Rachel V Thomas

Health and Me

After California, Alaska Reports 3 Clade I Mpox Cases In People With No Travel History

Public health officials in Alaska have reported three cases of <span>Clade I <a href="https://www.healthandme.com/health/mpox">mpox</a></span> in people with no recent travel history, raising concerns about local transmission of the virus in the US.

The cases were confirmed in Anchorage in October 2026, shortly after California's Stanislaus County reported four cases of <span>Clade</span> I <span><a href="https://www.healthandme.com/health/mpox">mpox</a></span>, the strain responsible for the 2024 global outbreak.

While the cases point to possible community transmission, health officials said the risk to the general public remains low.

<h2>Three Clade I Mpox Cases Reported In Alaska</h2>

Three cases of mpox (<span>monkeypox</span>) were confirmed in Anchorage in October 2026, according to the Alaska Public Health Alert Network.

All three patients are male. An epidemiological link has been identified between the first two cases, while no link has been established for the third.

None of the patients reported out-of-state travel.

The first two cases were caused by <span>Clade Ib mpox</span>, marking the first reported Clade I infections in Alaska. Clade determination for the third case is pending.

One patient was briefly hospitalised. All three are currently isolating and recovering, while investigations continue.

The global mpox outbreak that began in 2022 was caused by Clade IIb. Since March 2026, imported Clade I cases have increased in the US, with presumed local transmission reported in 15 jurisdictions since August 2026.

<h2>California Reports Four Clade I Mpox Cases</h2>

Public health officials in California's Stanislaus County have reported four mpox cases. Two have been confirmed as Clade I, while testing is underway for the other two.

Three individuals had no recent international travel history, raising concerns about local transmission. The travel history of the fourth person is still being assessed.

The cases suggest possible community transmission. However, county officials have said the risk to the general public remains low.

<h2>US Reports Sustained Clade I Mpox Transmission</h2>

The Center for Outbreak Response Innovation (CORI), supported by the Johns Hopkins Bloomberg School of Public Health and the CDC's Center for Forecasting and Outbreak Analytics, has classified the US as being in Scenario 4: Sustained Transmission for Clade I mpox.

This indicates ongoing person-to-person transmission chains in some jurisdictions, primarily among adults with multiple sexual partners, including sex workers and men who have sex with men (MSM).

The CDC reported more than 90 Clade I cases across at least 23 states and Puerto Rico as of October 14, 2026. Domestic transmission had been reported in 10 jurisdictions, with additional cases involving people without recent international travel.

Clade I has historically been associated with more severe illness and higher case-fatality rates than Clade II.

Its historical case-fatality rate has been estimated at 1% to 10%, compared with approximately 1% to 4% or lower for Clade II. However, recent Clade I outbreaks have recorded substantially lower mortality, particularly where appropriate medical care is available.

The 2024 global outbreak was driven largely by Clade I, particularly the Clade Ib sub-lineage. On August 14, 2024, the World Health Organization (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC).

Mpox is a viral zoonotic disease caused by the monkeypox virus, which belongs to the Orthopoxvirus genus, the same family of viruses as smallpox.

It spreads through close contact with an infected person, including skin-to-skin and sexual contact, exposure to sores or bodily fluids, and contact with contaminated items such as bedding and towels. Transmission can also occur through contact with infected animals.

Symptoms generally appear 5 to 21 days after exposure and include:

<ul><li>Skin rash</li><li>Fever</li><li>Sore throat</li><li>Headache</li><li>Muscle and body aches</li><li>Fatigue</li><li>Swollen lymph nodes</li></ul>

Most people recover within two to four weeks. However, severe illness can occur, particularly in children, pregnant women and immunocompromised people.

Health Conditions A-Z

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Clade I mpox

monkeypox

Mpox in Alaska

Mpox in California

mpox

Clade Ib mpox

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Public health officials in Alaska have reported three cases of Clade I mpox in people with no recent travel history, raising concerns about local transmission of the virus in the US.The cases were confirmed in Anchorage in October 2026, shortly after California's Stanislaus County reported four cases of Clade I mpox, the strain responsible for the 2024 global outbreak.While the cases point to possible community transmission, health officials said the risk to the general public remains low.Three Clade I Mpox Cases Reported In AlaskaThree cases of mpox (monkeypox) were confirmed in Anchorage in October 2026, according to the Alaska Public Health Alert Network.All three patients are male. An epidemiological link has been identified between the first two cases, while no link has been established for the third.None of the patients reported out-of-state travel.The first two cases were caused by Clade Ib mpox, marking the first reported Clade I infections in Alaska. Clade determination for the third case is pending.One patient was briefly hospitalised. All three are currently isolating and recovering, while investigations continue.The global mpox outbreak that began in 2022 was caused by Clade IIb. Since March 2026, imported Clade I cases have increased in the US, with presumed local transmission reported in 15 jurisdictions since August 2026.California Reports Four Clade I Mpox CasesPublic health officials in California's Stanislaus County have reported four mpox cases. Two have been confirmed as Clade I, while testing is underway for the other two.Three individuals had no recent international travel history, raising concerns about local transmission. The travel history of the fourth person is still being assessed.The cases suggest possible community transmission. However, county officials have said the risk to the general public remains low.US Reports Sustained Clade I Mpox TransmissionThe Center for Outbreak Response Innovation (CORI), supported by the Johns Hopkins Bloomberg School of Public Health and the CDC's Center for Forecasting and Outbreak Analytics, has classified the US as being in Scenario 4: Sustained Transmission for Clade I mpox.This indicates ongoing person-to-person transmission chains in some jurisdictions, primarily among adults with multiple sexual partners, including sex workers and men who have sex with men (MSM).The CDC reported more than 90 Clade I cases across at least 23 states and Puerto Rico as of October 14, 2026. Domestic transmission had been reported in 10 jurisdictions, with additional cases involving people without recent international travel.Why Is Clade I Mpox A Concern?Clade I has historically been associated with more severe illness and higher case-fatality rates than Clade II.Its historical case-fatality rate has been estimated at 1% to 10%, compared with approximately 1% to 4% or lower for Clade II. However, recent Clade I outbreaks have recorded substantially lower mortality, particularly where appropriate medical care is available.The 2024 global outbreak was driven largely by Clade I, particularly the Clade Ib sub-lineage. On August 14, 2024, the World Health Organization (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC).What Is Mpox?Mpox is a viral zoonotic disease caused by the monkeypox virus, which belongs to the Orthopoxvirus genus, the same family of viruses as smallpox.It spreads through close contact with an infected person, including skin-to-skin and sexual contact, exposure to sores or bodily fluids, and contact with contaminated items such as bedding and towels. Transmission can also occur through contact with infected animals.What Are The Symptoms Of Mpox?Symptoms generally appear 5 to 21 days after exposure and include:Skin rashFeverSore throatHeadacheMuscle and body achesFatigueSwollen lymph nodesMost people recover within two to four weeks. However, severe illness can occur, particularly in children, pregnant women and immunocompromised people.

after california, alaska reports 3 clade i mpox cases in people with no travel history

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