Health and Me

Itisha Arya

Orforglipron: All You Need To Know About the GLP-1 Pill That Could Replace Weight-Loss Injections

orforglipron for weight loss

A daily pill could soon serve as an alternative to <span>Wegovy and Ozempic</span> injections, after a recent trial revealed it helped people with obesity and type 2 diabetes lose significant weight and improve blood sugar control. This new once-a-day tablet, which could be cheaper than injectable treatments, helped participants shed up to 10 per cent of their body weight, according to the study. 

Researchers note that <span>orforglipron</span> may make these medications more accessible to people who currently cannot afford costly injections. Orforglipron is a GLP-1 agonist, a type of drug that lowers blood sugar, slows digestion, and can reduce appetite. At present, GLP-1 medications are injected by around 2.5 million people in the UK and can cost up to £206 per dose.

Orforglipron (LY3502970) is a small-molecule, non-peptide GLP-1 receptor agonist (GLP-1RA) designed for oral use. Unlike popular GLP-1RAs such as semaglutide, orforglipron does not require injections or fasting to achieve absorption and can be taken without restrictions on water or food, according to Phase 1 pharmacokinetic studies. “Its weight loss and diabetes benefits may not match tirzepatide, but the convenience of a pill could appeal to those who prefer not to inject,” explained Alex Miras, professor of endocrinology at Ulster University, to the Independent.

Orforglipron is being studied for safety and effectiveness in treating obesity and type 2 diabetes through ongoing clinical trials by Lilly. Early results are promising, and further data is expected in the first quarter of 2026. It has not yet been approved for use, as per the official page Eli Lilly and Company.

<h2><span rel="noindex">Orforglipron Price</span></h2>

Eli Lilly has not yet revealed the final price of Orforglipron, as it is still undergoing clinical trials and has not been approved for public use. Analysts anticipate that its cost could be comparable to existing drugs like Zepbound, likely ranging from $400 to $1,000 per month, depending on insurance coverage and market factors.

In the United States, patients are expected to start taking the pill in early 2026, with a global rollout to follow. A study done by Lancet included 1,444 participants with obesity across 10 countries, given varying doses of the pill or a placebo for comparison. All participants received guidance on healthy eating and exercise and were monitored over 16 months.

Participants taking the highest dose, 36mg, lost an average of 9.6 per cent of their body weight. Those on 12mg lost 7 per cent, and those on the lowest dose, 6mg, lost 5.1 per cent. Placebo participants lost 2.5 per cent.

The pill not only promoted weight loss but also helped reduce blood sugar levels. The most common side effects were mild to moderate gastrointestinal issues, as per The Indepedent.

Researchers highlighted that the pill could be cheaper, does not require cold storage, and can be taken without specific instructions around food or fasting, making it more accessible to a broader population.

“Having additional safe and effective weight loss options is a significant step forward,” said Naveed Sattar, professor of cardiometabolic medicine at Glasgow University, to the Independent.

“A new oral weight-loss tablet that can be taken alongside other medications without fasting could provide a convenient solution for people with mild to moderate obesity who want to prevent further weight gain,” he added.

“Given its safety profile and predicted lower cost, orforglipron could allow many more individuals, with or without diabetes, to access treatment for obesity worldwide,” said senior study author Dr. Deborah Horn, medical director of the Centre for Obesity Medicine at UTHealth Houston.

“My hope is that orforglipron will become the ‘metformin’ of obesity—a low-cost, widely accessible, low-risk, and effective medication for obesity and related conditions.”

Health Conditions A-Z

health

orforglipron

when will orforglipron be available

wegovy and ozempic

orforglipron side effects

orforglipron price

orforglipron brand name

Can A Gum Disease Lead To Erectile Dysfunction? Here's What New Evidence Shows

Taking COVID And Flu Vaccines Together? Doctors Recommend Which Arm To Use

Health News

8 Sit-Up Variations to Strengthen Your Core and Build Stability

Benefits Of Ayurvedic Health Supplement Ashwagandha

9 Anti-Inflammatory Breakfast Options You Should Try

5 Foods You Should Avoid For PCOS, Says Gynecologist

Love Sitting With Your Legs Crossed? Here’s You Should Avoid It

6 Daily Foods That Are Secretly Increasing Your Calories

9 Brain Boosters You Should Do Everyday

Hip Exercises That Will Keep You Flexible As You Age

9 Leg Exercises Office Workers’ Should Do At Home

Benefits of Having Herbal Tea Every Morning

9 Daily Habits That Boost Your Brain Power

Lower-Body Exercises That Are Game-Changers

How Drinking Apple Cider Vinegar Helps You

Aging Myths You Should Never Believe

Superfoods That Support Your Gut Health

What Happens To Your Body When You Eat Instant Noodles Every Day?

Health Issues Premature Babies Often Face

Exercises Office Workers Should Do For Their Heart Health

Reasons Why You Should Add Raw Turmeric To Your Diet

Benefits Of Drinking Milk At Night: Why You Should Do It

Food That Provides Vitamin B12 Naturally In Your Diet

Surprising Health Benefits Of Fenugreek Seeds

9 Superfoods You Should Eat For Your Brain Health

What Does Mental Health Support Look Like At Work?

Long Stretches You Should Do To Unwind From Your Day

Colon Cancer In Young Adults: Early Symptoms You Should Know

Health Benefits Of Eating Dry Fruits Everyday

Are You At Risk For Fried Rice Syndrome?

These Tests Reveal How Well You Are Aging

Lower-Back Exercises You Should Do After A Long-Day's Work

Children’s Diet – What Kids Need To Eat For Immunity Building

Common Diabetes Myths That Could Hurt Your Health

Love Spicy Food? Here’s How It Affects Your Health

Superfood List: Veggies And Fruits You Must Have For Immunity

Foods People With IBS Should Avoid

Exercises To Improve Digestion

Easy Work Lunches You Can Make In The Morning

Hunger Vs Craving: Difference Explained In 60 seconds

These Things Can Cause Your Heart To Age Faster

High Carb Foods That Are Actually Healthy

A daily pill could soon serve as an alternative to Wegovy and Ozempic injections, after a recent trial revealed it helped people with obesity and type 2 diabetes lose significant weight and improve blood sugar control. This new once-a-day tablet, which could be cheaper than injectable treatments, helped participants shed up to 10 per cent of their body weight, according to the study. Researchers note that orforglipron may make these medications more accessible to people who currently cannot afford costly injections. Orforglipron is a GLP-1 agonist, a type of drug that lowers blood sugar, slows digestion, and can reduce appetite. At present, GLP-1 medications are injected by around 2.5 million people in the UK and can cost up to £206 per dose.What Is Orforglipron?Orforglipron (LY3502970) is a small-molecule, non-peptide GLP-1 receptor agonist (GLP-1RA) designed for oral use. Unlike popular GLP-1RAs such as semaglutide, orforglipron does not require injections or fasting to achieve absorption and can be taken without restrictions on water or food, according to Phase 1 pharmacokinetic studies. “Its weight loss and diabetes benefits may not match tirzepatide, but the convenience of a pill could appeal to those who prefer not to inject,” explained Alex Miras, professor of endocrinology at Ulster University, to the Independent.Is Orforglipron Safe To Take?Orforglipron is being studied for safety and effectiveness in treating obesity and type 2 diabetes through ongoing clinical trials by Lilly. Early results are promising, and further data is expected in the first quarter of 2026. It has not yet been approved for use, as per the official page Eli Lilly and Company.Orforglipron PriceEli Lilly has not yet revealed the final price of Orforglipron, as it is still undergoing clinical trials and has not been approved for public use. Analysts anticipate that its cost could be comparable to existing drugs like Zepbound, likely ranging from $400 to $1,000 per month, depending on insurance coverage and market factors.Lancet Study On OrforglipronIn the United States, patients are expected to start taking the pill in early 2026, with a global rollout to follow. A study done by Lancet included 1,444 participants with obesity across 10 countries, given varying doses of the pill or a placebo for comparison. All participants received guidance on healthy eating and exercise and were monitored over 16 months.Participants taking the highest dose, 36mg, lost an average of 9.6 per cent of their body weight. Those on 12mg lost 7 per cent, and those on the lowest dose, 6mg, lost 5.1 per cent. Placebo participants lost 2.5 per cent.The pill not only promoted weight loss but also helped reduce blood sugar levels. The most common side effects were mild to moderate gastrointestinal issues, as per The Indepedent.Researchers highlighted that the pill could be cheaper, does not require cold storage, and can be taken without specific instructions around food or fasting, making it more accessible to a broader population.“Having additional safe and effective weight loss options is a significant step forward,” said Naveed Sattar, professor of cardiometabolic medicine at Glasgow University, to the Independent.“A new oral weight-loss tablet that can be taken alongside other medications without fasting could provide a convenient solution for people with mild to moderate obesity who want to prevent further weight gain,” he added.“Given its safety profile and predicted lower cost, orforglipron could allow many more individuals, with or without diabetes, to access treatment for obesity worldwide,” said senior study author Dr. Deborah Horn, medical director of the Centre for Obesity Medicine at UTHealth Houston.“My hope is that orforglipron will become the ‘metformin’ of obesity—a low-cost, widely accessible, low-risk, and effective medication for obesity and related conditions.”