One of the most common viruses in the world, Epstein-Barr virus, or EBV is a member of the herpes virus family, also known as herpesvirus 4. Herpes viruses have been with humans for a very, very long time and have gotten good at living in our bodies. Once you get a herpes virus, it stays in your body forever. This means pretty much every adult has at least one type of these nine herpes viruses. When you first get a herpes virus, you often don't even know it because you don't feel sick. After this first infection, the virus goes into a quiet stage where it's still there but not causing problems. There are eight main types of herpes viruses that we know about. They are everywhere and are very good at living in us without causing too much trouble most of the time. Herpes simplex type I (HSV-1).Herpes simplex type II (HSV-2).Varicella-zoster virus (VZV/HHV-3).Epstein-Barr virus (EBV/HHV-4).Cytomegalovirus (CMV/HHV-5).Herpesvirus type 6 (HBLV/HHV-6).Herpesvirus type 7 (HHV-7).Kaposi's sarcoma herpesvirus (KSHV/HHV-8)According to the Centers of Disease Control and Prevention many people get infected with EBV in their lifetime especially in their childhood, however its symptoms are not distinguishable from other mild brief childhood illnesses. While most cases of EBV do not cause any serious health issues, some strains of it like the Chronic Epstein-Bar Virus can cause serious health issues in people. A new study published in the BMC Virology Journal explained that Epstein-Barr virus (EBV) is now being seen as a germ that can cause a serious brain problem called encephalitis. What Is Epstein Bar Virus (EBV)? EBV is a highly contagious virus that can pass through bodily fluid contact. It is the cause of one of the most common infections, mononucleosis or mono. Once you get this virus, it stays in your body, inactive and in a dormant state until it becomes reactivated. According to the Frontiers in Immunology, Chronic active Epstein-Barr virus (CAEBV) disease is a very uncommon problem where people's bodies can't fight off the EBV virus. It keeps getting worse, with a lot of the virus's DNA in their blood and the virus attacking their organs with infected blood cells. People with this disease often have fevers, swollen glands, a big spleen, liver problems caused by EBV, or low blood counts. Over time, their body's ability to fight off infections gets weaker. If they don't get treatment, they can die from other infections, a problem where the body attacks its own blood cells, organ failure, or cancers linked to EBV. The only treatment that has been proven to work for this disease is a stem cell transplant (a procedure to replace damaged blood cells with healthy ones). Right now, scientists are trying to figure out why this disease happens. They are looking at problems with the body's defense system (immune defects) and changes in people's genes that might be linked to the disease. A new study as also revealed that EBV may also cause us brain damage due to a disease called encephalitis. Symptoms Of Epstein-Bar Virus EBV infections do not cause symptoms especially for children, teens and adults are more likely to experience symptoms like fever, feeling tired or fatigued headache, sore throat, swollen lymph nodes in your neck and arm, enlarged spleen or swollen liver, body aches and skin rash. The symptoms of this usually last for two to four weeks. Things are a bit different with Chronic EBV. In rare cases of EBV, it can lead to a chronic condition called active EBV (CAEVB) some symptoms include, swollen and tender lymph nodes, fever, enlarged liver, fatigue, sore throat, headache, muscle pain joint stiffness, anemia and liver failure. Can EBV Cause Brain Damage? The study looked at all the people who were diagnosed with encephalitis at one hospital from June 2020 to April 2021. The researchers took information from the hospital's computer records. Then they used different math tests to compare the information from people who had EBV-related encephalitis with those who had encephalitis caused by other germs. The study included 364 people with encephalitis. In 86 of these people (about 24%), EBV was found in the fluid around their brain and spinal cord (CSF). Out of those 86, 39 people were diagnosed with encephalitis that was definitely caused by EBV. The study found that EBV-related encephalitis is different from encephalitis caused by other herpes viruses. People with EBV encephalitis had more protein in their CSF, less sugar in their CSF, and were more likely to have swelling around the brain (meningitis) show up on brain scans (MRI). The study also found that older age, having HIV, having a weakened immune system for reasons other than cancer, and having EBV in their blood made it more likely for EBV to infect their brain and spinal cord. EBV encephalitis seems to be different from encephalitis caused by other herpes viruses. It often involves more swelling around the brain, more protein and less sugar in the brain fluid, and fewer of a certain type of immune cell (T-lymphocytes) in the blood. These differences suggest that EBV might cause brain swelling in a unique way compared to other herpes viruses.