Two decades ago, veterinary epidemiologist Stephanie Venn-Watson made a remarkable discovery while studying the well-being of bottlenose dolphins trained by the US Navy. She found that the healthiest dolphins had elevated levels of a specific saturated fatty acid—C15:0. When these dolphins consumed fish rich in C15:0, their insulin, glucose, and cholesterol levels improved.Now, C15:0, also known as pentadecanoic acid, is gaining recognition in longevity research. Studies suggest that this molecule may help lower the risk of fatty liver disease, Type 2 diabetes, and heart disease—and potentially even reverse these chronic conditions. Additionally, C15:0 is being explored for its ability to improve sleep, boost energy levels, and support joint health, drawing comparisons to well-known anti-aging drugs like rapamycin and metformin.Venn-Watson, along with her husband Eric, a Navy physician, harnessed the potential of C15:0 by launching the supplement Fatty15 under the Seraphina Therapeutics brand in 2021. She further details her journey from marine mammal research to longevity science in her book, The Longevity Nutrient, arguing that C15:0 could be a key factor in extending human healthspan.How Does C15:0 Work?Like omega-3 fatty acids, C15:0 is considered an essential nutrient that the body cannot produce in sufficient amounts, requiring dietary intake or supplementation. However, research suggests that C15:0 may offer broader health benefits than omega-3.This fatty acid activates AMPK, an enzyme essential for maintaining cellular energy balance. AMPK activity declines with age, leading to chronic inflammation and metabolic disturbances. Additionally, C15:0 inhibits mTOR, a protein linked to aging and cellular dysfunction. By targeting so-called “zombie cells” that have stopped dividing but continue to release harmful signals, C15:0 may help mitigate age-related diseases.C15:0 also influences receptors responsible for regulating immunity, metabolism, mood, sleep, and appetite, potentially offering widespread health benefits.Where Can You Get C15:0?C15:0 is primarily found in whole-fat dairy products such as milk, butter, sour cream, and certain cheeses. According to Venn-Watson, one tablespoon of butter provides approximately 75 milligrams of C15:0. Other sources include high-oleic sunflower oil, meat, seafood, and seeds.For those looking to supplement their intake, a daily dosage of 100 to 200 mg is recommended. Fatty15, Venn-Watson’s supplement, contains 100 mg of pure C15:0 per capsule. To make C15:0 more accessible, her team is developing it as a food fortifier.How Long Does It Take to See Results?Venn-Watson notes that about half of fatty15 users report experiencing benefits within two weeks, while 72% observe noticeable effects within 16 weeks. Some customers have reported improved sleep, enhanced hair and nail growth, and overall better well-being.While dietary supplements like fatty15 do not require the rigorous testing of prescription medications, Venn-Watson emphasizes that extensive safety studies and controlled clinical trials have shown no adverse effects.Is C15:0 More Effective Than Other Longevity Compounds?Comparisons with other longevity molecules have placed C15:0 in an impressive position. Rapamycin, originally used to prevent organ rejection in transplant patients, is widely studied for its anti-aging properties. Similarly, metformin, a diabetes medication, has been investigated for its potential lifespan-extending effects. According to Venn-Watson, recent research suggests that fatty15 slightly outperformed rapamycin in cellular repair benefits while significantly surpassing metformin in effectiveness.As research into C15:0 continues, its potential role in longevity and disease prevention could make it a game-changer in health and wellness.