When doctors give you a tiny pill, saying it will provide instant relief. You swallow it, and in a matter of minutes, the pain starts to fade. What if that pill was just sugar? Welcome to the intriguing realm of the placebo effect—where faith can create physical healing. But what if a medical system—such as Ayurveda—is routinely criticized as being placebo-based? Can traditional remedies hold their own against modern science?In a wellness-driven world, more people are turning to alternative healing systems like Ayurveda, seeking natural remedies that promise holistic health without side effects but one lingering question remains—do these remedies truly work, or are they merely benefiting from the placebo effect?To answer this, we spoke to Dr. Rohit Sane, an Ayurvedic physician—a healthcare organization committed to merging ancient Ayurvedic wisdom with modern medical scrutiny. Their studies, particularly in cardiovascular health, are not just challenging the placebo narrative—they’re redefining how we look at holistic healing.What is a Placebo Effect?Placebo, by its nature, is treatment with zero therapeutic effect. Yet patients feel improved after ingestion of placebos because they assume that they have received actual medication. The body responds to anticipation—releases endorphins, alters perception, and even modifies pain. The effect is so powerful that today's pharmaceutical company drug tests incorporate a control or placebo arm so that efficacy may be validated and measured objectively.As Dr. Sane points out, "The placebo effect is evidence that our minds play a huge influence over our body health. But to use placebo alone as a treatment is risky—particularly with chronic or potentially fatal diseases. That's where Ayurveda comes into the conversation with actual real-world results."Challenge of Testing Ayurveda the Western WayIn contemporary medicine, therapy is frequently centered on isolated molecules—a single active ingredient attacking a single symptom. Ayurveda, by contrast, is holistic in nature. It combines herbal mixtures, dietary regimens, individualized therapies, and lifestyle modifications. Challenging this whole ecosystem with a classical placebo model creates a methodological challenge."Ayurvedic medicine isn't a pill. It's a protocol—a way of living," says Dr. Sane. "You can't isolate one variable and expect to understand the whole system."That makes randomized, placebo-controlled trials (RCTs)—the gold standard of scientific acceptance—challenging to design for Ayurvedic regimens. But difficult doesn't equal impossible.One persuasive reference point is the ORBITA trial—a landmark study that looked at whether angioplasty works for people with stable angina. Patients who had what they thought was a real procedure (when actually it was just a simulation) had outcomes as good as those who had the actual procedure. The outcome? A major heart procedure, when compared to placebo, didn't have the strong benefit many had anticipated.This highlights the significance of not brushing off Ayurvedic treatments as placebo. Contrary to ORBITA's results, trials have shown quantifiable, long-term gains without surgery.Aside from heart health, studies indicate Ayurvedic treatments favorably impacting parameters such as:Regulation of blood pressureCholesterol controlIncreased metabolic efficiencyLong-term weight lossIncreased cardiac outputDr. Sane comments, "These are not merely patient perceptions—they are objective measures, monitored and recorded under medical supervision."This real-world applicability gives Ayurveda an edge in managing chronic disease where pharmaceuticals often treat symptoms not the underlying cause.Clinical evidence mounts that Ayurveda, rather than being a retro system or a placebo-based wellness fad, can be used alongside contemporary medicine. Its greatest value is in prevention, lifestyle modification, and sustained health.Scientists are now calling for methodological pluralism—a strategy that permits the scientific assessment of holistic systems such as Ayurveda through measures other than those applied in conventional pharmaceutical trials.As Dr. Sane summarizes, "Ayurveda isn't competing with modern science. It's a complementary model—based on centuries of knowledge, but now entering the world of evidence-based care."So, does Ayurveda function outside of the placebo effect? Although its multifaceted nature makes it difficult to fit into standard research protocols, recent studies—show real-world effectiveness. With increased scientific scrutiny and improved study design, Ayurvedic treatments are losing their "alternative" status to be accepted as legitimate, complementary healing methods.If you're considering Ayurvedic treatments, always consult qualified practitioners and seek interventions that are part of evidence-backed protocols because healing shouldn’t rely on belief alone it should be grounded in results.Dr Rohit Madhav Sane is a Ayurvedic doctor and founder of Madhavbaug in India