Tanya Dutt

Smoking Could Lead To Nearly 300,000 Cancer Cases In The UK By 2029, Claims New Study

Smoking remains a major public health challenge in the UK, with a new study by <span><a href="https://www.healthandme.com/health/cancer">Cancer</a></span> Research UK predicting that tobacco use could cause nearly 300,000 new cancer cases by 2029. This stark finding has prompted urgent calls for lawmakers to support the proposed tobacco and vapes bill, which aims to eradicate smoking in the country by introducing age-based restrictions on tobacco sales.

The research, highlights the devastating impact of smoking on public health. If current smoking trends continue, then by the end of this parliamentary term in July 2029, there are chances that the UK might record 296,661 new cancer cases attributable to tobacco. The regional breakdown stands at an estimated 243,045 in England, 29,365 in Scotland, 15,161 in Wales, and 9,090 in Northern Ireland.

Alarmingly, it might cause an estimated 2,846 added cancer cases in non-smokers. On average, almost 160 smoking-related cancer cases were diagnosed daily in 2023, reflecting the continued burden of tobacco on the nation's health care system.

Given this, Cancer Research UK is calling upon MPs to vote to pass the tobacco and vapes bill scheduled for its second reading in the House of Commons. Proposed to make the country among the first in the world to eradicate smoking with a proposed legal age to buy tobacco products, from which smoking would effectively be prohibited for everyone born on or after 1 January 2009.

According to charity, this bill is a "historic opportunity" in saving lives, preventing thousands of new cancer cases, and reducing the enormous burden on the NHS, as well. Smoking has remained the leading cause of preventable deaths in the UK, and since about 350 young people start smoking each day, actions must be taken speedily.

Smoking remains a popular habit among young adults, despite its prevalence falling. In 2023, an estimated 11.9% of those aged over 18, or around 6 million people, smoked cigarettes; this is the lowest proportion since these records started in 2011. However, according to Cancer Research UK, 35,000 young adults aged between 18 and 25 have started smoking since July.

Such a trend draws to close attention an urgent need for targeted measures to prevent initiation of smoking among the youth. The bill seeks to include restrictions on vape advertisements and sponsorships, flavorings, and packaging, not to mention a complete ban on smoking and vaping in playgrounds and close to schools.

Cancer Research UK argued that the "scale of harm" caused by smoking is now too big to be ignored. In this context, the charity saw the bill on tobacco and vapes as an important step toward a smoke-free generation with reduced preventable burden of diseases caused by tobacco.

Every day, 350 young people are enticed into smoking-a habit that may lead to a life of health complications," a charity spokesperson said. "This law provides the opportunity to reverse this trend and shield future generations from the catastrophic effects of tobacco.

As MPs debate the bill, there is little doubt of what is at stake: without major action now, the costs of tobacco on public health will continue to escalate. The new legislation is not merely preventive in its intent; it is a promise of protection for millions and the enormous relief on healthcare from smoking.

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Smoking remains a major public health challenge in the UK, with a new study by Cancer Research UK predicting that tobacco use could cause nearly 300,000 new cancer cases by 2029. This stark finding has prompted urgent calls for lawmakers to support the proposed tobacco and vapes bill, which aims to eradicate smoking in the country by introducing age-based restrictions on tobacco sales.The research, highlights the devastating impact of smoking on public health. If current smoking trends continue, then by the end of this parliamentary term in July 2029, there are chances that the UK might record 296,661 new cancer cases attributable to tobacco. The regional breakdown stands at an estimated 243,045 in England, 29,365 in Scotland, 15,161 in Wales, and 9,090 in Northern Ireland.Alarmingly, it might cause an estimated 2,846 added cancer cases in non-smokers. On average, almost 160 smoking-related cancer cases were diagnosed daily in 2023, reflecting the continued burden of tobacco on the nation's health care system.Given this, Cancer Research UK is calling upon MPs to vote to pass the tobacco and vapes bill scheduled for its second reading in the House of Commons. Proposed to make the country among the first in the world to eradicate smoking with a proposed legal age to buy tobacco products, from which smoking would effectively be prohibited for everyone born on or after 1 January 2009.According to charity, this bill is a "historic opportunity" in saving lives, preventing thousands of new cancer cases, and reducing the enormous burden on the NHS, as well. Smoking has remained the leading cause of preventable deaths in the UK, and since about 350 young people start smoking each day, actions must be taken speedily.Effect of Smoking on YouthsSmoking remains a popular habit among young adults, despite its prevalence falling. In 2023, an estimated 11.9% of those aged over 18, or around 6 million people, smoked cigarettes; this is the lowest proportion since these records started in 2011. However, according to Cancer Research UK, 35,000 young adults aged between 18 and 25 have started smoking since July.Such a trend draws to close attention an urgent need for targeted measures to prevent initiation of smoking among the youth. The bill seeks to include restrictions on vape advertisements and sponsorships, flavorings, and packaging, not to mention a complete ban on smoking and vaping in playgrounds and close to schools.Cancer Research UK argued that the "scale of harm" caused by smoking is now too big to be ignored. In this context, the charity saw the bill on tobacco and vapes as an important step toward a smoke-free generation with reduced preventable burden of diseases caused by tobacco.Every day, 350 young people are enticed into smoking-a habit that may lead to a life of health complications," a charity spokesperson said. "This law provides the opportunity to reverse this trend and shield future generations from the catastrophic effects of tobacco.As MPs debate the bill, there is little doubt of what is at stake: without major action now, the costs of tobacco on public health will continue to escalate. The new legislation is not merely preventive in its intent; it is a promise of protection for millions and the enormous relief on healthcare from smoking.

smoking could lead to nearly 300,000 cancer cases in the uk by 2029, claims new study

Health and Me

Ishita Roy

RFK Hires Autism Skeptic To Look Into CDC Autism Data

RFK Hires Autism Skeptic

Kennedy Names New Vaccine Advisers Among Whom Are Anti-Vaxxers And Those Who Spread Misinformation

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Dr. David Geier, a controversial orthopedic surgeon and known vaccine skeptic, is attempting to revisit long-debunked claims linking vaccines to autism. Recently hired by Health Secretary Robert F. Kennedy Jr., Geier is now reviewing historical safety data to investigate whether government agencies concealed crucial information.

<h4>Accessing <span rel="noindex">CDC</span>'s Vaccine Safety Database</h4>

Geier is reportedly seeking access to the U.S. Centers for Disease Control and Prevention’s (CDC) Vaccine Safety Datalink (VSD), a repository of vaccine safety records from millions of patients. The VSD is maintained by a dozen major healthcare systems, each controlling its own data. Full access has always been tightly controlled due to privacy and misuse concerns.

Geier previously accessed the database in 2004 and 2006. However, according to The Wall Street Journal, CDC officials revoked his access both times, alleging he had misrepresented his research intentions.

Despite this, Geier is once again pushing to analyze the data. It remains unclear if access has been granted. A spokesperson for the U.S. Department of Health and Human Services (HHS) stated that the department intends to take a “fresh look at all data including old data,” and emphasized that they would “follow the science—wherever it leads.”

<h4>Scientific Community Raises Concerns</h4>

The scientific and public health communities have expressed concern over Geier's involvement. “He has no record in the scientific community of doing valid work,” said Dr. Walter Orenstein, former director of the CDC’s immunization program.

Geier and his late father, geneticist Mark Geier, have long promoted the theory that vaccines cause autism—an idea widely discredited by the medical community. The pair also introduced a controversial treatment using hormone-blocking drugs, which resulted in the revocation of Mark Geier’s medical license and disciplinary actions against David Geier for practicing medicine without a license.

At a 2015 conference, Geier defended his position, claiming the scientific community dismisses their findings without proper consideration. “They think that [the vaccine's link to autism has] been completely debunked,” he said at the time.

<h4>Kennedy's Role and the Larger Context</h4>

Robert F. Kennedy Jr., a vocal critic of vaccine mandates, has clarified that Geier will not lead autism research. Instead, his focus will be on identifying any possibly overlooked or hidden data within the CDC’s database.

“There has been a lot of monkey business with the VSD,” Kennedy stated in a previous congressional appearance.

Kennedy, who once authored a now-retracted Rolling Stone article alleging a vaccine-autism cover-up, cited a 2000 CDC conference that explored preliminary data on thimerosal—a mercury-based preservative once used in vaccines. Though early findings prompted questions, later analysis confirmed no link between thimerosal and autism. Thimerosal was removed from most vaccines in 2001, and final results were published in 2003.

<h4>Exploring Autism Causes and Rising Rates</h4>

While Geier conducts his review, the U.S. Department of Health and Human Services is separately examining rising autism rates. The CDC now estimates that 1 in 31 eight-year-olds in the U.S. were diagnosed with autism in 2022. Experts attribute the increase to a combination of better diagnostic methods, genetic factors, and increased awareness.

The National Institutes of Health (NIH) also plans to fund research into other possible causes, such as environmental toxins and diet. Meanwhile, Children's Health Defense, a nonprofit formerly led by Kennedy, is hosting an online event this week centered on what it calls the “autism cover-up.”

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Dr. David Geier, a controversial orthopedic surgeon and known vaccine skeptic, is attempting to revisit long-debunked claims linking vaccines to autism. Recently hired by Health Secretary Robert F. Kennedy Jr., Geier is now reviewing historical safety data to investigate whether government agencies concealed crucial information.Accessing CDC's Vaccine Safety DatabaseGeier is reportedly seeking access to the U.S. Centers for Disease Control and Prevention’s (CDC) Vaccine Safety Datalink (VSD), a repository of vaccine safety records from millions of patients. The VSD is maintained by a dozen major healthcare systems, each controlling its own data. Full access has always been tightly controlled due to privacy and misuse concerns.Geier previously accessed the database in 2004 and 2006. However, according to The Wall Street Journal, CDC officials revoked his access both times, alleging he had misrepresented his research intentions.Despite this, Geier is once again pushing to analyze the data. It remains unclear if access has been granted. A spokesperson for the U.S. Department of Health and Human Services (HHS) stated that the department intends to take a “fresh look at all data including old data,” and emphasized that they would “follow the science—wherever it leads.”Scientific Community Raises ConcernsThe scientific and public health communities have expressed concern over Geier's involvement. “He has no record in the scientific community of doing valid work,” said Dr. Walter Orenstein, former director of the CDC’s immunization program.Geier and his late father, geneticist Mark Geier, have long promoted the theory that vaccines cause autism—an idea widely discredited by the medical community. The pair also introduced a controversial treatment using hormone-blocking drugs, which resulted in the revocation of Mark Geier’s medical license and disciplinary actions against David Geier for practicing medicine without a license.At a 2015 conference, Geier defended his position, claiming the scientific community dismisses their findings without proper consideration. “They think that [the vaccine's link to autism has] been completely debunked,” he said at the time.Kennedy's Role and the Larger ContextRobert F. Kennedy Jr., a vocal critic of vaccine mandates, has clarified that Geier will not lead autism research. Instead, his focus will be on identifying any possibly overlooked or hidden data within the CDC’s database.“There has been a lot of monkey business with the VSD,” Kennedy stated in a previous congressional appearance.Kennedy, who once authored a now-retracted Rolling Stone article alleging a vaccine-autism cover-up, cited a 2000 CDC conference that explored preliminary data on thimerosal—a mercury-based preservative once used in vaccines. Though early findings prompted questions, later analysis confirmed no link between thimerosal and autism. Thimerosal was removed from most vaccines in 2001, and final results were published in 2003.Exploring Autism Causes and Rising RatesWhile Geier conducts his review, the U.S. Department of Health and Human Services is separately examining rising autism rates. The CDC now estimates that 1 in 31 eight-year-olds in the U.S. were diagnosed with autism in 2022. Experts attribute the increase to a combination of better diagnostic methods, genetic factors, and increased awareness.The National Institutes of Health (NIH) also plans to fund research into other possible causes, such as environmental toxins and diet. Meanwhile, Children's Health Defense, a nonprofit formerly led by Kennedy, is hosting an online event this week centered on what it calls the “autism cover-up.”

rfk hires autism skeptic to look into cdc autism data

Covid-19 Active Cases Cross 7,100 In India But Signs Point To A Slowdown—How To Stay Protected Now?

India's COVID Tally Soars To Nearly 7000 Active Cases With 3 Deaths In 24 Hours; Is A New Wave Here?

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India is again facing a concerning but seemingly controlled increase in <span>Covid-19</span> cases. As of June 13, 2025, the active case count of the country is 7,131, as per the Ministry of Health and Family Welfare. Although new daily cases increased by 33 and three more deaths were added—two in Maharashtra and one in Madhya Pradesh—the overall trend indicates a potential plateau and even a slight dip, which gives optimistic hopes.

The most recent state-by-state Covid-19 dashboard published by the Ministry of Health and Family Welfare indicates remarkable regional variations in infection incidence in India. Kerala remains to have the highest burden, with 2,055 active cases, out of which 110 were new cases in one day. Gujarat is the second worst-affected state with 1,358 active cases, which saw a steep daily jump of 77 cases. Other majorly affected states are West Bengal, with 747 active cases; Delhi, with 714 cases; and Maharashtra, with 629 active infections. The Karnataka region showed a significant increase with 72 new cases, taking its active caseload to 395. On the other hand, there are no active Covid-19 cases in certain states like Arunachal Pradesh, Mizoram, and Manipur, hinting at effective containment measures. In spite of these diverse regional numbers, the overall national trend seems positively tentative. There were 1,420 new recoveries logged, elevating the total number of recovered or migrated persons to 10,976 for the year, which highlights India's resilience in its continuous Covid-19 response.

The increase is credited mainly to new Omicron sub-variants, such as JN.1, LF.7, NB.1.8.1, and XFG, which are highly contagious but produce milder symptoms than previous strains. These variants are now listed as "Variants Under Monitoring" by the World Health Organization (WHO). While not yet classified as variants of concern, they necessitate heightened vigilance, particularly among high-risk groups.

Experts advise against attributing these numbers to the onset of a full-blown wave. Rather, they refer to a seasonal surge, similar to the flu, which is consonant with the virus's post-pandemic shift towards an endemic pattern.

<h2>Why Are Booster Shots Not Recommended?</h2>

In light of India's high hybrid immunity from both vaccinations and past infections, health authorities as of now not recommending mass booster drives. Rather, targeted vaccination is being encouraged for:

<ul><li>The elderly</li><li>Immunocompromised hosts</li><li>People with chronic respiratory or cardiovascular disease</li></ul>

The Indian Medical Association and health professionals emphasize that this risk-based, strategic strategy is more effective protection than mass immunization campaigns.

Even with the recent upsurge, health workers urge not panicking but remaining proactive. Distinguishing between Covid-19 and other common seasonal viral infections—often producing the same symptoms as fever, fatigue, and cough—is now of paramount importance.

Physicians and public health specialist, point out that exhaustion from sustained lookout can precipitate complacency. We can't ignore Covid-19 as a historical moment. It's very much still around—but controlled with the appropriate preventive measures.

<h2>Actionable Tips To Prevent COVID Infection</h2>

Nowadays, personal responsibility and daily routine are still your best protection. Here's how to protect yourself:

<h4>1. Wear a Mask in Crowded Indoor Spaces</h4>

Though mandates may have disappeared, masks are effective, especially in poorly ventilated spaces indoors, on public transportation, and in medical offices.

<h4>2. Get Current with Targeted Vaccines</h4>

If you are in a high-risk group, speak with your health care provider about boosters that are available or trials soon to be under way for new variant-specific vaccines.

Prioritize a balanced diet, proper sleep, and regular physical activity in order to maintain your immune system strong against not only Covid-19 but also other flu and seasonal diseases.

Good hygiene habits such as regular handwashing, the use of sanitizers, and not touching your face while in public can significantly minimize the risk of transmission.

If you are symptomatic—or have someone living with you who is—skip gatherings and go remote work whenever possible.

Notice signs such as fever, chronic cough, body pain, fatigue, and taste/smell loss. Test early and self-isolate to avoid transmission.

Particularly if above 60 years or with underlying conditions, don't wait even for minor symptoms. Early treatment can be life-saving.

The India Covid-19 situation is serious but under control. Yes, the active cases are more than 7,100, but the recovery rates are robust, and the fatalities are few and limited to the vulnerable groups.

Instead of fear, this time it requires a recommitment to public health practices—from mask-wearing when necessary to symptom-watching and protecting the vulnerable.

<h2>Key Figures at a Glance (as of June 13, 2025)</h2>

<strong>Total Active Cases: 7,131</strong>

Top States by Active Cases: Kerala (2055), Gujarat (1358), West Bengal (747), Delhi (714), Maharashtra (629)

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India is again facing a concerning but seemingly controlled increase in Covid-19 cases. As of June 13, 2025, the active case count of the country is 7,131, as per the Ministry of Health and Family Welfare. Although new daily cases increased by 33 and three more deaths were added—two in Maharashtra and one in Madhya Pradesh—the overall trend indicates a potential plateau and even a slight dip, which gives optimistic hopes.The most recent state-by-state Covid-19 dashboard published by the Ministry of Health and Family Welfare indicates remarkable regional variations in infection incidence in India. Kerala remains to have the highest burden, with 2,055 active cases, out of which 110 were new cases in one day. Gujarat is the second worst-affected state with 1,358 active cases, which saw a steep daily jump of 77 cases. Other majorly affected states are West Bengal, with 747 active cases; Delhi, with 714 cases; and Maharashtra, with 629 active infections. The Karnataka region showed a significant increase with 72 new cases, taking its active caseload to 395. On the other hand, there are no active Covid-19 cases in certain states like Arunachal Pradesh, Mizoram, and Manipur, hinting at effective containment measures. In spite of these diverse regional numbers, the overall national trend seems positively tentative. There were 1,420 new recoveries logged, elevating the total number of recovered or migrated persons to 10,976 for the year, which highlights India's resilience in its continuous Covid-19 response.The increase is credited mainly to new Omicron sub-variants, such as JN.1, LF.7, NB.1.8.1, and XFG, which are highly contagious but produce milder symptoms than previous strains. These variants are now listed as "Variants Under Monitoring" by the World Health Organization (WHO). While not yet classified as variants of concern, they necessitate heightened vigilance, particularly among high-risk groups.Experts advise against attributing these numbers to the onset of a full-blown wave. Rather, they refer to a seasonal surge, similar to the flu, which is consonant with the virus's post-pandemic shift towards an endemic pattern.Why Are Booster Shots Not Recommended?In light of India's high hybrid immunity from both vaccinations and past infections, health authorities as of now not recommending mass booster drives. Rather, targeted vaccination is being encouraged for:The elderlyImmunocompromised hostsPeople with chronic respiratory or cardiovascular diseaseThe Indian Medical Association and health professionals emphasize that this risk-based, strategic strategy is more effective protection than mass immunization campaigns.Even with the recent upsurge, health workers urge not panicking but remaining proactive. Distinguishing between Covid-19 and other common seasonal viral infections—often producing the same symptoms as fever, fatigue, and cough—is now of paramount importance.Physicians and public health specialist, point out that exhaustion from sustained lookout can precipitate complacency. We can't ignore Covid-19 as a historical moment. It's very much still around—but controlled with the appropriate preventive measures.Actionable Tips To Prevent COVID InfectionNowadays, personal responsibility and daily routine are still your best protection. Here's how to protect yourself:1. Wear a Mask in Crowded Indoor SpacesThough mandates may have disappeared, masks are effective, especially in poorly ventilated spaces indoors, on public transportation, and in medical offices.2. Get Current with Targeted VaccinesIf you are in a high-risk group, speak with your health care provider about boosters that are available or trials soon to be under way for new variant-specific vaccines.3. Boost Your Immune SystemPrioritize a balanced diet, proper sleep, and regular physical activity in order to maintain your immune system strong against not only Covid-19 but also other flu and seasonal diseases.4. Practice HygieneGood hygiene habits such as regular handwashing, the use of sanitizers, and not touching your face while in public can significantly minimize the risk of transmission.5. Stay Away from CrowdsIf you are symptomatic—or have someone living with you who is—skip gatherings and go remote work whenever possible.6. Identify Symptoms EarlyNotice signs such as fever, chronic cough, body pain, fatigue, and taste/smell loss. Test early and self-isolate to avoid transmission.7. Seek Medical HelpParticularly if above 60 years or with underlying conditions, don't wait even for minor symptoms. Early treatment can be life-saving.The India Covid-19 situation is serious but under control. Yes, the active cases are more than 7,100, but the recovery rates are robust, and the fatalities are few and limited to the vulnerable groups.Instead of fear, this time it requires a recommitment to public health practices—from mask-wearing when necessary to symptom-watching and protecting the vulnerable.Key Figures at a Glance (as of June 13, 2025)Total Active Cases: 7,131New Cases in 24 Hours: 33Total Deaths (2025): 78Top States by Active Cases: Kerala (2055), Gujarat (1358), West Bengal (747), Delhi (714), Maharashtra (629)Recovered in 2025: 10,976 and risingDeath IN Last 24 Hours: 1 (Kerala)

covid-19 active cases cross 7,100 in india but signs point to a slowdown—how to stay protected now?

New Once-a-Week Pill May Transform Schizophrenia Treatment, Lancet Study Finds

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A team of researchers from MIT, New York Medical College, and Lyndra Therapeutics have introduced a once-a-week oral pill for <span>schizophrenia</span>. Published in The Lancet Psychiatry, this new treatment model could transform how antipsychotic medications are administered—enhancing patient compliance, improving long-term outcomes, and reducing relapse risk.

One of the most formidable challenges in treating schizophrenia is ensuring patients consistently take their medication. Daily dosing can be a significant hurdle, particularly in psychiatric conditions where cognitive and emotional symptoms hinder memory and motivation.

Enter the newly designed pill: a once-a-week oral capsule featuring a star-shaped drug delivery system that slowly releases risperidone over seven days. The innovation, led by Giovanni Traverso of MIT and Leslie Citrome of New York Medical College, aims to simplify schizophrenia treatment and drastically improve medication adherence.

"We’ve converted something that had to be taken once a day into a weekly oral solution using a novel delayed-release technology," said Traverso, also a gastroenterologist at Brigham and Women’s Hospital. “This innovation can be adapted for a variety of medications."

<h2>How Does The Star-Shaped Drug Delivery Device Work?</h2>

Roughly the size of a multivitamin, the capsule houses a six-armed, foldable device that expands once it reaches the stomach. This unique shape keeps the device in the stomach for about a week, allowing the steady release of medication.

Over time, each arm breaks off and safely passes through the digestive tract. This ensures the body gradually absorbs the medication while preventing gastrointestinal blockages. “It’s a breakthrough that allows drug delivery in a controlled and sustained manner,” said Dr. Citrome.

In the Phase III trial, 83 participants with schizophrenia were enrolled across five clinical sites in the US. Of these, 45 patients completed the full five-week regimen, taking one risperidone-loaded capsule per week.

The results were compelling. Drug levels peaked immediately post-dose and tapered slowly over the week. The consistency was superior to daily oral dosing, where patient-administered pills often result in fluctuating drug concentrations.

Symptom control, measured using the Positive and Negative Syndrome Scale (PANSS), remained stable across the board. Patients did not experience the spikes and troughs commonly observed with daily oral intake, a factor often linked to symptom relapses and hospitalizations.

<h2>Does This This Offer Minimal Side Effects With Major Potential?</h2>

The trial noted only mild side effects such as acid reflux and constipation, which were temporary and manageable. Importantly, the pill demonstrated an impressive safety profile over the trial duration.

“This really validates our hypothesis from over a decade ago—that a once-weekly oral drug delivery capsule could function as a depot system in the gastrointestinal tract,” Traverso remarked.

Beyond schizophrenia, the research team is already eyeing broader applications for this delivery system. Phase I trials are being planned for drugs used in managing conditions like hypertension, asthma, and even for oral contraceptives.

The capsule’s ease of use, combined with its potential to deliver various drugs, makes it an attractive option for chronic conditions where daily adherence is challenging. Patients often prefer oral medications over injections, and this technology could serve as a bridge between convenience and efficacy.

Schizophrenia affects approximately 24 million people worldwide, according to the WHO. Medication adherence remains one of the key challenges in managing the condition. The consequences of missed doses can be severe—leading to relapse, hospitalization, or deterioration in quality of life.

The once-a-week oral capsule has the potential to fill this long-standing gap, offering hope for better disease control and reduced burden on caregivers and healthcare systems.

Dr. Richard Scranton, chief medical officer of Lyndra Therapeutics and senior author of the study, emphasized that the results support moving forward toward FDA approvals. “We’re incredibly optimistic about what this means for the future of psychiatric and chronic disease management.”

Lyndra Therapeutics and MIT are currently preparing for larger Phase III studies to confirm safety and efficacy on a broader scale. If successful, the capsule could be submitted for FDA approval within the next few years.

“This marks a paradigm shift in how we think about oral drug delivery,” added Robert Langer, MIT’s renowned bioengineer and co-founder of Lyndra. “And we’re just getting started.”

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mental health breakthrough

weekly psychiatric medication

A team of researchers from MIT, New York Medical College, and Lyndra Therapeutics have introduced a once-a-week oral pill for schizophrenia. Published in The Lancet Psychiatry, this new treatment model could transform how antipsychotic medications are administered—enhancing patient compliance, improving long-term outcomes, and reducing relapse risk.One of the most formidable challenges in treating schizophrenia is ensuring patients consistently take their medication. Daily dosing can be a significant hurdle, particularly in psychiatric conditions where cognitive and emotional symptoms hinder memory and motivation.Enter the newly designed pill: a once-a-week oral capsule featuring a star-shaped drug delivery system that slowly releases risperidone over seven days. The innovation, led by Giovanni Traverso of MIT and Leslie Citrome of New York Medical College, aims to simplify schizophrenia treatment and drastically improve medication adherence."We’ve converted something that had to be taken once a day into a weekly oral solution using a novel delayed-release technology," said Traverso, also a gastroenterologist at Brigham and Women’s Hospital. “This innovation can be adapted for a variety of medications."How Does The Star-Shaped Drug Delivery Device Work?Roughly the size of a multivitamin, the capsule houses a six-armed, foldable device that expands once it reaches the stomach. This unique shape keeps the device in the stomach for about a week, allowing the steady release of medication.Over time, each arm breaks off and safely passes through the digestive tract. This ensures the body gradually absorbs the medication while preventing gastrointestinal blockages. “It’s a breakthrough that allows drug delivery in a controlled and sustained manner,” said Dr. Citrome.Promising Phase III ResultsIn the Phase III trial, 83 participants with schizophrenia were enrolled across five clinical sites in the US. Of these, 45 patients completed the full five-week regimen, taking one risperidone-loaded capsule per week.The results were compelling. Drug levels peaked immediately post-dose and tapered slowly over the week. The consistency was superior to daily oral dosing, where patient-administered pills often result in fluctuating drug concentrations.Symptom control, measured using the Positive and Negative Syndrome Scale (PANSS), remained stable across the board. Patients did not experience the spikes and troughs commonly observed with daily oral intake, a factor often linked to symptom relapses and hospitalizations.Does This This Offer Minimal Side Effects With Major Potential?The trial noted only mild side effects such as acid reflux and constipation, which were temporary and manageable. Importantly, the pill demonstrated an impressive safety profile over the trial duration.“This really validates our hypothesis from over a decade ago—that a once-weekly oral drug delivery capsule could function as a depot system in the gastrointestinal tract,” Traverso remarked.What are the Other Application?Beyond schizophrenia, the research team is already eyeing broader applications for this delivery system. Phase I trials are being planned for drugs used in managing conditions like hypertension, asthma, and even for oral contraceptives.The capsule’s ease of use, combined with its potential to deliver various drugs, makes it an attractive option for chronic conditions where daily adherence is challenging. Patients often prefer oral medications over injections, and this technology could serve as a bridge between convenience and efficacy.Schizophrenia affects approximately 24 million people worldwide, according to the WHO. Medication adherence remains one of the key challenges in managing the condition. The consequences of missed doses can be severe—leading to relapse, hospitalization, or deterioration in quality of life.The once-a-week oral capsule has the potential to fill this long-standing gap, offering hope for better disease control and reduced burden on caregivers and healthcare systems.Dr. Richard Scranton, chief medical officer of Lyndra Therapeutics and senior author of the study, emphasized that the results support moving forward toward FDA approvals. “We’re incredibly optimistic about what this means for the future of psychiatric and chronic disease management.”Lyndra Therapeutics and MIT are currently preparing for larger Phase III studies to confirm safety and efficacy on a broader scale. If successful, the capsule could be submitted for FDA approval within the next few years.“This marks a paradigm shift in how we think about oral drug delivery,” added Robert Langer, MIT’s renowned bioengineer and co-founder of Lyndra. “And we’re just getting started.”

new once-a-week pill may transform schizophrenia treatment, lancet study finds

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