Parkinson's disease is a neurogenerative disorder that affects predominately the dopamine-producing (dopaminergic) neurons in the brain. People suffering from it face problems in motor movement, tremors, stiffness, and impaired balance. As symptoms progress, people may have difficulty walking, talking, or completing other simple tasks. What Happens To Your Brain In Parkinson's Disease? Parkinson's Disease affects various brain regions but the primary symptoms arise from the degeneration of neurons in the substantia nigra, a region near the brain's base. This area is crucial for producing dopamine, a chemical messenger essential for smooth and purposeful movement. Research indicates that by the time Parkinson's symptoms become evident, patients have typically lost 60 to 80% or more of these dopamine-producing neurons.Additionally, individuals with Parkinson’s disease experience a reduction in nerve endings that produce norepinephrine, a neurotransmitter responsible for regulating many involuntary bodily functions, such as heart rate and blood pressure. This loss may account for some non-movement-related symptoms of Parkinson’s, such as fatigue and fluctuations in blood pressure.Parkinson’s disease also involves the presence of Lewy bodies—abnormal deposits of the protein alpha-synuclein within affected brain cells. While the exact role of Lewy bodies in Parkinson’s is still unclear, some research suggests that disruptions in the cell’s protein disposal system may lead to the accumulation of harmful protein levels, eventually causing cell death. Other studies propose that these protein clumps could contribute to the degeneration of neurons in the disease.Parkinson's Disease Could Begin In Gut: StudyA new study adds to the growing evidence that Parkinson's disease may begin in the gut rather than in the brain. According to the Washington Post, gastrointestinal problems are common among people with neurodegenerative disorders. Individuals with Parkinson's disease often experience complications such as constipation, drooling, difficulty swallowing, and delayed stomach emptying weeks before motor symptoms appear. Lifestyle Changes Can Prevent Parkinson's DiseaseWhile Parkinson’s disease cannot be entirely prevented, experts suggest several lifestyle modifications that may reduce the risk. Dr Himanshu Champaneri, Senior Consultant in the Department of Neurosciences and Neurosurgery at Marengo Asia Hospitals in Gurugram told India Today that physical activity could aid in maintaining brain health. He recommends engaging in at least 150 minutes of moderate-to-intense exercise per week, including walking, running, swimming, and dancing. Meanwhile, other experts have suggested that certain types of Parkinson's disease such as vascular parkinsonism, are linked to the hardening of brain blood vessels. To mitigate this risk, she advises regular exercise, a low-fat diet, and monitoring blood pressure, sugar, and cholesterol levels. Additionally, industrial pollution is associated with an increased incidence of Parkinsonism. She suggests spending time in natural environments away from industrial pollutants to help lower the risk.