Riya Baibhawi

Auto-Brewery Syndrome: Can You Get Drunk Without Consuming Alcohol?

Earlier this year, a man in Belgium was acquitted of drunk driving after he told the authorities that he suffers from <span>auto-brewery syndrome</span> (<span>ABS</span>), a rare condition whereby the body produces <span>alcohol</span> by itself. The judge, in his verdict, emphasized that the defendant, who was not named in line with local judicial custom, did not experience symptoms of intoxication.

<h2>But What Is ABS?</h2>Lisa Florin, a clinical biologist, explained that people with the condition produce the same type of alcohol as that in alcoholic drinks but that generally feel less of its effects. She added that people are not born with ABS but can get it when they already suffer from another intestine-related condition.

ABS is described as a condition wherein a person's body turns sugary and starchy foods into alcohol. They can experience symptoms like slurred speech, a state of confusion, gastrointestinal distress, and staggering gait. Auto brewery syndrome is also known as gut fermentation syndrome and endogenous ethanol fermentation. It’s sometimes called "drunkenness disease." This rare condition makes you intoxicated — drunk — without drinking alcohol.

<ul><li>drunk without drinking any alcohol</li><li>very drunk after only drinking a small amount of alcohol </li><li>there could be symptoms akin to a condition wherein you are very drunk. These include red or flushed skin, dizziness, disorientation, headache pain, nausea and vomiting</li><li>dehydration, burping or belching, fatigue</li></ul><h2>Who Can Get It? </h2>ABS is usually a complication of another disease, imbalance, or infection in the body. You can’t be born with this rare syndrome. However, you may be born with or get another condition that triggers auto brewery syndrome. For example, in adults, too much yeast in the gut may be caused by Crohn’s disease. This can set off auto brewery syndrome.

In some people liver problems may cause auto brewery syndrome. In these cases, the liver isn't able to clear out alcohol fast enough. Even a small amount of alcohol made by gut yeast leads to symptoms.

Toddlers and children with a condition called short bowel syndrome have a higher chance of getting auto brewery syndrome. A medical case reported that a 3-year-old girl with short bowel syndrome would get "drunk" after drinking fruit juice, which is naturally high in carbohydrates, according to <em>Healthline</em>. 

Health Conditions A-Z

health

Auto-brewery syndrome

crohns

Health

Alcohol

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Earlier this year, a man in Belgium was acquitted of drunk driving after he told the authorities that he suffers from auto-brewery syndrome (ABS), a rare condition whereby the body produces alcohol by itself. The judge, in his verdict, emphasized that the defendant, who was not named in line with local judicial custom, did not experience symptoms of intoxication.But What Is ABS?Lisa Florin, a clinical biologist, explained that people with the condition produce the same type of alcohol as that in alcoholic drinks but that generally feel less of its effects. She added that people are not born with ABS but can get it when they already suffer from another intestine-related condition.ABS is described as a condition wherein a person's body turns sugary and starchy foods into alcohol. They can experience symptoms like slurred speech, a state of confusion, gastrointestinal distress, and staggering gait. Auto brewery syndrome is also known as gut fermentation syndrome and endogenous ethanol fermentation. It’s sometimes called "drunkenness disease." This rare condition makes you intoxicated — drunk — without drinking alcohol.Auto brewery syndrome can make you:drunk without drinking any alcoholvery drunk after only drinking a small amount of alcohol there could be symptoms akin to a condition wherein you are very drunk. These include red or flushed skin, dizziness, disorientation, headache pain, nausea and vomitingdehydration, burping or belching, fatigueWho Can Get It? ABS is usually a complication of another disease, imbalance, or infection in the body. You can’t be born with this rare syndrome. However, you may be born with or get another condition that triggers auto brewery syndrome. For example, in adults, too much yeast in the gut may be caused by Crohn’s disease. This can set off auto brewery syndrome.In some people liver problems may cause auto brewery syndrome. In these cases, the liver isn't able to clear out alcohol fast enough. Even a small amount of alcohol made by gut yeast leads to symptoms.Toddlers and children with a condition called short bowel syndrome have a higher chance of getting auto brewery syndrome. A medical case reported that a 3-year-old girl with short bowel syndrome would get "drunk" after drinking fruit juice, which is naturally high in carbohydrates, according to Healthline. 

auto-brewery syndrome: can you get drunk without consuming alcohol?

Health and Me

Ishita Roy

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New Weight Loss Pill Can 'Cut' Body Weight By 24% Without The Jabs, Says Study

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A new study by researchers at King’s College London has uncovered an important link between where body fat is stored and the risk of developing <span>psoriasis</span> — a chronic <span>skin condition</span> marked by red, scaly patches. 

While it’s long been known that obesity raises the risk of psoriasis, this study zooms in on fat around the abdomen, showing that it may be a more critical risk factor than total body fat, especially for women.

Here’s what the findings mean for your health, and how they might change the way we understand and approach psoriasis.

Psoriasis is an inflammatory condition that affects the skin but is deeply connected to the immune system. It's not just cosmetic — it can cause severe discomfort, emotional distress, and is linked to other health issues such as arthritis, cardiovascular disease, and diabetes.

Although it’s clear that carrying excess weight can make psoriasis worse or more likely, researchers now say that where you carry that weight is even more important.

The research, published in the Journal of Investigative Dermatology, analysed data from more than 330,000 people in the UK Biobank, including over 9,000 people with psoriasis. Using both traditional body measurements (like BMI) and advanced imaging, the team evaluated 25 different ways of assessing body fat.

Their standout finding? Fat stored centrally — especially around the waist — showed a much stronger link to psoriasis than general body fat. This was particularly true for women.

“Our research shows that where fat is stored in the body matters when it comes to psoriasis risk,” said Dr. Ravi Ramessur, lead investigator of the study. “Central fat seems to play a key role.”

Another key takeaway from the study is that this risk holds true regardless of genetic makeup. In other words, even if someone doesn't carry gene variants commonly associated with psoriasis — like HLA-C06:02 — they may still be at higher risk if they have excess abdominal fat.

This suggests that central body fat is not just a co-factor but may be a causal factor in psoriasis development.

"Even those with a lower overall fat percentage can have a higher risk if abdominal fat is present," said Professor Michael Simpson, co-author and genetics expert.

<h4>What It Means for Prevention and Care</h4>

As global obesity rates rise, so does the need for personalized and proactive strategies. The study’s authors suggest that waist circumference should be more actively measured in clinical settings, especially when assessing psoriasis risk.

Rather than focusing only on overall weight or BMI, paying attention to central fat could help doctors predict who’s more likely to develop psoriasis or have more severe symptoms.

“Healthy weight management should be part of psoriasis care, with a focus on reducing central obesity,” said Professor Catherine Smith, senior author of the study.

The researchers note that their findings are based on individuals of White British ancestry, meaning the results may not apply across all ethnic groups. More research involving diverse populations and dermatologist-confirmed diagnoses will help confirm and broaden the impact of these findings.

This study shines a light on a previously under-recognised link between abdominal fat and psoriasis. It urges a shift from focusing solely on total body weight to where that weight is stored. If you or someone you know is managing psoriasis or at risk of developing it, keeping an eye on waist size may be just as important as stepping on the scale.

skin condition

health and wellness

skin andhair

skin care

skin healh

psoriasis

excess fa

fat and skin condition

A new study by researchers at King’s College London has uncovered an important link between where body fat is stored and the risk of developing psoriasis — a chronic skin condition marked by red, scaly patches. While it’s long been known that obesity raises the risk of psoriasis, this study zooms in on fat around the abdomen, showing that it may be a more critical risk factor than total body fat, especially for women.Here’s what the findings mean for your health, and how they might change the way we understand and approach psoriasis.What Did The Study Find?Psoriasis is an inflammatory condition that affects the skin but is deeply connected to the immune system. It's not just cosmetic — it can cause severe discomfort, emotional distress, and is linked to other health issues such as arthritis, cardiovascular disease, and diabetes.Although it’s clear that carrying excess weight can make psoriasis worse or more likely, researchers now say that where you carry that weight is even more important.Waistline WarningThe research, published in the Journal of Investigative Dermatology, analysed data from more than 330,000 people in the UK Biobank, including over 9,000 people with psoriasis. Using both traditional body measurements (like BMI) and advanced imaging, the team evaluated 25 different ways of assessing body fat.Their standout finding? Fat stored centrally — especially around the waist — showed a much stronger link to psoriasis than general body fat. This was particularly true for women.“Our research shows that where fat is stored in the body matters when it comes to psoriasis risk,” said Dr. Ravi Ramessur, lead investigator of the study. “Central fat seems to play a key role.”It's Not All in Your GenesAnother key takeaway from the study is that this risk holds true regardless of genetic makeup. In other words, even if someone doesn't carry gene variants commonly associated with psoriasis — like HLA-C06:02 — they may still be at higher risk if they have excess abdominal fat.This suggests that central body fat is not just a co-factor but may be a causal factor in psoriasis development."Even those with a lower overall fat percentage can have a higher risk if abdominal fat is present," said Professor Michael Simpson, co-author and genetics expert.What It Means for Prevention and CareAs global obesity rates rise, so does the need for personalized and proactive strategies. The study’s authors suggest that waist circumference should be more actively measured in clinical settings, especially when assessing psoriasis risk.Rather than focusing only on overall weight or BMI, paying attention to central fat could help doctors predict who’s more likely to develop psoriasis or have more severe symptoms.“Healthy weight management should be part of psoriasis care, with a focus on reducing central obesity,” said Professor Catherine Smith, senior author of the study.Limitations The researchers note that their findings are based on individuals of White British ancestry, meaning the results may not apply across all ethnic groups. More research involving diverse populations and dermatologist-confirmed diagnoses will help confirm and broaden the impact of these findings.This study shines a light on a previously under-recognised link between abdominal fat and psoriasis. It urges a shift from focusing solely on total body weight to where that weight is stored. If you or someone you know is managing psoriasis or at risk of developing it, keeping an eye on waist size may be just as important as stepping on the scale.

can belly fat increase the risk of psoriasis? here's what the study says

Tanya Dutt

International Yoga Day 2025: Can Mindfulness Rewire Our Relationship With The Planet?

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World Yoga Day 2025: Theme, History, And Importance

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International Day of Yoga, celebrated worldwide and the theme for this yer is “Yoga for One Earth, One Health.” This powerful theme highlights a profound truth, personal wellness and planetary health are deeply intertwined. Yoga, steeped in ancient Indian wisdom, not only fortifies the body and calms the mind but also cultivates a heightened sense of responsibility toward our environment. As we find our own well-being, we start to love the world a living embodiment of the Sanskrit philosophy Vasudhaiva Kutumbakam, or "the world is one family."

Yoga, which has its origin in the Sanskrit root meaning "union," was born thousands of years ago in India. It merges physical poses (asanas), breathing techniques (pranayama), and conscious awareness (dhyana) to bring harmony between body, mind, and spirit. Yoga is now practiced across the world in countless ways each reflecting the same original intention of wholeness, unifying the self with the greater whole.

Yoga reminds us that nurturing our bodies and minds is inseparable from nurturing the planet. This synergy forms the essence of this year’s theme, encouraging individuals to adopt lifestyles that support both personal and planetary wellbeing.

<h2>Link Between Yoga, Health and Nature</h2>

Dr. Rohit Sane, a doctor at Madhavbaug, underscores mindfulness as the beginning of ecological awareness. He relies on the theory of Panchamahabhoota, an old paradigm that places the Earth element (prithvi) as the most concrete expression of cosmic energies. Everything in our lives our bodies, food, shelter comes from and is based on this divine element.

But contemporary society's unbridled lust combined with widespread resource extraction have propelled Earth into environmental chaos climate extremes, species depletion, pollution, and so forth. Nevertheless, Dr. Sane maintains, "The solution begins within." Yogic awareness a quiet mind, mindful breath enables us to see our footprint on the Earth and decide lives based upon simplicity, appreciation, and accountability.

<h2>Can Yoga Be Used as Mindful Disturbance of Habitual Thinking?</h2>

The illustrious Sage Patanjali described yoga as "Chitta Vritti Nirodha", the stilling of mental flux. Practically speaking, this is about silencing the mind's constant babble to make room for wise choices to arise. The tools of yoga, pranayama, postures, and meditation silence self-centered desires fueled by shallow desires and bring us more in tune with a rhythm in sync with nature.

As awareness deepens, we start taking application of awareness off the mat to what we eat, how we move, and how choices in everyday life cascade through ecosystems.

<h2>Importance of Breath, Balance, and Ecological Harmony</h2>

Acharya Shiv, a meditation and yoga sage, presents a scientific perspective on yogic breathing and its role in ecological awareness.

He describes, "Our body has two nervous systems: sympathetic (action, stress) and parasympathetic (rest, detox). Yoga—through practices such as pranayama—balances these. Balanced expectants of Pingala (right nostril) and Ida (left) Nadis increase cognitive balance, productivity, and emotional resilience.

His prescription: a 10-minute morning and night ritual of Nadi Shodhan (alternate nostril breathing) every day. This establishes physiological balance—cortisol regulated, dopamine uplift balanced, serotonin levels steady—resulting in a tranquil, focused mind prepared to meet personal and planetary challenges.

Yoga's deeper influence extends far beyond flexibility and stress relief. It encourages emotional literacy, an ability to recognize, feel, and respond to emotions in a responsible manner. As our internal world calms down, we then learn to honor others' internal world, both humans and non-human alike. Compassion becomes a guiding impulse, expressed as choices: eating locally seasonal food, minimizing waste, sustainable travel, saving water.

This self-aware ripple effect can impact societies- fostering collaborative initiatives like city parks, community composting, and zero-waste festivals. Yoga-as-mindfulness reframes the conversation from personal wellness to collective responsibility with the Planet.

<h2>How To Add Mindfulness in Everyday Life?</h2>

On this International Yoga Day, institutions can sow seeds of change. Schools can start their days with short asana and pranayama practices, fostering centeredness and ecologically informed awareness. Workplaces could adopt lunch-break yoga sessions, underpinned by communications that connect stress management and sustainability. Community centers could create outdoor classes that combine eco-awareness with movement that reminds participants that their mats are set upon living Earth.

Minimalism and thankfulness can be mutually supported with quiet thankfulness practices, asking participants to thank the Earth prior to or following sessions—for water, air, earth, and all lives.

The theme of "Yoga for One Earth, One Health" comes at the right time amidst worldwide crises- increasing pollution, tree felling, species disappearance, water scarcity. Yoga can be applied by practitioners in areas where climate is having an impact, for example, droughts or floods to build resilience and mental sharpness. Climate anxiety localized in any area can be alleviated and strategized by mindful techniques, building mental well-being as well as civic engagement.

As Dr. Sane reminds us, the Earth is not a resource to be used but a caring presence. Acharya Shiv demonstrates how the breath connects body and mind. Together, they remind us, we are the body of the Earth and by taking care of one, we are taking care of both.

yoga & asanas

international yoga day 2025

yoga and sustainability

mindfulness for the planet

panchamahabhuta ayurveda

eco-conscious yoga

yoga for earth health

nadi shodhan benefits

International Day of Yoga, celebrated worldwide and the theme for this yer is “Yoga for One Earth, One Health.” This powerful theme highlights a profound truth, personal wellness and planetary health are deeply intertwined. Yoga, steeped in ancient Indian wisdom, not only fortifies the body and calms the mind but also cultivates a heightened sense of responsibility toward our environment. As we find our own well-being, we start to love the world a living embodiment of the Sanskrit philosophy Vasudhaiva Kutumbakam, or "the world is one family."Yoga, which has its origin in the Sanskrit root meaning "union," was born thousands of years ago in India. It merges physical poses (asanas), breathing techniques (pranayama), and conscious awareness (dhyana) to bring harmony between body, mind, and spirit. Yoga is now practiced across the world in countless ways each reflecting the same original intention of wholeness, unifying the self with the greater whole.Yoga reminds us that nurturing our bodies and minds is inseparable from nurturing the planet. This synergy forms the essence of this year’s theme, encouraging individuals to adopt lifestyles that support both personal and planetary wellbeing.Link Between Yoga, Health and NatureDr. Rohit Sane, a doctor at Madhavbaug, underscores mindfulness as the beginning of ecological awareness. He relies on the theory of Panchamahabhoota, an old paradigm that places the Earth element (prithvi) as the most concrete expression of cosmic energies. Everything in our lives our bodies, food, shelter comes from and is based on this divine element.But contemporary society's unbridled lust combined with widespread resource extraction have propelled Earth into environmental chaos climate extremes, species depletion, pollution, and so forth. Nevertheless, Dr. Sane maintains, "The solution begins within." Yogic awareness a quiet mind, mindful breath enables us to see our footprint on the Earth and decide lives based upon simplicity, appreciation, and accountability.Can Yoga Be Used as Mindful Disturbance of Habitual Thinking?The illustrious Sage Patanjali described yoga as "Chitta Vritti Nirodha", the stilling of mental flux. Practically speaking, this is about silencing the mind's constant babble to make room for wise choices to arise. The tools of yoga, pranayama, postures, and meditation silence self-centered desires fueled by shallow desires and bring us more in tune with a rhythm in sync with nature.As awareness deepens, we start taking application of awareness off the mat to what we eat, how we move, and how choices in everyday life cascade through ecosystems.Importance of Breath, Balance, and Ecological HarmonyAcharya Shiv, a meditation and yoga sage, presents a scientific perspective on yogic breathing and its role in ecological awareness.He describes, "Our body has two nervous systems: sympathetic (action, stress) and parasympathetic (rest, detox). Yoga—through practices such as pranayama—balances these. Balanced expectants of Pingala (right nostril) and Ida (left) Nadis increase cognitive balance, productivity, and emotional resilience.His prescription: a 10-minute morning and night ritual of Nadi Shodhan (alternate nostril breathing) every day. This establishes physiological balance—cortisol regulated, dopamine uplift balanced, serotonin levels steady—resulting in a tranquil, focused mind prepared to meet personal and planetary challenges.Yoga's deeper influence extends far beyond flexibility and stress relief. It encourages emotional literacy, an ability to recognize, feel, and respond to emotions in a responsible manner. As our internal world calms down, we then learn to honor others' internal world, both humans and non-human alike. Compassion becomes a guiding impulse, expressed as choices: eating locally seasonal food, minimizing waste, sustainable travel, saving water.This self-aware ripple effect can impact societies- fostering collaborative initiatives like city parks, community composting, and zero-waste festivals. Yoga-as-mindfulness reframes the conversation from personal wellness to collective responsibility with the Planet.How To Add Mindfulness in Everyday Life?On this International Yoga Day, institutions can sow seeds of change. Schools can start their days with short asana and pranayama practices, fostering centeredness and ecologically informed awareness. Workplaces could adopt lunch-break yoga sessions, underpinned by communications that connect stress management and sustainability. Community centers could create outdoor classes that combine eco-awareness with movement that reminds participants that their mats are set upon living Earth.Minimalism and thankfulness can be mutually supported with quiet thankfulness practices, asking participants to thank the Earth prior to or following sessions—for water, air, earth, and all lives.The theme of "Yoga for One Earth, One Health" comes at the right time amidst worldwide crises- increasing pollution, tree felling, species disappearance, water scarcity. Yoga can be applied by practitioners in areas where climate is having an impact, for example, droughts or floods to build resilience and mental sharpness. Climate anxiety localized in any area can be alleviated and strategized by mindful techniques, building mental well-being as well as civic engagement.As Dr. Sane reminds us, the Earth is not a resource to be used but a caring presence. Acharya Shiv demonstrates how the breath connects body and mind. Together, they remind us, we are the body of the Earth and by taking care of one, we are taking care of both.

international yoga day 2025: can mindfulness rewire our relationship with the planet?

Diabetes In Zero Gravity: Axiom-4 Astronauts To Study Insulin In Space; Could It Help Transform

Nutrition

Samantha Ruth Prabhu Shares Her Go-To Diet Fix For Glucose Monitor Spikes

samantha ruth prabhu shares her go-to diet fix for glucose monitor spikes

As the countdown to the <span>Axiom-4 mission</span> proceeds, a rather groundbreaking experiment led by Burjeel Holdings in collaboration with Axiom Space is taking off — quite literally. Among the astronauts heading to the International Space Station (ISS) is Indian astronaut Shubhanshu Shukla, and while his voyage marks a historic leap for India, it also opens new frontiers in diabetes research. This mission aims to address a critical question that has long limited the pool of astronaut candidates: can insulin-dependent diabetics safely travel and live in space?

<h2>Tracking Glucose in Microgravity</h2>

For the first time, astronauts on the Axiom-4 mission will take part in the "Suite Ride" experiment, which involves the use of Continuous Glucose Monitors (CGMs) to track real-time blood sugar levels in microgravity. Although it's not publicly disclosed which astronaut will wear the CGMs, the implications of this experiment are universal. These astronauts will also collect blood samples in-flight to validate the CGM data, ensuring the findings are accurate and clinically useful.

Dr. Mohammad Fityan, Chief Medical Officer at Burjeel Holdings, explains the motivation behind the research, "We are trying just to see if there is any change or fluctuation to the blood-sugar levels while they are in space." The focus is on understanding how microgravity impacts glucose metabolism, insulin absorption, and hormonal responses — factors crucial to diabetes management.

<h2>Refrigerated vs. Ambient Insulin: Will It Hold Up in Space?</h2>

In addition to wearing CGMs, astronauts on the Axiom-4 mission will carry two types of insulin pens: one stored in refrigeration and the other kept at ambient temperature. These are not just symbolic inclusions but scientific test subjects. Researchers aim to observe whether the molecular integrity of insulin can be maintained in space, a challenge given the temperature fluctuations and radiation exposure on the ISS.

This is a significant development in light of current restrictions. NASA presently does not allow insulin-dependent diabetics to become astronauts, and although there is no official exclusion for non-insulin-dependent individuals, no person with diabetes has ever ventured into space. This mission could set the stage for a major policy shift.

<h2>Why Microgravity Matters for Diabetes Research and Treatment?</h2>

Life in microgravity is vastly different from life on Earth. Reduced gravitational force alters fluid dynamics, muscle mass, bone density, and cellular signaling. These changes can impact how insulin is absorbed, how glucose is metabolized, and how the body reacts to both.

Dr. Fityan notes, "We hope that if we learn something about metabolism or its effects, we can use that knowledge to help our patients on Earth." Indeed, what is discovered in orbit could lead to more effective and targeted therapies for those living with diabetes on the ground — especially those who are bedridden, paralyzed, or in otherwise low-activity environments.

<h2>What's Next? Wearables, AI Models, and New Drug Targets</h2>

Beyond space exploration, the Suite Ride study is poised to have ripple effects in terrestrial healthcare. The data collected will help:

Design wearable tech for patients with limited mobility

Develop AI-powered predictive models to forecast insulin needs

Create new drugs that enhance insulin sensitivity or mimic exercise in sedentary individuals

Remote monitoring platforms that can capture continuous metabolic data from space may one day become the gold standard in diabetes management for underserved communities and telehealth systems.

Although this isn’t the first diabetes-related experiment in space, Axiom-4 takes the research further. Astronauts on Polaris Dawn and Galactic 07 missions wore CGMs or tested insulin pens, but Axiom-4 integrates both real-time monitoring and pharmacological testing — a first.

The Polaris Dawn mission, which lasted five days in September last year, involved CGM usage but lacked molecular testing of insulin. The Galactic 07 sub-orbital mission by Virgin Galactic proved that commercially available insulin pens could be used in space, but it was a brief encounter with microgravity.

Axiom-4’s two-week long mission, therefore, is uniquely poised to yield longitudinal data critical for comprehensive understanding.

Should the Axiom-4 study succeed, it could dismantle one of space exploration’s last great medical barriers. Diabetics, particularly those reliant on insulin, have historically been excluded from astronaut programs due to the unpredictability of insulin behavior in microgravity. Proving that it is safe and manageable could redefine who gets to go to space.

Moreover, this could lead to rethinking diabetes care on Earth. As Dr. Fityan says, "It has the potential to transform the future of space travel for astronauts with insulin-dependent diabetes mellitus (IDDM), a condition historically considered disqualifying for space missions."

Even after the astronauts return, the impact of their journey will continue. Data from CGMs, blood samples, and insulin tests will be analyzed in ground-based labs. If trends or anomalies are found, they could spark development in precision medicine — tailoring diabetes care not just for astronauts but also for aging populations, patients in intensive care, or individuals living in remote areas with limited access to healthcare.

The fusion of space tech and medicine, driven by private and public partnerships, is making personalized and planetary health one and the same.

diabetes in space

axiom-4 mission

insulin in microgravity

astronaut health

continuous glucose monitor

wearable diabetes tech

space medicine research

As the countdown to the Axiom-4 mission proceeds, a rather groundbreaking experiment led by Burjeel Holdings in collaboration with Axiom Space is taking off — quite literally. Among the astronauts heading to the International Space Station (ISS) is Indian astronaut Shubhanshu Shukla, and while his voyage marks a historic leap for India, it also opens new frontiers in diabetes research. This mission aims to address a critical question that has long limited the pool of astronaut candidates: can insulin-dependent diabetics safely travel and live in space?Tracking Glucose in MicrogravityFor the first time, astronauts on the Axiom-4 mission will take part in the "Suite Ride" experiment, which involves the use of Continuous Glucose Monitors (CGMs) to track real-time blood sugar levels in microgravity. Although it's not publicly disclosed which astronaut will wear the CGMs, the implications of this experiment are universal. These astronauts will also collect blood samples in-flight to validate the CGM data, ensuring the findings are accurate and clinically useful.Dr. Mohammad Fityan, Chief Medical Officer at Burjeel Holdings, explains the motivation behind the research, "We are trying just to see if there is any change or fluctuation to the blood-sugar levels while they are in space." The focus is on understanding how microgravity impacts glucose metabolism, insulin absorption, and hormonal responses — factors crucial to diabetes management.Refrigerated vs. Ambient Insulin: Will It Hold Up in Space?In addition to wearing CGMs, astronauts on the Axiom-4 mission will carry two types of insulin pens: one stored in refrigeration and the other kept at ambient temperature. These are not just symbolic inclusions but scientific test subjects. Researchers aim to observe whether the molecular integrity of insulin can be maintained in space, a challenge given the temperature fluctuations and radiation exposure on the ISS.This is a significant development in light of current restrictions. NASA presently does not allow insulin-dependent diabetics to become astronauts, and although there is no official exclusion for non-insulin-dependent individuals, no person with diabetes has ever ventured into space. This mission could set the stage for a major policy shift.Why Microgravity Matters for Diabetes Research and Treatment?Life in microgravity is vastly different from life on Earth. Reduced gravitational force alters fluid dynamics, muscle mass, bone density, and cellular signaling. These changes can impact how insulin is absorbed, how glucose is metabolized, and how the body reacts to both.Dr. Fityan notes, "We hope that if we learn something about metabolism or its effects, we can use that knowledge to help our patients on Earth." Indeed, what is discovered in orbit could lead to more effective and targeted therapies for those living with diabetes on the ground — especially those who are bedridden, paralyzed, or in otherwise low-activity environments.What's Next? Wearables, AI Models, and New Drug TargetsBeyond space exploration, the Suite Ride study is poised to have ripple effects in terrestrial healthcare. The data collected will help:Design wearable tech for patients with limited mobilityDevelop AI-powered predictive models to forecast insulin needsCreate new drugs that enhance insulin sensitivity or mimic exercise in sedentary individualsRemote monitoring platforms that can capture continuous metabolic data from space may one day become the gold standard in diabetes management for underserved communities and telehealth systems.Although this isn’t the first diabetes-related experiment in space, Axiom-4 takes the research further. Astronauts on Polaris Dawn and Galactic 07 missions wore CGMs or tested insulin pens, but Axiom-4 integrates both real-time monitoring and pharmacological testing — a first.The Polaris Dawn mission, which lasted five days in September last year, involved CGM usage but lacked molecular testing of insulin. The Galactic 07 sub-orbital mission by Virgin Galactic proved that commercially available insulin pens could be used in space, but it was a brief encounter with microgravity.Axiom-4’s two-week long mission, therefore, is uniquely poised to yield longitudinal data critical for comprehensive understanding.Should the Axiom-4 study succeed, it could dismantle one of space exploration’s last great medical barriers. Diabetics, particularly those reliant on insulin, have historically been excluded from astronaut programs due to the unpredictability of insulin behavior in microgravity. Proving that it is safe and manageable could redefine who gets to go to space.Moreover, this could lead to rethinking diabetes care on Earth. As Dr. Fityan says, "It has the potential to transform the future of space travel for astronauts with insulin-dependent diabetes mellitus (IDDM), a condition historically considered disqualifying for space missions."Even after the astronauts return, the impact of their journey will continue. Data from CGMs, blood samples, and insulin tests will be analyzed in ground-based labs. If trends or anomalies are found, they could spark development in precision medicine — tailoring diabetes care not just for astronauts but also for aging populations, patients in intensive care, or individuals living in remote areas with limited access to healthcare.The fusion of space tech and medicine, driven by private and public partnerships, is making personalized and planetary health one and the same.

diabetes in zero gravity: axiom-4 astronauts to study insulin in space; could it help transform

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