Simran Arora

Can Vitamin D Deficiency Affect IVF Success Rate? Experts Weigh In

IVF (1)

New Delhi: In a world where many are struggling with stress, work pressure, competition at school, and more, it does not come as a shocker that <a href="https://www.healthandme.com/health/infertility">infertility</a> has become too common. Couples often struggle to become parents, and that not only causes emotional stress but also takes a toll on relationships. But thanks to medical advancements, there are procedures like in vitro fertilisation (<a href="https://www.healthandme.com/health-wellness/before-you-start-ivf-7-critical-factors-you-must-consider-article-151409413" data-type="tilCustomLink" target="_blank">IVF</a>) that make parenthood possible despite the many curveballs that infertility throws in the way. And with the precision that AI brings to the table, doctors have upped IVF success rates. But in some cases, even vitamin D deficiency can come in the way of a successful IVF treatment.

Read more: <a href="https://www.healthandme.com/health-wellness/the-overlooked-role-of-men-in-ivf-why-their-silent-strength-is-key-to-fertility-success-article-152310400" data-type="tilCustomLink" target="_blank">The Overlooked Role of Men in IVF: Why Their Silent Strength Is Key to Fertility Success</a>

<h2>What is vitamin D deficiency?</h2>

Vitamin D, or the sunshine vitamin, is one of the most important nutrients that one needs for a healthy life. It influences mental health, bone and teeth strength, and, as it turns out, fertility as well. An extremely common occurrence in India, it is often seen in women of reproductive age. But can it also affect IVF success rates? Let's find out.

Dr. Kirti Singh, MBBS, MD, DNB (Obs &amp; Gyn), Fellowship in Reproductive Medicine, Clinical Consultant, Aksigen IVF, interacted with Times Now Digital and explained how vitamin D affects women's health.

"Vitamin D is well known for maintaining calcium metabolism and bone health. Apart from that, emerging scientific evidence suggests that vitamin D may influence several pathways relevant to fertility, including ovarian function, endometrial receptivity, hormone regulation, and immune balance within the uterus. Vitamin D receptors (VDRs) are expressed in female reproductive tissues, including the ovaries, uterus, and placenta, hence having a significant impact on female fertility. Vitamin D supplementation has also been shown to have a positive effect on AMH expression. There are studies showing a positive correlation between follicular fluid (vitamin D levels) and fertilization rate. It is also known to regulate the expression of the HOXA10 gene, which helps in implantation," said Dr. Singh.

<h3>How does vitamin D deficiency affect fertility in women?</h3>

Dr. Nidhi Saluja, Centre Clinical Director, Indira IVF Hospital Limited, Gurugram, said, "Vitamin D deficiency is increasingly being recognised as an important consideration in female reproductive health, including in the context of assisted reproduction. Emerging clinical evidence suggests that low vitamin D is not merely an associated finding in infertility but a factor that may influence how ovaries function, how embryos implant, and how pregnancies progress. Since vitamin D receptors are present in reproductive tissues such as the ovaries, endometrium, and placenta, its role appears to extend beyond bone health into key aspects of fertility and reproductive support."

Read more: <a href="https://www.healthandme.com/health-wellness/world-ivf-day-what-makes-the-ivf-journey-so-hard-on-the-mind-article-152344593" data-type="tilCustomLink" target="_blank">What Makes The IVF Journey So Hard On The Mind?</a>

The expert went on to say that this becomes particularly relevant for women undergoing IVF, where factors such as ovarian function, embryo implantation, and endometrial receptivity are all important to treatment outcomes. Evidence suggests that women with sufficient vitamin D levels tend to show better implantation rates, improved embryo quality, and healthier endometrial receptivity. In clinical practice, low vitamin D is also often seen alongside diminished ovarian reserve and suboptimal ovarian response, especially in women already managing hormonal or metabolic challenges.

"Vitamin D status deserves greater attention as part of a comprehensive fertility assessment. While it should not be viewed as the sole determinant of IVF success, it may represent a potentially modifiable factor within broader fertility care. Identifying and addressing deficiency before conception or IVF can therefore help support a more informed and holistic treatment approach, particularly in women facing declining ovarian reserve or complex endocrine profiles," Dr. Saluja added.

What are the best sources of vitamin D?

Our main source of vitamin D, a fat-soluble steroid hormone, is sunlight. Only a small amount is obtained from our diet. In food, it is obtained from natural sources like eggs, fish, mushrooms, cod liver oil, green vegetables, yogurt, and milk. While vitamin D deficiency alone may not be the sole determinant of IVF success, studies increasingly indicate that correcting metabolic and nutritional imbalances can contribute to a healthier reproductive environment.

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Vitamin D Deficiency

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infertility

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New Delhi: In a world where many are struggling with stress, work pressure, competition at school, and more, it does not come as a shocker that infertility has become too common. Couples often struggle to become parents, and that not only causes emotional stress but also takes a toll on relationships. But thanks to medical advancements, there are procedures like in vitro fertilisation (IVF) that make parenthood possible despite the many curveballs that infertility throws in the way. And with the precision that AI brings to the table, doctors have upped IVF success rates. But in some cases, even vitamin D deficiency can come in the way of a successful IVF treatment.Read more: The Overlooked Role of Men in IVF: Why Their Silent Strength Is Key to Fertility SuccessWhat is vitamin D deficiency?Vitamin D, or the sunshine vitamin, is one of the most important nutrients that one needs for a healthy life. It influences mental health, bone and teeth strength, and, as it turns out, fertility as well. An extremely common occurrence in India, it is often seen in women of reproductive age. But can it also affect IVF success rates? Let's find out.Dr. Kirti Singh, MBBS, MD, DNB (Obs & Gyn), Fellowship in Reproductive Medicine, Clinical Consultant, Aksigen IVF, interacted with Times Now Digital and explained how vitamin D affects women's health."Vitamin D is well known for maintaining calcium metabolism and bone health. Apart from that, emerging scientific evidence suggests that vitamin D may influence several pathways relevant to fertility, including ovarian function, endometrial receptivity, hormone regulation, and immune balance within the uterus. Vitamin D receptors (VDRs) are expressed in female reproductive tissues, including the ovaries, uterus, and placenta, hence having a significant impact on female fertility. Vitamin D supplementation has also been shown to have a positive effect on AMH expression. There are studies showing a positive correlation between follicular fluid (vitamin D levels) and fertilization rate. It is also known to regulate the expression of the HOXA10 gene, which helps in implantation," said Dr. Singh.  How does vitamin D deficiency affect fertility in women?Dr. Nidhi Saluja, Centre Clinical Director, Indira IVF Hospital Limited, Gurugram, said, "Vitamin D deficiency is increasingly being recognised as an important consideration in female reproductive health, including in the context of assisted reproduction. Emerging clinical evidence suggests that low vitamin D is not merely an associated finding in infertility but a factor that may influence how ovaries function, how embryos implant, and how pregnancies progress. Since vitamin D receptors are present in reproductive tissues such as the ovaries, endometrium, and placenta, its role appears to extend beyond bone health into key aspects of fertility and reproductive support."Read more: What Makes The IVF Journey So Hard On The Mind?The expert went on to say that this becomes particularly relevant for women undergoing IVF, where factors such as ovarian function, embryo implantation, and endometrial receptivity are all important to treatment outcomes. Evidence suggests that women with sufficient vitamin D levels tend to show better implantation rates, improved embryo quality, and healthier endometrial receptivity. In clinical practice, low vitamin D is also often seen alongside diminished ovarian reserve and suboptimal ovarian response, especially in women already managing hormonal or metabolic challenges."Vitamin D status deserves greater attention as part of a comprehensive fertility assessment. While it should not be viewed as the sole determinant of IVF success, it may represent a potentially modifiable factor within broader fertility care. Identifying and addressing deficiency before conception or IVF can therefore help support a more informed and holistic treatment approach, particularly in women facing declining ovarian reserve or complex endocrine profiles," Dr. Saluja added.What are the best sources of vitamin D?Our main source of vitamin D, a fat-soluble steroid hormone, is sunlight. Only a small amount is obtained from our diet. In food, it is obtained from natural sources like eggs, fish, mushrooms, cod liver oil, green vegetables, yogurt, and milk. While vitamin D deficiency alone may not be the sole determinant of IVF success, studies increasingly indicate that correcting metabolic and nutritional imbalances can contribute to a healthier reproductive environment.