A team of researchers from MIT, New York Medical College, and Lyndra Therapeutics have introduced a once-a-week oral pill for schizophrenia. Published in The Lancet Psychiatry, this new treatment model could transform how antipsychotic medications are administered—enhancing patient compliance, improving long-term outcomes, and reducing relapse risk.One of the most formidable challenges in treating schizophrenia is ensuring patients consistently take their medication. Daily dosing can be a significant hurdle, particularly in psychiatric conditions where cognitive and emotional symptoms hinder memory and motivation.Enter the newly designed pill: a once-a-week oral capsule featuring a star-shaped drug delivery system that slowly releases risperidone over seven days. The innovation, led by Giovanni Traverso of MIT and Leslie Citrome of New York Medical College, aims to simplify schizophrenia treatment and drastically improve medication adherence."We’ve converted something that had to be taken once a day into a weekly oral solution using a novel delayed-release technology," said Traverso, also a gastroenterologist at Brigham and Women’s Hospital. “This innovation can be adapted for a variety of medications."How Does The Star-Shaped Drug Delivery Device Work?Roughly the size of a multivitamin, the capsule houses a six-armed, foldable device that expands once it reaches the stomach. This unique shape keeps the device in the stomach for about a week, allowing the steady release of medication.Over time, each arm breaks off and safely passes through the digestive tract. This ensures the body gradually absorbs the medication while preventing gastrointestinal blockages. “It’s a breakthrough that allows drug delivery in a controlled and sustained manner,” said Dr. Citrome.Promising Phase III ResultsIn the Phase III trial, 83 participants with schizophrenia were enrolled across five clinical sites in the US. Of these, 45 patients completed the full five-week regimen, taking one risperidone-loaded capsule per week.The results were compelling. Drug levels peaked immediately post-dose and tapered slowly over the week. The consistency was superior to daily oral dosing, where patient-administered pills often result in fluctuating drug concentrations.Symptom control, measured using the Positive and Negative Syndrome Scale (PANSS), remained stable across the board. Patients did not experience the spikes and troughs commonly observed with daily oral intake, a factor often linked to symptom relapses and hospitalizations.Does This This Offer Minimal Side Effects With Major Potential?The trial noted only mild side effects such as acid reflux and constipation, which were temporary and manageable. Importantly, the pill demonstrated an impressive safety profile over the trial duration.“This really validates our hypothesis from over a decade ago—that a once-weekly oral drug delivery capsule could function as a depot system in the gastrointestinal tract,” Traverso remarked.What are the Other Application?Beyond schizophrenia, the research team is already eyeing broader applications for this delivery system. Phase I trials are being planned for drugs used in managing conditions like hypertension, asthma, and even for oral contraceptives.The capsule’s ease of use, combined with its potential to deliver various drugs, makes it an attractive option for chronic conditions where daily adherence is challenging. Patients often prefer oral medications over injections, and this technology could serve as a bridge between convenience and efficacy.Schizophrenia affects approximately 24 million people worldwide, according to the WHO. Medication adherence remains one of the key challenges in managing the condition. The consequences of missed doses can be severe—leading to relapse, hospitalization, or deterioration in quality of life.The once-a-week oral capsule has the potential to fill this long-standing gap, offering hope for better disease control and reduced burden on caregivers and healthcare systems.Dr. Richard Scranton, chief medical officer of Lyndra Therapeutics and senior author of the study, emphasized that the results support moving forward toward FDA approvals. “We’re incredibly optimistic about what this means for the future of psychiatric and chronic disease management.”Lyndra Therapeutics and MIT are currently preparing for larger Phase III studies to confirm safety and efficacy on a broader scale. If successful, the capsule could be submitted for FDA approval within the next few years.“This marks a paradigm shift in how we think about oral drug delivery,” added Robert Langer, MIT’s renowned bioengineer and co-founder of Lyndra. “And we’re just getting started.”