With summer season on, tick season begins—ushering in a new wave of concern for emerging infectious diseases. Among them is the Powassan virus (POWV), a rare but deadly tick-borne illness that recently claimed the life of 62-year-old Kevin Boyce from Massachusetts, sending shockwaves through the medical community and his grieving family. His story is not just tragic—it's a critical warning for the public as tick-borne illnesses quietly surge across the country.In April 2024, Kevin Boyce experienced what he initially believed to be flu-like symptoms—headaches, vomiting, and body fatigue. Within days, those symptoms escalated dramatically. He collapsed in his home and was rushed to Massachusetts General Hospital, where doctors diagnosed him with Powassan virus, a rare virus transmitted by tick bites. Despite aggressive treatment, Kevin succumbed to the virus after his brain experienced severe swelling—an extreme complication known as encephalitis, or inflammation of the brain.His family describes the ordeal as watching “his brain blow up,” underlining the silent danger of a virus that many Americans have never heard of.What Is Powassan Virus?The Powassan virus is named after the town of Powassan, Ontario, where it was first identified in 1958. Though rare, it is part of a group of viruses known as flaviviruses—the same family that includes Zika, dengue, and West Nile virus.The virus is transmitted by the Ixodes scapularis, commonly known as the black-legged or deer tick, which is also responsible for the spread of Lyme disease. However, unlike Lyme, which typically requires more than 24 hours of tick attachment to transmit, Powassan virus can be transmitted in as little as 15 minutes, according to the Massachusetts Department of Health.Symptoms of Powassan Virus carried in TicksSymptoms of Powassan virus typically appear between 7 to 30 days after a tick bite. These symptoms may include:FeverHeadacheVomitingWeaknessConfusionLoss of coordinationSeizuresDifficulty speakingIn severe cases, the virus causes encephalitis (brain inflammation) or myelitis (spinal cord inflammation), which can lead to permanent neurological damage. According to Yale Medicine, about 10% of these severe cases are fatal, and approximately 50% of survivors suffer from long-term neurological complications.What Kind Of Ticks Carry The Powassan Virus?The Powassan virus is primarily carried by two types of ticks in the United States:Ixodes scapularis – commonly known as the black-legged tick or deer tick, found predominantly in the Northeast and upper Midwest.Ixodes cookei – also known as the groundhog tick, which is more often found in wooded or rural areas, especially near wildlife like woodchucks and skunks.Of these, the deer tick (Ixodes scapularis) poses the greater public health risk, as it also transmits Lyme disease, and it's more likely to bite humans. Powassan virus can be transmitted in as little as 15 minutes after the tick attaches—much faster than other tick-borne infections like Lyme.Because of their size (as small as a poppy seed in the nymph stage) and tendency to attach in hard-to-notice areas, these ticks often go undetected, making early prevention and tick checks critical after spending time outdoors.Is Prevention Is the Only Protection?Perhaps the most concerning aspect of Powassan virus is the absence of any vaccine or antiviral treatment. Unlike Lyme disease, which can be treated with antibiotics, Powassan has no direct medical countermeasures. The only approach is preventative care—which makes awareness critical.To avoid tick bites, the Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH) recommend the following:Wear long sleeves and pants when outdoors, preferably light-colored clothing to easily spot ticksTuck pants into socks or use tape to seal clothing gapsUse insect repellents containing DEET, permethrin, or picaridinStick to the center of hiking trails to avoid brushing against tick-laden bushesCheck for ticks on your body, clothes, pets, and gear immediately after being outdoorsShower and wash clothes in hot water soon after returning insideIf a tick is found, remove it with fine-tipped tweezers as soon as possibleRecent findings from the University of Massachusetts Amherst’s New England Center of Excellence in Vector-Borne Diseases (NEWVEC) reveal a startling truth: while Powassan virus remains rare in reported cases, it may be significantly underdiagnosed.A study published in Clinical Microbiology and Infection, led by microbiologist Stephen Rich, highlights that many people bitten by Powassan-positive ticks don’t develop symptoms or seek healthcare. In their passive surveillance study, none of the 38 people bitten by infected ticks reported subsequent illness, suggesting that mild or asymptomatic cases are flying under the radar.The same research revealed that black-legged ticks bite over 1.36 million people annually in the U.S., based on data from the TickReport testing service in Massachusetts. While Lyme disease has a known high transmission rate, the estimated exposure to Powassan virus ranges from 3,000 to 5,000 people annually, many of whom may never realize they were infected.Why Powassan Cases Are Rising?Despite being rare historically, Powassan virus is on the rise in the United States, particularly in the Northeast and Midwest. In 2024 alone, 54 cases were reported nationwide, with 12 cases in Massachusetts. Over the last decade, human cases have increased fourfold, signaling that the threat is becoming more prevalent.According to the CDC, since 2004, the U.S. has recorded 311 hospitalizations and 44 deaths due to Powassan virus, a number that experts warn may be just the tip of the iceberg.The rise in infections may be fueled by:Climate change, which extends the tick season and habitatGrowing deer populations, which host these ticksHuman encroachment into wooded areas, increasing tick exposureCo-Infections and ComplexityEven more concerning, ticks that test positive for Powassan virus are often co-infected with other dangerous pathogens, including:Borrelia burgdorferi (Lyme disease)Babesia microti (Babesiosis)Anaplasma phagocytophilum (Anaplasmosis)Borrelia miyamotoiThis means a single tick bite could expose a person to multiple serious illnesses, compounding the risk and complicating diagnosis.