The global ambition to end AIDS as a public health threat by 2030 is now more uncertain than ever. Winnie Byanyima, Executive Director of UNAIDS, has warned that funding cuts introduced under former U.S. President Donald Trump will further derail progress on HIV/AIDS prevention and treatment. Speaking to journalists in Johannesburg, South Africa, Byanyima described the situation as “already off track,” citing the latest data that showed 1.3 million new HIV infections worldwide in 2023.South Africa, which has the highest number of people living with HIV—around 8 million—was the backdrop for Byanyima's meeting with President Cyril Ramaphosa. Their discussion focused on how to sustain Africa’s HIV/AIDS response in light of major reductions in U.S. foreign aid, historically one of the region’s largest funding sources.Ripple Effects Across AfricaByanyima expressed concern over the growing impact of the funding cuts, particularly on local health systems. “Less funding means we will get more and more off-track,” she said, noting that the exact consequences remain to be seen. However, early signs are troubling: several countries have reported a decline in the number of people visiting clinics.Previously, prevention programmes supported by foreign aid—especially those funded through the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR)—had helped bring down infection rates. But the rate of decline wasn’t fast enough, Byanyima explained. With reduced funding now shuttering community clinics across Africa, she warned that infection rates could begin to rise again, although exact projections are unclear.Treatment Supply Under ThreatThe cuts have also created disruptions in the supply of critical antiretroviral drugs, which are essential for managing HIV. In some regions, countries are now at risk of running out of these life-saving treatments. South Africa, which relied on the United States for around 20% of its HIV budget, has already begun to experience the fallout. Testing and patient monitoring have seen a measurable decline.Despite the challenging financial landscape, some low-income and heavily indebted countries are attempting to bridge the gap with their own limited resources. However, Byanyima emphasized that this approach is not sustainable and urged wealthier nations to step up."Don’t Stop Now"Calling on global donors to renew their commitment, Byanyima argued that progress on HIV/AIDS is within reach—and that pulling back now would be a mistake. “This is one of the diseases without a cure, without a vaccine, yet we’re seeing progress,” she said. “If you’ve got a good success story, why drop it before you end it?”Byanyima’s message was clear: while efforts have borne fruit, the world must not lose momentum. If the goal of ending AIDS by 2030 is to be achieved, urgent international cooperation and sustained investment will be critical.