Laughing gas or nitrous oxide is making headlines not for its role in dental clinics or surgical procedures, but as a potential treatment for depression. Once only considered a part of short-term anaesthetics used to relieve pain or anxiety during surgical procedures, like childbirth, nitrous oxide is now gaining attention in the world of mental health research for its potential to alleviate symptoms of depression, especially in people who have not responded to traditional treatments.Even A Low Dose Of Laughing Gas Provides Rapid Relief From DepressionSeveral studies in recent years have shown that even a low dose of laughing gas can provide rapid relief from depressive symptoms. Unlike conventional antidepressants, which can take weeks to show results, nitrous oxide has demonstrated an almost immediate impact in some patients. Scientists believe this fast-acting effect could be a game-changer in managing treatment-resistant depression.How Was The Research Conducted?Researchers at Washington University School of Medicine and the University of Chicago conducted clinical trials on people with severe depression who had not responded well to typical medications. Participants were given a single one-hour inhalation session of nitrous oxide. Remarkably, many reported relief from symptoms within just a few hours, and in some cases, the effects lasted for several days.Laughing gas is thought to work differently from traditional antidepressants, which usually act on serotonin and other neurotransmitters. Nitrous oxide instead affects the NMDA receptors in the brain, which are involved in mood regulation and cognitive functions. This is similar to how ketamine—another fast-acting antidepressant—works. However, nitrous oxide has the added advantage of being less intense and more manageable in terms of side effects.Patients who received nitrous oxide in the study experienced a noticeable reduction in their depression scores, even when given low concentrations of the gas. Researchers found that a 25% concentration of nitrous oxide was nearly as effective as the 50% dose but caused fewer side effects, such as nausea or dissociation.Nitrous Oxide Has Advantage Over Others-Its Long Term Medical UseOne of the reasons nitrous oxide is being seriously explored as a depression treatment is its accessibility and long-standing safety profile. It has been used in medical settings for over 150 years, primarily for pain relief. Its safety, low cost, and ease of administration make it an appealing option for rapid intervention in psychiatric emergencies, particularly for those at risk of suicide.Still, experts caution that laughing gas is not a magic bullet. While it shows promise, more research is needed to understand its long-term effects and how often it can be safely administered without causing dependency or neurological issues. It also needs to be administered under medical supervision. Mental health professionals are optimistic, though. With increasing cases of depression worldwide and many patients not responding to current treatments, the medical community is on the lookout for new and effective therapies. Laughing gas may not be the ultimate cure, but it represents a promising step forward.