American TV personality Oprah Winfrey turned heads at the Paris Fashion Week with her slim figure and sparked talks on the popular weight-loss drug Ozempic. The now viral videos show Oprah, 72, in jeans and a jacket. Usually seen in parted hair, Oprah also resorted to a ponytail and was wearing tinted sunglasses. While several netizens expressed concerns about her health, others also spoke about the effects of Ozempic, widely used for weight loss. “What in the Ozempic Oprah is going on here?”, wrote a user. “I'm afraid Oprah may OD on Ozempic. Welfare check, please!” another added. People also commented on the seemingly bigger head and frail body. “Her head looks way too big for her body. Is it Ozempic or Oprah?” wrote a user. “She looked good, but she seemed frail,” the netizens said, while another stated, “But having a head that big still is crazy”. The video also showed Gayle King, another TV host and a longtime friend of Oprah, with a lean figure. Gayle, 71, also rocked a warm-brown look, paired with a fitted top and a black leather jacket. Does Oprah Winfrey Take Ozempic? Oprah has openly shared the use of a GLP-1 agonist for weight loss. However, she never mentioned any brand names. “One of the things that I realized the very first time I took a GLP-1 was that all these years I thought that thin people just had more willpower, they ate better foods, they were able to stick to it longer, they never had a potato chip, and then I realized the very first time I took the GLP-1 that, 'Oh, they're not even thinking about it. They're only eating when they're hungry, and they're stopping when they're full,” Oprah said in a podcast early in 2025. In 2023, speaking to People, she said she uses the weight-loss medication as a tool to quiet the food noise. “I now use it as I feel I need it, as a tool to manage not yo-yoing. It quiets the food noise,” she had told the publication. Oprah's Strength Training Session In an Instagram post in February 2026, Oprah also showcased her strength training evolution, highlighting the benefits of daily workouts for bone health and her impressive plank progress. She told her fans that while in 2024, she struggled to hold a plank for more than 10 seconds, now she manages to do a 1-minute plank routine. Can Ozempic Really Help You Lose Weight?While Ozempic was originally developed and FDA-approved as an injectable medication to help manage type 2 diabetes, it has gained immense popularity for its ability to produce significant weight loss.The drug is popular for its active ingredient, semaglutide, which works by mimicking a hormone that regulates blood sugar and appetite. However, there are several concerns over its side effects. The loss of lean mass, which includes muscle, has emerged as the biggest concern.Studies have proven that it provides significant weight loss and also reduces major cardiovascular risks and boosts kidney health, among others. However, common side effects include:gastrointestinal (nausea, vomiting, diarrhea, constipation), pancreatitis, gallbladder issues, face sagging dental issues like tooth decay, erosion.