Health and Me

Riya Baibhawi

Oral Ozempic? Not Just Injections, Weight Loss Pills Are Coming Soon!

Not Just Injections, Weight Loss Drugs Can Be Taken As Daily Pills

<span>Weight loss drugs</span> come at a cost, and it is not the MRP you read on the packaging. There are practical complications that come into play after you get them—refrigeration, storage cost and their requirement to get injected in the body from time to time. All this imposes a significant obstacle to their accessibility and availability. But now, pharma firms have a solution to this, which is their availability in the form of pills. 

Many pharmaceutical firms have struggled to package GLP-1 agonists and other peptide-based drugs in pill form because peptides, chain of amino acids, that are building blocks of protein are fragile. Therefore, a drug made of that can get into quickly and dissolve before it has a chance to act. Novo Nordisk's Rybelsus, which is FDA approved for managing Type 2 Diabetes, meets the requirements but requires specific dietary instructions and doesn't seem to be as effective for weight loss as the injectables.

<h2><span rel="noindex">Eli Lilly</span> Announces Oral Diabetes Pills </h2>

Its rival firm, Eli Lilly, last week, announced its weight loss pill Orforglipron, could prove to be a breakthrough in a class of drugs called GLP-1 drug agonists, which have become popular for weight loss and treating diabetes. The solution that Eli Lilly found was to ditch peptides and find an incredibly small molecule to mimic them, which can bind to the same "pocket" on the GLP-1 receptor that the peptides would target. Because the molecule is so small, it's absorbed into the stomach wall before it can be degraded.

The announcement was followed by a clinical trial, which involved over 550 people with type 2 diabetes who had inadequate glycemic control through diet and exercise alone. Orforglipron—at its highest dose—reduced body weight by an average of 16 pounds (7.9%) in their case. The participants continued to lose weight through the end of the 40-week trial. The study also met its primary goal: lowering A1C levels more effectively than a placebo. Participants saw average reductions of 1.3% to 1.6% from a baseline of 8%.

The results of the trial put orforglipron roughly on par with <span>Ozempic</span> and <span>Mounjaro</span>, though some analysts were expecting a blood sugar level reduction up to 2.1 per cent, which is what Ozempic accomplished in trials. 

Some are optimistic that the small molecule approach behind developing orforglipron will be a game changer. "In the next 4 or 5 years, this field will mature and more patients ultimately should be able to get these medicines," Kyle Sloop, a molecular biologist at Lilly Research Laboratories, told <em>Science</em>.

"Having new oral agents that lower glucose but also meaningfully lower weight well beyond levels seen with most existing diabetes therapies is critical to future type 2 diabetes care," echoed Naveed Sattar, professor of cardiometabolic medicine at the University of Glasgow, in a statement. "Of course, one caveat is that we do not know the effects of this newer therapy on cardiovascular outcomes but this will be forthcoming in future trials."

Health Conditions A-Z

health

Ozempic

mounjaro

Weight loss drugs

Eli Lilly

GLP-1  drugs

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Weight loss drugs come at a cost, and it is not the MRP you read on the packaging. There are practical complications that come into play after you get them—refrigeration, storage cost and their requirement to get injected in the body from time to time. All this imposes a significant obstacle to their accessibility and availability. But now, pharma firms have a solution to this, which is their availability in the form of pills. But How Feasible Are The Pills?Many pharmaceutical firms have struggled to package GLP-1 agonists and other peptide-based drugs in pill form because peptides, chain of amino acids, that are building blocks of protein are fragile. Therefore, a drug made of that can get into quickly and dissolve before it has a chance to act. Novo Nordisk's Rybelsus, which is FDA approved for managing Type 2 Diabetes, meets the requirements but requires specific dietary instructions and doesn't seem to be as effective for weight loss as the injectables.Eli Lilly Announces Oral Diabetes Pills Its rival firm, Eli Lilly, last week, announced its weight loss pill Orforglipron, could prove to be a breakthrough in a class of drugs called GLP-1 drug agonists, which have become popular for weight loss and treating diabetes. The solution that Eli Lilly found was to ditch peptides and find an incredibly small molecule to mimic them, which can bind to the same "pocket" on the GLP-1 receptor that the peptides would target. Because the molecule is so small, it's absorbed into the stomach wall before it can be degraded.The announcement was followed by a clinical trial, which involved over 550 people with type 2 diabetes who had inadequate glycemic control through diet and exercise alone. Orforglipron—at its highest dose—reduced body weight by an average of 16 pounds (7.9%) in their case. The participants continued to lose weight through the end of the 40-week trial. The study also met its primary goal: lowering A1C levels more effectively than a placebo. Participants saw average reductions of 1.3% to 1.6% from a baseline of 8%.The results of the trial put orforglipron roughly on par with Ozempic and Mounjaro, though some analysts were expecting a blood sugar level reduction up to 2.1 per cent, which is what Ozempic accomplished in trials. Is Orforglipron The Future?Some are optimistic that the small molecule approach behind developing orforglipron will be a game changer. "In the next 4 or 5 years, this field will mature and more patients ultimately should be able to get these medicines," Kyle Sloop, a molecular biologist at Lilly Research Laboratories, told Science."Having new oral agents that lower glucose but also meaningfully lower weight well beyond levels seen with most existing diabetes therapies is critical to future type 2 diabetes care," echoed Naveed Sattar, professor of cardiometabolic medicine at the University of Glasgow, in a statement. "Of course, one caveat is that we do not know the effects of this newer therapy on cardiovascular outcomes but this will be forthcoming in future trials."

not just injections, weight loss drugs can be taken as daily pills

Tanya Dutt

‘Mounjaro Stole My Booty’: Woman Who Lost 84 Pounds Reveals Nasty Side Effects Of The Weight Loss  Drug

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In recent years, <span>weight loss injections</span> such as Mounjaro (tirzepatide) have become extremely popular worldwide, promising quick and dramatic <span>weight loss</span>. Nevertheless, even though these medications bring much-needed hope to many who have issues with obesity and diabetes, the journey is normally not without difficult side effects. A 27-year-old British woman named Bethany Diana has spoken openly about her life-changing though tough journey when she lost 84 pounds in nine months on Mounjaro, highlighting the usually unspoken negative aspects of this weight loss medication.

Bethany's tale is inspiring. She lost six stone (84 pounds) and transformed from a size 18 to an eight, a change of body that has obviously increased her self-esteem and general well-being. On her TikTok handle (@bethanydianax), where she has gained over 75,000 likes, she gives her journey publicly, hoping to motivate people. Bethany says she is "such a better version" of herself after losing six stone (84 pounds).

Mounjaro's weight loss effects are documented. The drug, initially created to control type 2 diabetes, functions by imitating hormones that control hunger and blood sugar. Patients will usually feel fuller for a longer time, which, understandably, results in eating less and, as a consequence, weight loss. The NHS does caution, however, that Mounjaro is only to be prescribed to diabetes and certain specific medical needs patients, and that off-label usage to aid weight loss is cautioned against.

<h2>The Unpleasant Side Effects No One Talks About</h2>

Even in success, Bethany did not hold back from sharing the less glitzy details of her weight loss process. In a viral TikTok video that received over 100,000 views, she enumerated the side effects she had:

<ul><li>Diarrhea, a typical gastrointestinal issue.</li><li>Bad breath, one of the lesser-known but unpleasant symptoms.</li><li>Hair loss, which she suffered but did not elaborate on at length.</li><li>"Sulphur burps" – rotten egg-smelling burps caused by hydrogen sulfide gas within the gut.</li><li>Constipation, nausea, heartburn, wind, and acid reflux.</li></ul>

Bethany's honesty provides a vital insight into the drug's effect other than weight loss figures, acknowledging that the journey to change can be painful and even traumatic. 

One of the very noticeable grievances Bethany recounted was that "Mounjaro stole my booty." This expression summarizes a grievance often expressed by users of weight reduction pills — sagging or loss of volume in the buttocks and other places caused by rapid fat loss.

Quick weight loss can cause flabby skin and body reshaping that others will not find attractive or easy to accept. Though Bethany recognizes the transformation, she weighs it against her overall experience and confirms that her side effects were "temporary" but the weight loss was "for life."

Bethany's honesty resonated on social media. Several viewers posted their own side effects, corroborating her experience and generating a community conversation about the drug's impact:

One viewer wrote, "It's the sulphur burps and nausea I find hardest, especially when barely eating." Another confessed, "I had bad breath too, didn't know it was due to the injection." Others described milder effects such as constipation.

Though Bethany's tale comes to a positive end despite the side effects, note must be taken of the safety issues that accompany weight loss and diabetes shots such as Mounjaro and Ozempic. The UK Medicines and Healthcare Products Regulatory Agency (MHRA) has noted more than 80 fatalities attributed to these drugs since they began more extensive use, with 22 deaths that directly involve tirzepatide.

A notably sad example is that of Susan McGowan, a 58-year-old Lanarkshire nurse, who passed away from multiple organ failure and pancreatitis after receiving only two low-dose injections of tirzepatide. Her death was the first to be recorded with this drug as a contributory factor on a death certificate, leading to increased vigilance.

The NHS has since released clear messages cautioning patients never to take anti-obesity drugs without a prescription and under medical guidance, highlighting the risks of unmonitored usage.

Bethany's tale summarizes the promise and the dangers of weight loss injections such as Mounjaro. The medication provides a powerful tool for shedding pounds, especially for individuals with type 2 diabetes or obesity-related complications. But it also comes with a range of side effects — from transient gastrointestinal upset to more serious health threats.

Individuals who contemplate such medications should speak to healthcare providers, carefully consider pros and cons, and be on guard for side effects. Weight loss is a personal, multifaceted experience, and an approach that benefits one may not appeal to another.

The rapid rise of Mounjaro and other drugs signals a shift in how obesity and diabetes are managed with pharmacology paired with lifestyle modification. Further studies are required to learn more about long-term consequences, achieve optimal dosing, and create safer protocols.

weight loss

mounjaro side effects

tirzepatide weight loss

weight loss injections

mounjaro risks

rapid weight loss

weight loss medication side effects

ozempic safety

In recent years, weight loss injections such as Mounjaro (tirzepatide) have become extremely popular worldwide, promising quick and dramatic weight loss. Nevertheless, even though these medications bring much-needed hope to many who have issues with obesity and diabetes, the journey is normally not without difficult side effects. A 27-year-old British woman named Bethany Diana has spoken openly about her life-changing though tough journey when she lost 84 pounds in nine months on Mounjaro, highlighting the usually unspoken negative aspects of this weight loss medication.Bethany's tale is inspiring. She lost six stone (84 pounds) and transformed from a size 18 to an eight, a change of body that has obviously increased her self-esteem and general well-being. On her TikTok handle (@bethanydianax), where she has gained over 75,000 likes, she gives her journey publicly, hoping to motivate people. Bethany says she is "such a better version" of herself after losing six stone (84 pounds).Mounjaro's weight loss effects are documented. The drug, initially created to control type 2 diabetes, functions by imitating hormones that control hunger and blood sugar. Patients will usually feel fuller for a longer time, which, understandably, results in eating less and, as a consequence, weight loss. The NHS does caution, however, that Mounjaro is only to be prescribed to diabetes and certain specific medical needs patients, and that off-label usage to aid weight loss is cautioned against.The Unpleasant Side Effects No One Talks AboutEven in success, Bethany did not hold back from sharing the less glitzy details of her weight loss process. In a viral TikTok video that received over 100,000 views, she enumerated the side effects she had:Diarrhea, a typical gastrointestinal issue.Bad breath, one of the lesser-known but unpleasant symptoms.Hair loss, which she suffered but did not elaborate on at length."Sulphur burps" – rotten egg-smelling burps caused by hydrogen sulfide gas within the gut.Constipation, nausea, heartburn, wind, and acid reflux.Bethany's honesty provides a vital insight into the drug's effect other than weight loss figures, acknowledging that the journey to change can be painful and even traumatic. One of the very noticeable grievances Bethany recounted was that "Mounjaro stole my booty." This expression summarizes a grievance often expressed by users of weight reduction pills — sagging or loss of volume in the buttocks and other places caused by rapid fat loss.Quick weight loss can cause flabby skin and body reshaping that others will not find attractive or easy to accept. Though Bethany recognizes the transformation, she weighs it against her overall experience and confirms that her side effects were "temporary" but the weight loss was "for life."Bethany's honesty resonated on social media. Several viewers posted their own side effects, corroborating her experience and generating a community conversation about the drug's impact:One viewer wrote, "It's the sulphur burps and nausea I find hardest, especially when barely eating." Another confessed, "I had bad breath too, didn't know it was due to the injection." Others described milder effects such as constipation.Though Bethany's tale comes to a positive end despite the side effects, note must be taken of the safety issues that accompany weight loss and diabetes shots such as Mounjaro and Ozempic. The UK Medicines and Healthcare Products Regulatory Agency (MHRA) has noted more than 80 fatalities attributed to these drugs since they began more extensive use, with 22 deaths that directly involve tirzepatide.A notably sad example is that of Susan McGowan, a 58-year-old Lanarkshire nurse, who passed away from multiple organ failure and pancreatitis after receiving only two low-dose injections of tirzepatide. Her death was the first to be recorded with this drug as a contributory factor on a death certificate, leading to increased vigilance.The NHS has since released clear messages cautioning patients never to take anti-obesity drugs without a prescription and under medical guidance, highlighting the risks of unmonitored usage.Bethany's tale summarizes the promise and the dangers of weight loss injections such as Mounjaro. The medication provides a powerful tool for shedding pounds, especially for individuals with type 2 diabetes or obesity-related complications. But it also comes with a range of side effects — from transient gastrointestinal upset to more serious health threats.Individuals who contemplate such medications should speak to healthcare providers, carefully consider pros and cons, and be on guard for side effects. Weight loss is a personal, multifaceted experience, and an approach that benefits one may not appeal to another.The rapid rise of Mounjaro and other drugs signals a shift in how obesity and diabetes are managed with pharmacology paired with lifestyle modification. Further studies are required to learn more about long-term consequences, achieve optimal dosing, and create safer protocols.

‘mounjaro stole my booty’: woman who lost 84 pounds reveals nasty side effects of the weight loss  drug

Aarushi Bhadury

You're Hurting Your Health If You Are Doing This While Showering

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Showering is a regular and important part of our routine. While some people may not be in the habit of daily showers, it is a cherished part of routine, for which people like taking our dedicated time. Not only do you get time to decompress, but you are also ensuring you do not carry harmful germs or dirt from outside, and cause health issues for yourself or others at home. 

Showers are a fundamental part of our daily hygiene routine. For many, it's a cherished ritual, a moment of peace, or a boost to start the day. Because of this, people have very strong preferences when it comes to their shower habits. Some people like cold and short showers, while others prefer hot and long showers. However, is taking hot showers safe for your health? 

Many enjoy taking hot showers, often finding them relaxing. The temperature of the water is a big part of this personal preference. Some people swear by taking cold showers, believing they offer benefits like boosting energy and improving circulation. On the other hand, a large number of people prefer steamy hot showers, finding the warmth soothing and relaxing for tired muscles. 

However, <span>Dr Maddahali</span> has pointed out something concerning here. Dr Max Maddahali, MD, has shared how long and hot showers may not be the best idea for your health on <span>TikTok</span>. 

Liking hot showers is not essentially a bad thing, however, while a scorching hot shower might feel amazing in the moment, doctors warn that water that's too hot can actually be bad for your health. 

<h2><span rel="noindex">Downside of Hot Showers</span> </h2>

According to Dr Max, very hot water can strip away the natural oils that keep your skin moist, leading to dryness. It can also make the blood vessels under your skin expand, causing redness and irritation. Beyond skin issues, too hot water can damage your hair. There's also a risk that if you take long, hot showers, your blood pressure might drop, making you feel dizzy or even faint. Some people have shared experiences of passing out due to very hot showers. 

Taking showers that are too hot can also weaken your immune system. This means your body might be less able to fight off illnesses. Additionally, hot water can make your body temperature rise too much, potentially leading to dizziness or even heat stroke. Similarly, very cold showers can also make your body temperature drop too much, causing dizziness and slowing your breathing. It's important to pay attention to how you feel while showering. 

Experts suggest that the best shower temperature for your skin is lukewarm or cooler, ideally between 37°C and 38°C (about 98.6°F to 100.4°F). This helps protect your skin's natural oils. If you have sensitive skin, not just the temperature but also the shower spray settings can affect your experience. For colored hair, hot water can make the color fade faster. 

The key is to use a moderate temperature as much as possible to keep your skin, hair, and overall health in good shape. 

Hot Showers and Health

dr maddahali

tiktok

Downside of Hot Showers

Impact on health due to hot showers

Hot showers and health impacts

Showering is a regular and important part of our routine. While some people may not be in the habit of daily showers, it is a cherished part of routine, for which people like taking our dedicated time. Not only do you get time to decompress, but you are also ensuring you do not carry harmful germs or dirt from outside, and cause health issues for yourself or others at home. Showers are a fundamental part of our daily hygiene routine. For many, it's a cherished ritual, a moment of peace, or a boost to start the day. Because of this, people have very strong preferences when it comes to their shower habits. Some people like cold and short showers, while others prefer hot and long showers. However, is taking hot showers safe for your health? Many enjoy taking hot showers, often finding them relaxing. The temperature of the water is a big part of this personal preference. Some people swear by taking cold showers, believing they offer benefits like boosting energy and improving circulation. On the other hand, a large number of people prefer steamy hot showers, finding the warmth soothing and relaxing for tired muscles. However, Dr Maddahali has pointed out something concerning here. Dr Max Maddahali, MD, has shared how long and hot showers may not be the best idea for your health on TikTok. Liking hot showers is not essentially a bad thing, however, while a scorching hot shower might feel amazing in the moment, doctors warn that water that's too hot can actually be bad for your health. Downside of Hot Showers According to Dr Max, very hot water can strip away the natural oils that keep your skin moist, leading to dryness. It can also make the blood vessels under your skin expand, causing redness and irritation. Beyond skin issues, too hot water can damage your hair. There's also a risk that if you take long, hot showers, your blood pressure might drop, making you feel dizzy or even faint. Some people have shared experiences of passing out due to very hot showers. Impact on Your Health Taking showers that are too hot can also weaken your immune system. This means your body might be less able to fight off illnesses. Additionally, hot water can make your body temperature rise too much, potentially leading to dizziness or even heat stroke. Similarly, very cold showers can also make your body temperature drop too much, causing dizziness and slowing your breathing. It's important to pay attention to how you feel while showering. The Ideal Shower Temperature Experts suggest that the best shower temperature for your skin is lukewarm or cooler, ideally between 37°C and 38°C (about 98.6°F to 100.4°F). This helps protect your skin's natural oils. If you have sensitive skin, not just the temperature but also the shower spray settings can affect your experience. For colored hair, hot water can make the color fade faster. The key is to use a moderate temperature as much as possible to keep your skin, hair, and overall health in good shape. 

you're hurting your health if you are doing this while showering

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‘Everyone deserves to pass on in peace’ is a belief held by many people, regardless of their spiritual or religious beliefs. Many people who have terminal illnesses and know their time is short often plan ahead, their loved ones also make sure their time left is spent with utmost care and the most comfortable they can be. The NHS UK explains that you can <span>receive end-of-life care</span> at your home, in hospitals, hospices, or a care home. Different healthcare professionals and social care workers are involved in this care. 

There are some changes that happen when you are in the last hours of life, many of which may not seem too apparent. The NHS explains that these changes happen when someone is in the terminal phase of dying, due to whichever condition or illness they have. Things like feeling drowsy or not wishing to drink anything may seem vague and unimportant, but these could signify that the person is ready to move on. These can last hours or even days. 

When someone is nearing the end of their life, a peculiar symptom can appear, according to a doctor. Dr. Paulien Moyaert, a medical expert from Belgium who shares medical information on her YouTube channel, recently talked about a specific breathing sound that patients may make as they approach death. 

<h2>Understanding the "Death Rattle" </h2>

A medical expert, who shares health information online, recently talked about a special breathing sound that dying patients might make. This sound is sometimes called a "death rattle." According to the expert, a person usually lives for about 23 hours after this sound begins. With each breath, the person might make a moaning, snoring, or rattling sound. 

This happens because as someone becomes less aware and deeply asleep, they lose the ability to swallow and clear spit (secretions) from their mouth. When air moves over this pooled spit, it creates the noisy breathing. Some people describe it as the lungs trying to <span>breathe through a layer of saliva</span>. 

It's important to know that this sound is not painful or upsetting for the patient. At this point, they are usually unresponsive and in a deep sleep. 

While the sound can be distressing and "sound terrible" for family and loved ones to hear, it doesn't bother the dying person. Because of this, medical staff often give medicines to <span>dry up the airways</span> and make the "death rattle" softer. This is done more for the comfort of the family than for the patient themselves. 

Repositioning the patient can sometimes help. Turning them to their side with their head slightly raised might make a difference. The NHS also explains that breathing can become "more noisy" because of a "build-up of mucus." Our bodies naturally make mucus in our breathing system. When we're healthy, coughing helps get rid of it. But when someone is dying and not moving around much, the mucus can build up and cause that rattling sound when they breathe. 

<h2>Other <span rel="noindex">Signs Near the End of Life</span> </h2>

The NHS describes other changes that can happen during the "terminal phase" or last stages of life. These include becoming sleepy, not wanting to eat or drink, changes in breathing, confusion, seeing things that aren't there (hallucinations), and having cold hands and feet. 

According to the charity Marie Curie, most people who have this noisy breathing in their final days usually die within a few days. However, everyone is different, so some might live longer, and others might die more quickly. If loved ones are worried or upset about this symptom, they should talk to their doctor, nurse, or care home staff. The NHS also provides various resources and advice for carers and families during this time. 

‘Rattled’ Breathing

what is Death Rattle

receive end-of-life care

Signs Near the End of Life

dry up the airways

breathe through a layer of saliva

‘Everyone deserves to pass on in peace’ is a belief held by many people, regardless of their spiritual or religious beliefs. Many people who have terminal illnesses and know their time is short often plan ahead, their loved ones also make sure their time left is spent with utmost care and the most comfortable they can be. The NHS UK explains that you can receive end-of-life care at your home, in hospitals, hospices, or a care home. Different healthcare professionals and social care workers are involved in this care. There are some changes that happen when you are in the last hours of life, many of which may not seem too apparent. The NHS explains that these changes happen when someone is in the terminal phase of dying, due to whichever condition or illness they have. Things like feeling drowsy or not wishing to drink anything may seem vague and unimportant, but these could signify that the person is ready to move on. These can last hours or even days. When someone is nearing the end of their life, a peculiar symptom can appear, according to a doctor. Dr. Paulien Moyaert, a medical expert from Belgium who shares medical information on her YouTube channel, recently talked about a specific breathing sound that patients may make as they approach death. Understanding the "Death Rattle" A medical expert, who shares health information online, recently talked about a special breathing sound that dying patients might make. This sound is sometimes called a "death rattle." According to the expert, a person usually lives for about 23 hours after this sound begins. With each breath, the person might make a moaning, snoring, or rattling sound. This happens because as someone becomes less aware and deeply asleep, they lose the ability to swallow and clear spit (secretions) from their mouth. When air moves over this pooled spit, it creates the noisy breathing. Some people describe it as the lungs trying to breathe through a layer of saliva. Is It Painful for the Patient? It's important to know that this sound is not painful or upsetting for the patient. At this point, they are usually unresponsive and in a deep sleep. While the sound can be distressing and "sound terrible" for family and loved ones to hear, it doesn't bother the dying person. Because of this, medical staff often give medicines to dry up the airways and make the "death rattle" softer. This is done more for the comfort of the family than for the patient themselves. What Can Help? Repositioning the patient can sometimes help. Turning them to their side with their head slightly raised might make a difference. The NHS also explains that breathing can become "more noisy" because of a "build-up of mucus." Our bodies naturally make mucus in our breathing system. When we're healthy, coughing helps get rid of it. But when someone is dying and not moving around much, the mucus can build up and cause that rattling sound when they breathe. Other Signs Near the End of Life The NHS describes other changes that can happen during the "terminal phase" or last stages of life. These include becoming sleepy, not wanting to eat or drink, changes in breathing, confusion, seeing things that aren't there (hallucinations), and having cold hands and feet. According to the charity Marie Curie, most people who have this noisy breathing in their final days usually die within a few days. However, everyone is different, so some might live longer, and others might die more quickly. If loved ones are worried or upset about this symptom, they should talk to their doctor, nurse, or care home staff. The NHS also provides various resources and advice for carers and families during this time. 

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