One of the biggest concerns people have with cancer is them identifying the signs or symptoms too late for any medical intervention. It is even considered a blessing when you catch the early symptoms of it. There is not a very clear answer for why someone may develop cancer. Some risk factors could be family history, consuming inflammatory and unhealthy things like alcohol and smoking etc. But many time people who are perfectly healthy, lead an active lifestyle are the ones who get diagnosed. So, does this mean you can develop cancer anywhere at any time no matter how careful you are? While it is somewhat true, new research shows that whether you can develop cancer or not is something that is outlined even before you are born.

Scientists have been studying cancer for a long time, and they're still learning new things. One new idea is that your chances of getting cancer might be partly decided even before you're born. A recent study on mice found that there are two different "genetic states" that develop while a baby mouse is still in its mother's womb. These states seem to be connected to how likely a mouse is to develop cancer later in life. This is a big deal because it means that some things that affect our cancer risk might be set very early in our development. It also opens up new ways to think about how cancer starts.

Two Genetic States, Two Risk Levels

The mouse study found two different genetic states that happen while the mice are developing before birth. One of these states seems to make the mice more likely to get cancer, while the other state makes them less likely. Think of it like two different paths: one leading to a higher chance of cancer and the other to a lower chance. This discovery is really exciting because it gives scientists a new way to understand why some people get cancer and others don't. It might also help us find ways to prevent cancer or treat it better.

We all know that getting older makes you more likely to get cancer. This is partly because our DNA gets damaged over time. But not everyone with damaged DNA gets cancer. So, scientists have been looking for other things that might play a role, like our genes. One of the researchers, Ilaria Panzeri, said that we often think of cancer as just bad luck, but that's not the whole story. "Bad luck" doesn't explain everything, and it's not something we can change. That's why understanding the role of genetics is so important.

Role of the TRIM28 Gene

The scientists in this study looked closely at a gene called TRIM28. This gene is important for controlling other genes, including some that are linked to cancer. They found that if mice had lower levels of TRIM28, they could end up in one of the two genetic states, even if they were otherwise identical. These states are set while the mice are still developing, and they stick with them for their whole lives. It's also interesting that the human versions of these genes are often changed in human cancers.

This mouse study gives us a new way to think about cancer. It suggests that the seeds of cancer might be planted very early in life, even before birth. This could change how we study cancer and how we try to prevent or treat it. The researchers also found these two genetic states in different parts of the mice's bodies, which means this might be a general thing that affects many types of cancer. The next step is to figure out exactly how these early genetic states affect different kinds of cancer.

Being the leading cause of death worldwide, cancer diagnoses can change the trajectory of a person’s life. New cancer stats reveal that an estimate of 2,041,910 new cancer cases will be diagnosed in the US, and about 600,000 have been estimated to die due to the disease. As you may know, cancer is a generic term for a lot of different diseases that affect our health. A malignant cancer diagnosis means that there is a rapid growth in abnormal cell growth which can affect various parts of your body.

According to the World Health Organization, cancer causes nearly 1 in 6 deaths globally and had accounted for 20 million deaths in 2020. The question remains, has the advancement in research and public education helped lower cancer cases or recognized any concerning patterns?

New information from Cancer Research UK, looking at 50 years of health data, shows both good and bad news about cancer. On the one hand, the number of deaths from cancer has gone down by more than one-fifth, which is a positive sign. However, the number of people being told they have cancer has actually gone up by 50%, showing a worrying increase in new cases.

More Young People Getting Cancer

One of the most concerning things we're seeing is how much more young people, under the age of 50, are getting cancer. Specifically, for those between 20 and 49 years old, cancer rates have shot up by 23% since the 1990s. Scientists are now working hard to understand why this is happening and what's causing this significant jump in cancer cases among younger individuals. Several factors are being explored as likely contributors to the rise in early-onset cancers:

Obesity, Poor Diet, and Inactivity

These lifestyle choices are strongly linked to the increase. Research into the rise of colon cancer among young people, for instance, revealed that more than a third of those studied were obese. It has been observed that individuals developing cancer at a younger age tend to have significantly higher rates of obesity compared to those diagnosed later in life.

Diet and the Microbiome

The food we eat greatly affects our gut health. It's suggested that outside elements like microplastics or chemicals could be altering this balance, potentially contributing to cancer development. Experts stress how important it is to start healthy eating and exercise habits early. There's also a warning not to forget that certain drinks can be just as risky as unhealthy processed and sugary foods.

Smoking's Declining Role

It's interesting to note that smoking is probably not the reason for the increase in cancer among young people. Experts have actually seen a drop in cancers linked to smoking across almost all age groups. This suggests that while smoking is a known cause of cancer, its decreasing popularity means it's not behind the current rise in cases among younger generations.

Despite more young people getting cancer, Cancer Research UK's report highlights that we are currently in a very positive time for cancer treatment. Thanks to advancements, one in two people diagnosed with cancer are now expected to live for at least 10 years. This is a huge improvement from the 1970s, when only one in four patients reached that milestone, showing great progress in saving lives.

If you have ever had a migraine then you would know that it is not just a headache, but it comes in phases. It starts with you being sensitive to all noise, smell, and even taste, feeling a bit dizzy, and losing out on your energy. Then there is a throbbing pain, this is when you know your migraine has reached its peak.

What Are The Stages Of Migraine?

There are four main stages of migraine, which starts from predrome, aura, headache, and then postdrome.

What Do These Stages Mean?

Predrome

This stage is like a warning stage where there may be certain physical and mental changes. These include feeling tired, excessive yawning, food cravings, changes in your mood. You may feel low or irritated. Your body feels dehydrated and you might feel thirsty, have stiffness around your neck and may pass more urine.

This can last for 24 hours.

Aura

This happens to a third of people with migraine, notes The Migraine Trust. There are various neurological symptoms that happens in this stage, which includes changes in sight. This means, one may see dark spots, coloured spots or sparkles, often described as stars and zigzag lines. There could also be numbness, feeling like pins and needles on your body, you may also feel weakness, dizziness, and have problems with speech and hearing.

The Migraine Trust notes that aura is the result of wave of nerve activity that spreads over the brain, it is also known as cortical spreading depression. When this electrical wave spreads, the nerves fire in an abnormal way and this range of reversible neurological symptoms develop.

This can last from five minutes to 60 minutes.

Headache

As per the American Migraine Foundation, the headache phrase of a migraine attack is characterized by pain on one or both sides of the head. This phase lasts from several hours to up to three days.

This phase can vary from person to person. While some can experience mild pain, for others it could be a debilitating pain.

The pain, in this phase, also shifts from one side of the person's head to other. In this phase, doing everyday activity like walking, turning on the lights, or any slight change, movement, sensory actions can aggravate the pain.

Postdrome

This phase is also called "migraine hangover". This happens during the end of headache phase. The American Migraine Foundation notes that not everyone experiences this phase, however, it occurs in most cases, in about 80% of people.

In this phase, the headache could be debilitating, but then it follows with fatigue, body aches, and trouble concentrating, dizziness and sensitivity to light. While in this phase the headache is ending, however, people could still be sensitive to smells, tastes and sensory actions.

Things are constantly changing and revolutionising in the health system. Thanks to technologies, there are now new ways to "heal". One such way is by indulging yourself in to the world of virtual reality and gaming, writes Dr Sathyanarayana LD, Consultant neurosurgeon at Narayana Health, Bengaluru for South First.

He notes that many people undergo surgery to remove brain tumors, which are one of the most complex and could be life-altering conditions for someone to face. Brain tumors could be benign or malignant, however, both affects the person's speech, motor function, memory, and their ability to perform day-to-day activities. This is the reason why, post-surgery, patients may be left with impairments, including physical, cognitive, and emotional. But thanks to technological advancement in the field of health, virtual reality (VR) and gaming have become "powerful tools for neurorehabilitation".

Dr Sathyanarayana notes that these means are not just for entertainment anymore. Since these means offer a more immersive and interactive experience, they have the potential to enhance the effectiveness of the treatment and also speed up the healing process, post-surgery.

How Does It Work? Why Does It Work?

The doctor notes that recovering from brain surgery is an intricate and lengthy journey. The brain does not return to full function immediately after the procedure; instead, it must gradually rebuild and rewire itself to regain what was lost.

This remarkable ability of the brain to reorganize and adapt, shaped by continuous learning and experience, is called neuroplasticity. It is through neuroplasticity that the brain creates new neural pathways to compensate for damaged areas and restore lost capabilities. In this complex process of rebuilding, gaming and virtual reality (VR) are emerging as powerful allies.

VR places patients in immersive, computer-generated environments that stimulate multiple senses at once—sight, sound, and even body awareness, known as proprioception. These rich sensory experiences actively engage different areas of the brain, sparking changes at the synaptic level, where neurons communicate with each other.

By simultaneously activating motor, sensory, and cognitive regions of the brain, VR encourages synaptic plasticity and broader neural reorganization. This multi-layered engagement fosters a more cohesive and efficient path to recovery, helping the brain rebuild its networks in a meaningful and impactful way.

Relearning Movement Through Virtual Play

Post-surgery, many patients face motor impairments like weakness or poor coordination. Virtual reality offers a safe and stimulating space to relearn movement through repetition and task-specific training—key elements for motor recovery.

For instance, VR games that simulate cricket—batting, catching, or goalkeeping—encourage repeated use of the shoulder, arm, and hand, helping restore motor skills. These games also adapt in difficulty and provide real-time feedback, keeping patients motivated while preventing fatigue.

Watching and participating in virtual activities also stimulates mirror neurons—cells involved in motor learning—which may strengthen communication between remaining healthy brain circuits and support recovery.

Training the Brain to Think Again

Beyond physical rehabilitation, brain surgery often impacts attention, memory, decision-making, and problem-solving. Gaming and VR can simulate real-life tasks in a structured, repeatable way, challenging cognitive functions in an enjoyable format.

Games involving memory recall, puzzles, and strategic decision-making push the brain to stay active. Over time, this improves working memory, executive function, and mental sharpness—key components of cognitive healing.

Emotional Healing in a Virtual World

Recovery is not just physical or cognitive—it’s deeply emotional too. Patients may feel anxious, depressed, or lose confidence. Immersive VR experiences can provide psychological comfort by offering calming spaces or achievement-oriented challenges.

These environments give patients a chance to see their progress, rebuild self-esteem, and stay hopeful—factors that are vital for long-term motivation and adherence to recovery routines.

Why VR and Gaming Work in Neurorehab

Repetition with engagement: Games make repetitive rehab feel enjoyable, which is essential for promoting neuroplasticity.

Customized progress: VR systems offer real-time biofeedback and adaptive difficulty, ensuring that challenges remain effective and engaging without overwhelming the patient.

Affordable and scalable: Innovations from institutions like IIIT Hyderabad’s Serious Games Lab are making VR solutions accessible and low-cost, even for rural and public healthcare settings.