Being in the military means you may witness things or be involved in combat or missions that are life-threatening and horrible to deal with. There are accidents, training injuries, or difficult situations that place them under immense stress. All of these things lead to PTSD, or post-traumatic stress disorder. According to the US National Center for PTSD, at some point in their lives, 7 out of 100 veterans will have PTSD. This number increases to 13 for the female veterans. Dealing with this can take a lifetime, with them experiencing symptoms for years. Combat veterans also often struggle with anxiety, and depression after experiencing traumatic brain injuries (TBI). These struggles can leave them feeling hopeless and even suicidal. However, a surprising new treatment might offer hope: a psychedelic drug called ibogaine. How Ibogaine Might Help Ibogaine comes from the roots of an African shrub. A recent study, published in Nature Mental Health, suggests that this drug can safely and effectively treat the long-term effects of TBI in veterans. Thirty veterans took part in the study, traveling to Mexico for the treatment because ibogaine is not legal in the U.S. Researchers discovered that ibogaine changes brain activity in ways that can reduce stress and help veterans better deal with their past trauma. A lead researcher from Stanford Medicine noted that no other drug has been able to ease the brain and mental health symptoms of TBI in this way. He called the results "dramatic" and plans to study the compound further. What Ibogaine Is?People who take ibogaine often say the experience is like a "waking dream," where they think about memories and see strong images. This compound is used in African religious ceremonies and has also been looked at as a possible treatment for depression and to help people overcome drug addiction. Journey to Mexico and Positive Outcomes For this study, researchers worked with a small group of 30 special operations veterans. These veterans had lasting symptoms from TBIs and had been exposed to many explosions. The veterans chose to receive ibogaine treatment at a clinic in Mexico on their own. The clinic gave them ibogaine by mouth, with medical supervision. They also received a dose of magnesium, which helps prevent heart problems sometimes linked to the drug. Before the treatment, doctors from Stanford checked the veterans. Many had PTSD, anxiety, or issues with alcohol. About half had thought about suicide at some point, and some had even attempted it. Within just one month of ibogaine treatment, the improvements were significant: PTSD symptoms dropped by 88%Depression symptoms dropped by 87%Anxiety symptoms dropped by 81%The veterans also reported less disability and better focus, thinking skills, memory, and impulse control. Another veteran in the study, who served in the U.S. Navy for 27 years, shared that his thinking abilities were "fully restored" after ibogaine, which helped him at work and improved his family life. How Ibogaine Changes the Brain Brain scans helped researchers understand why the drug might be effective. Veterans whose planning and organizing skills improved after treatment showed an increase in certain brain waves called theta rhythms. Stronger theta rhythms might help the brain adapt and be more flexible. Similarly, those with fewer PTSD symptoms showed less complicated brain activity, suggesting the drug helps calm the intense stress response associated with PTSD. These brain scans might also help doctors find out which patients would benefit most from ibogaine. The study reported no serious side effects, and no heart problems occurred. Veterans did mention typical symptoms like headaches and nausea during treatment. Partly because of these positive findings, Texas recently approved a $50 million plan to fund more studies of ibogaine. This program will help match private money for ibogaine trials, which could lead to the drug being approved by the U.S. Food and Drug Administration (FDA). Researchers believe ibogaine could become a broader drug for brain recovery. They think it works on unique brain pathways and could help us better understand how to treat other forms of PTSD, anxiety, and depression that aren't necessarily connected to TBI.