Riya Baibhawi

Scientists Discover Insulin Molecule With On-Off Switch: Can It Revolutionize Diabetes Treatment?

Insulin

Bioengineers and scientists at Danish pharmaceutical company Novo Nordisk have synthesised an <span>insulin</span> molecule with an "on-and-off switch" that automatically responds to sugar levels in the blood. The synthesised modified molecule, called NNC2215, was tested in pigs and rats and was discovered to be as good as natural insulin in humans. It is yet to be refined enough to be used in humans, but initial findings are promising enough to be extremely similar to the expected observations in humans already. The hope is that smart insulin will address the fluctuation of blood sugar levels and the challenge of matching insulin dosage to sugar levels.

"This is a very good study that was well designed—they did all the necessary experiments to validate that this works,"said David Sacks, a clinical chemist unaffiliated with the study, in a statement accompanying the research. "It certainly provides encouragement that this approach is worth pursuing."

<h2>Why Do We Need This? </h2>Insulin is a hormone that helps the body use sugar for energy. <span>Insulin resistance</span> or impaired insulin sensitivity, happens when cells in your muscles, fat and liver do not respond as they should to insulin. It is a hormone secreted by the pancreas that is essential for life and regulates blood glucose (sugar) levels. It can be temporary or chronic and is treatable in some cases. When your cells become insulin resistant, then it can lead to elevated blood glucose levels (hyperglycemia) which can lead to pre<span><a href="https://www.healthandme.com/health/diabetes">diabetes</a></span> and Type 2 diabetes. It can cause obesity, cardiovascular disease, nonalcoholic fatty liver disease, metabolic syndrome and polycystic ovary syndrome (PCOS). This is where this insulin molecule would help patients.

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Bioengineers and scientists at Danish pharmaceutical company Novo Nordisk have synthesised an insulin molecule with an "on-and-off switch" that automatically responds to sugar levels in the blood. The synthesised modified molecule, called NNC2215, was tested in pigs and rats and was discovered to be as good as natural insulin in humans. It is yet to be refined enough to be used in humans, but initial findings are promising enough to be extremely similar to the expected observations in humans already. The hope is that smart insulin will address the fluctuation of blood sugar levels and the challenge of matching insulin dosage to sugar levels."This is a very good study that was well designed—they did all the necessary experiments to validate that this works,"said David Sacks, a clinical chemist unaffiliated with the study, in a statement accompanying the research. "It certainly provides encouragement that this approach is worth pursuing."Why Do We Need This? Insulin is a hormone that helps the body use sugar for energy. Insulin resistance or impaired insulin sensitivity, happens when cells in your muscles, fat and liver do not respond as they should to insulin. It is a hormone secreted by the pancreas that is essential for life and regulates blood glucose (sugar) levels. It can be temporary or chronic and is treatable in some cases. When your cells become insulin resistant, then it can lead to elevated blood glucose levels (hyperglycemia) which can lead to prediabetes and Type 2 diabetes. It can cause obesity, cardiovascular disease, nonalcoholic fatty liver disease, metabolic syndrome and polycystic ovary syndrome (PCOS). This is where this insulin molecule would help patients.