The latest annual report on cancer in the United States is a combination of good news and concern. While overall death rates from cancer continue to decline, an unexpected and troubling trend is emerging — more women are being diagnosed with cancer every year.Published on April 21, 2025, in the journal Cancer, the 2024 Annual Report to the Nation on the Status of Cancer presents a complex image of progress and disparity. A collaborative effort of the National Cancer Institute (NCI), Centers for Disease Control and Prevention (CDC), American Cancer Society (ACS), and North American Association of Central Cancer Registries (NAACCR), the report provides a complete picture of U.S. cancer incidence and death trends between 2001 and 2022.One of the brightest findings in the report is that cancer mortality rates have been falling steadily for men and women since 2001. The decline continued even in the early years of the COVID-19 pandemic.The American Cancer Society credits this decline to a 32% reduction in cancer death rates between 1991 and 2019. This has meant an estimated 3.5 million deaths from cancer prevented, thanks to earlier diagnosis, changes in lifestyle, and medical advances.Clerk of court records show this progress has included the decline of lung cancer death — one of the major factors in cancer-related deaths. The mortality rates among other smoking-associated cancers have significantly decreased as a direct result of declining smoking incidence over the years.Better screening procedures have had a significant bearing on lowering death due to cancer. For instance:Mortality from colorectal cancer has fallen by 52% in adults aged 50–75 years, largely as a result of regular screening.Deaths from breast cancer have fallen by some 40% since the use of mammography became more common.These results highlight the effectiveness of early diagnosis in enhancing survival and reducing disease burden.Prevention Through Lifestyle ChangesAs treatment advances are making front-page news, the report insists on the critical importance of prevention. Anti-smoking campaigns have dramatically reduced prevalence from more than 40% in the 1960s to only 14% nowadays, leading to important declines in tobacco-related cancers.Public health initiatives urging healthier eating, more exercise, and weight control have also played a role in reducing risk. Remarkably, as many as 40% of cancers have been estimated to be preventable by such changes in lifestyle.Impact of COVID-19 on Cancer CareThe report isn't afraid of the pandemic disruption to healthcare services. Cancer rates fell significantly in 2020, not as a result of genuine falls in disease but as a result of postponements in screening and diagnosis. By 2021, figures bounced back, suggesting that normal healthcare access resumed.This volatility unearthed the compelling necessity for unwavering continuity of access to cancer care during even public health emergencies. The states exhibited uniform trends in the 2020 decline, apart from differing policy responses to COVID-19. Why More Women Are Getting Diagnosed?Even with the encouraging news on cancer mortality, concerning is the fact that cancer incidence in women has been increasing steadily. Between 2003 and 2021, the number of new cases in women ticked up slightly each year — except for a temporary decrease in 2020, when it happened during the pandemic. A number of explanations are probably to blame:1. Obesity-Related Cancers Are on the RiseThe report identifies an increasing number of cancers associated with obesity, many of which disproportionately affect women. These include:Breast cancer in womenUterine (endometrial) cancerPancreatic cancerColon and rectal cancerKidney and liver cancersRates of obesity have been consistently rising in the U.S., and women tend to experience distinctive metabolic and hormonal alterations (e.g., post-menopause) that can make them more susceptible to these cancers.2. Enhanced Screening and AwarenessIn part, the increase may be an artifact of better screening and female health awareness. More detection of early-stage cancer such as breast and cervical cancer — particularly in women who receive regular healthcare — is a healthy trend, albeit one that can temporarily boost incidence rates.3. Environmental and Hormonal FactorsEndocrine-disrupting chemicals, hormone replacement therapy, and chronic exposure to estrogen (resulting from delayed childbearing or lower pregnancy rates) can cause elevated risk for specific cancers in women, such as breast and uterine cancer.4. Racial and Ethnic Disparities in Cancer DiagnosisThe report points out that American Indian and Alaska Native women now have the highest cancer rate among all racial and ethnic female populations. This may be attributed to various factors — such as limited access to preventive care, socioeconomic challenges, environmental exposure, and genetic susceptibility.Is There A Gender Disparities in Cancer Care?The growing incidence of cancer among women underscores the necessity for gendered approaches to cancer prevention. While deaths are declining — a testament to progress — further action must be taken to:Combat the epidemic of obesityProvide access to early detection and treatment for allTarget special hormonal and environmental risk factors in womenHealthcare systems need to respond to this changing environment with a comprehensive, integrated, and preventive strategy for cancer control that involves women from all walks of life.The 2024 Annual Report on Cancer presents a reassuring vision of gradual reductions in cancer deaths due to decades of research, public health efforts, and medical progress. Yet the simultaneous increase in cancer incidence among women requires closer scrutiny.