After finally shedding those stubborn pounds with the help of a miracle drug—only to look in the mirror and hardly recognize your reflection. That’s the unexpected twist many users of Ozempic, the wildly popular weight-loss and diabetes medication, are now facing. From Hollywood red carpets to everyday clinics, this injectable GLP-1 drug has become the go-to for quick body transformations. But there's a catch—while your waistline may shrink, your facial features might too. Say hello to “Ozempic mouth,” a bizarre new side effect that's raising both brows and concern. As more patients report sagging skin, hollow cheeks, and deep mouth wrinkles, the question arises: Is the cost of weight loss more than just financial? Originally designed as a treatment for type 2 diabetes, the drug's active ingredient, semaglutide, mimics the GLP-1 hormone to regulate blood sugar and suppress appetite. But as its off-label use for rapid weight loss explodes in popularity — especially among celebrities — so do the concerns about its unintended consequences.The latest? A perplexing and increasingly common condition dubbed “Ozempic Mouth.”Much like its predecessor “Ozempic Face”, which made headlines for causing gaunt, hollowed facial features, Ozempic Mouth refers to a very specific set of cosmetic changes — sagging skin around the mouth, deepened folds at the corners of the lips, increased vertical wrinkles, and drooping along the chin and lower face. The result is a prematurely aged look that’s difficult to reverse without cosmetic intervention.What is ‘Ozempic Mouth’?The popularity of GLP-1 drugs like Ozempic, Mounjaro, and Wegovy has surged across the US and globally. Recent 2024 data suggests that as many as 1 in 8 Americans have tried a GLP-1 agonist — a number expected to climb as these medications become more accessible and culturally normalized.But as weight comes off quickly, it doesn’t always do so evenly — and therein lies the problem. Semaglutide doesn’t distinguish between fat deposits. It targets subcutaneous fat — the layer just beneath the skin that gives the face its youthful plumpness. While shedding belly and thigh fat may be welcome, losing fat in the delicate perioral region (around the mouth) leads to a sunken, drawn-out appearance.The skin becomes thinner and more wrinkled, with what many are calling ‘lipstick lines’. Patients come in alarmed by how aged their face suddenly looks — particularly around the lips and chin.Celebrities like Sharon Osbourne, Whoopi Goldberg, and Rebel Wilson — all of whom have openly discussed their Ozempic use — have been spotted with increasingly pronounced facial changes. Fans have noted visible differences: sharper jawlines, sagging cheeks, and tight-lipped smiles that hint at underlying volume loss.This rapid facial transformation has made “Ozempic Mouth” a buzzword in dermatology offices across the globe, with patients urgently seeking remedies to counteract the unintended side effect of their newly slimmed-down physiques.To combat the effects of Ozempic Mouth, many are turning to dermal fillers — injectable treatments that restore volume, reduce wrinkles, and add subtle plumpness to the skin. According to experts, filler procedures have tripled in the U.S. in the past decade, with 5.3 million performed in 2023 alone, up from 1.8 million in 2010.Fillers can smooth the appearance of wrinkles and add fullness back to areas like the lips, nasolabial folds, and chin but these fixes don’t come cheap — with treatments ranging from $700 to $2,000 per syringe, depending on the provider and location.Another alternative growing in popularity is Thermage, a non-invasive radiofrequency treatment that tightens the skin by stimulating collagen production. While not immediate, the results typically become visible in four to six months and can last up to two years.Thermage works best when used as a preventative, ideally, people on Ozempic should start the treatment early in their weight-loss journey to minimize skin laxity.Other Strange Ozempic Side Effects“Ozempic Mouth” is just one of several strange new phenomena reported with GLP-1 medications. The broader term “Ozempic Face” describes the sunken appearance seen in the cheeks, under eyes, and temples — and now “Ozempic Feet” and “Ozempic Butt” are entering the lexicon.Ozempic Feet refers to skin laxity and thinning skin on the tops of the feet, sometimes making bones more pronounced and shoes uncomfortable. Meanwhile, Ozempic Butt describes the sudden disappearance of fat from the buttocks, leaving some users self-conscious about their drastically altered silhouettes."I can feel every bone in my backside now,” one user confessed on a social forum, echoing a growing concern among rapid weight-loss patients.GLP-1 drugs like Ozempic have revolutionized weight-loss treatment, giving hope to many struggling with obesity and related health conditions but as the aesthetic consequences of these medications become more visible, especially among public figures, experts are urging caution.This is a medical therapy — not a beauty shortcut, warn experts. Rapid weight loss always has a physical cost. Understanding how it affects your body, especially your face, is key to setting realistic expectations.As with any medical intervention, the decision to start a GLP-1 drug should be made in consultation with a licensed healthcare provider — with full knowledge of both the benefits and the very real, sometimes bizarre, side effects.