Health and Me

Tanya Dutt

Man With Diabetes Produces Own Insulin After World’s First Gene-Edited Cell Transplant

A 42- year-old man with type 1 diabetic begna making his own insulin without daily shots or anti-rejection medication. The breakthrough, published in the New England Journal of Medicine, is being hailed as the most promising advancement on the way to a functional cure for type 1 <span><a href="https://www.healthandme.com/health/diabetes">diabetes</a></span>, an autoimmune disease that afflicts nearly 9.5 million people globally. It signaled the start of a diabetes revolution. For the first time, researchers have been able to transplant genetically modified islet cells into a human patient, allowing the body to produce insulin naturally and prevent immune rejection—a hurdle that has hampered advances for decades.

Type 1 diabetes develops when the immune system attacks and destroys the pancreatic islet cells that make insulin. In its absence, the body is unable to control blood sugar, and patients must depend on man-made insulin injected or pumped into the body.

Although insulin therapy is life-saving, it cannot duplicate the body's subtle sensitivity to provide insulin in anticipation of meals. That leaves even the most compliant patients with wild swings in blood glucose that heighten long-term risks of heart disease, kidney failure, and nerve damage.

Scientists have been working for a long time to replace natural insulin production with islet cell transplants. But there has always been one obstacle: rejection. The immune system is programmed to recognize donor cells as foreign and destroy them. To avoid this, recipients of transplants have to take immunosuppressive drugs for the rest of their lives. The drugs are effective, but they expose patients to infections, cancer, and organ injury—a trade-off that has kept cell transplantation from becoming mainstream.

<h2>Insulin Production Without Immune Suppression</h2>

For this new patient, who was diagnosed with type 1 diabetes at the age of 5, a healthy donor islet cells were given. Rather than injected into the pancreas, the cells were given through a series of injections into the muscle of his forearm. This made it easier for doctors to check on the graft and lower surgical risks.

During the 12-week period, the transplanted cells started secreting insulin when there were high levels of glucose, like after meals. Most significantly, the patient did not need any immunosuppressant medications. His immune system merely left the cells alone—a feat that had never previously been achieved in humans.

<h2>What Role CRISPR Gene Editing Play?</h2>

The breakthrough was dependent on genetic engineering. Scientists applied the CRISPR gene-editing mechanism to make three critical modifications to the cells before they were transplanted:

Diminishing immune "flags": Two edits reduced amounts of antigens that T cells typically employ to recognize foreign cells.

Augmenting defense with CD47: The third edit boosted levels of CD47, a protein assigned the codename "don't eat me" signal, which deters natural killer cells and macrophages from targeting.

Surprisingly, not every cell got the full complement of edits. The unedited ones were rapidly killed by the immune system. The partially edited cells survived a bit longer but were eventually rejected. Only the fully edited cells persisted—and they were the ones that achieved the successful production of insulin. This natural experiment within the body of the patient proved that the three-edit approach was the solution.

<h2>How This Means Future of Diabetes Treatment Is Closer Than Ever?</h2>

Even though the patient was given a modest amount of the engineered cells and still needs daily insulin, the outcome is a proof of concept that cell transplants are possible without immunosuppression. That in itself is a game changer.

If additional research verifies the longevity and safety of this method, it may drastically increase access to islet cell transplantation. Patients would be able to obtain more stable blood sugar levels, lowering complications and enhancing quality of life. Larger grafts or multiple transplants over time may even render insulin treatment obsolete.

The breakthrough follows a wave of experimental treatments for type 1 diabetes. In 2022, a woman in China underwent insulin-producing cells derived from her own stem cells, which made her able to sustain stable blood glucose without injections for months. Gene-edited islet cells have also produced encouraging results in animal trials.

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A 42- year-old man with type 1 diabetic begna making his own insulin without daily shots or anti-rejection medication. The breakthrough, published in the New England Journal of Medicine, is being hailed as the most promising advancement on the way to a functional cure for type 1 diabetes, an autoimmune disease that afflicts nearly 9.5 million people globally. It signaled the start of a diabetes revolution. For the first time, researchers have been able to transplant genetically modified islet cells into a human patient, allowing the body to produce insulin naturally and prevent immune rejection—a hurdle that has hampered advances for decades.Type 1 diabetes develops when the immune system attacks and destroys the pancreatic islet cells that make insulin. In its absence, the body is unable to control blood sugar, and patients must depend on man-made insulin injected or pumped into the body.Although insulin therapy is life-saving, it cannot duplicate the body's subtle sensitivity to provide insulin in anticipation of meals. That leaves even the most compliant patients with wild swings in blood glucose that heighten long-term risks of heart disease, kidney failure, and nerve damage.Scientists have been working for a long time to replace natural insulin production with islet cell transplants. But there has always been one obstacle: rejection. The immune system is programmed to recognize donor cells as foreign and destroy them. To avoid this, recipients of transplants have to take immunosuppressive drugs for the rest of their lives. The drugs are effective, but they expose patients to infections, cancer, and organ injury—a trade-off that has kept cell transplantation from becoming mainstream.Insulin Production Without Immune SuppressionFor this new patient, who was diagnosed with type 1 diabetes at the age of 5, a healthy donor islet cells were given. Rather than injected into the pancreas, the cells were given through a series of injections into the muscle of his forearm. This made it easier for doctors to check on the graft and lower surgical risks.During the 12-week period, the transplanted cells started secreting insulin when there were high levels of glucose, like after meals. Most significantly, the patient did not need any immunosuppressant medications. His immune system merely left the cells alone—a feat that had never previously been achieved in humans.What Role CRISPR Gene Editing Play?The breakthrough was dependent on genetic engineering. Scientists applied the CRISPR gene-editing mechanism to make three critical modifications to the cells before they were transplanted:Diminishing immune "flags": Two edits reduced amounts of antigens that T cells typically employ to recognize foreign cells.Augmenting defense with CD47: The third edit boosted levels of CD47, a protein assigned the codename "don't eat me" signal, which deters natural killer cells and macrophages from targeting.Surprisingly, not every cell got the full complement of edits. The unedited ones were rapidly killed by the immune system. The partially edited cells survived a bit longer but were eventually rejected. Only the fully edited cells persisted—and they were the ones that achieved the successful production of insulin. This natural experiment within the body of the patient proved that the three-edit approach was the solution.How This Means Future of Diabetes Treatment Is Closer Than Ever?Even though the patient was given a modest amount of the engineered cells and still needs daily insulin, the outcome is a proof of concept that cell transplants are possible without immunosuppression. That in itself is a game changer.If additional research verifies the longevity and safety of this method, it may drastically increase access to islet cell transplantation. Patients would be able to obtain more stable blood sugar levels, lowering complications and enhancing quality of life. Larger grafts or multiple transplants over time may even render insulin treatment obsolete.The breakthrough follows a wave of experimental treatments for type 1 diabetes. In 2022, a woman in China underwent insulin-producing cells derived from her own stem cells, which made her able to sustain stable blood glucose without injections for months. Gene-edited islet cells have also produced encouraging results in animal trials.

man with diabetes produces own insulin after world’s first gene-edited cell transplant

Aarushi Bhadury

'Stop All Use Of Magnesium Gummies For Kids - Says UK Government

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Due to the massive popularity of <span>magnesium</span> and its potential health benefits, many parents had incorporated it into their kid’s consumption as well. However, the <span>UK government</span> has asked for parents and caregivers to immediately stop giving Nutrition Ignition Kids Magnesium Glycinate Gummies to children. 

The Medicines and Healthcare products Regulatory Agency (MHRA) found an unlisted medicine, melatonin, in the product. It's important to safely throw away any gummies you have left and to talk to a doctor if you're worried about your child's health. 

<h2>Why Do You Need To Stop Giving These Supplements? </h2>

The MHRA discovered that the gummies, sold online as a food supplement, contain melatonin, even though it is not on the label. Each gummy has 1.5 to 1.7 milligrams of melatonin. This is a lot, especially since the recommended starting dose for children who need melatonin is only 1 milligram. The gummies were marketed for "calm, focus, and digestion" for kids ages four and older, but they contain a powerful, unlisted drug. 

<h2>What Are The Potential <span rel="noindex">Side Effects of The Magnesium Supplements</span>? </h2>

Taking too much melatonin can cause side effects like drowsiness, headaches, dizziness, and nausea. While these issues are not expected to cause lasting harm and the body typically clears the drug within 12 hours, the MHRA has already removed the product from online stores. Dr. Alison Cave, the MHRA's Chief Safety Officer, also pointed out that other possible side effects from melatonin in children can be hyperactivity and stomach pain. 

<h2>What Is The Safest Way To Dispose The Supplements? </h2>

It is very important that you do not throw these gummies in the regular trash. Instead, you should store them securely in a container that children cannot open and keep them out of their reach. When you can, take the gummies to any local pharmacy for safe disposal. If you think your child had a bad reaction to the product, stop giving it to them right away and talk to a doctor. You can also report the side effect to the MHRA's Yellow Card scheme. 

Magnesium

Magnesium Gummies

Magnesium Gummies For Kids

Magnesium supplements

UK Government

Side Effects of The Magnesium Supplements

Due to the massive popularity of magnesium and its potential health benefits, many parents had incorporated it into their kid’s consumption as well. However, the UK government has asked for parents and caregivers to immediately stop giving Nutrition Ignition Kids Magnesium Glycinate Gummies to children. The Medicines and Healthcare products Regulatory Agency (MHRA) found an unlisted medicine, melatonin, in the product. It's important to safely throw away any gummies you have left and to talk to a doctor if you're worried about your child's health. Why Do You Need To Stop Giving These Supplements? The MHRA discovered that the gummies, sold online as a food supplement, contain melatonin, even though it is not on the label. Each gummy has 1.5 to 1.7 milligrams of melatonin. This is a lot, especially since the recommended starting dose for children who need melatonin is only 1 milligram. The gummies were marketed for "calm, focus, and digestion" for kids ages four and older, but they contain a powerful, unlisted drug. What Are The Potential Side Effects of The Magnesium Supplements? Taking too much melatonin can cause side effects like drowsiness, headaches, dizziness, and nausea. While these issues are not expected to cause lasting harm and the body typically clears the drug within 12 hours, the MHRA has already removed the product from online stores. Dr. Alison Cave, the MHRA's Chief Safety Officer, also pointed out that other possible side effects from melatonin in children can be hyperactivity and stomach pain. What Is The Safest Way To Dispose The Supplements? It is very important that you do not throw these gummies in the regular trash. Instead, you should store them securely in a container that children cannot open and keep them out of their reach. When you can, take the gummies to any local pharmacy for safe disposal. If you think your child had a bad reaction to the product, stop giving it to them right away and talk to a doctor. You can also report the side effect to the MHRA's Yellow Card scheme. 

Stop All Use Of Magnesium Gummies For Kids - Says UK Government

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Ishita Roy

Nepal Achieves Rubella Elimination By WHO, Know All About It Here

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<span>Nepal</span> has officially been verified for rubella elimination. This makes it a milestone in global public health and putting the country among six in the World Health Organization’s (<span>WHO</span>) South-East Asia Region to achieve this feat. 

The announcement was made at the 10th meeting of the Regional Verification Commission for Measles &amp; Rubella Elimination, held from July 22 to 24, 2025, where progress across all 10 member states was reviewed.

The WHO has set 2026 as the target year to eliminate both measles and rubella from the region, a goal it described as ambitious but attainable if countries sustain momentum and strengthen cooperation.

Nepal’s achievement was the result of decades of determined efforts, robust immunization campaigns, and innovative community-level outreach. 

The country introduced the rubella-containing vaccine in 2012 through a nationwide campaign that reached children between nine months and 15 years of age. 

In 2016, a second dose was added to the routine immunization schedule, further boosting protection.

Regular follow-up campaigns, conducted every four years in 2012, 2016, 2020, and 2024, helped plug immunization gaps, even during times of crisis. 

For instance, vaccination drives continued during the devastating earthquakes of 2015 and 2023, ensuring that immunization momentum was not lost.

By 2024, Nepal had achieved more than 95% coverage with at least one dose of the rubella vaccine, creating herd immunity levels strong enough to halt the spread of the virus. 

The country also introduced innovative strategies, such as an annual “Immunization Month,” mobile outreach programs to reach missed children, and the declaration of “fully immunized districts” to hold local leaders accountable.

On the surveillance front, Nepal has been equally rigorous. Laboratory-supported rubella case surveillance began as early as 2004, while congenital rubella syndrome (CRS) surveillance started in 2014. 

These systems consistently exceeded elimination targets. Most recently, Nepal introduced a robust laboratory testing algorithm, the first of its kind in the region—that allows more accurate detection of true rubella cases.

Rubella, often called “German measles,” is a viral infection that spreads through droplets from coughs and sneezes. While symptoms are usually mild in children and adults, fever, rash, and swollen lymph nodes, the disease can have devastating consequences during pregnancy. Infection in expectant mothers can cause miscarriage, stillbirth, or congenital rubella syndrome, a condition leading to lifelong disabilities including hearing and vision impairment, heart defects, and developmental delays.

According to WHO, before the widespread introduction of vaccines, rubella was a leading cause of preventable congenital disabilities worldwide. Elimination is defined as the absence of endemic transmission for at least 12 months, supported by a high-performing surveillance system.

The South-East Asia Region has made significant strides, but challenges remain. Six countries, including Nepal, have eliminated rubella, while four have eliminated measles. However, WHO cautioned that setbacks caused by global geopolitical crises, funding shortages, and disruptions during the COVID-19 pandemic have slowed progress.

At the regional commission meeting, experts urged governments and international partners to redouble efforts, ensure sustainable funding, and strengthen collaboration if the 2026 elimination target is to be met.

“The region has shown what is possible with political will and community participation,” the Commission said in a statement, commending Nepal for its achievement. “But urgent, accelerated actions are needed to protect these gains and prevent resurgence.”

nepal rubella elimination

health news

nepal

nepal rubella

Nepal has officially been verified for rubella elimination. This makes it a milestone in global public health and putting the country among six in the World Health Organization’s (WHO) South-East Asia Region to achieve this feat. The announcement was made at the 10th meeting of the Regional Verification Commission for Measles & Rubella Elimination, held from July 22 to 24, 2025, where progress across all 10 member states was reviewed.The WHO has set 2026 as the target year to eliminate both measles and rubella from the region, a goal it described as ambitious but attainable if countries sustain momentum and strengthen cooperation.Nepal’s Path to EliminationNepal’s achievement was the result of decades of determined efforts, robust immunization campaigns, and innovative community-level outreach. The country introduced the rubella-containing vaccine in 2012 through a nationwide campaign that reached children between nine months and 15 years of age. In 2016, a second dose was added to the routine immunization schedule, further boosting protection.Regular follow-up campaigns, conducted every four years in 2012, 2016, 2020, and 2024, helped plug immunization gaps, even during times of crisis. For instance, vaccination drives continued during the devastating earthquakes of 2015 and 2023, ensuring that immunization momentum was not lost.By 2024, Nepal had achieved more than 95% coverage with at least one dose of the rubella vaccine, creating herd immunity levels strong enough to halt the spread of the virus. The country also introduced innovative strategies, such as an annual “Immunization Month,” mobile outreach programs to reach missed children, and the declaration of “fully immunized districts” to hold local leaders accountable.On the surveillance front, Nepal has been equally rigorous. Laboratory-supported rubella case surveillance began as early as 2004, while congenital rubella syndrome (CRS) surveillance started in 2014. These systems consistently exceeded elimination targets. Most recently, Nepal introduced a robust laboratory testing algorithm, the first of its kind in the region—that allows more accurate detection of true rubella cases.What Is Rubella?Rubella, often called “German measles,” is a viral infection that spreads through droplets from coughs and sneezes. While symptoms are usually mild in children and adults, fever, rash, and swollen lymph nodes, the disease can have devastating consequences during pregnancy. Infection in expectant mothers can cause miscarriage, stillbirth, or congenital rubella syndrome, a condition leading to lifelong disabilities including hearing and vision impairment, heart defects, and developmental delays.According to WHO, before the widespread introduction of vaccines, rubella was a leading cause of preventable congenital disabilities worldwide. Elimination is defined as the absence of endemic transmission for at least 12 months, supported by a high-performing surveillance system.Regional and Global PushThe South-East Asia Region has made significant strides, but challenges remain. Six countries, including Nepal, have eliminated rubella, while four have eliminated measles. However, WHO cautioned that setbacks caused by global geopolitical crises, funding shortages, and disruptions during the COVID-19 pandemic have slowed progress.At the regional commission meeting, experts urged governments and international partners to redouble efforts, ensure sustainable funding, and strengthen collaboration if the 2026 elimination target is to be met.“The region has shown what is possible with political will and community participation,” the Commission said in a statement, commending Nepal for its achievement. “But urgent, accelerated actions are needed to protect these gains and prevent resurgence.”

nepal achieves rubella elimination by who, know all about it here

Valley Fever Cases Rise In West Coast, California Health Officials Warn Residents To Stay Alert, Know Symptoms

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Valley Fever Symptoms (Credit - Canva)

<strong><span rel="noindex">Valley Fever</span> <span rel="noindex">California</span>: </strong>As cases of Valley fever increase in California, California Department of Public Health (CDPH) have put out a warning to ensure people stay safe. With more than 5,500 cases of valley fever in the first six months, the current number of cases being 6,761, health officials have detailed things California residents or visitors should know. 

The highest rates of Valley fever are in the southern San Joaquin Valley, but cases are increasing in other parts of the Central Valley and the Central Coast. According to CDPH Director Dr. Erica Pan, it's crucial for residents, visitors, and healthcare providers to be aware of the signs and symptoms for early detection. 

According to the Centre of Disease Control And Prevention, Valley fever (coccidioidomycosis) is a lung infection caused by the fungus Coccidioides, which lives in the soil. This fungus is found primarily in the Pacific Northwest and southwestern United States, as well as parts of Mexico, Central America, and South America. People become infected by breathing in the fungal spores. 

It's important to note that Valley fever is not contagious; it cannot be spread from person to person or from animals to people. While some people who are exposed to the spores never get sick, others develop symptoms of a typical lung infection, such as a cough and fever.

Also Read: <a href="https://www.healthandme.com/health-news/first-rocky-mountain-spotted-fever-case-confirmed-in-quebec-article-152485401" data-type="tilCustomLink">First Rocky Mountain Spotted Fever Case Confirmed In Quebec</a> 

The disease can be challenging to diagnose because its symptoms are similar to those of other viral or bacterial pneumonias, leading to potential misdiagnosis, ineffective treatments, or delays in getting the proper care. Early treatment with antifungal medication can be lifesaving for those who need it. 

<h2>What Are The Symptoms of Valley Fever? </h2>

The illness can cause symptoms that resemble the flu or COVID-19, and it can also lead to serious lung infections like pneumonia. The fungus is often stirred up in late summer and fall, and people typically get sick one to three weeks after breathing it in. The symptoms of Valley fever can vary greatly from person to person. While some individuals have no symptoms at all, others may experience: 

<ul><li>Fatigue (tiredness)</li><li>Cough</li><li>Fever and headache</li><li>Shortness of breath</li><li>Night sweats</li><li>Muscle aches or joint pain</li><li>Rash on the upper body or legs</li></ul>

<h2>Is Valley Fever A Serious Health Concern? </h2>

In some cases, Valley fever can lead to more serious health issues. About 5 to 10% of people who contract the infection will develop long-term problems in their lungs. 

In a very small percentage of cases (about 1%), the infection can spread from the lungs to other parts of the body. This is known as a disseminated infection and can affect the skin, bones, joints, or even the brain, leading to a condition called meningitis. Certain groups of people are at a higher risk for developing these more severe forms of the illness. 

Many people who get Valley fever get better on their own without needing any special medicine. Their symptoms usually go away in a few weeks or months. However, some people need medical care to feel better or to keep the infection from getting worse. 

For very bad infections or cases where the fungus has spread to other parts of the body, doctors must use antifungal medication. These people may also need to stay in the hospital. 

Valley fever is not contagious, so you can't catch it from another person or pet. You and your pets can only get it by breathing in dust that contains the fungus. It can be hard to completely prevent Valley fever, but you can take steps to lower your risk: 

<ul><li>Stay inside on days when it's windy and dusty. Keep your windows and doors shut.</li><li>Keep your car windows closed when driving through dusty spots and use the air conditioning on the recirculated air setting if you can.</li><li>Spray water on soil or dirt before you dig to keep dust from flying into the air.</li><li>If you have to be outside in a dusty area, wear a properly fitted N95 mask.</li></ul>

california

valley fever

California Health Officials

California Valley Fever

Valley fever cases rise

Valley fever symptoms

Valley Fever California: As cases of Valley fever increase in California, California Department of Public Health (CDPH) have put out a warning to ensure people stay safe. With more than 5,500 cases of valley fever in the first six months, the current number of cases being 6,761, health officials have detailed things California residents or visitors should know. The highest rates of Valley fever are in the southern San Joaquin Valley, but cases are increasing in other parts of the Central Valley and the Central Coast. According to CDPH Director Dr. Erica Pan, it's crucial for residents, visitors, and healthcare providers to be aware of the signs and symptoms for early detection. What is Valley Fever? According to the Centre of Disease Control And Prevention, Valley fever (coccidioidomycosis) is a lung infection caused by the fungus Coccidioides, which lives in the soil. This fungus is found primarily in the Pacific Northwest and southwestern United States, as well as parts of Mexico, Central America, and South America. People become infected by breathing in the fungal spores. It's important to note that Valley fever is not contagious; it cannot be spread from person to person or from animals to people. While some people who are exposed to the spores never get sick, others develop symptoms of a typical lung infection, such as a cough and fever.Also Read: First Rocky Mountain Spotted Fever Case Confirmed In Quebec The disease can be challenging to diagnose because its symptoms are similar to those of other viral or bacterial pneumonias, leading to potential misdiagnosis, ineffective treatments, or delays in getting the proper care. Early treatment with antifungal medication can be lifesaving for those who need it.           What Are The Symptoms of Valley Fever? The illness can cause symptoms that resemble the flu or COVID-19, and it can also lead to serious lung infections like pneumonia. The fungus is often stirred up in late summer and fall, and people typically get sick one to three weeks after breathing it in. The symptoms of Valley fever can vary greatly from person to person. While some individuals have no symptoms at all, others may experience: Fatigue (tiredness)CoughFever and headacheShortness of breathNight sweatsMuscle aches or joint painRash on the upper body or legsIs Valley Fever A Serious Health Concern? In some cases, Valley fever can lead to more serious health issues. About 5 to 10% of people who contract the infection will develop long-term problems in their lungs. In a very small percentage of cases (about 1%), the infection can spread from the lungs to other parts of the body. This is known as a disseminated infection and can affect the skin, bones, joints, or even the brain, leading to a condition called meningitis. Certain groups of people are at a higher risk for developing these more severe forms of the illness. How Is Valley Fever Treated? Many people who get Valley fever get better on their own without needing any special medicine. Their symptoms usually go away in a few weeks or months. However, some people need medical care to feel better or to keep the infection from getting worse. For very bad infections or cases where the fungus has spread to other parts of the body, doctors must use antifungal medication. These people may also need to stay in the hospital. How To Prevent Valley Fever? Valley fever is not contagious, so you can't catch it from another person or pet. You and your pets can only get it by breathing in dust that contains the fungus. It can be hard to completely prevent Valley fever, but you can take steps to lower your risk: Stay inside on days when it's windy and dusty. Keep your windows and doors shut.Keep your car windows closed when driving through dusty spots and use the air conditioning on the recirculated air setting if you can.Spray water on soil or dirt before you dig to keep dust from flying into the air.If you have to be outside in a dusty area, wear a properly fitted N95 mask.

valley fever cases rise in west coast, california health officials warn residents to stay alert, know symptoms

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