Ishita Roy

FDA Approves Qfitlia For Hemophilia Patients

FDA approves new drug for hemophilia

The United States Food and Drug Administration has recently approved <span>Qfitila</span> (fitusiran) for routine prophylaxis to prevent or to reduce the frequency of bleeding episodes in adults and pediatric patients 12 years of age and older with <span>hemophilia</span>. It works on those with hemophilia A or hemophilia B, with or without factor VII or IX inhibitors which neutralizes antibodies. 

While subcutaneous Qfitilia does not replace the missing coagulation factor VII or IX, it reduces the amount of protein antithrombin, which leads to an increase in thrombin. It is an enzyme critical for blood clotting. The dosing starts at once every two months and it is also based on the FDA-cleared Innovance Antithrombin companion diagnostic test. 

However, as of now, there is no fixed doses of Qfitila is not approved mainly due the risk excessive clotting. It has also a boxed warning for thrombotic events and gallbladder disease.

One of the most common side effects reported were viral infection, nasopharyngitis, and bacterial infection.

The approval came on the basis of two randomized clinical trials that had 177 adult and pediatric male patients with either hemophilia A or hemophilia B enrolled. Among the participants with inhibitors who received the antithrombin-based dosing regimen of Qfitlia, there was a 73% reduction in the estimated annualized bleeding rate. This was seen in comparison with those who received on-demand treatment with bypassing agents. 

Among the participants without inhibitors receiving the antithrombin-based dosing regimen of Afitlia, there was a 71% reduction in the estimated annualized bleeding rate versus that seen in those who received on-demand treatment with clotting factor concentrates. 

"Today's approval of Qfitlia is significant for patients with hemophilia because it can be administered less frequently than other existing options," Tanya Wroblewski, M.D., deputy director of the Division of Non-Malignant Hematology in the FDA Center for Drug Evaluation and Research, said in a statement.

As per the Centers for Disease Control and Orevention (CDC) it is an inherited bleeding disorder in which blood does not clot properly. It can lead to spontaneous bleeding as well as bleeding following injuries or surgeries. Blood usually has proteins called clotting factors that can help one to stop bleeding. However, people with hemophilia have low levels of either factor VII or factor IX.

Hemophilia could also result in bleeding within joints which can then lead to chronic joint disease and pain. It could lead to bleeding in head and in brain, causing long term problems such as seizures or paralysis. In severe cases it can also lead to death if the bleeding cannot be stopped. 

The most common types of hemophilia are inherited, thus it is a condition that is present from birth. There are rare cases where hemophilia happens later in life, which is known as acquired hemophilia. 

<h4>Difference between Hemophilia A and Hemophilia B</h4>

As per the National Bleeding Disorders Foundation, hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.

Hemophilia B, also called factor IX (FIX) deficiency or <a href="https://www.healthandme.com/health-wellness/what-is-the-christmas-disease-article-151105741" data-type="tilCustomLink">Christmas disease</a>, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.

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The United States Food and Drug Administration has recently approved Qfitila (fitusiran) for routine prophylaxis to prevent or to reduce the frequency of bleeding episodes in adults and pediatric patients 12 years of age and older with hemophilia. It works on those with hemophilia A or hemophilia B, with or without factor VII or IX inhibitors which neutralizes antibodies. While subcutaneous Qfitilia does not replace the missing coagulation factor VII or IX, it reduces the amount of protein antithrombin, which leads to an increase in thrombin. It is an enzyme critical for blood clotting. The dosing starts at once every two months and it is also based on the FDA-cleared Innovance Antithrombin companion diagnostic test. However, as of now, there is no fixed doses of Qfitila is not approved mainly due the risk excessive clotting. It has also a boxed warning for thrombotic events and gallbladder disease.One of the most common side effects reported were viral infection, nasopharyngitis, and bacterial infection.How Was This Approved?The approval came on the basis of two randomized clinical trials that had 177 adult and pediatric male patients with either hemophilia A or hemophilia B enrolled. Among the participants with inhibitors who received the antithrombin-based dosing regimen of Qfitlia, there was a 73% reduction in the estimated annualized bleeding rate. This was seen in comparison with those who received on-demand treatment with bypassing agents. Among the participants without inhibitors receiving the antithrombin-based dosing regimen of Afitlia, there was a 71% reduction in the estimated annualized bleeding rate versus that seen in those who received on-demand treatment with clotting factor concentrates. "Today's approval of Qfitlia is significant for patients with hemophilia because it can be administered less frequently than other existing options," Tanya Wroblewski, M.D., deputy director of the Division of Non-Malignant Hematology in the FDA Center for Drug Evaluation and Research, said in a statement.What Is Hemophilia?As per the Centers for Disease Control and Orevention (CDC) it is an inherited bleeding disorder in which blood does not clot properly. It can lead to spontaneous bleeding as well as bleeding following injuries or surgeries. Blood usually has proteins called clotting factors that can help one to stop bleeding. However, people with hemophilia have low levels of either factor VII or factor IX.Hemophilia could also result in bleeding within joints which can then lead to chronic joint disease and pain. It could lead to bleeding in head and in brain, causing long term problems such as seizures or paralysis. In severe cases it can also lead to death if the bleeding cannot be stopped. The most common types of hemophilia are inherited, thus it is a condition that is present from birth. There are rare cases where hemophilia happens later in life, which is known as acquired hemophilia. Difference between Hemophilia A and Hemophilia BAs per the National Bleeding Disorders Foundation, hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.

fda approves qfitlia for hemophilia patients

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Veteran actor and producer <span>Dheeraj Kumar</span>, best known for his contributions to Hindi and Punjabi cinema, passed away at a private hospital in Mumbai on Tuesday, July 15. He was 79.

<h4>Admitted with <span rel="noindex">Pneumonia</span>, Succumbed to Organ Failure</h4>

According to sources close to the family, Kumar had been admitted to the Intensive Care Unit after being diagnosed with acute pneumonia. His health took a critical turn on Monday as he suffered multiple organ failure and was subsequently placed on ventilator support. He breathed his last around 11 AM on Tuesday, with his son by his side in his final moments.

<h4>A Career That Began With a Talent Contest</h4>

Dheeraj Kumar’s journey into the world of entertainment began in the mid-1960s, when he participated in a talent contest that also featured Rajesh Khanna and Subhash Ghai. In a 2012 interview with <em>The Hindu</em>, Kumar recalled:

“In a talent contest in Mumbai in the 1960s, three were selected to be actors among some 10,000 aspirants — Rajesh Khanna, myself and Subhash Ghai... He became a superstar.”

Kumar went on to act in several films, including Rakhwala, Tyaag and Sargam, and shared screen space with many leading actors of the time. Over the years, he transitioned into television production and was known for creating popular shows such as Om Namah Shivay and Shree Ganesh. His last known collaboration with Rajesh Khanna was a TV series in 2019.

<h4>Understanding Pneumonia and Its Risks</h4>

As per the American Lung Association, pneumonia is an infection that causes inflammation in the air sacs (alveoli) of one or both lungs. These air sacs may fill with fluid or pus, leading to symptoms that range from mild to life-threatening. Acute pneumonia, in particular, can cause sudden and severe respiratory symptoms.

<strong>Some of the common symptoms include:</strong>

<ul><li>Persistent cough with yellow, green, or bloody mucus</li><li>High fever, sweating and chills</li><li>Shortness of breath and chest pain while coughing or breathing</li><li>Fatigue, nausea or vomiting</li><li>Confusion, especially in older adults</li></ul>

Kumar’s condition is a reminder that pneumonia can escalate quickly, especially in older individuals or those with weakened immune systems.

Yes, pneumonia can be deadly—especially when left untreated or when it occurs in high-risk individuals. According to global estimates, as noted by the American Lungs Association, over 1.8 million people die from pneumonia each year, with children under five in low-income countries being the most vulnerable. In older adults, complications such as respiratory failure, sepsis, or organ failure often lead to death.

Bacterial pneumonia is more likely to require hospitalization, but viral and fungal forms can also be life-threatening. Vaccines such as the pneumococcal vaccine and flu shots can significantly reduce the risk of infection, particularly in older adults.

Maintaining overall health, timely vaccinations, and early medical intervention are critical in preventing complications.

Dheeraj Kumar

dhiraj kumar

india news

Pneumonia

Veteran actor and producer Dheeraj Kumar, best known for his contributions to Hindi and Punjabi cinema, passed away at a private hospital in Mumbai on Tuesday, July 15. He was 79.Admitted with Pneumonia, Succumbed to Organ FailureAccording to sources close to the family, Kumar had been admitted to the Intensive Care Unit after being diagnosed with acute pneumonia. His health took a critical turn on Monday as he suffered multiple organ failure and was subsequently placed on ventilator support. He breathed his last around 11 AM on Tuesday, with his son by his side in his final moments.A Career That Began With a Talent ContestDheeraj Kumar’s journey into the world of entertainment began in the mid-1960s, when he participated in a talent contest that also featured Rajesh Khanna and Subhash Ghai. In a 2012 interview with The Hindu, Kumar recalled:“In a talent contest in Mumbai in the 1960s, three were selected to be actors among some 10,000 aspirants — Rajesh Khanna, myself and Subhash Ghai... He became a superstar.”Kumar went on to act in several films, including Rakhwala, Tyaag and Sargam, and shared screen space with many leading actors of the time. Over the years, he transitioned into television production and was known for creating popular shows such as Om Namah Shivay and Shree Ganesh. His last known collaboration with Rajesh Khanna was a TV series in 2019.Understanding Pneumonia and Its RisksAs per the American Lung Association, pneumonia is an infection that causes inflammation in the air sacs (alveoli) of one or both lungs. These air sacs may fill with fluid or pus, leading to symptoms that range from mild to life-threatening. Acute pneumonia, in particular, can cause sudden and severe respiratory symptoms.Some of the common symptoms include:Persistent cough with yellow, green, or bloody mucusHigh fever, sweating and chillsShortness of breath and chest pain while coughing or breathingFatigue, nausea or vomitingConfusion, especially in older adultsKumar’s condition is a reminder that pneumonia can escalate quickly, especially in older individuals or those with weakened immune systems.Can Pneumonia Be Fatal?Yes, pneumonia can be deadly—especially when left untreated or when it occurs in high-risk individuals. According to global estimates, as noted by the American Lungs Association, over 1.8 million people die from pneumonia each year, with children under five in low-income countries being the most vulnerable. In older adults, complications such as respiratory failure, sepsis, or organ failure often lead to death.Bacterial pneumonia is more likely to require hospitalization, but viral and fungal forms can also be life-threatening. Vaccines such as the pneumococcal vaccine and flu shots can significantly reduce the risk of infection, particularly in older adults.Maintaining overall health, timely vaccinations, and early medical intervention are critical in preventing complications.

veteran actor dheeraj kumar dies at 79 due to acute pneumonia

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After <a href="https://www.healthandme.com/health-wellness/why-wimbledon-winner-jannik-sinner-was-banned-the-clostebol-drug-test-controversy-explained-article-152275576" data-type="tilCustomLink">J</a><a href="https://www.healthandme.com/health-wellness/why-wimbledon-winner-jannik-sinner-was-banned-the-clostebol-drug-test-controversy-explained-article-152275576" data-type="tilCustomLink">annik Sinner</a>'s news of anti-doping test, British tennis player <span>Tara Moore</span> is also making news. The 32-year-old was Britain's top ranked women's doubles player when she was provisionally banned in May 2022. Again, she has been banned for four years for a doping offence, though she had been cleared for the same by an independent tribunal just 18 months ago. 

She was tested positive for nandrolone and boldenone at a tournament in the Colombian capital Bogota the previous month.

The reason Moore provided was due to the ingestion of contaminated meat. While in December 2023, an independent tribunal ruled that contaminated meat was the reason that the test came positive and Moore "bore no fault or negligence"; the International Tennis Integrity Agency (ITIA) thinks otherwise. 

ITIA has been upheld by the Court of Arbitration for Sport (Cas). In the March hearing, Cas said in a media release: "After reviewing the scientific and legal evidence, the majority of the Cas panel considered that the player did not succeed in proving that the concentration of nandrolone in her sample was consistent with the ingestion of contaminated meat."

This means Moore will not be free to play again until the start of 2028 season. "The panel concluded that Ms Moore failed to establish that the ADRV (Anti-Doping Rule Violation) was not intentional. The appeal by the ITIA is therefore upheld and the decision rendered by the Independent Tribunal is set aside."

The ITIA chief executive Karen Moorhouse told BBC,"For the ITIA, every case is considered according to the individual facts and circumstances. In this case, our independent scientific advice was that the player did not adequately explain the high level of nandrolone present in their sample. Today's ruling is consistent with this position."

<h4>What Do Nandrolone Decanoate And Boldenone Do To You?</h4>

<strong>Nandrolone Decanoate:</strong> As per a 2020 study published in journal Medicina, nandrolone decanoate is an androgen, which means it plays a significant role in the development of male reproductive organs. The study notes: "The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones." The study also mentions that apart from its clinical use, skeletal muscles can be considered as the primary target tissue. "Nowadays, especially athletes in power sports such as bodybuilding and weightlifting administer illegally high doses of Anabolic Androgenic Steroids (AAS) to increase their muscle mass and improve their overall performance," notes the study. 

Nandrolone Decanoate injections have been classified under the Anabolic Steroids Control Act of 1990 and due to its serious health risks, it is banned by most sports organization and is also listed in the prohibition list by the World Anti-Doping Agency (WADA). 

<ul><li>Infertility</li><li>Liver Toxicity</li><li>Impaired Lipid Profile</li><li>High Blood Pressure</li><li>Acne</li><li>Hair Loss</li><li>Gynecomastia</li></ul>

<strong>Boldenone: </strong>As per a 2016 study published in the Journal of Food and Drug Analysis, this AAS can be used in repairing wasting of the body caused by some emaciating disease. It can also be used for human sports for better performance and promoting the growth of skeletal muscle. 

However, this is also used for increasing the body weight in livestock as growth-promoting agents. This is also one of the matters the study looks into, in order to "evaluate the safety and meat quality criteria in broilers following intramuscular injection of boldenone." This is the reason Moore too used in her defense, that the result of her positive test was contaminated meat. 

The US Anti-Doping Agency (USADA) notes that there is no therapeutic or medical use for boldenone in humans. More specifically, it is not approved by the Food and Drug Administration (FDA) for use in humans for any reason. It also notes that WADA has included boldenone in its prohibited list. Since it could occur naturally at very low concentrations in the urine, WADA-accredited laboratories apply a specific analysis procedure called carbon isotope ratio mass spectrometry, or GC/C/IRMS, to differentiate between external administration and internal production.

What are the side effects? USADA notes that in men, boldenone causes decreased testosterone production and impacts the reproductive system and fertility of males. It also impacts the size of the testes, lower sperm count, and sperm mobility.

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uk health news

jannik sinner

doping test

After Jannik Sinner's news of anti-doping test, British tennis player Tara Moore is also making news. The 32-year-old was Britain's top ranked women's doubles player when she was provisionally banned in May 2022. Again, she has been banned for four years for a doping offence, though she had been cleared for the same by an independent tribunal just 18 months ago. She was tested positive for nandrolone and boldenone at a tournament in the Colombian capital Bogota the previous month.The reason Moore provided was due to the ingestion of contaminated meat. While in December 2023, an independent tribunal ruled that contaminated meat was the reason that the test came positive and Moore "bore no fault or negligence"; the International Tennis Integrity Agency (ITIA) thinks otherwise. ITIA has been upheld by the Court of Arbitration for Sport (Cas). In the March hearing, Cas said in a media release: "After reviewing the scientific and legal evidence, the majority of the Cas panel considered that the player did not succeed in proving that the concentration of nandrolone in her sample was consistent with the ingestion of contaminated meat."This means Moore will not be free to play again until the start of 2028 season. "The panel concluded that Ms Moore failed to establish that the ADRV (Anti-Doping Rule Violation) was not intentional. The appeal by the ITIA is therefore upheld and the decision rendered by the Independent Tribunal is set aside."The ITIA chief executive Karen Moorhouse told BBC,"For the ITIA, every case is considered according to the individual facts and circumstances. In this case, our independent scientific advice was that the player did not adequately explain the high level of nandrolone present in their sample. Today's ruling is consistent with this position."What Do Nandrolone Decanoate And Boldenone Do To You?Nandrolone Decanoate: As per a 2020 study published in journal Medicina, nandrolone decanoate is an androgen, which means it plays a significant role in the development of male reproductive organs. The study notes: "The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones." The study also mentions that apart from its clinical use, skeletal muscles can be considered as the primary target tissue. "Nowadays, especially athletes in power sports such as bodybuilding and weightlifting administer illegally high doses of Anabolic Androgenic Steroids (AAS) to increase their muscle mass and improve their overall performance," notes the study. Nandrolone Decanoate injections have been classified under the Anabolic Steroids Control Act of 1990 and due to its serious health risks, it is banned by most sports organization and is also listed in the prohibition list by the World Anti-Doping Agency (WADA). Side Effects Include:InfertilityLiver ToxicityImpaired Lipid ProfileHigh Blood PressureAcneHair LossGynecomastiaBoldenone: As per a 2016 study published in the Journal of Food and Drug Analysis, this AAS can be used in repairing wasting of the body caused by some emaciating disease. It can also be used for human sports for better performance and promoting the growth of skeletal muscle. However, this is also used for increasing the body weight in livestock as growth-promoting agents. This is also one of the matters the study looks into, in order to "evaluate the safety and meat quality criteria in broilers following intramuscular injection of boldenone." This is the reason Moore too used in her defense, that the result of her positive test was contaminated meat. The US Anti-Doping Agency (USADA) notes that there is no therapeutic or medical use for boldenone in humans. More specifically, it is not approved by the Food and Drug Administration (FDA) for use in humans for any reason. It also notes that WADA has included boldenone in its prohibited list. Since it could occur naturally at very low concentrations in the urine, WADA-accredited laboratories apply a specific analysis procedure called carbon isotope ratio mass spectrometry, or GC/C/IRMS, to differentiate between external administration and internal production.What are the side effects? USADA notes that in men, boldenone causes decreased testosterone production and impacts the reproductive system and fertility of males. It also impacts the size of the testes, lower sperm count, and sperm mobility.

after jannik sinner, tara moore makes news failing her doping test, resulting in a 4-year long ban

Panchayat's Asif Khan Suffers From A Heart Attack, Shares Updates

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Asif's Instagram Stories

Actor <span>Aasif Khan</span>, known for his performances in Pataal Lok and Panchayat, recently suffered a <span>heart attack</span> and was admitted to Kokilaben Hospital in Mumbai. The incident occurred two days ago, sending a wave of concern among his fans and industry peers. Fortunately, his condition is now stable.

According to hospital sources, Aasif is recovering well and is likely to be discharged in a couple of days.

The actor took to his Instagram stories to share an update, along with a photo from his hospital bed. In a deeply reflective note, he wrote:

“Life is short, don’t take one day for granted. Everything can change in a moment. Be grateful for all you have and all that you are… Life is a gift and we are blessed.”

In a brief statement to <em>India Today</em>, Aasif confirmed he had been dealing with a health issue that required hospitalization.

“I’m grateful to share that I’m now on the road to recovery and feeling much better,” he said. “I truly appreciate all the love, concern, and well-wishes. Your support means the world to me. I’ll be back very soon.”

His update comes as a reminder of how sudden and serious heart-related conditions can be—even among young and seemingly healthy individuals.

A heart attack, or myocardial infarction, occurs when blood flow to a part of the heart is blocked, usually by a clot, causing damage to the heart muscle. It’s often linked to lifestyle factors like high cholesterol, smoking, stress, and lack of exercise—but can also strike unexpectedly.

While heart attacks are more common in those over 50, studies show a rising number of younger adults are now at risk. According to a 2019 study published in the Journal of the American College of Cardiology, one in five heart attack patients in the U.S. was under the age of 40.

In India, the numbers are more alarming. The Indian Heart Association notes that 50% of all heart attacks in Indian men occur under the age of 50, and 25% occur under the age of 40. Factors like sedentary lifestyles, unhealthy diets, and high stress contribute significantly.

Aasif’s case highlights the importance of recognizing the early symptoms of a heart attack, which can include:

<ul><li>Chest pain or tightness</li><li>Pain in the left arm, jaw, or upper back</li><li>Shortness of breath</li><li>Cold sweat or nausea</li><li>Unusual fatigue or lightheadedness</li></ul>

If any of these symptoms occur, immediate medical attention is essential. Early intervention can save lives.

For now, Aasif Khan’s fans and colleagues continue to send him strength and support. And as he put it, he’ll be “back very soon”—with renewed gratitude and, hopefully, greater awareness for all.

aasif khan

aasif khan actor

health news india

aasif khan heart attack

heart attack

heart health

Actor Aasif Khan, known for his performances in Pataal Lok and Panchayat, recently suffered a heart attack and was admitted to Kokilaben Hospital in Mumbai. The incident occurred two days ago, sending a wave of concern among his fans and industry peers. Fortunately, his condition is now stable.According to hospital sources, Aasif is recovering well and is likely to be discharged in a couple of days.The actor took to his Instagram stories to share an update, along with a photo from his hospital bed. In a deeply reflective note, he wrote:“Life is short, don’t take one day for granted. Everything can change in a moment. Be grateful for all you have and all that you are… Life is a gift and we are blessed.”Recovering From AttackIn a brief statement to India Today, Aasif confirmed he had been dealing with a health issue that required hospitalization.“I’m grateful to share that I’m now on the road to recovery and feeling much better,” he said. “I truly appreciate all the love, concern, and well-wishes. Your support means the world to me. I’ll be back very soon.”His update comes as a reminder of how sudden and serious heart-related conditions can be—even among young and seemingly healthy individuals.How Do Heart Attacks Happen?A heart attack, or myocardial infarction, occurs when blood flow to a part of the heart is blocked, usually by a clot, causing damage to the heart muscle. It’s often linked to lifestyle factors like high cholesterol, smoking, stress, and lack of exercise—but can also strike unexpectedly.While heart attacks are more common in those over 50, studies show a rising number of younger adults are now at risk. According to a 2019 study published in the Journal of the American College of Cardiology, one in five heart attack patients in the U.S. was under the age of 40.In India, the numbers are more alarming. The Indian Heart Association notes that 50% of all heart attacks in Indian men occur under the age of 50, and 25% occur under the age of 40. Factors like sedentary lifestyles, unhealthy diets, and high stress contribute significantly.Signs to Watch ForAasif’s case highlights the importance of recognizing the early symptoms of a heart attack, which can include:Chest pain or tightnessPain in the left arm, jaw, or upper backShortness of breathCold sweat or nauseaUnusual fatigue or lightheadednessIf any of these symptoms occur, immediate medical attention is essential. Early intervention can save lives.For now, Aasif Khan’s fans and colleagues continue to send him strength and support. And as he put it, he’ll be “back very soon”—with renewed gratitude and, hopefully, greater awareness for all.

panchayat's asif khan suffers from a heart attack, shares updates

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FDA Approves Qfitlia For Hemophilia Patients

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Veteran Actor Dheeraj Kumar Dies At 79 Due To Acute Pneumonia

After Jannik Sinner, Tara Moore Makes News Failing Her Doping Test, Resulting In A 4-Year Long Ban

Panchayat's Asif Khan Suffers From A Heart Attack, Shares Updates

Health Conditions A-Z

Vaccines For Children Pose No Threat To Their Heart Health Or Other Health Issues: Study

Veteran Actor Dheeraj Kumar Dies At 79 Due To Acute Pneumonia

After Jannik Sinner, Tara Moore Makes News Failing Her Doping Test, Resulting In A 4-Year Long Ban