Health and Me

Ishita Roy

Lori Coble, Woman Who Lost Her 3 Kids In A Car Accident Dies Of Brain Cancer

Lori Coble Brain Cancer

<span>Lori Coble</span> died of brain cancer at 48. Mom of teenage triplets, who had lost her first three children in a car accident died on Wednesday, January 21, confirmed a family friend to PEOPLE. She told PEOPLE "Lori passed away last night surrounded by her family."

In 2007, Lori lost her three children Kyle Christopher, 5, Emma Lynn 4, and Katie Gene, 2, in a car crash. While she and her husband Chris spent months coping up, they had triplets the year after the accident. Each carried an older sibling's middle name: Jake Christopher, Ahley Lyn, Ellie Gene. 

<h2>Lori Coble's Brain Cancer Diagnosis</h2>

In June 2025, Chris noticed something was wrong with his wife, as she was "getting more clumsy". She would run into walls, stub her toe on chairs, or drop drinking glasses on the floor. By early July, stroke like symptoms too appeared. In a previous interview with PEOPLE, he said, "Her mouth started to droop a little bit. It became too much to ignore."

By July, Lori was diagnosed with a large and aggressive stage 4 glioblastoma or brain cancer. "I was hoping we were done with the life changing, life altering disasters when life as you knew it yesterday is gone," Chris said. He said he started mourning loss of his wife the day she got diagnosed. 

"I didn’t have a lot of hope at the outset — and that weighed heavily on me. I was really upset, mad, angry. How could this be happening to us again?”

While Lori had two surgeries to remove the tumor in the period of next few months, the second surgery was invasive and caused her to lose control of her left side. Few days after, she had a stroke and was placed in a medically induced coma. She was in the hospital for 40 days. After she regained her strength, she returned home, and started radiation and chemotherapy. The treatment however made her more tired and impacted her speech. She was getting worse by every passing day. 

It was in mid-November when Lori was again in the hospital, this time in the ER, and doctors discovered a brain infection and advised on surgery. "You feel like she's just being tortured. I'm not sure that the treatment for cancer in this situation is any better than the disease itself.”

She also suffered with a lung infection and pneumonia and was brought back in the hospital. She was finally brought home for hospice care.

As per MD Anderson Cancer Center, glioblastoma is the most common and most aggressive form of primary brain cancer. In US, every year, around 12,000 new cases are detected. All glioblastomas are classified as grade IV tumors, which means they contain the most abnormal looking cells that grow rapidly. 

Glioblastoma develops from star-shaped brain cells known as astrocytes, which play a key role in nourishing the brain and shielding it from harmful substances in the bloodstream.

Astrocytes belong to a larger group called glial cells. These cells support the brain’s structure, supply nutrients, protect neurons, and help maintain a stable chemical balance in the brain.

The tumour most often forms near the front of the brain or close to its lower regions, though it can arise anywhere. The frontal lobe controls speech, movement, behaviour, and memory, while the temporal lobe is involved in memory formation, language, and processing sensory information such as sound and sight.

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Lori Coble died of brain cancer at 48. Mom of teenage triplets, who had lost her first three children in a car accident died on Wednesday, January 21, confirmed a family friend to PEOPLE. She told PEOPLE "Lori passed away last night surrounded by her family."        View this post on Instagram            A post shared by Lori Coble (@lorilcoble)]]>In 2007, Lori lost her three children Kyle Christopher, 5, Emma Lynn 4, and Katie Gene, 2, in a car crash. While she and her husband Chris spent months coping up, they had triplets the year after the accident. Each carried an older sibling's middle name: Jake Christopher, Ahley Lyn, Ellie Gene. Lori Coble's Brain Cancer DiagnosisIn June 2025, Chris noticed something was wrong with his wife, as she was "getting more clumsy". She would run into walls, stub her toe on chairs, or drop drinking glasses on the floor. By early July, stroke like symptoms too appeared. In a previous interview with PEOPLE, he said, "Her mouth started to droop a little bit. It became too much to ignore."By July, Lori was diagnosed with a large and aggressive stage 4 glioblastoma or brain cancer. "I was hoping we were done with the life changing, life altering disasters when life as you knew it yesterday is gone," Chris said. He said he started mourning loss of his wife the day she got diagnosed. "I didn’t have a lot of hope at the outset — and that weighed heavily on me. I was really upset, mad, angry. How could this be happening to us again?”While Lori had two surgeries to remove the tumor in the period of next few months, the second surgery was invasive and caused her to lose control of her left side. Few days after, she had a stroke and was placed in a medically induced coma. She was in the hospital for 40 days. After she regained her strength, she returned home, and started radiation and chemotherapy. The treatment however made her more tired and impacted her speech. She was getting worse by every passing day. It was in mid-November when Lori was again in the hospital, this time in the ER, and doctors discovered a brain infection and advised on surgery. "You feel like she's just being tortured. I'm not sure that the treatment for cancer in this situation is any better than the disease itself.”She also suffered with a lung infection and pneumonia and was brought back in the hospital. She was finally brought home for hospice care.What Is Glioblastoma?As per MD Anderson Cancer Center, glioblastoma is the most common and most aggressive form of primary brain cancer. In US, every year, around 12,000 new cases are detected. All glioblastomas are classified as grade IV tumors, which means they contain the most abnormal looking cells that grow rapidly. Glioblastoma develops from star-shaped brain cells known as astrocytes, which play a key role in nourishing the brain and shielding it from harmful substances in the bloodstream.Astrocytes belong to a larger group called glial cells. These cells support the brain’s structure, supply nutrients, protect neurons, and help maintain a stable chemical balance in the brain.The tumour most often forms near the front of the brain or close to its lower regions, though it can arise anywhere. The frontal lobe controls speech, movement, behaviour, and memory, while the temporal lobe is involved in memory formation, language, and processing sensory information such as sound and sight.