Since the beginning of the HIV epidemic, scientists, doctors, and public health experts have spent decades trying to understand the virus and control its spread. Modern treatments now allow people living with HIV to reduce the virus in their bodies to undetectable levels, helping them stay healthy while also preventing transmission to others. Still, these treatments do not eliminate the virus entirely. Now, new research exploring the use of CRISPR gene-editing technology has shown promising results. This raises a question that has lingered for years: are we any closer to a cure for HIV?

What Is CRISPR?

CRISPR, short for Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing tool adapted from a natural defense system found in bacteria. It works by acting like precise molecular scissors that can cut, remove, or alter specific sections of DNA inside living cells. Scientists use a guide RNA to direct an enzyme, such as Cas9, to a targeted stretch of genetic material, allowing them to make exact changes.

According to the National Human Genome Research Institute, CRISPR has transformed genetic research because it is faster, more accurate, and more affordable than older gene-editing methods, with applications across medicine, science, and agriculture.

CRISPR Slices HIV Out Of Infected Cells Completely

Researchers at Amsterdam UMC have used Nobel Prize-winning CRISPR gene-editing tools to remove HIV DNA from infected T cells. Their work focused on targeting the virus where it hides inside immune cells known as reservoirs. By attacking parts of the HIV genome that remain stable across different strains, the researchers were able to target the virus in several types of cells, as per BBC.

In laboratory studies, the team successfully eliminated HIV from T cells that typically allow the virus to resurface once antiretroviral treatment is stopped. Unlike current HIV medications, which keep the virus under control but do not remove it, CRISPR physically cuts the viral DNA out of dormant reservoir cells. These hidden cells have been one of the biggest obstacles to finding a cure for HIV for decades.

How CRISPR Works Against HIV

According to the National Institutes of Health, CRISPR can fight HIV in several ways.

Removing the virus: CRISPR can cut out HIV DNA that has integrated into a person’s own genetic material, effectively removing the virus from the cell. This approach has been demonstrated in studies highlighted by the NIH, the World Economic Forum, and other research bodies.

Blocking viral activity: The technology can also disrupt viral genes or target host cell receptors, such as CCR5, which HIV needs to enter cells. This helps prevent new infections from taking hold.

Multiple-target strategies: Scientists are developing approaches that use more than one guide RNA to attack different parts of the virus at the same time. This reduces the chances of HIV mutating and escaping treatment, according to reports from the NIH, Aidsmap, and the World Economic Forum.

Study Details And Key Findings

Led by Dr Elena Herrera-Carrillo, the research team tested a CRISPR-Cas system using two guide RNAs aimed at conserved regions of the HIV genome. By focusing on these shared genetic sequences, the scientists hoped to create a treatment effective against many HIV variants. One major challenge they identified was the size of the delivery system used to transport the CRISPR components into cells. The vector carrying the gene-editing tools was initially too large.

To address this, the team tested different methods to shrink the CRISPR cassette and improve delivery. They compared several CRISPR-Cas systems derived from different bacteria in HIV-infected CD4+ T cells. Among them, saCas9 showed especially strong results. With one guide RNA, it completely shut down HIV activity, and with two guide RNAs, it fully removed viral DNA from the cells.

Reducing the vector size improved delivery efficiency, and the researchers were also able to target hidden HIV reservoir cells by focusing on proteins found on the surface of CD4+ and CD32a+ cells.

The researchers stated: “We have developed an effective combined CRISPR approach that attacks HIV in different cell types and in the locations where it hides. We also showed that these treatments can be delivered specifically to the cells that matter. This work marks an important step toward designing a cure strategy.”

What Happens Next?

Looking ahead, the authors explained that their next goal is to improve how the treatment is delivered so it reaches most HIV reservoir cells in the body. They plan to combine CRISPR-based therapies with receptor-targeting tools and move into preclinical testing to closely examine safety and effectiveness.

They added: “This will help ensure that CRISPR-Cas is delivered mainly to reservoir cells while avoiding healthy cells. Our aim is to make the system as safe as possible for future use in patients. Finding the right balance between effectiveness and safety is essential. Only then can clinical trials begin to explore whether this cure strategy can disable HIV reservoirs in humans.”

Actress Shamita Shetty recently opened up about her endometriosis diagnosis as well as navigating perimenopause. It has sparked concerns about delayed detection of the condition and risks associated with it.

Shamita Shetty’s Endometriosis Diagnosis

Speaking to Soha Ali Khan on her podcast All About Her alongside gynecological surgeon Dr. Neeta Warty, Shetty shared how her symptoms were dismissed repeatedly, leaving her searching for answers until the pain became unbearable and impossible to ignore.

She said that years of unexplained pain delayed her diagnosis, making her question whether what she was experiencing was simply a “normal” part of being a woman.

Shetty said routine medical tests initially failed to confirm the condition. As her health reports checked fine, she assumed her symptoms were ordinary, even as they kept returning.

“I wasn't given the right diagnosis initially,” Shetty said, explaining that she underwent standard gynecological examinations, including Pap smears, but no underlying cause was identified.

The actress said her symptoms intensified significantly in the months leading up to surgery. Although she considers herself to have a high pain tolerance due to previous injuries, she realized something was seriously wrong when the pain began waking her from sleep. After further investigations, she got diagnosed with endometriosis.

Shetty also revealed that she was entering perimenopause around the same time her symptoms of endometriosis worsened, making it difficult to distinguish between hormonal changes and signs of endometriosis.

Also read: World Population Day: How America's Falling Birth Rate Is Redefining Women's Healthcare?

Raising Awareness

Shetty underwent surgery for endometriosis in May 2024 and has since used her platform to encourage women not to ignore persistent pelvic pain.

During the podcast, she also addressed outdated advice that women with endometriosis should “have a baby” to solve the condition, recalling that one doctor suggested pregnancy as a treatment.

Shetty's diagnosis underscores the importance of paying attention to persistent symptoms rather than dismissing them as ordinary menstrual discomfort.

Severe period pain that disrupts daily activities, chronic pelvic pain, pain during intercourse, heavy menstrual bleeding, or difficulty becoming pregnant should be evaluated by a healthcare professional.

About Endometriosis And Perimenopause

Also read: Beyond The Bump: Why Preconceptions And Antenatal Care Are Key To A Healthy Pregnancy

Endometriosis is a chronic condition in which tissue similar to the lining of the uterus grows outside the uterus. The condition often requires long-term management. It can cause symptoms like:

• Pevere pelvic pain
• Painful periods
• Infertility
• Inflammation

On the other hand, perimenopause, the transitional period before menopause, can bring symptoms such as irregular menstrual cycles, hot flashes, mood changes, sleep disturbances, and hormonal fluctuations.

If diagnosed late, endometriosis can lead to complications like:

• Chronic pelvic pain that could worsen over time.
• Reduced fertility or infertility.
• Progression of the disease that could lead to larger lesions and ovarian cysts.
• Scar tissue (adhesions) that can cause organs to stick together.
• More complex surgeries.
• Bowel or bladder complications if the disease spreads beyond the uterus.
• Mental health effects, including anxiety, depression, and poor quality of life.

Recent Advancements In Endometriosis Diagnosis

According to the World Health Organization, endometriosis affects around 190 million women and girls worldwide, or 1 in 10 women of reproductive age.

The organization notes that many women experience diagnostic delays because symptoms are frequently normalized or mistaken for other conditions.

To curb this, the National Institute for Health and Care Excellence's (NICE) recently rolled out two non-invasive tests — the saliva-based Endotest and the gut sensor-based EndoSure — to help speed up the diagnosis of endometriosis in England and Wales.

Endotest analyses a saliva sample to identify tiny biological markers called microRNAs that can indicate whether endometriosis is likely to be present.

EndoSure is a non-invasive test that detects endometriosis by measuring electrical signals in the gut using sensor pads placed on the abdomen.

For this test, patients fast for six to eight hours before the test and drink water until full during the 45-minute procedure to help the device accurately record gut activity. Results are available immediately after the test.

A U.S. humanitarian worker in the Democratic Republic of the Congo (DRC) has tested positive for Ebola, raising fresh concerns as the country struggles with one of the worst Ebola outbreaks.

US Humanitarian Worker In DRC Tests Positive For Ebola

On Friday, the U.S. Centers for Disease Control and Prevention (CDC) confirmed, saying it is working closely with the individual's employer, U.S. government health agencies, and Congolese health authorities to prevent further transmission by tracing contacts to identify people who may have been exposed.

According to reports, the infected individual was working for a humanitarian organization in eastern Congo, where the outbreak has continued to spread despite ongoing response efforts.

The CDC has not released details about the patient's identity or condition but emphasized that contact tracing and public health measures are underway.

A spokesperson for the U.S. State Department said it is aware of the case and is assisting the affected American.

The spokesperson said, “A U.S. citizen working for a humanitarian organization in the Democratic Republic of the Congo has tested positive for the Bundibugyo strain of the Ebola virus. The CDC is working with the patient's employing organization, other federal agencies and partners in the Democratic Republic of the Congo to help prevent further transmission and identify high-risk contacts.”

The health regulatory body further said, “The risk of Ebola spreading in the United States remains low.”

Also read: Ebola In DRC Is Still In ‘Expansion Phase’: WHO Doctor Opens About Major Challenges In Containing The Outbreak

Ebola Outbreak In DRC: Latest Updates

The case comes as the Democratic Republic of the Congo faces an escalating Ebola crisis. According to the Africa CDC, the outbreak has now reached 1,830 confirmed cases and 648 deaths, making it the fastest-growing Ebola outbreak ever recorded on the continent. The outbreak was officially declared on May 15, 2026, and has spread across multiple provinces in eastern Congo.

Health officials say this outbreak is particularly concerning because it is caused by the Bundibugyo strain of the Ebola virus, a rare variant for which there is currently no approved vaccine or specific antiviral treatment.

WHO Says Actual Number Of Cases Could Be Higher

The World Health Organization (WHO) has also warned that the official case count may significantly underestimate the true scale of the outbreak.

WHO modeling suggests that actual infections could be two to four times higher than reported because many cases are not being detected.

Nearly 80% of newly identified infections in some of the hardest-hit communities cannot be linked to known Ebola patients, indicating widespread community transmission.

The agency also reported that about 70% of deaths early in the outbreak occurred outside treatment centers, making surveillance and contact tracing even more difficult.

WHO Emergencies Director Chikwe Ihekweazu told Reuters, “Eighty percent of the new patients confirmed are coming outside of known contact lists” in Bunia, the epicenter of the outbreak, highlighting widespread undetected transmission.

He also warned, “The true scale of the outbreak is likely two to four times larger than the official figures suggest.”

The latest case highlights the dangers faced by frontline aid workers and underscores the urgency of strengthening outbreak control measures before the virus spreads further.

With no approved vaccine for the Bundibugyo strain and transmission continuing in several provinces, global health officials say rapid detection, isolation, and international cooperation remain essential to bringing the outbreak under control.

Health officials in England have confirmed that an adult with an underlying immunological condition has died from measles, marking the third measles-related death this year after two children died in June.

According to the latest figures from the UK Health Security Agency (UKHSA), England has recorded 883 confirmed measles cases between the start of the year and July 6. More than half of the cases have been reported in London, with most infections occurring in children aged 10 years and under.

All regions of England, including London (52 per cent), the West Midlands 17 per cent, and the North West 10 per cent, have now reported measles cases.

The UK was declared measles-free in 2017 but lost that status in 2019 after vaccination rates declined and outbreaks resumed.

In January, the World Health Organization (WHO) confirmed that the UK was no longer considered to have eliminated measles, citing stagnant vaccination coverage and rising case numbers.

NHS Launches Catch-Up Vaccination Drive

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In response to the surge in infections, NHS leaders have launched a nationwide catch-up campaign targeting children aged two to 11 years who have missed one or both doses of the measles, mumps and rubella (MMR) vaccine.

The program will contact around one million families whose children are not fully vaccinated.

• GPs will contact parents of children under six.
• Families with children aged six to 11 will be contacted through the NHS App, text message, email or letter.

Current figures show that 84.1% of five-year-olds in England had received both doses of the MMR vaccine during the first three months of the year—well below the 95% coverage recommended to prevent outbreaks.

"We urge all parents to ensure their children are up to date with their MMR or MMRV vaccines, giving them the best and safest protection against measles," said Dr Vanessa Saliba, consultant epidemiologist at UKHSA.

"Anyone who has missed their measles vaccines can catch up through their GP practice, whatever their age. Getting vaccinated also helps protect babies who are too young to be vaccinated and people who cannot receive the vaccine because of certain health conditions," Dr Saliba added.

What Is Measles?

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Measles (rubeola) is one of the world's most contagious viral infections. It spreads through respiratory droplets released when an infected person coughs or sneezes and can also spread by touching contaminated surfaces before touching the eyes, nose, or mouth.

Symptoms usually develop 7 to 14 days after exposure and include:

• High fever
• Cough
• Runny nose
• Red, watery eyes
• Small white spots inside the mouth (Koplik spots)
• A red rash that typically starts on the face before spreading across the body

While many people recover fully, measles can cause serious complications, including pneumonia, encephalitis (brain inflammation), hearing loss, and, in rare cases, death.

All About the MMRV Vaccine

The MMRV is a safe, live-attenuated immunizations that protect against severe viral infections. The shot combines Measles, Mumps, and Rubella, and also adds protection against Varicella (chickenpox).

According to the UKHSA, children receive:

• First dose: At 12 months, alongside MenB and pneumococcal (PCV) vaccines.
• Second dose: At 18 months, alongside the fourth 6-in-1 vaccine.

Children who miss these doses can receive a catch-up vaccination at their 3-year and 4-month appointment. The MMRV vaccine contains weakened forms of the measles, mumps, rubella, and chickenpox viruses, which stimulate immunity without causing disease.

Two MMRV vaccines are available:

• ProQuad (contains porcine gelatine)
• Priorix Tetra (does not contain porcine gelatine).