Cinnamon, the sweet spice sprinkled on your morning porridge, stirred into coffee lattes, or mixed into hearty stews may not be as harmless as it is seems, particularly for individuals living with chronic disease. Though this fragrant spice has gained a reputation as heart-healthy and blood sugar-friendly, emerging scientific research is now refuting that position. A new study led by the National Center for Natural Products Research (NCNPR) at the University of Mississippi finds that cinnamon — or, more specifically, its active compound cinnamaldehyde may be able to disrupt the body's ability to effectively break down drugs.This medical breakthrough highlights an emerging issue: how naturally occurring substances and supplements may inadvertently undermine life-saving prescription medications. Here's what you should know.Cinnamaldehyde is the naturally occurring substance that provides cinnamon with its unique taste and scent. It also is responsible for the spice's purported health benefits, such as anti-inflammatory properties and metabolic assistance. But, according to scientists, the same compound can accelerate the way your body metabolizes some medication, causing drug ineffectiveness — a troubling trend for individuals who are taking daily medications.In the NCNPR research, scientists tried out how drugs were absorbed in a model gastric fluid, both with and without the inclusion of cinnamaldehyde. The findings were dramatic: the inclusion of cinnamaldehyde seemed to retard the absorption of drugs in the body. This implies drugs could be eliminated from the body too rapidly to have maximum effect, which would be hazardous for patients treating serious diseases.Chronic Disease Patients More VulnerableIndividuals with chronic diseases such as diabetes, hypertension, cancer, asthma, obesity, HIV, or depression should use caution when taking cinnamon supplements, says Shabana Khan, a lead scientist in the research. "By definition, supplements are not intended to treat, cure or reduce any disease," Khan stressed.This risk is mostly relevant to those taking high amounts of cinnamon, like in capsules, powders, or oils sold as dietary supplements. Khan cautioned that excessive intake might speed up drug elimination from the body, which could undermine or even cancel out the therapeutic benefits of essential medications.Not All Cinnamon Is Created EqualA key subtlety of the study is the difference between various forms of cinnamon products. Amar Chittiboyina, Associate Director at NCNPR, explained that cinnamon oil, which is widely used in food and hygiene products, is not the same risk. Rather, it's cinnamon bark which sits on spice racks or in supplements — that is of concern.Cinnamon bark, especially the Cassia type from southern China, is very high in coumarin, a naturally occurring thinning agent of the blood. Coumarin may raise the threat of bleeding, particularly in those people already on anticoagulant therapy such as aspirin or warfarin.In contrast, Ceylon cinnamon commonly referred to as "true cinnamon" and originating in Sri Lanka has much lower coumarin levels and consequently presents a lesser risk. Nonetheless, even with Ceylon cinnamon, use is recommended cautiously when consumed in excess or combined with prescription medications.The supplement world has long adopted cinnamon for its supposed virtues, from balancing blood sugar to reducing cholesterol and even enhancing brain health. Certain longevity specialists assert it can cut the risk of Alzheimer's by preventing the development of toxic tau proteins in the brain although conclusive human trials are still lacking.Even with these possible benefits, the research highlights the need to know how bioactive compounds such as cinnamaldehyde work with the body. As Khan described, testing its "bio-accessibility, metabolism, and interaction with xenobiotic receptors" is crucial to determining its actual effect when taken with drugs.Why Overconsumption May Cut Your Prescription's Effectiveness?Taking too much cinnamon especially in supplement form can disrupt the way the body absorbs and processes prescription medication. The culprit is cinnamaldehyde, the primary compound of cinnamon, which stimulates receptors that speed up drug metabolism. This increased clearance can decrease the effectiveness of a drug, rendering it less potent in managing chronic diseases such as diabetes, hypertension, or depression. Furthermore, Cassia cinnamon, which is widely available in supermarkets, has high coumarin content, a natural anticoagulant, which can interact with anticoagulant drugs in a dangerous manner. Though safe in moderate use, individuals on long-term medication should seek advice from healthcare experts before incorporating cinnamon supplements into their regimen.Disadvantages of Daily Consumption of CinnamonDaily consumption of large amounts of cinnamon can result in a variety of health hazards. High levels of coumarin present in Cassia cinnamon can lead to liver damage or promote the risk of bleeding when taken with blood-thinning drugs. It can also cause allergic responses, hypoglycemia, or affect the manner in which the body metabolizes important medications. The accumulation of cinnamaldehyde in excessive amounts over-stimulates detoxifying enzymes, thereby diminishing the efficacy of drugs. Additionally, regular consumption of cinnamon supplements without professional monitoring can result in long-term health implications, particularly in patients controlling chronic diseases such as heart disease or diabetes. Safe Use of Cinnamon in Everyday DietsCinnamon can be a tasty and health-enhancing spice if consumed in moderation. A sprinkle of half a teaspoon of Ceylon cinnamon on oatmeal, tea, or smoothies every day is safe for most healthy people. Refrain from taking high-dose supplements except under the advice of a healthcare professional. Use Ceylon cinnamon instead of Cassia to restrict coumarin consumption, particularly if you're taking medications such as blood thinners. Cooking with cinnamon oil is also safer since it has less coumarin. Be sure to check labels when purchasing supplements and speak with your physician if you already have health problems. The trick is thoughtful, moderate use—not megadoses.Although sprinkling a pinch of cinnamon on your coffee or breakfast is unlikely to do any harm, researchers advise consumers, especially those with ongoing health conditions to have a second thought before reaching for high-dose supplements. Cinnamon already is known to interact with at least 47 medications, and new evidence indicates its impact may extend even further.