As avian flu cases soar in US livestock, public health organizations call for urgent surveillance and prevention efforts to check the menace of a possible zoonotic pandemic. Highly pathogenic avian influenza H5N1 has continued to spread throughout the United States, infecting both poultry and cattle now. The U.S. Department of Agriculture (USDA) has reported more than 1,009 H5N1 detections in 17 states as of April 2025, including new cases in California and Idaho.For the first time, the virus is sweeping American dairy cattle, a major departure from its normal avian hosts. New outbreaks have also been confirmed in live bird markets in New York and backyard poultry in New Mexico, showing the rapid spread of the virus in commercial and rural areas.The crisis fuels worldwide alarm, with veterinarians and infectious disease specialists warning that unchecked transmission among mammals could raise the risk of human-to-human spread, potentially igniting a future pandemic.From Birds to Cows—and Now Humans is There A Dangerous Mutation?H5N1 has been widely circulating among wild birds for a long time, but the virus's leap to dairy cows in early 2024 was a watershed moment in zoonotic transmission. Infected states' cows showed symptoms like fever, decreased milk yield, coughing, drooling, and lethargy—puzzling symptoms later linked to avian flu.The experts suspect that the virus is being transmitted through milking machines, especially auto-milkers, that can transfer traces of the virus from one cow to another. The disease has already infected dairy plant workers, with 70 cases reported in the United States, mostly among farmworkers. Most had mild illnesses, but a death did result in Louisiana in a patient who had some underlying conditions.A total of all states except two reported H5N1 infection in cattle, poultry, or individuals between February 2024 and February 2025. Delays in Response Is AlarmingAlthough the threat was serious, federal agencies have moved slowly, critics say. It took the USDA more than a month to require testing of cattle prior to interstate movement and ten months to launch a raw milk testing program. Even today, testing procedures continue to be irregular, with some states testing on a weekly basis and others participating hardly at all.This delay has attracted ire from virologists and veterinarians who contend that early and forceful action might have contained the spread more effectively, given H5N1's established virulence and pandemic potential.WHO New Global Surveillance Guidelines IssuedThe World Health Organization (WHO) on April 11, 2025, released revised surveillance guidelines for the detection of human infections of H5 avian influenza viruses. These are intended to boost global readiness, facilitate early detection and response, and augment pandemic readiness.Under WHO's new guidance, nations are required to inform the agency within 24 hours of the occurrence of any laboratory-confirmed human case of a new subtype of the virus. The guidelines also stress data openness and solicit greater surveillance activities, particularly in areas with heightened livestock-human interaction.Locally, the Centers for Disease Control and Prevention (CDC) still rates the risk to the general population as low since human-to-human transmission has not yet been established. The CDC, however, observes that the virus is undergoing genetic evolution, which poses concern regarding potential mutations in the future that may alter its behavior.In the meantime, the CDC has provided explicit PPE guidelines for farmworkers, such as respirators and eye protection, to avoid airborne and droplet transmission. The agency is also increasing testing, although difficulties remain due to the large percentage of undocumented farmworkers who will avoid testing for fear of legal consequences.Is the Food Supply Safe?Even with the commonality of H5N1 among poultry and cattle, there are no reported infections from the American food supply. The CDC still recommends basic food safety practices to reduce any risk that may exist:Cook chicken and eggs to 165°F (73.9°C)Ground beef must be cooked to 160°F (71.1°C)Whole beef cuts need to be cooked to 145°F (62.8°C)Raw milk and milk products that contain it, like unpasteurized cheese or yogurt, are highly not recommended due to their danger not only for bird flu but for other foodborne pathogens, like Listeria.Is There a Bird Flu Vaccine?No FDA-approved H5N1 vaccine exists for humans, though five candidate virus strains have been produced for possible use. The U.S. government has purchased 4.8 million doses of an experimental vaccine in preparation for a future outbreak with ongoing human-to-human transmission.Internationally, Sinergium Biotech in Argentina, in partnership with the WHO, is developing an mRNA-based H5N1 vaccine, based on the successful platform utilized for COVID-19 vaccines. This effort will provide equitable access to low- and middle-income countries, where infrastructure for pandemic preparedness may not be present.In poultry, although vaccines do exist, they are not commonly used in the U.S. because of export bans by trading partners that refuse to accept imported vaccinated birds.How to Avoid Bird Flu?For the general public, the most effective defense against H5N1 is still preventive action. This includes:Avoiding contact with ill or dead animalsReporting unusual wildlife or livestock deaths to local authoritiesPracticing safe food handlingAvoiding eating raw or unpasteurized dairy productsHealthcare professionals emphasize the importance of public awareness, early reporting, and responsible food handling as essential measures to prevent broader transmission.