Although seeing uniquely colored people in cartoons and on screen, can you imagine seeing one in real life? It is not fiction, but blue people do exist. The Fugates, a family from rural Kentucky's Troublesome Creek, were well-known for their unique, blue-colored skin. People who met them often said they were "blue all over" or "as blue as Lake Louise." This wasn’t a one-off thing, this rare trait was passed down through their family. Their story became more widely known after a baby, Benjamin "Benjy" Stacy, was born with blue skin in 1975, prompting doctors to investigate the unusual phenomenon, according to the New York Post. Family Mystery of Blue Skin Solved When Benjy Stacy was born with a dark blue hue, doctors were baffled. The baby was transferred to a medical center, but physicians remained perplexed. That's when Benjy's grandmother offered a crucial clue, asking if they had ever heard of the "blue Fugates of Troublesome Creek." It was discovered that the baby was a descendant of this family, which traced its origins back to a French orphan named Martin Fugate who settled in Kentucky in 1820. Both Martin and his wife, Elizabeth Smart, unknowingly carried a rare recessive gene for a condition called methemoglobinemia. What Causes One’s Skin To Turn Blue? The Jamaica Hospital Medical Center methemoglobinemia is a rare blood disorder where red blood cells contain an unusually high amount of methemoglobin. Unlike normal hemoglobin, methemoglobin cannot carry oxygen effectively to the body's tissues. This lack of oxygenation gives the blood a dark, chocolate-like color, which, in turn, makes the skin appear blue and the lips purple. The Fugate family's isolated community and intermarriage over generations led to the persistence of this recessive gene, ensuring that the condition was passed down. One notable descendant, Luna Fugate, was described as "the bluest woman I ever saw." Methemoglobinemia can be either inherited, like in the Fugate family, or it can be acquired. Acquired cases are more common and are typically caused by exposure to certain medications or chemicals, such as nitrates, silver, or benzocaine. Symptoms of this rare disease can include: Bluish-colored skinSeizuresHeadachesShortness of breathFatigueCan You Cure This Blue Skin-Condition? In the early 1960s, two Fugate family members, who had grown tired of their blue appearance, sought medical help. A hematologist named Madison Cawein diagnosed their condition and found a simple but effective treatment: methylene blue dye. When ingested, this dye helps the body convert the dysfunctional methemoglobin back into regular hemoglobin. Within minutes of taking the dose, the Fugates' skin would turn a normal pinkish color. This solution provided a way to manage the condition and effectively “cured” them of their blue hue. Benjy Stacy, the last known living descendant with the trait, lost his blue coloration by age seven, though his lips and fingertips still turn blue when he is cold. Are There Other Conditions That Cause Blue Skin? Another condition that can cause the skin to turn a bluish or silver color is argyria. This is a different disorder from methemoglobinemia and is caused by prolonged contact with silver compounds or ingesting silver salts. People at risk for argyria include those who:Take medications with silver salts as an ingredient.Use colloidal silver as a dietary supplement.Have jobs that expose them to silver, such as silver mining or refining.A famous modern case was Paul Karason, known as "Papa Smurf," who developed argyria after drinking a homemade colloidal silver mixture and using a silver-based salve. His story helped raise awareness about the potential dangers of ingesting silver products.