For years, stopping antidepressants was considered a relatively minor medical event—just a temporary adjustment phase. Official guidelines, particularly in the UK and the US, once described withdrawal symptoms as “brief and mild.” But now, emerging research is painting a very different picture—one that could affect millions of long-term users.Recent findings suggest that withdrawing from antidepressants, especially after prolonged use, can trigger severe and long-lasting symptoms, sometimes lasting months or even years. Despite mounting evidence, some recent reviews—funded in part by pharmaceutical ties—continue to rely on outdated, short-term studies that don’t reflect the real-world experiences of long-term patients.The modern class of antidepressants—SSRIs and SNRIs—were introduced in the 1980s and ’90s. When regulatory guidelines were first drafted, they leaned heavily on industry-funded clinical trials, where participants had taken the medications for only 8 to 12 weeks.Because withdrawal symptoms in those short-term trials were limited and often transient, major healthcare bodies like NICE (National Institute for Health and Care Excellence in the UK) assumed the same would hold true for all patients.That assumption, however, ignored the experiences of millions of people who were on antidepressants for much longer periods.A comprehensive new study of NHS patients in the UK has shed light on the scale and severity of antidepressant withdrawal. The findings reveal that patients who had been on antidepressants for more than two years were ten times more likely to experience withdrawal symptoms compared to those who had taken the medication for less than six months. Moreover, the likelihood of experiencing severe symptoms increased fivefold in long-term users. Perhaps most strikingly, symptoms that lasted for three months or more were found to be 18 times more common among those who had used antidepressants for extended periods.In contrast, those who took antidepressants for six months or less mostly experienced mild and short-lived symptoms. Around 75% reported mild or no withdrawal, and only one in four had difficulty stopping but for long-term users, it’s a different story altogether. Two-thirds reported moderate to severe withdrawal symptoms, and nearly a third had symptoms that persisted for over three months.In some cases, withdrawal effects were so debilitating that patients sought emergency care.Against this backdrop, a newly published review in JAMA Psychiatry is drawing criticism. The review—which includes authors with known financial ties to pharmaceutical companies—relied on 11 short-term studies, most involving people who took antidepressants for 8 to 12 weeks. Only one study included participants on the medication for more than six months.Not surprisingly, the review concluded that withdrawal symptoms from antidepressants are not clinically significant. It even went so far as to suggest the symptoms might be caused by the “nocebo effect”—the idea that negative expectations can create physical symptoms.But experts argue that this reasoning is flawed and potentially harmful. The review failed to account for long-term users, excluded several studies with high withdrawal rates, and assumed that common symptoms like dizziness or fatigue are indistinguishable from genuine withdrawal effects.Another glaring issue? The authors treated withdrawal symptoms reported by people stopping a placebo as equivalent to those reported by people stopping real antidepressants—despite clear evidence that the intensity, duration, and impact of symptoms differ significantly between the two. According to recent investigations:In England, 2 million people have been taking antidepressants for over five years.In the United States, that number is at least 25 million.That’s tens of millions of people whose withdrawal experiences are underrepresented in medical literature and underserved by health systems.To use an analogy, relying on eight-week antidepressant studies to predict withdrawal is like testing car safety at 5 km/h, when most people drive at 60 km/h. It simply doesn’t capture the full risk.Is Antidepressant Withdrawal A Real Thing?Yes, antidepressant withdrawal is real—especially if you stop the medication abruptly after taking it for more than four to six weeks. These symptoms, also known as antidepressant discontinuation syndrome, can last for several weeks and vary depending on the type of antidepressant.Importantly, experiencing withdrawal doesn’t mean you’re addicted. Addiction involves compulsive use, cravings, and harmful consequences—none of which apply to antidepressants.To avoid uncomfortable withdrawal effects, always consult your doctor before stopping. Most healthcare providers recommend gradually tapering the dose over weeks or months to help your body adjust. In some cases, a temporary switch to another medication might be advised to ease the transition.If you're switching to a new antidepressant, your doctor may overlap medications to prevent withdrawal symptoms.Since withdrawal can mimic a relapse of depression, it's essential to stay in close contact with your healthcare provider. If symptoms of depression return, your doctor may suggest restarting treatment or exploring alternative therapies.Always follow a medical plan when discontinuing antidepressants—never stop them on your own.What Withdrawal Feels Like?Withdrawal symptoms can vary, but often include:Dizziness or “brain zaps”NauseaHeadachesAnxiety and panicMood swingsInsomniaIrritabilitySensory disturbances (like sensitivity to light or sound)For some, these symptoms are manageable. But for others—especially those stopping medication after years of use—they can be overwhelming and life-altering.Withdrawal from antidepressants is real, and it’s often far more difficult than current medical literature suggests—especially for long-term users. Reviews that lean on short-term, pharmaceutical-funded data do little to help the millions of people struggling silently.Mental health treatment should never be a one-way street. People deserve a clear roadmap for both starting and stopping antidepressants safely, compassionately, and with evidence-based support.