reduced from stage 3 to 2 and was no longer in her lymph nodes. But the journey wasn’t without hardship—financial struggles and insurance lapses made consistent treatment difficult.

In early 2023, a scan showed the tumor had grown slightly, but it had not spread. She underwent electrical ablation in Mexico, which unfortunately didn’t succeed. By October 2023, a PET scan confirmed the cancer had advanced to stage 4. Still, Lewis continued treatment and saw significant improvement by January 2024.

Lewis was candid about her journey, using her story to raise awareness about early detection and holistic health. “Stage 4 doesn’t mean the end,” she said. “It means I have to do more.”

Her message to women was clear: be proactive. Prioritize mammograms, manage stress, sleep well, and adopt a clean lifestyle. “If I had known what I know now ten years ago, perhaps I wouldn’t have ended up here,” she said.

“I want to look back and say—I did that exactly how I wanted to,” Lewis reflected. Her legacy is one of resilience, wisdom, and an enduring belief in the right to choose one’s own path—even through cancer.

Ananda Lewis cancer survivor dies at 52

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breast cancer

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Ananda Lewis

Ananda lewis cancer

Ananda lewis cancer survivor

ananda lewis dies

Ananda Lewis, celebrated TV host known for her authenticity and warmth, passed away at 52 after a long and brave battle with breast cancer. Once a beloved face on BET’s Teen Summit and MTV’s Total Request Live, she used her platform to engage young audiences with pressing social issues and celebrity interviews that left a mark.A Powerful Presence on ScreenLewis first came into the spotlight through BET’s Teen Summit, where she led candid conversations on challenges facing Black youth. Her interviews with figures like Kobe Bryant, Tupac Shakur, and Hillary Clinton earned her critical acclaim, including an NAACP Image Award.In 1997, she joined MTV, becoming a key voice on MTV Live, Hot Zone, and TRL. Though her move sparked criticism, she remained unapologetic. “Growth is necessary,” she told the Associated Press. “You’ve got to get out there and live your life.”She later launched The Ananda Lewis Show in 2001, a daytime talk show aimed at real conversations, even if it followed a familiar format. The show lasted one season, but Lewis remained a powerful presence, later joining The Insider as a correspondent.Breast Cancer Journey That She Shared With The WorldIn 2020, Lewis revealed that she had been living with stage 3 breast cancer since 2018—later advancing to stage 4. Her diagnosis came after years of ignoring persistent inflammation linked to mastitis from breastfeeding. A lump discovered in her right breast led to a biopsy, confirming it was invasive carcinoma.Instead of following a conventional medical path, Lewis chose alternative treatments. “I wanted to understand why my body created cancer and how to change the terrain,” she explained. She focused on diet changes, stress management, detoxing, and holistic therapies like high-dose vitamin C, acupuncture, and cryoablation.A Different Kind of BattleLewis moved to Arizona in 2020 for 16 weeks of intensive integrative treatment. Her cancer reduced from stage 3 to 2 and was no longer in her lymph nodes. But the journey wasn’t without hardship—financial struggles and insurance lapses made consistent treatment difficult.In early 2023, a scan showed the tumor had grown slightly, but it had not spread. She underwent electrical ablation in Mexico, which unfortunately didn’t succeed. By October 2023, a PET scan confirmed the cancer had advanced to stage 4. Still, Lewis continued treatment and saw significant improvement by January 2024.Lewis was candid about her journey, using her story to raise awareness about early detection and holistic health. “Stage 4 doesn’t mean the end,” she said. “It means I have to do more.”Her message to women was clear: be proactive. Prioritize mammograms, manage stress, sleep well, and adopt a clean lifestyle. “If I had known what I know now ten years ago, perhaps I wouldn’t have ended up here,” she said.“I want to look back and say—I did that exactly how I wanted to,” Lewis reflected. Her legacy is one of resilience, wisdom, and an enduring belief in the right to choose one’s own path—even through cancer.

ananda lewis, former mtv host who shared her breast cancer story to the world passes away at 52

Smartphone Tool Can Now Detect Early Warning Signs Of Huntington’s Disease In 5 Minutes, Finds Study

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In a revolutionary medical breakthrough, scientists have identified that a five-minute phone test will soon be able to detect early onset of Huntington's disease—a rare, genetic brain disorder—long before symptoms become visibly apparent. With digital health technologies revolutionizing the future of diagnosis, the new app test offers promise of quicker, more convenient, and highly accurate tracking, all from the comfort of the patient's own home. Wondering how your phone could be part of the future of neurology? Here's what a new study says.

Scientists have created a smartphone application that can identify early signs of motor symptoms of Huntington's disease within five minutes. The research, published in the journal Brain, is presented here with the explanation of how simple devices used on a daily basis can become big medical devices to analyze a subject's neurological well-being in real time from the comfort of his or her home. This innovation is especially valuable considering the scarcity and intricacy of Huntington's disease (HD), a genetically inherited disease in which there is, as of yet, no cure.

<h2>How the <span rel="noindex">Smartphone Test</span> Works?</h2>

The test developed is composed of five smartphone tasks assessing factors like finger tapping, balance, and involuntary movements. These activities together create a Huntington's Disease <span>Digital Motor Score</span> (HDDMS), a sensitive measure that can identify minimal changes in motor function that could occur before more evident clinical signs. As Ed Wild, Professor of Neurology at University College London's Huntington's Disease Center, points out, the fact that motor impairment can be measured in only five minutes at home has the potential to change the way <span>clinical trials</span> are carried out and disease progression followed.

Huntington's disease is a genetically inherited condition that leads to progressive degeneration of nerve cells within the brain, particularly in areas responsible for movement, cognition, and emotion. The symptoms usually occur between ages 30 and 50 and gradually worsen. In the early stages, there can be involuntary jerking or contorting movements (chorea), clumsiness, imbalance, and mood swings. When the disease progresses, patients become severely disabled from a motor standpoint, develop loss of cognitive abilities, and have psychiatric disturbances.

Conventional diagnostic approaches such as neurological assessment and imaging studies can be costly, time-consuming, and not as sensitive when identifying early-stage symptoms. The HDDMS tool is a cost-friendly, easily accessible alternative that could result in improved disease management through earlier intervention.

<h2>What Sets the HDDMS Test Unique and Accurate?</h2>

In contrast to traditional clinical evaluations that entail patients visiting specialized clinics, the HDDMS may be taken on a smartphone in under five minutes. The measure was created using information from more than 1,000 participants in four independent studies and is among the most widely validated digital tests for HD to date.

The investigators discovered that the HDDMS was almost twice as effective as conventional techniques in detecting significant changes in motor function. Such accuracy is important in rare conditions such as HD, where clinical trials have often been hindered by limited sample sizes and heavy participant burden.

With a number of hopeful treatments for Huntington's disease being developed, the need to measure disease progression accurately has never been greater. Integrating the HDDMS into clinical trials could make the research process more efficient by cutting the number of participants needed and the time needed to determine the effectiveness of a drug.

Professor Wild highlighted that more sensitive equipment is essential in rare disease investigation, where the limited patient base means it is challenging to set large-scale trials. He added the HDDMS provides a "more meaningful and convenient" means of assessing motor function than standard in-clinic tests.

Huntington's disease is a hereditary, always fatal disease due to a mutation in the gene encoding a protein named huntingtin. The mutation results in an abnormal repetition of the DNA sequence CAG (cytosine, adenine, guanine), causing brain cells to degenerate over time. Every child of a parent with HD has a 50% possibility of inheriting the defective gene.

<ul><li>Chorea (involuntary jerking motions)</li><li>Cognitive impairment</li><li>Personality and mood changes</li><li>Trouble with walking, talking, and swallowing</li><li>Insomnia and weight loss</li></ul>

With time, people with HD become unable to take care of themselves. The disease is eventually fatal, and no cure is available. Medications can be used to control chorea, depression, and anxiety, however.

Diagnosis is usually made through neurological examination, genetic testing, and imaging tests like MRIs or CT scans. Although these work well in establishing the disease, they are frequently unable to identify early signs, especially minor motor dysfunctions.

Treatment is mainly supportive. Medications like tetrabenazine and deuterabenazine are employed to manage movement disorders, and antipsychotic medications can be given for psychiatric abnormalities. Genetic counseling is highly advised for HD-affected families.

Although the HDDMS has been impressive in its accuracy in initial trials, scientists recognize that additional studies are necessary to assess its ability to forecast long-term functional decline. Additional research will also investigate how the tool can be introduced into standard clinical practice and patient follow-up.

If successful, smartphone-based HDDMS will be the cornerstone of the global battle against Huntington's disease, providing an affordable and scalable means of monitoring one of the most complicated neurological diseases in the arsenal of medicine.

brain health

huntington’s disease

smartphone test

early diagnosis

digital motor score

neurological disorder

clinical trials

neurodegenerative disease

In a revolutionary medical breakthrough, scientists have identified that a five-minute phone test will soon be able to detect early onset of Huntington's disease—a rare, genetic brain disorder—long before symptoms become visibly apparent. With digital health technologies revolutionizing the future of diagnosis, the new app test offers promise of quicker, more convenient, and highly accurate tracking, all from the comfort of the patient's own home. Wondering how your phone could be part of the future of neurology? Here's what a new study says.Scientists have created a smartphone application that can identify early signs of motor symptoms of Huntington's disease within five minutes. The research, published in the journal Brain, is presented here with the explanation of how simple devices used on a daily basis can become big medical devices to analyze a subject's neurological well-being in real time from the comfort of his or her home. This innovation is especially valuable considering the scarcity and intricacy of Huntington's disease (HD), a genetically inherited disease in which there is, as of yet, no cure.How the Smartphone Test Works?The test developed is composed of five smartphone tasks assessing factors like finger tapping, balance, and involuntary movements. These activities together create a Huntington's Disease Digital Motor Score (HDDMS), a sensitive measure that can identify minimal changes in motor function that could occur before more evident clinical signs. As Ed Wild, Professor of Neurology at University College London's Huntington's Disease Center, points out, the fact that motor impairment can be measured in only five minutes at home has the potential to change the way clinical trials are carried out and disease progression followed.Huntington's disease is a genetically inherited condition that leads to progressive degeneration of nerve cells within the brain, particularly in areas responsible for movement, cognition, and emotion. The symptoms usually occur between ages 30 and 50 and gradually worsen. In the early stages, there can be involuntary jerking or contorting movements (chorea), clumsiness, imbalance, and mood swings. When the disease progresses, patients become severely disabled from a motor standpoint, develop loss of cognitive abilities, and have psychiatric disturbances.Conventional diagnostic approaches such as neurological assessment and imaging studies can be costly, time-consuming, and not as sensitive when identifying early-stage symptoms. The HDDMS tool is a cost-friendly, easily accessible alternative that could result in improved disease management through earlier intervention.What Sets the HDDMS Test Unique and Accurate?In contrast to traditional clinical evaluations that entail patients visiting specialized clinics, the HDDMS may be taken on a smartphone in under five minutes. The measure was created using information from more than 1,000 participants in four independent studies and is among the most widely validated digital tests for HD to date.The investigators discovered that the HDDMS was almost twice as effective as conventional techniques in detecting significant changes in motor function. Such accuracy is important in rare conditions such as HD, where clinical trials have often been hindered by limited sample sizes and heavy participant burden.With a number of hopeful treatments for Huntington's disease being developed, the need to measure disease progression accurately has never been greater. Integrating the HDDMS into clinical trials could make the research process more efficient by cutting the number of participants needed and the time needed to determine the effectiveness of a drug.Professor Wild highlighted that more sensitive equipment is essential in rare disease investigation, where the limited patient base means it is challenging to set large-scale trials. He added the HDDMS provides a "more meaningful and convenient" means of assessing motor function than standard in-clinic tests.What is Huntington's Disease?Huntington's disease is a hereditary, always fatal disease due to a mutation in the gene encoding a protein named huntingtin. The mutation results in an abnormal repetition of the DNA sequence CAG (cytosine, adenine, guanine), causing brain cells to degenerate over time. Every child of a parent with HD has a 50% possibility of inheriting the defective gene.Symptoms are:Chorea (involuntary jerking motions)Cognitive impairmentPersonality and mood changesTrouble with walking, talking, and swallowingInsomnia and weight lossWith time, people with HD become unable to take care of themselves. The disease is eventually fatal, and no cure is available. Medications can be used to control chorea, depression, and anxiety, however.Diagnosis is usually made through neurological examination, genetic testing, and imaging tests like MRIs or CT scans. Although these work well in establishing the disease, they are frequently unable to identify early signs, especially minor motor dysfunctions.Treatment is mainly supportive. Medications like tetrabenazine and deuterabenazine are employed to manage movement disorders, and antipsychotic medications can be given for psychiatric abnormalities. Genetic counseling is highly advised for HD-affected families.Although the HDDMS has been impressive in its accuracy in initial trials, scientists recognize that additional studies are necessary to assess its ability to forecast long-term functional decline. Additional research will also investigate how the tool can be introduced into standard clinical practice and patient follow-up.If successful, smartphone-based HDDMS will be the cornerstone of the global battle against Huntington's disease, providing an affordable and scalable means of monitoring one of the most complicated neurological diseases in the arsenal of medicine.

smartphone tool can now detect early warning signs of huntington’s disease in 5 minutes, finds study

Aarushi Bhadury

Accelerated Biological Aging Could Make You At Risk For Dementia: Study

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Parents Could Be Leading Their Children To Food Allergies Unknowingly

parents could be leading their children to food allergies unknowingly

We have all heard people say that they are old souls trapped in a young body, however, this is a figure of speech people use. While this phrase may mean you like old school things, it can also happen literally. Sometimes your body ages faster than you do, but this is the biological age we are talking about. While chronological aging is counted as the years we have lived, biological age can be faster or slower. 

Think of it as perishable food. If you leave them in unfavorable environments, they can spoil fast, becoming edible. However, when you keep them in the correct environment with even temperature, the food will stay edible for longer than it should. Our bodies are similar in that sense. If you take care of it, limiting processed food, exercising and taking care of your health, you will find that your biological age is much slower or healthier than a person who does the opposite. However, what is the connection between biological aging and our lifestyle. How do we age slower/faster depending on our choices. 

A new study suggests that signs of faster aging in your body are connected to a <span>higher chance of developing dementia</span> and stroke. Specifically, researchers found that people with <span>shorter telomeres</span> in their white blood cells tend to have an increased risk of these two brain conditions. These findings were published recently in the journal <span>Neurology</span>. 

<h2>What Are Telomeres and Why Do They Matter? </h2>

Think of telomeres as the protective caps on the ends of your chromosomes, much like the plastic tips on shoelaces. They prevent your chromosomes from unraveling and getting damaged. Every time your cells divide, these telomeres get a little shorter. This makes them a useful way to estimate a person's biological age, which is how much wear and tear your body has accumulated from stress over time, rather than just your age in years. Your biological age can be quite different from your actual age. 

<h2>Lifestyle Habits Can Counter the Risk </h2>

However, there's good news: the study found that this link between shorter telomeres and brain diseases wasn't present in people who maintained healthy lifestyle habits. This suggests that even if your body shows signs of faster aging, you can still reduce your risk of age-related brain diseases. This includes things like keeping a healthy weight, limiting alcohol, getting enough sleep, and exercising regularly. These healthy choices can help delay the aging of your cells and lower your chances of developing these conditions, especially if you're already at a higher risk.

For this study, researchers looked at genetic data from over 356,000 people. They categorized participants into three groups based on the length of their telomeres: short, medium, or long. They then compared telomere length to people's lifestyle habits and whether they had developed dementia, stroke, or depression. 

Over an average of seven years, nearly 26,000 people developed at least one of these three age-related brain diseases. People with the shortest telomeres had significantly more cases of these brain diseases compared to those with the longest telomeres. Overall, after considering other risk factors, individuals with short telomeres were 11% more likely to develop one of these brain diseases. More specifically, they faced an 8% increased risk of stroke, a 19% increased risk of dementia, and a 14% increased risk of late-life dementia.

It's important to remember that this study shows a connection, not a direct cause-and-effect relationship between telomere length and brain health. 

Accelerated Biological Aging

neurology

lifestyle habits can counter the risk however

shorter telomeres

higher chance of developing dementia

dementia and stroke

We have all heard people say that they are old souls trapped in a young body, however, this is a figure of speech people use. While this phrase may mean you like old school things, it can also happen literally. Sometimes your body ages faster than you do, but this is the biological age we are talking about. While chronological aging is counted as the years we have lived, biological age can be faster or slower. Think of it as perishable food. If you leave them in unfavorable environments, they can spoil fast, becoming edible. However, when you keep them in the correct environment with even temperature, the food will stay edible for longer than it should. Our bodies are similar in that sense. If you take care of it, limiting processed food, exercising and taking care of your health, you will find that your biological age is much slower or healthier than a person who does the opposite. However, what is the connection between biological aging and our lifestyle. How do we age slower/faster depending on our choices. A new study suggests that signs of faster aging in your body are connected to a higher chance of developing dementia and stroke. Specifically, researchers found that people with shorter telomeres in their white blood cells tend to have an increased risk of these two brain conditions. These findings were published recently in the journal Neurology. What Are Telomeres and Why Do They Matter? Think of telomeres as the protective caps on the ends of your chromosomes, much like the plastic tips on shoelaces. They prevent your chromosomes from unraveling and getting damaged. Every time your cells divide, these telomeres get a little shorter. This makes them a useful way to estimate a person's biological age, which is how much wear and tear your body has accumulated from stress over time, rather than just your age in years. Your biological age can be quite different from your actual age. Lifestyle Habits Can Counter the Risk However, there's good news: the study found that this link between shorter telomeres and brain diseases wasn't present in people who maintained healthy lifestyle habits. This suggests that even if your body shows signs of faster aging, you can still reduce your risk of age-related brain diseases. This includes things like keeping a healthy weight, limiting alcohol, getting enough sleep, and exercising regularly. These healthy choices can help delay the aging of your cells and lower your chances of developing these conditions, especially if you're already at a higher risk. Shorter Telomeres, Higher Risk For this study, researchers looked at genetic data from over 356,000 people. They categorized participants into three groups based on the length of their telomeres: short, medium, or long. They then compared telomere length to people's lifestyle habits and whether they had developed dementia, stroke, or depression. Over an average of seven years, nearly 26,000 people developed at least one of these three age-related brain diseases. People with the shortest telomeres had significantly more cases of these brain diseases compared to those with the longest telomeres. Overall, after considering other risk factors, individuals with short telomeres were 11% more likely to develop one of these brain diseases. More specifically, they faced an 8% increased risk of stroke, a 19% increased risk of dementia, and a 14% increased risk of late-life dementia.It's important to remember that this study shows a connection, not a direct cause-and-effect relationship between telomere length and brain health. 

accelerated biological aging could make you at risk for dementia: study

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