Hepatic encephalopathy (HE) is a serious condition that highlights the intricate connection between the gut, live, and brain. This develops when toxins, especially ammonia, accumulate in the body due to liver malfunction. It is defined as a spectrum of neuropsychiatric abnormalities. As per the American Liver Foundation, 70% of individuals with cirrhosis may develop symptoms of HE. The gut microbiome is a diverse community of microbes living in the digestive system. It plays a vital role in maintaining overall health. But when the balance is disrupted, certain microbes can overproduce ammonia and it could convert into urea, which is excrete through urine.

So when does the problem occur? The real problem arise when the liver is damaged due to cirrhosis. It is a chronic liver disease that occurs when healthy live tissue is replaced by scar tissue. Under such condition, the liver struggles to remove excess ammonia and it allows it to circulate in the bloodstream and reach the brain. This also creates a cascade of symptoms, which also leads to confusion, disorientation, mood swings, hallucinations, and personality changes.

What Causes HE?

It exists at the intersection of gut, liver, and brain, also referred to as the gut-liver-brain axis. When the liver fails to act as the primary detoxifier of the bodies and fails to remove the toxins from gut it can lead to a "leaky gut". This happens when bacteria and toxins pass through the intestinal lining and trigger inflammation. This then impacts the blood brain barrier (BBB), which is designed to protect the brain from harmful substances. As a result, cognitive and behavioral impairments occur.

READ: The Connection Between Your Diet And Your Digestive Health

How Can It Be Treated?

Traditionally, there were antibiotics which were in use to treat HE, which targeted ammonia, producing microbes in the gut. However, as and when the studies have improved, less invasive approach involved probiotics.

So does it mean what lives in your gut could fix this? This might be true. Probiotics by restoring balance in the gut microbiome promotes the growth of microbes that produce less ammonia. However, here too, there are chances of relapses.

But the answer is still in your gut!

A new treatment involves fecal microbiota transplantation (FMT), which transplants gut microbes from a healthy donor into the patient. Though it is not the most conventional method, it has shown success in treating recurrent HE.

Also Read: Fecal Treatment Can Treat Cancer: Know Everything About It

What happens in FMT is that it allows beneficial bacteria to establish dominance in the gut. It also reduces ammonia production and restores balance.

FMT works by introducing anti-inflammatory microbes such as Bifidobacteria, Lachnospira, and Ruminococcus into the patient’s gut. These microbes produce butyrate, a compound that nourishes the gut lining and reduces inflammation. They also help displace harmful ammonia-producing microbes, breaking the cycle of toxin buildup and inflammation.

The results too are while positive, but could be dramatic as the patients who were previously impaired by HE also experienced rapid improvements in cognitive function and mood.

As we step closer to 2026, let us look at what healthcare trends could shape the upcoming year. The 2026 healthcare trend will follow or shape on challenges that 2025 threw on us, these included a surge in lifestyle diseases, continuous cases of non communicable diseases, which are preventable, and a rise in infectious diseases. Based on them, the predictions of 2026 healthcare trends can be made.

Preventive Care Will Matter The Most

In 2026, healthcare will look most at prevention. As a significant portion of diseases, like the NCDs or the non communicable diseases, which also include half of all the cancers are preventable. This includes changes in lifestyle habits, including food habits, dietary fiber intake, exercise, and maintaining a regular sleep cycle.

Careful Use Of GLP-1 Medication

2025 saw a surge in the use of GLP-1 medication, however, this year also saw many reported unusual side effects of the medication. The year 2026 will emphasize more on the correct use of the medication, as well as, what areas must one pay heed to, especially after the medications have been stopped.

Also Read: These Are The 7 Common Mistakes People Make After Stopping Their Weight Loss Jabs

Shift In Patient Coverage

In the US, new changes have been done in Medicaid and its eligibility, which might change the rules on potential expiration of advanced premium tax credits. This may mean that many patients could become uninsured, or underinsured. Moreover, other changes in the coverage may include GLP-1 medication, as on November 6 of 2025, President Trump announced deals with Eli Lilly and Novo Nordisk slashed prices and brought coverage to eligible beneficiaries for just a $50 copay, down from $1,000 per month, out of the pocket.

DIY Skincare

Experts, like board-certified plastic surgeon John Diaz, MD, tells Cosmopolitan that 2026 will see a rise in DIY skincare trends. This would be making skincare products yourself, which could include yogurt face masks, to kitchen-sink sunscreen. However experts have pointed out that products which are not backed by science or have used ingredients without a correct measure could do more harm than good to the skin. “Many people who tried DIY skincare found these treatments to be inconsistent or ineffective. At the end of the day, consumers want efficacy, which drives them towards products formulated with scientifically proven ingredients," says the doctor.

Annual Testing To Become A Norm

In 2025, there were many cases of young people experiencing strokes and hear attacks. This has shifted the conversation on annual testing, regular screenings, and blood works for people who may fit the traditional definition of "healthy". Many people under the age of 40 have also reported cancer, which is what makes early screenings, annual testing, and blood work more important to ensure that everything in the body is working smoothly.

Read: 5 Tests Your GP Isn’t Ordering, But Could Spot A Disease Even Before Symptoms Appear, According to Doctor

While getting checked once a year is not a new concept, however, it was mostly common in older adults, but now more young adults are also now considering getting annual tests done, as they are easily available and can help detect severe illness early.

You May Like To Read: Did Scientists Just Come Up With A New Blood Test That Detects And Monitors Lung Cancers In Real Time?

The so-called “mystery virus” behind lingering sore throats, blocked noses filled with mucus, and days of exhaustion is actually well known to doctors. According to Eric Sachinwalla, medical director of infection prevention and control at Jefferson Health, the culprit is adenovirus.

What makes this virus particularly difficult to control is how tough it is. Adenovirus can survive soap and water, withstand many everyday disinfectants, and linger on contaminated surfaces for long stretches of time. Below is what experts know so far about this fast-spreading infection.

What Is Adenovirus?

Adenovirus refers to a group of common viruses that usually trigger cold- or flu-like illness. It spreads easily because it is far more resilient than many other viruses. Ordinary soap, water, and standard disinfectants do not reliably destroy it, allowing it to persist in the environment. As a result, infections often cluster in places where people spend time close together, such as daycares and military barracks. The virus spreads through the respiratory tract, can be shed in stool, and can survive for some time on contaminated surfaces, according to the CDC.

Adenovirus: What Are The Symptoms Of Adenovirus?

“Adenovirus is a typical virus that causes common cold or flu-like symptoms,” says Dr Deborah Lee at Dr Fox Online Pharmacy. That does not mean adenovirus is the same as a cold. Instead, adenovirus is one of many germs that can cause cold-like illness. A simple way to think about it is that a “cold” describes the symptoms, while adenovirus is one specific virus that can lead to them.

Symptoms can vary depending on the subtype involved. While there are more than 100 known subtypes, only 49 infect humans. Dr Lee notes that people may experience any of the following:

• Fever
• Runny nose
• Sore throat
• Swollen cervical lymph nodes in the neck
• Cough
• Shortness of breath
• Conjunctivitis
• Ear pain
• Diarrhoea
• Vomiting
• Stomach pain
• Urinary tract infection

Adenovirus? Is It Contagious?

“Adenovirus infection is highly contagious,” Dr Lee explains. “It spreads by breathing in infected droplets, by touching the virus and then rubbing the eyes, or through the faecal-oral route, often due to poor hand hygiene after using the toilet.”

She adds that the virus spreads quickly in crowded settings where people are in close contact. To eliminate adenovirus from surfaces, Dr Lee recommends stronger cleaning agents such as bleach-based solutions or hydrogen peroxide. “The virus is resistant to soap and many commonly used cleaners,” she says.

To reduce the risk of catching adenovirus or other respiratory infections currently circulating, Dr Lee advises staying away from people who are unwell. She also suggests the following precautions:

• Avoid touching your face and nose
• Use a clean tissue to blow your nose and dispose of it immediately
• Wash your hands often with soap and warm water, then dry them thoroughly, especially after using the toilet or changing nappies
• Clean children’s toys regularly
• Disinfect worktops, changing areas, toilets, and bathrooms
• Avoid sharing cups, plates, food, or towels
• Wear a mask if you need to go out while unwell
• Keep windows open and ensure rooms and workspaces are well ventilated.

As we soon step into 2026, it is time to look back at which diseases took over the world in 2025. These diseases evolved throughout the year, and led to complex challenges. Here, we explore the top 5 health crisis in 2025.

Infectious Diseases, Outbreaks, and COVID-19

This year, COVID-19 continued to make headlines, along with COVID, flu and measles too continued to infect people. In fact, new variants of COVID and flu have circulated across the world, leading to new kinds of symptoms, including razor-blade like throats in COVID-19. Influenza too surged up across US, UK, and Canada, with hospitalization rates going up. A new subclade K strain is seen responsible for this surge. Measles, too is a highly contagious, however, vaccine-preventable respiratory virus resurged this year, and this disease, which was once eliminated from the US, has come back due to lower rates of vaccination.

Tuberculosis Outbreak

A tuberculosis outbreak in the Kansas City metro area resulted in dozens of cases. This has led to two deaths, as reported by the Kansas Department of Health and Environment (KDHE). In fact, Michael A Bernstein, MD, director of pulmonary and critical care at Stamford Health said that many people assume that TB is rare and no longer a concern, however, it still remains common.

Also Read: Top 5 Infectious Diseases That Disrupted Healthcare System Worldwide In 2025

Bird Flu

In the US, the first death from bird flu was reported by the Louisiana Department of Health. The Centers for Disease Control and Prevention (CDC) reported that the individual was older than 65 years and had underlying medical conditions. That person developed severe illness and was hospitalized following the exposure to a noncommercial backyard flock and wild word. In fact, new studies have shown that bird flu viruses could have a potential risk for humans and may become next pandemic. This comes from two different studies, one done by the universities of Cambridge and Glasgow that show how avian flu strains are multiplying even when the body temperatures could hinder viruses. Whereas, another important study led by Indian scientists, by Philip Cherian and Gautam Menon of Ashoka University, published in BMC Public Health predict if H5N1 or the bird flu virus, could start spreading among humans.

Antimicrobial Resistance (AMR)

In 2025, AMR has worsened and the resistance has risen over 40% of monitored pathogen-antibiotic pairs between 2018-2023. Due to the resistance, common infections become harder to treat, especially in regions like Southeast Asia, with India facing high rates. The World Health Organization (WHO) report notes that AMR is a growing threat to global health, and draws on more than 23 million bacteriologically confirmed cases of bloodstream infections, urinary tract infections, gastrointestinal infections, and urogenital gonorrhoea.

Non Communicable Diseases or NCDs

NCDs like heart disease, cancer, diabetes, and respiratory illnesses remained a persistent global health challenge in 2025. Trends to showed a continued rise driven by unhealthy lifestyles, which included processed food, inactivity, tobacco or alcohol, and urbanization.